isoflurane has been researched along with Cognitive Decline in 68 studies
Isoflurane: A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.
| Excerpt | Relevance | Reference |
|---|---|---|
| " One patient in the propofol group developed delirium compared to zero in desflurane." | 9.24 | The effect of desflurane versus propofol anesthesia on postoperative delirium in elderly obese patients undergoing total knee replacement: A randomized, controlled, double-blinded clinical trial. ( Goodman, S; Huddleston, J; Lemmens, HJ; Maloney, W; Sommer, BR; Tanaka, P, 2017) |
| "To compare the incidence of postoperative cognitive dysfunction (POCD) in elderly surgical patients (>60years) receiving different anesthetics (propofol, sevoflurane, or isoflurane) and to identify potential biomarkers of POCD in this patient population." | 9.24 | Effect of propofol, sevoflurane, and isoflurane on postoperative cognitive dysfunction following laparoscopic cholecystectomy in elderly patients: A randomized controlled trial. ( Geng, YJ; Wu, QH; Zhang, RQ, 2017) |
| "Based on these findings, this study suggested that isoflurane exposure during pregnancy in rats could cause neuroinflammation and death of embryos as well as impairment of cognitive function in the offspring rats." | 8.31 | Alfaxalone Alleviates Neurotoxicity and Cognitive Impairment Induced by Isoflurane Anesthesia in Offspring Rats. ( Chen, Y; Guo, Y; Li, Z; Liu, Q; Qing, M; Sheng, Y; Xie, L; Zhao, X; Zhou, Z, 2023) |
| "In isoflurane-induced neuro-inflammation and cognitive dysfunction, BDNF-AS showed a significant protective effect on the neurological impairment induced by isoflurane through modulating miR-214-3p." | 8.31 | Knockdown of lncRNA BDNF-AS alleviates isoflurane-induced neuro-inflammation and cognitive dysfunction through modulating miR-214-3p. ( Jin, Y; Lu, Y; Mao, Y; Wang, L; Yuan, Y, 2023) |
| "6-h duration isoflurane anesthesia induced cognitive dysfunction and increased RyR3 mRNA levels in hippocampus." | 8.31 | Activating ryanodine receptor improves isoflurane-induced cognitive dysfunction. ( Gu, X; Liu, B; Ma, Z; Qian, Y; Su, Y; Xia, T; Zhou, Q; Zhu, X, 2023) |
| " The aim and objective of the current experimental study was to access the neuroprotective effect of sevoflurane against isoflurane induced cognitive dysfunction in rats." | 8.31 | Neuroprotective potential of sevoflurane against isoflurane induced cognitive dysfunction in rats via anti-inflammatory and antioxidant effect. ( Chen, Y; Gong, Y; Kang, P; Wang, J; Wei, Z, 2023) |
| " Compared to isoflurane anesthesia, propofol anesthesia exhibited less effect on spatial learning and memory of rats with cardiac surgery and contributed to a relative reduction in activated microglia in the hippocampus, a notable increase in miR-223-3p expression, and a decrease in inflammation." | 8.12 | Propofol alleviates postoperative cognitive dysfunction by inhibiting inflammation via up-regulating miR-223-3p in aged rats. ( Cao, C; Deng, F; Lian, F; Liu, C; Zhou, Z, 2022) |
| "This study aimed to investigate the role and mechanism of long non-coding RNA maternally expressed gene 3 (MEG3) in cognitive dysfunction induced by isoflurane (ISO)." | 8.12 | Long non-coding RNA maternally expressed 3 (MEG3) regulates isoflurane-induced cognitive dysfunction by targeting miR-7-5p. ( Jin, Y; Li, G; Li, R; Li, X; Wang, H; Yao, Q, 2022) |
| "Enhancing GJs-Cx43 coupling can improve brain network abnormalities and cognitive impairment induced by long-term isoflurane anesthesia, its mechanisms might be associated with the regulation of oxidative stress and neuroinflammation." | 8.12 | Enhancement of astrocytic gap junctions Connexin43 coupling can improve long-term isoflurane anesthesia-mediated brain network abnormalities and cognitive impairment. ( Dong, R; Gu, X; Han, Y; Jiang, L; Lv, P; Ma, Z; Peng, L; Wang, Z; Xia, T; Zhang, B, 2022) |
| "To investigate the protective effects of metformin on the diabetic mice with cognitive impairment induced by the combination of streptozotocin (STZ) and isoflurane anesthesia." | 8.02 | Metformin improves cognitive impairment in diabetic mice induced by a combination of streptozotocin and isoflurane anesthesia. ( Li, P; Lv, Z; Zhang, J; Zhang, W; Zhao, L, 2021) |
| "Isoflurane is a commonly used inhalation anesthetic in the clinic, which can induce cognitive dysfunction and neuroinflammation." | 8.02 | Neuroprotective effect of miR-212-5p on isoflurane-induced cognitive dysfunction by inhibiting neuroinflammation. ( Cui, M; Jin, Y; Li, R; Li, X; Si, J; Yao, Q, 2021) |
| " Notably, multiple exposures to isoflurane (ISO) cause acute apoptotic cell death in the developing brain and long-term cognitive dysfunction." | 8.02 | Intranasal levosimendan prevents cognitive dysfunction and apoptotic response induced by repeated isoflurane exposure in newborn rats. ( Akyol, O; Demirgan, S; Erkalp, K; Pekmez, M; Selcan, A; Şengelen, A; Sevdi, MS; Temel, Z; Ulaş, O, 2021) |
| " To investigate the intervention of exogenous adiponectin in the elderly rats with cognitive dysfunction induced by isoflurane through mitogen-activated protein kinase (MAPK) signaling pathway in hippocampus." | 7.91 | Adiponectin improves isoflurane-induced cognitive dysfunction in elderly rats via inhibiting p38-MAPK signal pathway in hippocampus. ( Chen, BN; Luo, YP; Wang, X; Zhang, FX; Zhang, JC; Zhang, WJ; Zhao, Q, 2019) |
| "Volatile anesthetics, including isoflurane, have been reported to have negative effects on cognitive dysfunction characterized by cognitive deficits following anesthesia." | 7.91 | Effects of ADAM2 silencing on isoflurane-induced cognitive dysfunction via the P13K/Akt signaling pathway in immature rats. ( Yuan, CX; Zhang, BJ, 2019) |
| " The aim of the present study was to determine the role of HIF‑1α in isoflurane‑induced neuroinflammation and the resulting cognitive impairment." | 7.88 | Isoflurane‑induced postoperative cognitive dysfunction is mediated by hypoxia‑inducible factor‑1α‑dependent neuroinflammation in aged rats. ( Cao, Y; Guo, X; Li, L; Li, Z; Ma, L; Ni, C; Shi, C; Yang, N, 2018) |
| "VB12 can attenuate cognitive dysfunction induced by isoflurane anesthesia." | 7.85 | Effects of Vitamin B12 on postoperative cognitive dysfunction induced by isoflurane anesthesia in rats. ( Guo, SM; Sha, HY; Sha, MX; Zhao, JB, 2017) |
| " We aimed to investigate whether apigenin can attenuate isoflurane exposure-induced cognitive decline by regulating histone acetylation and inflammatory signaling." | 7.85 | Apigenin attenuates isoflurane-induced cognitive dysfunction via epigenetic regulation and neuroinflammation in aged rats. ( Chen, L; Jiang, C; Liu, N; Xie, W; Zhuang, W, 2017) |
| "These results suggest that ginsenoside Rb1 may attenuate the isoflurane/surgery-induced cognitive impairment by inhibiting neuroinflammation and oxidative stress pending future studies." | 7.85 | Ginsenoside Rb1 Attenuates Isoflurane/surgery-induced Cognitive Dysfunction via Inhibiting Neuroinflammation and Oxidative Stress. ( Ding, GN; Dong, P; Hong, FX; Miao, HH; Tian, M; Zhang, Y, 2017) |
| " Therefore, the present study aimed to determine the neuroprotective effects of nobiletin, and to evaluate whether it could ameliorate isoflurane‑induced cognitive impairment via antioxidant, anti‑inflammatory and anti‑apoptotic effects in aging rats." | 7.83 | Nobiletin ameliorates isoflurane-induced cognitive impairment via antioxidant, anti-inflammatory and anti-apoptotic effects in aging rats. ( Bi, J; Lei, W; Lu, J; Zhang, H, 2016) |
| "Mitochondrial dysfunction has been linked to the earliest pathogenesis of isoflurane-induced cognitive impairments in developing or aging mammalian brain." | 7.83 | BDNF pathway is involved in the protective effects of SS-31 on isoflurane-induced cognitive deficits in aging mice. ( Hao, S; Ji, M; Li, H; Li, K; Sun, X; Wu, J; Yang, J; Zhang, M, 2016) |
| "Isoflurane post-treatment may enhance autophagy by activating the AMPK/ULK1 signaling pathway and further inhibit the release of inflammatory factors from NLRP3 inflammasomes, thereby ameliorating neurological function and cognitive impairment and exerting a protective effect on the brain in CIRI rats." | 5.91 | Isoflurane Enhances Autophagy by Activating AMPK/ULK1, Inhibits NLRP3, and Reduces Cognitive Impairment After Cerebral Ischemia-Reperfusion Injury in Rats. ( Li, N; Li, Y; Ma, K; Qin, X; Wang, R; Wang, S; Yin, J; Zhai, J; Zhang, X, 2023) |
| "Metformin pretreatment before anesthesia enhanced cognitive performance in the novel object test." | 5.72 | Metformin alleviates prolonged isoflurane inhalation induced cognitive decline via reducing neuroinflammation in adult mice. ( Fang, X; Gu, X; Liu, S; Peng, L; Xia, T; Xie, W; Xu, J, 2022) |
| "Melatonin has been considered as an effective remedy for circadian rhythm shift." | 5.48 | Circadian rhythm resynchronization improved isoflurane-induced cognitive dysfunction in aged mice. ( Chu, S; Cui, Y; Gu, X; Li, X; Ma, Z; Qian, Y; Shao, X; Song, J; Xia, T; Xu, F, 2018) |
| "To compare the incidence of postoperative cognitive dysfunction (POCD) in elderly surgical patients (>60years) receiving different anesthetics (propofol, sevoflurane, or isoflurane) and to identify potential biomarkers of POCD in this patient population." | 5.24 | Effect of propofol, sevoflurane, and isoflurane on postoperative cognitive dysfunction following laparoscopic cholecystectomy in elderly patients: A randomized controlled trial. ( Geng, YJ; Wu, QH; Zhang, RQ, 2017) |
| " One patient in the propofol group developed delirium compared to zero in desflurane." | 5.24 | The effect of desflurane versus propofol anesthesia on postoperative delirium in elderly obese patients undergoing total knee replacement: A randomized, controlled, double-blinded clinical trial. ( Goodman, S; Huddleston, J; Lemmens, HJ; Maloney, W; Sommer, BR; Tanaka, P, 2017) |
| " The aim and objective of the current experimental study was to access the neuroprotective effect of sevoflurane against isoflurane induced cognitive dysfunction in rats." | 4.31 | Neuroprotective potential of sevoflurane against isoflurane induced cognitive dysfunction in rats via anti-inflammatory and antioxidant effect. ( Chen, Y; Gong, Y; Kang, P; Wang, J; Wei, Z, 2023) |
| "6-h duration isoflurane anesthesia induced cognitive dysfunction and increased RyR3 mRNA levels in hippocampus." | 4.31 | Activating ryanodine receptor improves isoflurane-induced cognitive dysfunction. ( Gu, X; Liu, B; Ma, Z; Qian, Y; Su, Y; Xia, T; Zhou, Q; Zhu, X, 2023) |
| "In isoflurane-induced neuro-inflammation and cognitive dysfunction, BDNF-AS showed a significant protective effect on the neurological impairment induced by isoflurane through modulating miR-214-3p." | 4.31 | Knockdown of lncRNA BDNF-AS alleviates isoflurane-induced neuro-inflammation and cognitive dysfunction through modulating miR-214-3p. ( Jin, Y; Lu, Y; Mao, Y; Wang, L; Yuan, Y, 2023) |
| "Based on these findings, this study suggested that isoflurane exposure during pregnancy in rats could cause neuroinflammation and death of embryos as well as impairment of cognitive function in the offspring rats." | 4.31 | Alfaxalone Alleviates Neurotoxicity and Cognitive Impairment Induced by Isoflurane Anesthesia in Offspring Rats. ( Chen, Y; Guo, Y; Li, Z; Liu, Q; Qing, M; Sheng, Y; Xie, L; Zhao, X; Zhou, Z, 2023) |
| "Enhancing GJs-Cx43 coupling can improve brain network abnormalities and cognitive impairment induced by long-term isoflurane anesthesia, its mechanisms might be associated with the regulation of oxidative stress and neuroinflammation." | 4.12 | Enhancement of astrocytic gap junctions Connexin43 coupling can improve long-term isoflurane anesthesia-mediated brain network abnormalities and cognitive impairment. ( Dong, R; Gu, X; Han, Y; Jiang, L; Lv, P; Ma, Z; Peng, L; Wang, Z; Xia, T; Zhang, B, 2022) |
| "This study aimed to investigate the role and mechanism of long non-coding RNA maternally expressed gene 3 (MEG3) in cognitive dysfunction induced by isoflurane (ISO)." | 4.12 | Long non-coding RNA maternally expressed 3 (MEG3) regulates isoflurane-induced cognitive dysfunction by targeting miR-7-5p. ( Jin, Y; Li, G; Li, R; Li, X; Wang, H; Yao, Q, 2022) |
| " Compared to isoflurane anesthesia, propofol anesthesia exhibited less effect on spatial learning and memory of rats with cardiac surgery and contributed to a relative reduction in activated microglia in the hippocampus, a notable increase in miR-223-3p expression, and a decrease in inflammation." | 4.12 | Propofol alleviates postoperative cognitive dysfunction by inhibiting inflammation via up-regulating miR-223-3p in aged rats. ( Cao, C; Deng, F; Lian, F; Liu, C; Zhou, Z, 2022) |
| "Isoflurane is a commonly used inhalation anesthetic in the clinic, which can induce cognitive dysfunction and neuroinflammation." | 4.02 | Neuroprotective effect of miR-212-5p on isoflurane-induced cognitive dysfunction by inhibiting neuroinflammation. ( Cui, M; Jin, Y; Li, R; Li, X; Si, J; Yao, Q, 2021) |
| " Notably, multiple exposures to isoflurane (ISO) cause acute apoptotic cell death in the developing brain and long-term cognitive dysfunction." | 4.02 | Intranasal levosimendan prevents cognitive dysfunction and apoptotic response induced by repeated isoflurane exposure in newborn rats. ( Akyol, O; Demirgan, S; Erkalp, K; Pekmez, M; Selcan, A; Şengelen, A; Sevdi, MS; Temel, Z; Ulaş, O, 2021) |
| "To investigate the protective effects of metformin on the diabetic mice with cognitive impairment induced by the combination of streptozotocin (STZ) and isoflurane anesthesia." | 4.02 | Metformin improves cognitive impairment in diabetic mice induced by a combination of streptozotocin and isoflurane anesthesia. ( Li, P; Lv, Z; Zhang, J; Zhang, W; Zhao, L, 2021) |
| "DUSP14 may effectively protect against isoflurane-induced neuro-inflammation, brain damage and cognitive dysfunction, indicating that DUSP14 may be a potential predictor and therapeutic target for POCD." | 3.96 | Neuroprotective effect of DUSP14 overexpression against isoflurane-induced inflammatory response, pyroptosis and cognitive impairment in aged rats through inhibiting the NLRP3 inflammasome. ( Peng, J; Que, YY; Zhang, FX; Zhu, T, 2020) |
| "Volatile anesthetics, including isoflurane, have been reported to have negative effects on cognitive dysfunction characterized by cognitive deficits following anesthesia." | 3.91 | Effects of ADAM2 silencing on isoflurane-induced cognitive dysfunction via the P13K/Akt signaling pathway in immature rats. ( Yuan, CX; Zhang, BJ, 2019) |
| " To investigate the intervention of exogenous adiponectin in the elderly rats with cognitive dysfunction induced by isoflurane through mitogen-activated protein kinase (MAPK) signaling pathway in hippocampus." | 3.91 | Adiponectin improves isoflurane-induced cognitive dysfunction in elderly rats via inhibiting p38-MAPK signal pathway in hippocampus. ( Chen, BN; Luo, YP; Wang, X; Zhang, FX; Zhang, JC; Zhang, WJ; Zhao, Q, 2019) |
| "Isoflurane may not only accelerate the process of Alzheimer's disease (AD), but increase the risk of incidence of postoperative cognitive dysfunction (POCD)." | 3.88 | Isoflurane anesthesia in aged mice and effects of A1 adenosine receptors on cognitive impairment. ( Hao, XR; Lian, QQ; Lin, H; Liu, HC; Liu, J; Pan, YZ; Shen, T; Wang, CM; Zhou, JP; Zuo, CL, 2018) |
| " The aim of the present study was to determine the role of HIF‑1α in isoflurane‑induced neuroinflammation and the resulting cognitive impairment." | 3.88 | Isoflurane‑induced postoperative cognitive dysfunction is mediated by hypoxia‑inducible factor‑1α‑dependent neuroinflammation in aged rats. ( Cao, Y; Guo, X; Li, L; Li, Z; Ma, L; Ni, C; Shi, C; Yang, N, 2018) |
| " Isoflurane induced cognitive impairment and hippocampal inflammation in aged mice but not in young mice." | 3.88 | Critical role of NLRP3-caspase-1 pathway in age-dependent isoflurane-induced microglial inflammatory response and cognitive impairment. ( Cao, L; Chen, Y; Meng, S; Peng, S; Wang, Z; Zuo, Z, 2018) |
| "VB12 can attenuate cognitive dysfunction induced by isoflurane anesthesia." | 3.85 | Effects of Vitamin B12 on postoperative cognitive dysfunction induced by isoflurane anesthesia in rats. ( Guo, SM; Sha, HY; Sha, MX; Zhao, JB, 2017) |
| " We aimed to investigate whether apigenin can attenuate isoflurane exposure-induced cognitive decline by regulating histone acetylation and inflammatory signaling." | 3.85 | Apigenin attenuates isoflurane-induced cognitive dysfunction via epigenetic regulation and neuroinflammation in aged rats. ( Chen, L; Jiang, C; Liu, N; Xie, W; Zhuang, W, 2017) |
| "These results suggest that ginsenoside Rb1 may attenuate the isoflurane/surgery-induced cognitive impairment by inhibiting neuroinflammation and oxidative stress pending future studies." | 3.85 | Ginsenoside Rb1 Attenuates Isoflurane/surgery-induced Cognitive Dysfunction via Inhibiting Neuroinflammation and Oxidative Stress. ( Ding, GN; Dong, P; Hong, FX; Miao, HH; Tian, M; Zhang, Y, 2017) |
| "Mitochondrial dysfunction has been linked to the earliest pathogenesis of isoflurane-induced cognitive impairments in developing or aging mammalian brain." | 3.83 | BDNF pathway is involved in the protective effects of SS-31 on isoflurane-induced cognitive deficits in aging mice. ( Hao, S; Ji, M; Li, H; Li, K; Sun, X; Wu, J; Yang, J; Zhang, M, 2016) |
| "Although it is known that isoflurane exposure or surgery leads to post-operative cognitive dysfunction in aged rodents, there are few clinical interventions and treatments available to prevent this disorder." | 3.83 | Minocycline attenuates post-operative cognitive impairment in aged mice by inhibiting microglia activation. ( Fang, H; Liao, QW; Liu, H; Wang, HL; Xue, ZG, 2016) |
| " Therefore, the present study aimed to determine the neuroprotective effects of nobiletin, and to evaluate whether it could ameliorate isoflurane‑induced cognitive impairment via antioxidant, anti‑inflammatory and anti‑apoptotic effects in aging rats." | 3.83 | Nobiletin ameliorates isoflurane-induced cognitive impairment via antioxidant, anti-inflammatory and anti-apoptotic effects in aging rats. ( Bi, J; Lei, W; Lu, J; Zhang, H, 2016) |
| "Isoflurane post-treatment may enhance autophagy by activating the AMPK/ULK1 signaling pathway and further inhibit the release of inflammatory factors from NLRP3 inflammasomes, thereby ameliorating neurological function and cognitive impairment and exerting a protective effect on the brain in CIRI rats." | 1.91 | Isoflurane Enhances Autophagy by Activating AMPK/ULK1, Inhibits NLRP3, and Reduces Cognitive Impairment After Cerebral Ischemia-Reperfusion Injury in Rats. ( Li, N; Li, Y; Ma, K; Qin, X; Wang, R; Wang, S; Yin, J; Zhai, J; Zhang, X, 2023) |
| "Metformin pretreatment before anesthesia enhanced cognitive performance in the novel object test." | 1.72 | Metformin alleviates prolonged isoflurane inhalation induced cognitive decline via reducing neuroinflammation in adult mice. ( Fang, X; Gu, X; Liu, S; Peng, L; Xia, T; Xie, W; Xu, J, 2022) |
| "Isoflurane treatment led to the increase of neurological function score and escape latency, and the reduction of time spent in the original quadrant in rats." | 1.56 | Neuroprotective effects of miR-142-5p downregulation against isoflurane-induced neurological impairment. ( Wang, H; Wei, Y; Xie, C; Zhang, Y, 2020) |
| "Melatonin has been considered as an effective remedy for circadian rhythm shift." | 1.48 | Circadian rhythm resynchronization improved isoflurane-induced cognitive dysfunction in aged mice. ( Chu, S; Cui, Y; Gu, X; Li, X; Ma, Z; Qian, Y; Shao, X; Song, J; Xia, T; Xu, F, 2018) |
| "Cognitive dysfunction is one of the most common postoperative complications experienced by older patients after anesthesia and surgery but the cause remains unknown." | 1.48 | Isoflurane anesthesia impairs the expression of immune neuromodulators in the hippocampus of aged mice. ( Crosby, G; Culley, DJ; Friese, MB; Nathan, M, 2018) |
| "However, the pathogenesis of AD-related cognitive impairments induced by isoflurane anesthesia remains elusive." | 1.46 | Isoflurane anesthesia promotes cognitive impairment by inducing expression of β-amyloid protein-related factors in the hippocampus of aged rats. ( Fan, H; Guan, W; Hu, X; Li, B; Luan, L; Tang, Q; Zhang, S, 2017) |
| "After 36 days, the rats with mild cognitive impairment were randomly divided into 4 groups (n=18)." | 1.43 | [Effect of sub-anesthetic doses of isoflurane and propofol on postoperative cognition and underlying mechanism in rats with mild cognitive impairment]. ( Liu, SY; Wang, GL; Wang, HB; Wang, HY, 2016) |
| "Morris water maze analysis showed cognitive impairments in isoflurane-exposed rats." | 1.43 | Postnatal Isoflurane Exposure Induces Cognitive Impairment and Abnormal Histone Acetylation of Glutamatergic Systems in the Hippocampus of Adolescent Rats. ( Fang, J; Liang, B, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 38 (55.88) | 24.3611 |
| 2020's | 30 (44.12) | 2.80 |
| Authors | Studies |
|---|---|
| Han, F | 1 |
| Zhao, J | 2 |
| Zhao, G | 1 |
| Zhang, W | 2 |
| Zhao, L | 1 |
| Zhang, J | 3 |
| Li, P | 1 |
| Lv, Z | 1 |
| Lian, F | 2 |
| Cao, C | 1 |
| Deng, F | 1 |
| Liu, C | 2 |
| Zhou, Z | 2 |
| Wang, Y | 2 |
| Zhao, S | 1 |
| Li, G | 2 |
| Wang, D | 1 |
| Jin, Y | 4 |
| Liu, T | 2 |
| Song, J | 2 |
| Zhou, Q | 2 |
| Chu, S | 2 |
| Liu, Y | 1 |
| Zhao, X | 3 |
| Ma, Z | 7 |
| Xia, T | 7 |
| Gu, X | 7 |
| Li, X | 4 |
| Yao, Q | 2 |
| Li, R | 2 |
| Wang, H | 4 |
| Dong, R | 2 |
| Han, Y | 2 |
| Jiang, L | 2 |
| Liu, S | 2 |
| Zhang, F | 2 |
| Peng, L | 3 |
| Wang, Z | 3 |
| Que, Y | 1 |
| Peng, J | 3 |
| Zhang, Z | 2 |
| Zhang, D | 1 |
| He, M | 1 |
| Zuo, C | 1 |
| Ma, J | 2 |
| Pan, Y | 1 |
| Zheng, D | 1 |
| Chen, C | 1 |
| Ruan, N | 1 |
| Su, Y | 2 |
| Nan, H | 1 |
| Lian, Q | 1 |
| Lin, H | 3 |
| Agarwal, S | 1 |
| Schaefer, ML | 1 |
| Krall, C | 1 |
| Johns, RA | 2 |
| Xu, J | 2 |
| Xie, W | 3 |
| Fang, X | 1 |
| Ma, Y | 2 |
| Ji, Y | 1 |
| Xu, L | 1 |
| Li, Z | 7 |
| Ge, S | 1 |
| Lv, P | 1 |
| Zhang, B | 1 |
| Huang, X | 1 |
| Su, Z | 1 |
| Zhang, S | 2 |
| Xu, X | 2 |
| Yang, B | 1 |
| Guo, Y | 1 |
| Liu, Q | 2 |
| Qing, M | 1 |
| Sheng, Y | 1 |
| Chen, Y | 4 |
| Xie, L | 1 |
| Wang, L | 1 |
| Mao, Y | 1 |
| Lu, Y | 1 |
| Yuan, Y | 1 |
| Wu, N | 1 |
| Liu, H | 3 |
| Lv, X | 1 |
| Sun, Y | 2 |
| Jiang, H | 1 |
| Abdelkareem, E | 1 |
| Tayee, EM | 1 |
| Taha, AM | 1 |
| Abdelellatif, MS | 1 |
| Zhai, J | 1 |
| Li, N | 1 |
| Zhang, X | 2 |
| Li, Y | 2 |
| Ma, K | 1 |
| Wang, R | 1 |
| Qin, X | 1 |
| Yin, J | 1 |
| Wang, S | 1 |
| Liu, B | 1 |
| Zhu, X | 2 |
| Qian, Y | 2 |
| Gong, Y | 1 |
| Kang, P | 1 |
| Wang, J | 3 |
| Wei, Z | 1 |
| Joseph, DJ | 1 |
| Liang, G | 1 |
| Wei, H | 1 |
| Tang, X | 1 |
| Li, S | 4 |
| Chi, X | 1 |
| Luo, A | 2 |
| Zhao, Y | 3 |
| Song, Y | 1 |
| Gong, X | 1 |
| Lu, Q | 1 |
| Peng, S | 2 |
| Li, J | 3 |
| Huang, S | 1 |
| Du, X | 1 |
| Xie, C | 1 |
| Zhang, Y | 3 |
| Wei, Y | 1 |
| Que, YY | 1 |
| Zhu, T | 1 |
| Zhang, FX | 2 |
| Nie, Y | 1 |
| Yan, T | 1 |
| Ni, C | 3 |
| Zheng, H | 1 |
| Kang, Z | 1 |
| Zeng, J | 1 |
| Demirgan, S | 2 |
| Akyol, O | 2 |
| Temel, Z | 2 |
| Şengelen, A | 2 |
| Pekmez, M | 2 |
| Ulaş, O | 1 |
| Sevdi, MS | 2 |
| Erkalp, K | 2 |
| Selcan, A | 2 |
| Si, J | 1 |
| Cui, M | 1 |
| Geng, YJ | 1 |
| Wu, QH | 1 |
| Zhang, RQ | 1 |
| Hu, X | 1 |
| Guan, W | 1 |
| Luan, L | 1 |
| Li, B | 1 |
| Tang, Q | 1 |
| Fan, H | 1 |
| Sha, HY | 1 |
| Zhao, JB | 1 |
| Sha, MX | 1 |
| Guo, SM | 1 |
| Tanaka, P | 1 |
| Goodman, S | 1 |
| Sommer, BR | 1 |
| Maloney, W | 1 |
| Huddleston, J | 1 |
| Lemmens, HJ | 1 |
| Miao, HH | 1 |
| Ding, GN | 1 |
| Hong, FX | 1 |
| Dong, P | 1 |
| Tian, M | 1 |
| Kang, E | 1 |
| Jiang, D | 1 |
| Ryu, YK | 1 |
| Lim, S | 1 |
| Kwak, M | 1 |
| Gray, CD | 1 |
| Xu, M | 2 |
| Choi, JH | 1 |
| Junn, S | 1 |
| Kim, J | 1 |
| Schaefer, M | 1 |
| Song, H | 1 |
| Ming, GL | 1 |
| Mintz, CD | 1 |
| Chen, L | 1 |
| Zhuang, W | 1 |
| Jiang, C | 1 |
| Liu, N | 1 |
| Zuo, CL | 1 |
| Wang, CM | 1 |
| Liu, J | 1 |
| Shen, T | 1 |
| Zhou, JP | 1 |
| Hao, XR | 1 |
| Pan, YZ | 1 |
| Liu, HC | 1 |
| Lian, QQ | 1 |
| Cao, Y | 4 |
| Ma, L | 2 |
| Li, L | 1 |
| Yang, N | 3 |
| Shi, C | 2 |
| Guo, X | 5 |
| Cui, Y | 1 |
| Xu, F | 2 |
| Shao, X | 1 |
| Meng, S | 1 |
| Cao, L | 1 |
| Zuo, Z | 2 |
| Kawano, T | 1 |
| Yamanaka, D | 1 |
| Aoyama, B | 1 |
| Tateiwa, H | 1 |
| Shigematsu-Locatelli, M | 1 |
| Nishigaki, A | 1 |
| Iwata, H | 1 |
| Locatelli, FM | 1 |
| Yokoyama, M | 1 |
| Wang, YB | 1 |
| Xie, JQ | 1 |
| Liu, W | 2 |
| Zhang, RZ | 1 |
| Huang, SH | 1 |
| Xing, YH | 1 |
| Zhu, H | 1 |
| Fang, H | 2 |
| Zhang, BJ | 1 |
| Yuan, CX | 1 |
| Friese, MB | 1 |
| Nathan, M | 1 |
| Culley, DJ | 1 |
| Crosby, G | 1 |
| Lu, X | 1 |
| Xiao-Qing, C | 1 |
| Demirgan, R | 1 |
| Sasaki Russell, JM | 1 |
| Chinn, GA | 1 |
| Maharjan, D | 1 |
| Eichbaum, Y | 1 |
| Sall, JW | 1 |
| Yang, S | 1 |
| Xu, H | 1 |
| Guo, M | 1 |
| Yao, Y | 1 |
| Huang, Z | 1 |
| Lin, D | 1 |
| He, J | 1 |
| Han, D | 1 |
| Tian, X | 1 |
| Manyande, A | 1 |
| Xiang, H | 1 |
| Zhang, JC | 1 |
| Zhang, WJ | 1 |
| Zhao, Q | 1 |
| Chen, BN | 1 |
| Wang, X | 1 |
| Luo, YP | 1 |
| Liu, SY | 1 |
| Wang, HB | 1 |
| Wang, HY | 1 |
| Wang, GL | 1 |
| Wu, J | 1 |
| Zhang, M | 1 |
| Li, H | 1 |
| Sun, X | 2 |
| Hao, S | 1 |
| Ji, M | 1 |
| Yang, J | 1 |
| Li, K | 1 |
| Wang, HL | 1 |
| Xue, ZG | 1 |
| Liao, QW | 1 |
| Liang, B | 1 |
| Fang, J | 1 |
| Cai, N | 1 |
| Zhou, S | 1 |
| Chen, X | 2 |
| Zheng, S | 1 |
| Si, Q | 1 |
| Hua, FZ | 1 |
| Ying, J | 1 |
| Wang, XF | 1 |
| Hu, YH | 1 |
| Liang, YP | 1 |
| Xu, GH | 1 |
| Sen, N | 1 |
| Tan, L | 1 |
| Wang, W | 1 |
| Bi, J | 1 |
| Zhang, H | 1 |
| Lu, J | 1 |
| Lei, W | 1 |
| Xia, C | 1 |
| Jaw, J | 1 |
| Liang, L | 1 |
| Dong, M | 1 |
| Jiang, A | 1 |
| Zheng, B | 1 |
| Lai, R | 1 |
| Yi, D | 1 |
| Zhou, Y | 1 |
| Chui, D | 1 |
| Xu, G | 1 |
| Huang, YL | 1 |
| Li, PL | 1 |
| Guo, HM | 1 |
| Han, XP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Gut Microbiome and Blood Indices in Patients With AD and Their Spousal Caregivers[NCT05601856] | 104 participants (Anticipated) | Observational | 2022-12-15 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for isoflurane and Cognitive Decline
| Article | Year |
|---|---|
Effect of propofol, sevoflurane, and isoflurane on postoperative cognitive dysfunction following laparoscopic cholecystectomy in elderly patients: A randomized controlled trial.
Topics: Aged; Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Biomarkers; Cholecystectomy, La | 2017 |
The effect of desflurane versus propofol anesthesia on postoperative delirium in elderly obese patients undergoing total knee replacement: A randomized, controlled, double-blinded clinical trial.
Topics: Aged; Anesthesia, General; Arthroplasty, Replacement, Knee; Cognitive Dysfunction; Delirium; Desflur | 2017 |
66 other studies available for isoflurane and Cognitive Decline
| Article | Year |
|---|---|
Prolonged Volatile Anesthetic Exposure Exacerbates Cognitive Impairment and Neuropathology in the 5xFAD Mouse Model of Alzheimer's Disease.
Topics: Alzheimer Disease; Anesthetics, Inhalation; Animals; Cognitive Dysfunction; Disease Models, Animal; | 2021 |
Metformin improves cognitive impairment in diabetic mice induced by a combination of streptozotocin and isoflurane anesthesia.
Topics: Anesthesia; Animals; Cognitive Dysfunction; Diabetes Mellitus, Experimental; Disease Models, Animal; | 2021 |
Propofol alleviates postoperative cognitive dysfunction by inhibiting inflammation via up-regulating miR-223-3p in aged rats.
Topics: Animals; Cognitive Dysfunction; Humans; Inflammation; Isoflurane; MicroRNAs; Postoperative Cognitive | 2022 |
Neuroprotective Effect of HOTAIR Silencing on Isoflurane-Induced Cognitive Dysfunction via Sponging microRNA-129-5p and Inhibiting Neuroinflammation.
Topics: Animals; Apoptosis; Cognitive Dysfunction; Isoflurane; MicroRNAs; Neuroinflammatory Diseases; Neurop | 2022 |
The role of 5-HT
Topics: Anesthetics, Inhalation; Animals; Cognitive Dysfunction; Hippocampus; Isoflurane; Learning; Male; Me | 2022 |
Long non-coding RNA maternally expressed 3 (MEG3) regulates isoflurane-induced cognitive dysfunction by targeting miR-7-5p.
Topics: Animals; Apoptosis; Cell Proliferation; Cognitive Dysfunction; Isoflurane; MicroRNAs; Rats; RNA, Lon | 2022 |
Connexin 43 gap junction-mediated astrocytic network reconstruction attenuates isoflurane-induced cognitive dysfunction in mice.
Topics: Animals; Astrocytes; Cognitive Dysfunction; Connexin 43; Gap Junctions; Isoflurane; Male; Mice; Mice | 2022 |
Repeated isoflurane exposures of neonatal rats contribute to cognitive dysfunction in juvenile animals: the role of miR-497 in isoflurane-induced neurotoxicity.
Topics: Animals; Animals, Newborn; Apoptosis; Cognitive Dysfunction; Hippocampus; Isoflurane; MicroRNAs; Rat | 2021 |
Isoflurane and Sevoflurane Induce Cognitive Impairment in Neonatal Rats by Inhibiting Neural Stem Cell Development Through Microglial Activation, Neuroinflammation, and Suppression of VEGFR2 Signaling Pathway.
Topics: Anesthetics; Anesthetics, Inhalation; Animals; Animals, Newborn; Cognitive Dysfunction; Hippocampus; | 2022 |
Isoflurane Disrupts Postsynaptic Density-95 Protein Interactions Causing Neuronal Synapse Loss and Cognitive Impairment in Juvenile Mice via Canonical NO-mediated Protein Kinase-G Signaling.
Topics: Animals; Cognitive Dysfunction; Cyclic GMP-Dependent Protein Kinases; Disks Large Homolog 4 Protein; | 2022 |
Metformin alleviates prolonged isoflurane inhalation induced cognitive decline via reducing neuroinflammation in adult mice.
Topics: Anesthetics; Animals; Cognitive Dysfunction; COVID-19; Isoflurane; Metformin; Mice; Microglia; Neuro | 2022 |
Obesity aggravated hippocampal-dependent cognitive impairment after sleeve gastrectomy in C57/BL6J mice via SIRT1/CREB/BDNF pathway.
Topics: Animals; Blood Glucose; Brain-Derived Neurotrophic Factor; Cognitive Dysfunction; Dimethyl Sulfoxide | 2022 |
Enhancement of astrocytic gap junctions Connexin43 coupling can improve long-term isoflurane anesthesia-mediated brain network abnormalities and cognitive impairment.
Topics: Anesthesia; Animals; Astrocytes; Brain; Brain Diseases; Cognitive Dysfunction; Connexin 43; Gap Junc | 2022 |
ANGPTL2 Deletion Attenuates Neuroinflammation and Cognitive Dysfunction Induced by Isoflurane in Aged Mice through Modulating MAPK Pathway.
Topics: Angiopoietin-Like Protein 2; Animals; Cognitive Dysfunction; Inflammation; Isoflurane; Mice; Neuroin | 2023 |
Alfaxalone Alleviates Neurotoxicity and Cognitive Impairment Induced by Isoflurane Anesthesia in Offspring Rats.
Topics: Anesthesia; Anesthetics, Inhalation; Animals; Cognitive Dysfunction; Cytokines; Female; Hippocampus; | 2023 |
Knockdown of lncRNA BDNF-AS alleviates isoflurane-induced neuro-inflammation and cognitive dysfunction through modulating miR-214-3p.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cognitive Dysfunction; Inflammation; Isoflurane; MicroRN | 2023 |
Neobaicalein prevents isoflurane anesthesia-induced cognitive impairment in neonatal mice via regulating CREB1.
Topics: Anesthesia; Animals; Animals, Newborn; Apoptosis; Cognitive Dysfunction; Hippocampus; Isoflurane; Mi | 2023 |
Effect of Sevoflurane and Isoflurane on Post-Anaesthesia Cognitive Dysfunction in Normal and Type II Diabetic Rats.
Topics: Anesthesia; Animals; Caspase 3; Cognitive Dysfunction; Diabetes Mellitus, Experimental; Diabetes Mel | 2023 |
Isoflurane Enhances Autophagy by Activating AMPK/ULK1, Inhibits NLRP3, and Reduces Cognitive Impairment After Cerebral Ischemia-Reperfusion Injury in Rats.
Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Autophagy-Related Protein-1 Homolog; Brain Ischem | 2023 |
Activating ryanodine receptor improves isoflurane-induced cognitive dysfunction.
Topics: Anesthetics, Inhalation; Animals; Caffeine; Cognitive Dysfunction; Hippocampus; Isoflurane; Male; Mi | 2023 |
Neuroprotective potential of sevoflurane against isoflurane induced cognitive dysfunction in rats via anti-inflammatory and antioxidant effect.
Topics: Acetylcholine; Amyloid beta-Peptides; Anesthetics, Inhalation; Animals; Anti-Inflammatory Agents; An | 2023 |
Isoflurane mediated neuropathological and cognitive impairments in the triple transgenic Alzheimer's mouse model are associated with hippocampal synaptic deficits in an age-dependent manner.
Topics: Aging; Alzheimer Disease; Amyloid; Animals; Animals, Newborn; Apoptosis; Biomarkers; Cognitive Dysfu | 2019 |
NR2B receptor- and calpain-mediated KCC2 cleavage resulted in cognitive deficiency exposure to isoflurane.
Topics: Animals; Brain; Calpain; Cognitive Dysfunction; Isoflurane; K Cl- Cotransporters; Rats, Sprague-Dawl | 2020 |
Green tea polyphenols improve isoflurane-induced cognitive impairment via modulating oxidative stress.
Topics: Anesthetics, Inhalation; Animals; Cognitive Dysfunction; Hippocampus; Isoflurane; Male; Mice; Mice, | 2019 |
L-Theanine Attenuates Isoflurane-Induced Injury in Neural Stem Cells and Cognitive Impairment in Neonatal Mice.
Topics: Animals; Animals, Newborn; Apoptosis; Cell Survival; Cells, Cultured; Cognitive Dysfunction; Glutama | 2020 |
Neuroprotective effects of miR-142-5p downregulation against isoflurane-induced neurological impairment.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Cell Survival; Cognitive Dysfunction; Down-Regul | 2020 |
Neuroprotective effect of DUSP14 overexpression against isoflurane-induced inflammatory response, pyroptosis and cognitive impairment in aged rats through inhibiting the NLRP3 inflammasome.
Topics: Aging; Animals; Cognitive Dysfunction; Dual-Specificity Phosphatases; Inflammasomes; Inflammation; I | 2020 |
Propofol Attenuates Isoflurane-Induced Neurotoxicity and Cognitive Impairment in Fetal and Offspring Mice.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Animals, Newborn; Brain Chemistry; CA1 R | 2020 |
Sarm1 is Essential for Anesthesia-Induced Neuroinflammation and Cognitive Impairment in Aged Mice.
Topics: Aged; Anesthesia; Animals; Armadillo Domain Proteins; Calpain; Cognitive Dysfunction; Cytoskeletal P | 2022 |
Intranasal levosimendan prevents cognitive dysfunction and apoptotic response induced by repeated isoflurane exposure in newborn rats.
Topics: Administration, Intranasal; Anesthetics, Inhalation; Animals; Animals, Newborn; Apoptosis; Cognitive | 2021 |
Neuroprotective effect of miR-212-5p on isoflurane-induced cognitive dysfunction by inhibiting neuroinflammation.
Topics: Animals; Cognitive Dysfunction; Hippocampus; Isoflurane; Maze Learning; MicroRNAs; Neurons; Neuropro | 2021 |
Isoflurane anesthesia promotes cognitive impairment by inducing expression of β-amyloid protein-related factors in the hippocampus of aged rats.
Topics: Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Anesthesia, Inhalation; Anesthetics, In | 2017 |
Effects of Vitamin B12 on postoperative cognitive dysfunction induced by isoflurane anesthesia in rats.
Topics: Anesthetics, Inhalation; Animals; Caspase 3; Cognitive Dysfunction; Hippocampus; Interleukin-1beta; | 2017 |
Ginsenoside Rb1 Attenuates Isoflurane/surgery-induced Cognitive Dysfunction via Inhibiting Neuroinflammation and Oxidative Stress.
Topics: Anesthetics, Inhalation; Animals; Cognition; Cognitive Dysfunction; Female; Ginsenosides; Hippocampu | 2017 |
Early postnatal exposure to isoflurane causes cognitive deficits and disrupts development of newborn hippocampal neurons via activation of the mTOR pathway.
Topics: Anesthetics, Inhalation; Animals; Cognitive Dysfunction; Dendritic Spines; Environmental Exposure; H | 2017 |
Apigenin attenuates isoflurane-induced cognitive dysfunction via epigenetic regulation and neuroinflammation in aged rats.
Topics: Acetylation; Animals; Apigenin; Cognition; Cognition Disorders; Cognitive Dysfunction; Epigenesis, G | 2017 |
Isoflurane anesthesia in aged mice and effects of A1 adenosine receptors on cognitive impairment.
Topics: Aging; Amyloid beta-Peptides; Anesthetics, Inhalation; Animals; Cognitive Dysfunction; Isoflurane; M | 2018 |
Isoflurane‑induced postoperative cognitive dysfunction is mediated by hypoxia‑inducible factor‑1α‑dependent neuroinflammation in aged rats.
Topics: Anesthetics, Inhalation; Animals; Cognitive Dysfunction; Hippocampus; Hypoxia-Inducible Factor 1, al | 2018 |
Circadian rhythm resynchronization improved isoflurane-induced cognitive dysfunction in aged mice.
Topics: Aging; Anesthetics, Inhalation; Animals; Body Temperature; Circadian Rhythm; CLOCK Proteins; Cogniti | 2018 |
Critical role of NLRP3-caspase-1 pathway in age-dependent isoflurane-induced microglial inflammatory response and cognitive impairment.
Topics: Aging; Amino Acid Chloromethyl Ketones; Anesthetics, Inhalation; Animals; Caspase 1; Cell Line, Tran | 2018 |
Involvement of acute neuroinflammation in postoperative delirium-like cognitive deficits in rats.
Topics: Animals; Brain; Cognition; Cognition Disorders; Cognitive Dysfunction; Cytokines; Delirium; Fear; Hi | 2018 |
BACE1 gene silencing alleviates isoflurane anesthesia‑induced postoperative cognitive dysfunction in immature rats by activating the PI3K/Akt signaling pathway.
Topics: Amyloid Precursor Protein Secretases; Anesthetics, Inhalation; Animals; Apoptosis; Aspartic Acid End | 2018 |
Inflammation caused by peripheral immune cells across into injured mouse blood brain barrier can worsen postoperative cognitive dysfunction induced by isoflurane.
Topics: Animals; Blood-Brain Barrier; CD4-Positive T-Lymphocytes; Cognitive Dysfunction; Disease Models, Ani | 2018 |
Effects of ADAM2 silencing on isoflurane-induced cognitive dysfunction via the P13K/Akt signaling pathway in immature rats.
Topics: Age Factors; Anesthetics, Inhalation; Animals; Cognitive Dysfunction; Female; Fertilins; Gene Silenc | 2019 |
Isoflurane anesthesia impairs the expression of immune neuromodulators in the hippocampus of aged mice.
Topics: Aged; Aging; Anesthetics, Inhalation; Animals; Chemokine CCL2; Cognitive Dysfunction; Gene Expressio | 2018 |
Eleutheroside E attenuates isoflurane-induced cognitive dysfunction by regulating the α7-nAChR-NMDAR pathway.
Topics: Acetylcholine; Animals; Cognition; Cognitive Dysfunction; Glucosides; Hippocampus; Isoflurane; Ligna | 2019 |
Isoflurane exposure in infant rats acutely increases aquaporin 4 and does not cause neurocognitive impairment.
Topics: Anesthetics, Inhalation; Animals; Aquaporin 4; Brain Chemistry; Cognitive Dysfunction; Female; Hippo | 2019 |
Female rats are more vulnerable to lasting cognitive impairment after isoflurane exposure on postnatal day 4 than 7.
Topics: Age Factors; Anesthetics, Inhalation; Animals; Animals, Newborn; Behavior, Animal; Cell Death; Cereb | 2019 |
Lidocaine Attenuates Cognitive Impairment After Isoflurane Anesthesia by Reducing Mitochondrial Damage.
Topics: Anesthetics; Anesthetics, Inhalation; Animals; Apoptosis; bcl-2-Associated X Protein; Cell Line, Tum | 2019 |
Isoflurane-Induced Postoperative Neurovascular and Cognitive Dysfunction Is Associated with VEGF Overexpression in Aged Rats.
Topics: Aging; Anesthetics, Inhalation; Animals; Blood-Brain Barrier; Cognitive Dysfunction; Hippocampus; Is | 2019 |
Regional Metabolic Patterns of Abnormal Postoperative Behavioral Performance in Aged Mice Assessed by
Topics: Aging; Anesthesia; Animals; Anxiety; Aspartic Acid; Brain; Cerebral Cortex; Cognitive Dysfunction; F | 2020 |
Adiponectin improves isoflurane-induced cognitive dysfunction in elderly rats via inhibiting p38-MAPK signal pathway in hippocampus.
Topics: Adiponectin; Aging; Animals; Cognitive Dysfunction; Disease Models, Animal; Hippocampus; Isoflurane; | 2019 |
[Effect of sub-anesthetic doses of isoflurane and propofol on postoperative cognition and underlying mechanism in rats with mild cognitive impairment].
Topics: Anesthetics; Animals; Apoptosis; Cognition; Cognitive Dysfunction; Hippocampus; Humans; Isoflurane; | 2016 |
BDNF pathway is involved in the protective effects of SS-31 on isoflurane-induced cognitive deficits in aging mice.
Topics: Aging; Anesthetics, Inhalation; Animals; Brain-Derived Neurotrophic Factor; Cognitive Dysfunction; D | 2016 |
Minocycline attenuates post-operative cognitive impairment in aged mice by inhibiting microglia activation.
Topics: Aging; Animals; Anti-Inflammatory Agents; Appendectomy; Calcium-Binding Proteins; Cell Count; Cognit | 2016 |
Postnatal Isoflurane Exposure Induces Cognitive Impairment and Abnormal Histone Acetylation of Glutamatergic Systems in the Hippocampus of Adolescent Rats.
Topics: Acetylation; Animals; Butyric Acid; Cognitive Dysfunction; Excitatory Amino Acid Transporter 2; Glut | 2016 |
Neuroprotective effect of ginsenoside Rg1 prevents cognitive impairment induced by isoflurane anesthesia in aged rats via antioxidant, anti-inflammatory and anti-apoptotic effects mediated by the PI3K/AKT/GSK-3β pathway.
Topics: Age Factors; Anesthetics, Inhalation; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Bi | 2016 |
Naringenin pre-treatment inhibits neuroapoptosis and ameliorates cognitive impairment in rats exposed to isoflurane anesthesia by regulating the PI3/Akt/PTEN signalling pathway and suppressing NF-κB-mediated inflammation.
Topics: Administration, Inhalation; Anesthesia; Animals; Apoptosis; Behavior, Animal; Caspase 3; Cognitive D | 2016 |
Anesthetics and epigenetics.
Topics: Anesthetics; Brain; Cognitive Dysfunction; Epigenesis, Genetic; Histone Deacetylases; Humans; Isoflu | 2016 |
Pharmacological inhibition of PTEN attenuates cognitive deficits caused by neonatal repeated exposures to isoflurane via inhibition of NR2B-mediated tau phosphorylation in rats.
Topics: Animals; Animals, Newborn; Cognitive Dysfunction; Disks Large Homolog 4 Protein; Hippocampus; Intrac | 2017 |
Nobiletin ameliorates isoflurane-induced cognitive impairment via antioxidant, anti-inflammatory and anti-apoptotic effects in aging rats.
Topics: Aging; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Brain | 2016 |
Calcineurin/nuclear factor-κB signaling mediates isoflurane-induced hippocampal neuroinflammation and subsequent cognitive impairment in aged rats.
Topics: Aging; Anesthetics, Inhalation; Animals; Calcineurin; Cognitive Dysfunction; Hippocampus; Humans; In | 2017 |
Protective effects of salidroside against isoflurane-induced cognitive impairment in rats.
Topics: Acetylcholine; Acetylcholinesterase; Anesthetics, Inhalation; Animals; Antioxidants; Choline O-Acety | 2017 |
Critical role of P2X7 receptors in the neuroinflammation and cognitive dysfunction after surgery.
Topics: Anesthetics, Inhalation; Animals; Carotid Arteries; Cognitive Dysfunction; Desflurane; Encephalitis; | 2017 |
Anti-RAGE antibody attenuates isoflurane-induced cognitive dysfunction in aged rats.
Topics: Aging; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies; Blood-Br | 2017 |
Neuroprotective effects of artemisinin against isoflurane-induced cognitive impairments and neuronal cell death involve JNK/ERK1/2 signalling and improved hippocampal histone acetylation in neonatal rats.
Topics: Acetylation; Animals; Animals, Newborn; Apoptosis; Artemisinins; Cell Death; Cognitive Dysfunction; | 2017 |