isoflurane has been researched along with Cerebral Infarction in 19 studies
Isoflurane: A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.
Cerebral Infarction: The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of the cerebrum are generally classified by hemisphere (i.e., left vs. right), lobe (e.g., frontal lobe infarction), arterial distribution (e.g., INFARCTION, ANTERIOR CEREBRAL ARTERY), and etiology (e.g., embolic infarction).
| Excerpt | Relevance | Reference |
|---|---|---|
| "To obtain more information on the cerebral ischemia and reperfusion injury under desflurane anesthesia, we compared the infarct volume and lactate dehydrogenase (LDH) activity in rats subjected to focal cerebral ischemia during different concentration of desflurane anesthesia." | 7.72 | The effect of desflurane on ameliorating cerebral infarction in rats subjected to focal cerebral ischemia-reperfusion injury. ( Chih, CL; Huang, SS; Hung, WC; Lin, SM; Mok, MS; Tsai, SK, 2004) |
| " Our data show that isoflurane dosing typically used for general anesthesia (1%) or sedation (0." | 5.62 | Anesthetic and subanesthetic doses of isoflurane conditioning provides strong protection against delayed cerebral ischemia in a mouse model of subarachnoid hemorrhage. ( Athiraman, U; Jayaraman, K; Liu, M; Mehla, J; Yuan, J; Zipfel, GJ, 2021) |
| "The volumes of cerebral infarction and selective neuronal necrosis in the animals were determined by image analysis of hematoxylin and eosin-stained coronal brain sections." | 5.31 | Isoflurane delays but does not prevent cerebral infarction in rats subjected to focal ischemia. ( Cole, DJ; Drummond, JC; Kawaguchi, M; Kelly, PJ; Kimbro, JR; Patel, PM, 2000) |
| " Transient MCAO was induced during either isoflurane or ketamine/xylazine (ket/xyl) anesthesia with simultaneously measurement of cerebral blood flow (CBF) in 60 male Wistar rats (380-420 g)." | 5.17 | Effect of anesthesia and cerebral blood flow on neuronal injury in a rat middle cerebral artery occlusion (MCAO) model. ( Bleilevens, C; Dang, J; Goetzenich, A; Hein, M; Kipp, M; Roehl, AB; Rossaint, R; Tolba, R; Zoremba, N, 2013) |
| "To obtain more information on the cerebral ischemia and reperfusion injury under desflurane anesthesia, we compared the infarct volume and lactate dehydrogenase (LDH) activity in rats subjected to focal cerebral ischemia during different concentration of desflurane anesthesia." | 3.72 | The effect of desflurane on ameliorating cerebral infarction in rats subjected to focal cerebral ischemia-reperfusion injury. ( Chih, CL; Huang, SS; Hung, WC; Lin, SM; Mok, MS; Tsai, SK, 2004) |
| " Our data show that isoflurane dosing typically used for general anesthesia (1%) or sedation (0." | 1.62 | Anesthetic and subanesthetic doses of isoflurane conditioning provides strong protection against delayed cerebral ischemia in a mouse model of subarachnoid hemorrhage. ( Athiraman, U; Jayaraman, K; Liu, M; Mehla, J; Yuan, J; Zipfel, GJ, 2021) |
| "Because cerebral infarct develops within 24 h after the onset of ischemia, and several therapeutic agents have been shown to reduce the infarct volume when administered at 6 h post-ischemia, we hypothesized that attenuating BBB disruption at its peak (6 h post-ischemia) can also decrease the infarct volume measured at 24 h." | 1.46 | Anesthesia-Induced Hypothermia Attenuates Early-Phase Blood-Brain Barrier Disruption but Not Infarct Volume following Cerebral Ischemia. ( Chen, KB; Lai, TW; Lee, YD; Liao, KH; Liu, YC; Pan, YL; Poon, KS; Wang, HL, 2017) |
| "Isoflurane post-treatment increased the tolerance of rabbits to the amount of clots." | 1.42 | Isoflurane Post-Treatment Improves Outcome after an Embolic Stroke in Rabbits. ( Chen, F; Li, H; Long, Z; Yin, J; Zuo, Z, 2015) |
| "In the short-duration groups, cerebral infarct volumes were not significantly different between anaesthetics (short-duration halothane: 288 (61) mm(3), mean (SD); short-duration desflurane: 269 (71) mm(3), P>0." | 1.32 | Desflurane affords greater protection than halothane against focal cerebral ischaemia in the rat. ( Ducouret, P; Gérard, JL; Haelewyn, B; Hanouz, JL; MacKenzie, ET; Roussel, S; Yvon, A, 2003) |
| "The volumes of cerebral infarction and selective neuronal necrosis in the animals were determined by image analysis of hematoxylin and eosin-stained coronal brain sections." | 1.31 | Isoflurane delays but does not prevent cerebral infarction in rats subjected to focal ischemia. ( Cole, DJ; Drummond, JC; Kawaguchi, M; Kelly, PJ; Kimbro, JR; Patel, PM, 2000) |
| "Halothane-pretreated animals were subjected to MCAO 24 hours after AP." | 1.31 | Tolerance against ischemic neuronal injury can be induced by volatile anesthetics and is inducible NO synthase dependent. ( Dirnagl, U; Fütterer, C; Isaev, NK; Kapinya, KJ; Löwl, D; Maurer, M; Waschke, KF, 2002) |
| "The presence of cerebral hemorrhage after reperfusion was checked macroscopically and infarct volume with 2,3,5-triphenyltetrazolium staining." | 1.30 | Hyperglycemia and the vascular effects of cerebral ischemia. ( Betz, AL; Kawai, N; Keep, RF, 1997) |
| "Seven days later, the volume of cerebral infarction in the animals was determined by image analysis of hematoxylin and eosin-stained coronal brain sections." | 1.30 | Fentanyl does not increase brain injury after focal cerebral ischemia in rats. ( Cole, DJ; Drummond, JC; Kelly, PJ; Patel, PM; Soonthon-Brant, V; Watson, M, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.26) | 18.7374 |
| 1990's | 5 (26.32) | 18.2507 |
| 2000's | 5 (26.32) | 29.6817 |
| 2010's | 5 (26.32) | 24.3611 |
| 2020's | 3 (15.79) | 2.80 |
| Authors | Studies |
|---|---|
| Li, N | 1 |
| Zhang, X | 1 |
| Zhai, J | 1 |
| Yin, J | 2 |
| Ma, K | 1 |
| Wang, R | 1 |
| Qin, X | 1 |
| Li, Y | 1 |
| Dong, X | 1 |
| Wang, S | 1 |
| Liu, M | 2 |
| Jayaraman, K | 2 |
| Norris, AJ | 1 |
| Hussein, A | 1 |
| Nelson, JW | 1 |
| Mehla, J | 2 |
| Diwan, D | 1 |
| Vellimana, A | 1 |
| Abu-Amer, Y | 1 |
| Zipfel, GJ | 2 |
| Athiraman, U | 2 |
| Yuan, J | 1 |
| Zhao, L | 1 |
| Nowak, TS | 1 |
| Chen, F | 1 |
| Long, Z | 1 |
| Zuo, Z | 1 |
| Li, H | 1 |
| Liu, YC | 1 |
| Lee, YD | 1 |
| Wang, HL | 1 |
| Liao, KH | 1 |
| Chen, KB | 1 |
| Poon, KS | 1 |
| Pan, YL | 1 |
| Lai, TW | 1 |
| Lückl, J | 1 |
| Dreier, JP | 1 |
| Szabados, T | 1 |
| Wiesenthal, D | 1 |
| Bari, F | 1 |
| Greenberg, JH | 1 |
| Bleilevens, C | 1 |
| Roehl, AB | 1 |
| Goetzenich, A | 1 |
| Zoremba, N | 1 |
| Kipp, M | 1 |
| Dang, J | 1 |
| Tolba, R | 1 |
| Rossaint, R | 1 |
| Hein, M | 1 |
| Haelewyn, B | 1 |
| Yvon, A | 1 |
| Hanouz, JL | 1 |
| MacKenzie, ET | 1 |
| Ducouret, P | 1 |
| Gérard, JL | 1 |
| Roussel, S | 1 |
| Tsai, SK | 1 |
| Lin, SM | 1 |
| Hung, WC | 1 |
| Mok, MS | 1 |
| Chih, CL | 1 |
| Huang, SS | 1 |
| Kawai, N | 1 |
| Keep, RF | 1 |
| Betz, AL | 1 |
| Lavine, SD | 1 |
| Masri, LS | 1 |
| Levy, ML | 1 |
| Giannotta, SL | 1 |
| Patel, PM | 5 |
| Drummond, JC | 5 |
| Cole, DJ | 5 |
| Kelly, PJ | 5 |
| Watson, M | 2 |
| Soonthon-Brant, V | 1 |
| Harada, H | 1 |
| Kimbro, JR | 2 |
| Kawaguchi, M | 1 |
| Kapinya, KJ | 1 |
| Löwl, D | 1 |
| Fütterer, C | 1 |
| Maurer, M | 1 |
| Waschke, KF | 1 |
| Isaev, NK | 1 |
| Dirnagl, U | 1 |
| Milde, LN | 1 |
| Milde, JH | 1 |
| Lanier, WL | 1 |
| Michenfelder, JD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Inhalatorial Sedation in Patient With SAH Versus Conventional Intravenous Sedation (GAS-SAH)[NCT00830843] | Phase 4 | 13 participants (Actual) | Interventional | 2009-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for isoflurane and Cerebral Infarction
| Article | Year |
|---|---|
Effect of anesthesia and cerebral blood flow on neuronal injury in a rat middle cerebral artery occlusion (MCAO) model.
Topics: Anesthesia; Anesthetics; Animals; Blood Pressure; Brain Edema; Brain Injuries; Cerebral Infarction; | 2013 |
18 other studies available for isoflurane and Cerebral Infarction
| Article | Year |
|---|---|
Isoflurane and Netrin-1 combination therapy enhances angiogenesis and neurological recovery by improving the expression of HIF-1α-Netrin-1-UNC5B/VEGF cascade to attenuate cerebral ischemia injury.
Topics: Animals; Brain Injuries; Brain Ischemia; Cerebral Infarction; Disease Models, Animal; Hypoxia-Induci | 2022 |
Isoflurane Conditioning-Induced Delayed Cerebral Ischemia Protection in Subarachnoid Hemorrhage-Role of Inducible Nitric Oxide Synthase.
Topics: Animals; Brain Ischemia; Cerebral Infarction; Isoflurane; Male; Mice; Mice, Inbred C57BL; Mice, Knoc | 2023 |
Anesthetic and subanesthetic doses of isoflurane conditioning provides strong protection against delayed cerebral ischemia in a mouse model of subarachnoid hemorrhage.
Topics: Animals; Brain Ischemia; Cerebral Infarction; Disease Models, Animal; Isoflurane; Male; Mice; Mice, | 2021 |
Preconditioning cortical lesions reduce the incidence of peri-infarct depolarizations during focal ischemia in the Spontaneously Hypertensive Rat: interaction with prior anesthesia and the impact of hyperglycemia.
Topics: Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Cerebellar Cortex; Cerebral | 2015 |
Isoflurane Post-Treatment Improves Outcome after an Embolic Stroke in Rabbits.
Topics: Anesthetics, Inhalation; Animals; Cerebral Infarction; Embolism; Isoflurane; Male; Rabbits; Treatmen | 2015 |
Anesthesia-Induced Hypothermia Attenuates Early-Phase Blood-Brain Barrier Disruption but Not Infarct Volume following Cerebral Ischemia.
Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Arterial Occlusive Diseases; Blood-Brain B | 2017 |
Peri-infarct flow transients predict outcome in rat focal brain ischemia.
Topics: Anesthesia; Anesthesia, Inhalation; Animals; Basal Ganglia; Blood Pressure; Brain Ischemia; Carbon D | 2012 |
Desflurane affords greater protection than halothane against focal cerebral ischaemia in the rat.
Topics: Analysis of Variance; Anesthetics, Inhalation; Animals; Blood Pressure; Brain Ischemia; Carbon Dioxi | 2003 |
The effect of desflurane on ameliorating cerebral infarction in rats subjected to focal cerebral ischemia-reperfusion injury.
Topics: Animals; Cerebral Infarction; Cerebrovascular Circulation; Desflurane; Hemodynamics; Humans; Infarct | 2004 |
Hyperglycemia and the vascular effects of cerebral ischemia.
Topics: Anesthetics; Animals; Blood Glucose; Body Temperature; Cerebral Arteries; Cerebral Hemorrhage; Cereb | 1997 |
Temporary occlusion of the middle cerebral artery in intracranial aneurysm surgery: time limitation and advantage of brain protection.
Topics: Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, Intravenous; Aneurysm, Ruptured; Brai | 1997 |
Isoflurane and pentobarbital reduce the frequency of transient ischemic depolarizations during focal ischemia in rats.
Topics: Adjuvants, Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Cerebral Infarcti | 1998 |
Fentanyl does not increase brain injury after focal cerebral ischemia in rats.
Topics: Analgesics, Opioid; Anesthetics, Inhalation; Animals; Blood Pressure; Body Temperature; Carbon Dioxi | 1999 |
Isoflurane reduces N-methyl-D-aspartate toxicity in vivo in the rat cerebral cortex.
Topics: Anesthetics, Inhalation; Animals; Binding, Competitive; Cerebral Cortex; Cerebral Infarction; Dizoci | 1999 |
Isoflurane and pentobarbital reduce AMPA toxicity in vivo in the rat cerebral cortex.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthetics, Inhalation; Animals; Blood Pr | 2000 |
Isoflurane delays but does not prevent cerebral infarction in rats subjected to focal ischemia.
Topics: Anesthetics, Inhalation; Animals; Brain Ischemia; Cerebral Infarction; Hemodynamics; Isoflurane; Neu | 2000 |
Tolerance against ischemic neuronal injury can be induced by volatile anesthetics and is inducible NO synthase dependent.
Topics: Anesthetics, Inhalation; Animals; Body Temperature; Brain; Brain Infarction; Brain Ischemia; Cells, | 2002 |
Comparison of the effects of isoflurane and thiopental on neurologic outcome and neuropathology after temporary focal cerebral ischemia in primates.
Topics: Animals; Blood Gas Analysis; Blood Glucose; Blood Pressure; Brain; Cerebral Infarction; Electroencep | 1988 |