Page last updated: 2024-10-29

isoflurane and Cerebral Hemorrhage

isoflurane has been researched along with Cerebral Hemorrhage in 7 studies

Isoflurane: A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.

Cerebral Hemorrhage: Bleeding into one or both CEREBRAL HEMISPHERES including the BASAL GANGLIA and the CEREBRAL CORTEX. It is often associated with HYPERTENSION and CRANIOCEREBRAL TRAUMA.

Research Excerpts

ExcerptRelevanceReference
"5% isoflurane posttreatment, there was a significant reduction in brain edema, a decrease in apoptotic cell death, and a significant improvement in neurobehavioral deficits."7.77Isoflurane posttreatment reduces brain injury after an intracerebral hemorrhagic stroke in mice. ( Applegate, R; Fathali, N; Khatibi, NH; Ma, Q; Martin, R; Ostrowski, R; Rolland, W; Stier, G; Tang, J; Zhang, JH, 2011)
"24 h prior to intracerebral hemorrhage, C57BL/6J mice were preconditioned with a 4-h exposure to 1% isoflurane gas or room air."7.77Isoflurane preconditioning affords functional neuroprotection in a murine model of intracerebral hemorrhage. ( Appelboom, G; Connolly, ES; Ducruet, AF; Gigante, PR; Gorski, J; Haque, RM; Hwang, BY; Keesecker, SE; Kellner, CP; Yeh, ML, 2011)
"Isoflurane treatment did not reduce brain edema compared with controls in any of the applied isoflurane concentrations."5.39Lower doses of isoflurane treatment has no beneficial effects in a rat model of intracerebral hemorrhage. ( Esposito, E; Lo, EH; Mandeville, ET, 2013)
"Included in the study were 19 consecutive ventilated patients with intracerebral hemorrhage (12), subarachnoid hemorrhage (4), and ischemic stroke (3) who were switched from intravenous propofol or midazolam to inhalative isoflurane sedation for an average of 3."5.16Volatile isoflurane sedation in cerebrovascular intensive care patients using AnaConDa(®): effects on cerebral oxygenation, circulation, and pressure. ( Bösel, J; Brunn, B; Hacke, W; Nowak, F; Pérez, EB; Poli, S; Purrucker, JC; Renzland, J; Schiller, P; Steiner, T, 2012)
"Because the potential neuroprotective effect of isoflurane is controversial, we attempted to study whether isoflurane after treatment provides neuroprotection in a rat model of hyperglycemia-induced ischemic hemorrhagic transformation."3.77Isoflurane enhanced hemorrhagic transformation by impairing antioxidant enzymes in hyperglycemic rats with middle cerebral artery occlusion. ( He, Z; Hu, Q; Ma, Q; Tang, J; Zhan, Y; Zhang, J; Zhou, C, 2011)
"5% isoflurane posttreatment, there was a significant reduction in brain edema, a decrease in apoptotic cell death, and a significant improvement in neurobehavioral deficits."3.77Isoflurane posttreatment reduces brain injury after an intracerebral hemorrhagic stroke in mice. ( Applegate, R; Fathali, N; Khatibi, NH; Ma, Q; Martin, R; Ostrowski, R; Rolland, W; Stier, G; Tang, J; Zhang, JH, 2011)
"24 h prior to intracerebral hemorrhage, C57BL/6J mice were preconditioned with a 4-h exposure to 1% isoflurane gas or room air."3.77Isoflurane preconditioning affords functional neuroprotection in a murine model of intracerebral hemorrhage. ( Appelboom, G; Connolly, ES; Ducruet, AF; Gigante, PR; Gorski, J; Haque, RM; Hwang, BY; Keesecker, SE; Kellner, CP; Yeh, ML, 2011)
"Isoflurane treatment did not reduce brain edema compared with controls in any of the applied isoflurane concentrations."1.39Lower doses of isoflurane treatment has no beneficial effects in a rat model of intracerebral hemorrhage. ( Esposito, E; Lo, EH; Mandeville, ET, 2013)
"The presence of cerebral hemorrhage after reperfusion was checked macroscopically and infarct volume with 2,3,5-triphenyltetrazolium staining."1.30Hyperglycemia and the vascular effects of cerebral ischemia. ( Betz, AL; Kawai, N; Keep, RF, 1997)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (14.29)18.2507
2000's0 (0.00)29.6817
2010's5 (71.43)24.3611
2020's1 (14.29)2.80

Authors

AuthorsStudies
Wilkinson, CM1
Kalisvaart, ACJ1
Kung, TFC1
Maisey, DR1
Klahr, AC1
Dickson, CT1
Colbourne, F1
Esposito, E1
Mandeville, ET1
Lo, EH1
Hu, Q1
Ma, Q2
Zhan, Y1
He, Z1
Tang, J2
Zhou, C1
Zhang, J1
Khatibi, NH1
Rolland, W1
Ostrowski, R1
Fathali, N1
Martin, R1
Applegate, R1
Stier, G1
Zhang, JH1
Gigante, PR1
Appelboom, G1
Hwang, BY1
Haque, RM1
Yeh, ML1
Ducruet, AF1
Kellner, CP1
Gorski, J1
Keesecker, SE1
Connolly, ES1
Bösel, J1
Purrucker, JC1
Nowak, F1
Renzland, J1
Schiller, P1
Pérez, EB1
Poli, S1
Brunn, B1
Hacke, W1
Steiner, T1
Kawai, N1
Keep, RF1
Betz, AL1

Trials

1 trial available for isoflurane and Cerebral Hemorrhage

ArticleYear
Volatile isoflurane sedation in cerebrovascular intensive care patients using AnaConDa(®): effects on cerebral oxygenation, circulation, and pressure.
    Intensive care medicine, 2012, Volume: 38, Issue:12

    Topics: Aged; Aged, 80 and over; Anesthetics, Inhalation; Cerebral Hemorrhage; Cerebrovascular Circulation;

2012

Other Studies

6 other studies available for isoflurane and Cerebral Hemorrhage

ArticleYear
The collagenase model of intracerebral hemorrhage in awake, freely moving animals: The effects of isoflurane.
    Brain research, 2020, 02-01, Volume: 1728

    Topics: Animals; Blood Glucose; Cerebral Hemorrhage; Collagenases; Disease Models, Animal; Electroencephalog

2020
Lower doses of isoflurane treatment has no beneficial effects in a rat model of intracerebral hemorrhage.
    BMC neuroscience, 2013, Oct-20, Volume: 14

    Topics: Anesthetics, Inhalation; Animals; Brain; Brain Edema; Cerebral Hemorrhage; Disease Models, Animal; D

2013
Isoflurane enhanced hemorrhagic transformation by impairing antioxidant enzymes in hyperglycemic rats with middle cerebral artery occlusion.
    Stroke, 2011, Volume: 42, Issue:6

    Topics: Anesthetics, Inhalation; Animals; Antioxidants; Brain Ischemia; Catalase; Cerebral Hemorrhage; Hyper

2011
Isoflurane posttreatment reduces brain injury after an intracerebral hemorrhagic stroke in mice.
    Anesthesia and analgesia, 2011, Volume: 113, Issue:2

    Topics: Anesthetics, Inhalation; Animals; Apoptosis; Basal Ganglia; Behavior, Animal; Body Water; Brain; Bra

2011
Isoflurane preconditioning affords functional neuroprotection in a murine model of intracerebral hemorrhage.
    Acta neurochirurgica. Supplement, 2011, Volume: 111

    Topics: Albumins; Anesthetics, Inhalation; Animals; Brain; Brain Edema; Cerebral Hemorrhage; Disease Models,

2011
Hyperglycemia and the vascular effects of cerebral ischemia.
    Stroke, 1997, Volume: 28, Issue:1

    Topics: Anesthetics; Animals; Blood Glucose; Body Temperature; Cerebral Arteries; Cerebral Hemorrhage; Cereb

1997