isoflurane has been researched along with Brain Swelling in 25 studies
Isoflurane: A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of induced hypotension with isoflurane and labetalol on cerebral edema formation were compared following a cryogenic brain injury in dogs." | 9.07 | Cerebral edema formation in dogs following hypotension induced with isoflurane and labetalol. ( Bendo, AA; Capuano, C; Cottrell, JE; Kozlowski, PB; Mendeszoon, MH, 1993) |
| "Isoflurane significantly improved neurobehavioral function and brain edema at 24 hrs but not 72 hrs after subarachnoid hemorrhage." | 7.78 | Isoflurane delays the development of early brain injury after subarachnoid hemorrhage through sphingosine-related pathway activation in mice. ( Altay, O; Hasegawa, Y; Khatibi, NH; Sherchan, P; Suzuki, H; Tang, J; Zhang, JH, 2012) |
| "SAH aggravated neurological scores, brain edema, and blood-brain barrier permeability, which were prevented by 2% but not 1% isoflurane posttreatment." | 7.78 | Isoflurane attenuates blood-brain barrier disruption in ipsilateral hemisphere after subarachnoid hemorrhage in mice. ( Altay, O; Caner, B; Fujii, M; Hasegawa, Y; Krafft, PR; Suzuki, H; Tang, J; Zhang, JH, 2012) |
| "5% isoflurane posttreatment, there was a significant reduction in brain edema, a decrease in apoptotic cell death, and a significant improvement in neurobehavioral deficits." | 7.77 | Isoflurane posttreatment reduces brain injury after an intracerebral hemorrhagic stroke in mice. ( Applegate, R; Fathali, N; Khatibi, NH; Ma, Q; Martin, R; Ostrowski, R; Rolland, W; Stier, G; Tang, J; Zhang, JH, 2011) |
| "24 h prior to intracerebral hemorrhage, C57BL/6J mice were preconditioned with a 4-h exposure to 1% isoflurane gas or room air." | 7.77 | Isoflurane preconditioning affords functional neuroprotection in a murine model of intracerebral hemorrhage. ( Appelboom, G; Connolly, ES; Ducruet, AF; Gigante, PR; Gorski, J; Haque, RM; Hwang, BY; Keesecker, SE; Kellner, CP; Yeh, ML, 2011) |
| " Since volatile anesthetics elevate plasma amino acid concentrations, the influence of isoflurane on arterial plasma glutamate levels and brain edema formation was investigated in brain-injured rats." | 7.70 | Isoflurane doubles plasma glutamate and increases posttraumatic brain edema. ( Kempski, OS; Kroppenstedt, SN; Stover, JF; Thomale, UW; Unterberg, AW, 2000) |
| "To evaluate the impact of anesthetics on the evolution of a cerebral injury, 33 rabbits were subjected to a cryogenic brain lesion, followed by 10 h of anesthesia with 1 MAC halothane or isoflurane (n = 11 each) or with an equipotent dose of pentobarbital (n = 11)." | 7.67 | A comparison of the effects of halothane, isoflurane, and pentobarbital anesthesia on intracranial pressure and cerebral edema formation following brain injury in rabbits. ( Kaieda, R; Todd, MM; Warner, DS; Weeks, JB, 1989) |
| "The first step to treat aneurysmal subarachnoid hemorrhage (SAH) is aneurysmal obliteration under general anesthesia but not treat the SAH itself and the secondary effects." | 5.56 | Isoflurane versus sevoflurane for early brain injury and expression of sphingosine kinase 1 after experimental subarachnoid hemorrhage. ( Altay, BN; Altay, O; Calisir, V; Suzuki, H; Tang, J; Zhang, JH, 2020) |
| "Isoflurane treatment did not reduce brain edema compared with controls in any of the applied isoflurane concentrations." | 5.39 | Lower doses of isoflurane treatment has no beneficial effects in a rat model of intracerebral hemorrhage. ( Esposito, E; Lo, EH; Mandeville, ET, 2013) |
| " Transient MCAO was induced during either isoflurane or ketamine/xylazine (ket/xyl) anesthesia with simultaneously measurement of cerebral blood flow (CBF) in 60 male Wistar rats (380-420 g)." | 5.17 | Effect of anesthesia and cerebral blood flow on neuronal injury in a rat middle cerebral artery occlusion (MCAO) model. ( Bleilevens, C; Dang, J; Goetzenich, A; Hein, M; Kipp, M; Roehl, AB; Rossaint, R; Tolba, R; Zoremba, N, 2013) |
| "The study indicates that before as well as during hyperventilation, subdural ICP and AVDo2 are lower and CPP higher in propofol-anesthetized patients compared with patients anesthetized with isoflurane or sevoflurane." | 5.10 | Intracranial pressure and cerebral hemodynamic in patients with cerebral tumors: a randomized prospective study of patients subjected to craniotomy in propofol-fentanyl, isoflurane-fentanyl, or sevoflurane-fentanyl anesthesia. ( Cold, GE; Hauerberg, J; Holst, P; Landsfeldt, U; Mau, S; Olsen, KS; Petersen, CB; Petersen, KD, 2003) |
| "The effects of induced hypotension with isoflurane and labetalol on cerebral edema formation were compared following a cryogenic brain injury in dogs." | 5.07 | Cerebral edema formation in dogs following hypotension induced with isoflurane and labetalol. ( Bendo, AA; Capuano, C; Cottrell, JE; Kozlowski, PB; Mendeszoon, MH, 1993) |
| "Isoflurane significantly improved neurobehavioral function and brain edema at 24 hrs but not 72 hrs after subarachnoid hemorrhage." | 3.78 | Isoflurane delays the development of early brain injury after subarachnoid hemorrhage through sphingosine-related pathway activation in mice. ( Altay, O; Hasegawa, Y; Khatibi, NH; Sherchan, P; Suzuki, H; Tang, J; Zhang, JH, 2012) |
| "SAH aggravated neurological scores, brain edema, and blood-brain barrier permeability, which were prevented by 2% but not 1% isoflurane posttreatment." | 3.78 | Isoflurane attenuates blood-brain barrier disruption in ipsilateral hemisphere after subarachnoid hemorrhage in mice. ( Altay, O; Caner, B; Fujii, M; Hasegawa, Y; Krafft, PR; Suzuki, H; Tang, J; Zhang, JH, 2012) |
| "5% isoflurane posttreatment, there was a significant reduction in brain edema, a decrease in apoptotic cell death, and a significant improvement in neurobehavioral deficits." | 3.77 | Isoflurane posttreatment reduces brain injury after an intracerebral hemorrhagic stroke in mice. ( Applegate, R; Fathali, N; Khatibi, NH; Ma, Q; Martin, R; Ostrowski, R; Rolland, W; Stier, G; Tang, J; Zhang, JH, 2011) |
| "24 h prior to intracerebral hemorrhage, C57BL/6J mice were preconditioned with a 4-h exposure to 1% isoflurane gas or room air." | 3.77 | Isoflurane preconditioning affords functional neuroprotection in a murine model of intracerebral hemorrhage. ( Appelboom, G; Connolly, ES; Ducruet, AF; Gigante, PR; Gorski, J; Haque, RM; Hwang, BY; Keesecker, SE; Kellner, CP; Yeh, ML, 2011) |
| " Anesthesia was shown to interrupt soman-induced seizures and to attenuate edema and cell change in certain sensitive brain areas." | 3.74 | Cerebral edema induced in mice by a convulsive dose of soman. Evaluation through diffusion-weighted magnetic resonance imaging and histology. ( Bernabé, D; Carpentier, P; Delacour, C; Dorandeu, F; Foquin, A; Lahrech, H; Montigon, O; Segebarth, C; Testylier, G, 2007) |
| " Since volatile anesthetics elevate plasma amino acid concentrations, the influence of isoflurane on arterial plasma glutamate levels and brain edema formation was investigated in brain-injured rats." | 3.70 | Isoflurane doubles plasma glutamate and increases posttraumatic brain edema. ( Kempski, OS; Kroppenstedt, SN; Stover, JF; Thomale, UW; Unterberg, AW, 2000) |
| "To evaluate the impact of anesthetics on the evolution of a cerebral injury, 33 rabbits were subjected to a cryogenic brain lesion, followed by 10 h of anesthesia with 1 MAC halothane or isoflurane (n = 11 each) or with an equipotent dose of pentobarbital (n = 11)." | 3.67 | A comparison of the effects of halothane, isoflurane, and pentobarbital anesthesia on intracranial pressure and cerebral edema formation following brain injury in rabbits. ( Kaieda, R; Todd, MM; Warner, DS; Weeks, JB, 1989) |
| "The first step to treat aneurysmal subarachnoid hemorrhage (SAH) is aneurysmal obliteration under general anesthesia but not treat the SAH itself and the secondary effects." | 1.56 | Isoflurane versus sevoflurane for early brain injury and expression of sphingosine kinase 1 after experimental subarachnoid hemorrhage. ( Altay, BN; Altay, O; Calisir, V; Suzuki, H; Tang, J; Zhang, JH, 2020) |
| "Isoflurane treatment did not reduce brain edema compared with controls in any of the applied isoflurane concentrations." | 1.39 | Lower doses of isoflurane treatment has no beneficial effects in a rat model of intracerebral hemorrhage. ( Esposito, E; Lo, EH; Mandeville, ET, 2013) |
| "The degree of cerebral edema formation was determined by Evans blue dye and coronal magnetic resonance imaging." | 1.28 | Brain retractor edema during induced hypotension: the effect of the rate of return of blood pressure. ( Gelb, AW; Karlik, S; Lownie, S; Wu, X, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (8.00) | 18.7374 |
| 1990's | 5 (20.00) | 18.2507 |
| 2000's | 8 (32.00) | 29.6817 |
| 2010's | 8 (32.00) | 24.3611 |
| 2020's | 2 (8.00) | 2.80 |
| Authors | Studies |
|---|---|
| Poon, KS | 1 |
| Pan, YL | 1 |
| Liao, KH | 1 |
| Wang, HL | 1 |
| Chen, KB | 1 |
| Chen, HY | 1 |
| Liu, YC | 1 |
| Lai, TW | 1 |
| Altay, O | 3 |
| Suzuki, H | 3 |
| Altay, BN | 1 |
| Calisir, V | 1 |
| Tang, J | 4 |
| Zhang, JH | 4 |
| Esposito, E | 1 |
| Mandeville, ET | 1 |
| Lo, EH | 1 |
| Heinemann, U | 1 |
| Tétrault, S | 1 |
| Chever, O | 1 |
| Sik, A | 1 |
| Amzica, F | 1 |
| Bilotta, F | 1 |
| Doronzio, A | 1 |
| Cuzzone, V | 1 |
| Caramia, R | 1 |
| Rosa, G | 1 |
| Khatibi, NH | 2 |
| Ma, Q | 1 |
| Rolland, W | 1 |
| Ostrowski, R | 1 |
| Fathali, N | 1 |
| Martin, R | 1 |
| Applegate, R | 1 |
| Stier, G | 1 |
| Gigante, PR | 1 |
| Appelboom, G | 1 |
| Hwang, BY | 1 |
| Haque, RM | 1 |
| Yeh, ML | 1 |
| Ducruet, AF | 1 |
| Kellner, CP | 1 |
| Gorski, J | 1 |
| Keesecker, SE | 1 |
| Connolly, ES | 1 |
| Hasegawa, Y | 2 |
| Sherchan, P | 1 |
| Caner, B | 1 |
| Krafft, PR | 1 |
| Fujii, M | 1 |
| Bedirli, N | 1 |
| Bagriacik, EU | 1 |
| Emmez, H | 1 |
| Yilmaz, G | 1 |
| Unal, Y | 1 |
| Ozkose, Z | 1 |
| Bleilevens, C | 1 |
| Roehl, AB | 1 |
| Goetzenich, A | 1 |
| Zoremba, N | 1 |
| Kipp, M | 1 |
| Dang, J | 1 |
| Tolba, R | 1 |
| Rossaint, R | 1 |
| Hein, M | 1 |
| Thal, SC | 1 |
| Luh, C | 1 |
| Schaible, EV | 1 |
| Timaru-Kast, R | 1 |
| Hedrich, J | 1 |
| Luhmann, HJ | 1 |
| Engelhard, K | 1 |
| Zehendner, CM | 1 |
| Petersen, KD | 1 |
| Landsfeldt, U | 1 |
| Cold, GE | 1 |
| Petersen, CB | 1 |
| Mau, S | 1 |
| Hauerberg, J | 1 |
| Holst, P | 1 |
| Olsen, KS | 1 |
| Mavroudis, G | 1 |
| Prior, MJ | 1 |
| Lister, T | 1 |
| Nolan, CC | 1 |
| Ray, DE | 1 |
| Ritz, MF | 1 |
| Schmidt, P | 1 |
| Mendelowitsch, A | 1 |
| Testylier, G | 1 |
| Lahrech, H | 1 |
| Montigon, O | 1 |
| Foquin, A | 1 |
| Delacour, C | 1 |
| Bernabé, D | 1 |
| Segebarth, C | 1 |
| Dorandeu, F | 1 |
| Carpentier, P | 1 |
| Murr, R | 1 |
| Berger, S | 1 |
| Schürer, L | 1 |
| Peter, K | 1 |
| Baethmann, A | 1 |
| Bendo, AA | 1 |
| Kozlowski, PB | 1 |
| Capuano, C | 1 |
| Cottrell, JE | 1 |
| Mendeszoon, MH | 1 |
| Hartung, J | 1 |
| Mills, CD | 1 |
| Robertson, CS | 1 |
| Contant, CF | 1 |
| Henley, CM | 1 |
| Stover, JF | 1 |
| Kroppenstedt, SN | 1 |
| Thomale, UW | 1 |
| Kempski, OS | 1 |
| Unterberg, AW | 1 |
| Smith, AL | 1 |
| Marque, JJ | 1 |
| Lownie, S | 1 |
| Wu, X | 1 |
| Karlik, S | 1 |
| Gelb, AW | 1 |
| Kaieda, R | 1 |
| Todd, MM | 1 |
| Weeks, JB | 1 |
| Warner, DS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Influence of Vasopressors on Brain Oxygenation and Microcirculation in Anesthetized Patients With Cerebral Tumors[NCT02713087] | Phase 4 | 48 participants (Actual) | Interventional | 2015-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 trials available for isoflurane and Brain Swelling
| Article | Year |
|---|---|
Early postoperative cognitive recovery and gas exchange patterns after balanced anesthesia with sevoflurane or desflurane in overweight and obese patients undergoing craniotomy: a prospective randomized trial.
Topics: Adolescent; Adult; Aged; Anesthesia, Inhalation; Anesthetics, Inhalation; Brain Edema; Cognition; Cr | 2009 |
Effect of anesthesia and cerebral blood flow on neuronal injury in a rat middle cerebral artery occlusion (MCAO) model.
Topics: Anesthesia; Anesthetics; Animals; Blood Pressure; Brain Edema; Brain Injuries; Cerebral Infarction; | 2013 |
Intracranial pressure and cerebral hemodynamic in patients with cerebral tumors: a randomized prospective study of patients subjected to craniotomy in propofol-fentanyl, isoflurane-fentanyl, or sevoflurane-fentanyl anesthesia.
Topics: Adolescent; Adult; Aged; Anesthesia, General; Anesthesia, Inhalation; Anesthetics, Inhalation; Anest | 2003 |
Cerebral edema formation in dogs following hypotension induced with isoflurane and labetalol.
Topics: Animals; Brain; Brain Edema; Brain Injuries; Dogs; Hypotension; Isoflurane; Labetalol; Male | 1993 |
21 other studies available for isoflurane and Brain Swelling
| Article | Year |
|---|---|
Isoflurane attenuates carbogen-induced blood-brain barrier disruption independent of body temperature in mice and rats.
Topics: Animals; Blood-Brain Barrier; Body Temperature; Brain; Brain Edema; Capillary Permeability; Carbon D | 2020 |
Isoflurane versus sevoflurane for early brain injury and expression of sphingosine kinase 1 after experimental subarachnoid hemorrhage.
Topics: Animals; Apoptosis; Brain Edema; Disease Models, Animal; Isoflurane; Male; Mice; Neuroprotective Age | 2020 |
Lower doses of isoflurane treatment has no beneficial effects in a rat model of intracerebral hemorrhage.
Topics: Anesthetics, Inhalation; Animals; Brain; Brain Edema; Cerebral Hemorrhage; Disease Models, Animal; D | 2013 |
New dangers of anesthesia: isoflurane induced opening of the blood-brain barrier (Commentary on Tétrault et al.).
Topics: Anesthetics, Inhalation; Blood-Brain Barrier; Brain; Brain Diseases, Metabolic; Brain Edema; Epileps | 2008 |
Opening of the blood-brain barrier during isoflurane anaesthesia.
Topics: Anesthetics, Inhalation; Animals; Blood-Brain Barrier; Brain; Brain Edema; Cats; Cerebral Cortex; Co | 2008 |
Isoflurane posttreatment reduces brain injury after an intracerebral hemorrhagic stroke in mice.
Topics: Anesthetics, Inhalation; Animals; Apoptosis; Basal Ganglia; Behavior, Animal; Body Water; Brain; Bra | 2011 |
Isoflurane preconditioning affords functional neuroprotection in a murine model of intracerebral hemorrhage.
Topics: Albumins; Anesthetics, Inhalation; Animals; Brain; Brain Edema; Cerebral Hemorrhage; Disease Models, | 2011 |
Isoflurane delays the development of early brain injury after subarachnoid hemorrhage through sphingosine-related pathway activation in mice.
Topics: Animals; Apoptosis; Brain Edema; Brain Injuries; Isoflurane; Lysophospholipids; Male; Mice; Neuropro | 2012 |
Isoflurane attenuates blood-brain barrier disruption in ipsilateral hemisphere after subarachnoid hemorrhage in mice.
Topics: Anesthetics, Inhalation; Animals; Biomarkers; Blood-Brain Barrier; Blotting, Western; Brain Edema; C | 2012 |
Sevoflurane and isoflurane preconditioning provides neuroprotection by inhibition of apoptosis-related mRNA expression in a rat model of focal cerebral ischemia.
Topics: Anesthetics, Inhalation; Animals; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Brain Edem | 2012 |
Volatile anesthetics influence blood-brain barrier integrity by modulation of tight junction protein expression in traumatic brain injury.
Topics: Anesthetics, Inhalation; Animals; Blood-Brain Barrier; Brain Edema; Brain Injuries; Cell Line; Claud | 2012 |
Neurochemical and oedematous changes in 1,3-dinitrobenzene-induced astroglial injury in rat brain from a 1H-nuclear magnetic resonance perspective.
Topics: Anesthesia; Anesthetics, Inhalation; Animals; Astrocytes; Brain; Brain Chemistry; Brain Edema; Dinit | 2006 |
Effects of isoflurane on glutamate and taurine releases, brain swelling and injury during transient ischemia and reperfusion.
Topics: Anesthetics; Animals; Brain Edema; Glutamic Acid; Ischemic Attack, Transient; Isoflurane; Male; Neur | 2006 |
Cerebral edema induced in mice by a convulsive dose of soman. Evaluation through diffusion-weighted magnetic resonance imaging and histology.
Topics: Anesthesia; Anesthetics, Inhalation; Animals; Body Water; Brain; Brain Edema; Convulsants; Diffusion | 2007 |
Influence of isoflurane, fentanyl, thiopental, and alpha-chloralose on formation of brain edema resulting from a focal cryogenic lesion.
Topics: Anesthetics; Animals; Brain; Brain Edema; Brain Injuries; Cerebrovascular Circulation; Chloralose; F | 1995 |
Isoflurane, fentanyl, thiopental, and brain edema.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Brain; Brain Edema; Chloralose; Fentanyl | 1996 |
Effects of anesthesia on polyamine metabolism and water content in the rat brain.
Topics: Anesthesia, General; Anesthetics, General; Animals; Biogenic Polyamines; Body Water; Brain Chemistry | 1997 |
Isoflurane doubles plasma glutamate and increases posttraumatic brain edema.
Topics: Animals; Brain Concussion; Brain Edema; Cerebral Cortex; Chloral Hydrate; Glutamic Acid; Intracrania | 2000 |
Anesthetics and cerebral edema.
Topics: Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics; Animals; Brain; Brain Edema; Dogs; Dro | 1976 |
Brain retractor edema during induced hypotension: the effect of the rate of return of blood pressure.
Topics: Animals; Blood Pressure; Blood-Brain Barrier; Brain Edema; Cats; Hypotension; Hypotension, Controlle | 1990 |
A comparison of the effects of halothane, isoflurane, and pentobarbital anesthesia on intracranial pressure and cerebral edema formation following brain injury in rabbits.
Topics: Anesthesia; Anesthesia, Inhalation; Anesthesia, Intravenous; Animals; Brain Edema; Brain Injuries; C | 1989 |