isoflurane has been researched along with Brain Ischemia in 131 studies
Isoflurane: A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the previous study, the neuroprotection of isoflurane postconditioning (ISPOC) against cerebral ischemia-reperfusion (I/R) injury has been addressed, with particular relevance to the role of BMP7." | 8.02 | Isoflurane post-conditioning attenuates cerebral ischemia/reperfusion injury by reducing apoptotic through activating the BMP7/SMAD signaling pathway in rats. ( Dai, Z; Fan, S; Ge, M; Li, Y; Qin, X; Shao, X; Wang, R; Wang, S; Yin, J; Zhai, J, 2021) |
| "We recently reported that isoflurane conditioning provided multifaceted protection against subarachnoid hemorrhage (SAH)-induced delayed cerebral ischemia (DCI), and this protection was through the upregulation of endothelial nitric oxide synthase (eNOS)." | 8.02 | Role of SIRT1 in Isoflurane Conditioning-Induced Neurovascular Protection against Delayed Cerebral Ischemia Secondary to Subarachnoid Hemorrhage. ( Athiraman, U; Giri, T; Jayaraman, K; Liu, M; Zipfel, GJ, 2021) |
| "The brain protection effects induced by isoflurane preconditioning after an ischemic injury are mainly mediated by the SPK2 isoform and are somewhat impaired in hypertension." | 7.96 | Isoflurane cerebral preconditioning in a spontaneous hypertension rat model is associated with sphingosine kinases. ( Cheng, X; Ge, J; Kong, K; Liu, D; Lu, G; Peng, L; Shen, Y; Shen, Z; Wu, T, 2020) |
| "Isoflurane postconditioning alleviates cerebral ischemic-reperfusion injury (CIRI), but the underlying mechanism has not been fully clarified." | 7.96 | TGF-β3/Smad3 Contributes to Isoflurane Postconditioning Against Cerebral Ischemia-Reperfusion Injury by Upregulating MEF2C. ( Chen, L; Li, Y; Ma, K; Si, J; Wang, S; Yang, C; Yang, Y; Yin, J, 2020) |
| " This study aimed to investigate the relationship between AQP4, bone morphogenetic protein 4 (BMP4)/Smad1/5/8 signaling pathway and isoflurane post-conditiong, which has effects on brain edema in rats with cerebral ischemia/reperfusion (I/R) injury." | 7.88 | Isoflurane post-conditioning down-regulates expression of aquaporin 4 in rats with cerebral ischemia/reperfusion injury and is possibly related to bone morphogenetic protein 4/Smad1/5/8 signaling pathway. ( Dai, Z; Ge, M; Li, Y; Liu, X; Ma, K; Peng, L; Si, J; Wang, S; Xie, L; Yin, J; Yuan, M; Zhang, G, 2018) |
| " We compared microregional O2 balance in cerebral ischemia-reperfusion during pentobarbital and isoflurane anesthesia." | 7.81 | Local O2 Balance in Cerebral Ischemia-Reperfusion Improved during Pentobarbital Compared with Isoflurane Anesthesia. ( Barsoum, S; Chi, OZ; Liu, X; Rah, KH; Weiss, HR, 2015) |
| "Cerebral blood flow (CBF) and blood-brain barrier (BBB) permeability by arterial spin labeling (ASL)- and dynamic contrast enhanced (DCE)-magnetic resonance imaging (MRI), respectively were repeatedly measured under either halothane (N = 5) or isoflurane (N = 5) anesthesia in a rat stroke model of embolic occlusion of middle cerebral artery (MCA)." | 7.80 | Rate and extent of leakage of a magnetic resonance contrast agent tend to be lower under isoflurane anesthesia in comparison to halothane in a rat model of embolic stroke. ( Alarcon, W; Bezerra, FJ; Brown, M; Karki, K; Keenan, KA; Knight, RA; Nagaraja, TN, 2014) |
| "This study presents our findings on the extent of neuronal damage in the hippocampal CA1-4 subfields following global (forebrain) cerebral ischemia in rats when using different blood pressure levels (37 vs 45 mmHg) and bilateral carotid occlusion durations (8 vs 10 min) under isoflurane anesthesia." | 7.77 | The effect of blood pressure (37 vs 45 mmHg) and carotid occlusion duration (8 vs 10 min) on CA1-4 neuronal damage when using isoflurane in a global cerebral ischemia rat model. ( Campbell, K; Knuckey, NW; Li, LX; Meloni, BP; Zhao, S, 2011) |
| "We performed experiments to test whether isoflurane pretreatment produces vascular effects, especially at the levels of arterioles and capillaries affecting regional cerebral blood flow (rCBF), O(2) supply and consumption, or capillary permeability in focal cerebral ischemia." | 7.76 | The effects of isoflurane pretreatment on cerebral blood flow, capillary permeability, and oxygen consumption in focal cerebral ischemia in rats. ( Chi, OZ; Hunter, C; Liu, X; Weiss, HR, 2010) |
| "Isoflurane preconditioning improved short-term neurological outcome after focal brain ischemia in adult rats." | 7.75 | Isoflurane preconditioning improves short-term and long-term neurological outcome after focal brain ischemia in adult rats. ( Li, L; Zuo, Z, 2009) |
| "Desflurane shows better preservation of mitochondrial function at 4 h after cerebral ischemia reperfusion injury, indicated by inhibition of mitochondrial swelling, increase of membrane potential, and improvement of functions of mitochondria respiratory complexes I + III and IV when compared with halothane." | 7.74 | Desflurane affords greater protection than halothane in the function of mitochondria against forebrain ischemia reperfusion injury in rats. ( Cui, X; Ding, W; Li, W; Wei, X; Zhang, B; Zhou, H, 2008) |
| "Isoflurane improves outcome against cerebral ischemia in the rat." | 7.73 | The dose-dependent effects of isoflurane on outcome from severe forebrain ischemia in the rat. ( Hoshikawa, T; Miura, Y; Nasu, I; Okada, M; Takaoka, S; Takata, K; Yokoo, N, 2006) |
| "We compared the postischemic cerebral protective effects of sevoflurane and desflurane in rats with incomplete cerebral ischemia." | 7.73 | Effects of sevoflurane and desflurane in CA1 after incomplete cerebral ischemia in rats. ( Alici, HA; Cesur, M; Dogan, N; Erdem, AF; Erdogan, F; Kursad, H; Yuksek, MS, 2005) |
| "To investigate the role of the adenosine A1 receptor in the rapid tolerance to cerebral ischemia induced by isoflurane preconditioning." | 7.73 | Isoflurane tolerance against focal cerebral ischemia is attenuated by adenosine A1 receptor antagonists. ( Chen, S; Liu, Y; Wang, Q; Xiong, L, 2006) |
| "This study found no change in the percent alive CA1 hippocampal neurons as a function of duration of recovery from severe forebrain ischemia in isoflurane anesthetized rats." | 7.72 | Effects of isoflurane versus fentanyl-nitrous oxide anesthesia on long-term outcome from severe forebrain ischemia in the rat. ( Elsersy, H; Lynch, JR; Moldovan, M; Pearlstein, RD; Sheng, H; Warner, DS, 2004) |
| "The effect of isoflurane on neuronal apoptosis was investigated in rats subjected to focal cerebral ischemia." | 7.72 | Effect of isoflurane on neuronal apoptosis in rats subjected to focal cerebral ischemia. ( Cole, DJ; Drummond, JC; Kawaguchi, M; Kelly, PJ; Patel, PM; Spurlock, MP, 2004) |
| "Isoflurane improves outcome from near-complete forebrain ischemia in rats compared with fentanyl-nitrous oxide (N2O)." | 7.70 | Periischemic cerebral blood flow (CBF) does not explain beneficial effects of isoflurane on outcome from near-complete forebrain ischemia in rats. ( Kudo, M; Mackensen, GB; Nellgârd, B; Pearlstein, RD; Sheng, H; Warner, DS, 2000) |
| "Isoflurane-anesthetized rats have better outcome from global cerebral ischemia than rats anesthetized with fentanyl and nitrous oxide." | 7.70 | Sympathetic ganglionic blockade masks beneficial effect of isoflurane on histologic outcome from near-complete forebrain ischemia in the rat. ( Chu, CT; Dexter, F; Mackensen, GB; Miura, Y; Nellgård, B; Pearlstein, RD; Warner, DS, 1999) |
| " To determine the degree of anesthetic effect on the collapse of cytoskeletal proteins, we compared the effect of three inhalation anesthetics; isoflurane, halothane, and nitrous oxide (N2O), on MAP2 degradation during 20 min of forebrain ischemia in the rat." | 7.69 | Nitrous oxide attenuates the protective effect of isoflurane on microtubule-associated protein2 degradation during forebrain ischemia in the rat. ( Kitani, Y; Sugaya, T, 1997) |
| "This study was designed to test the hypothesis that propofol, which possesses antioxidant properties, would produce greater protection than isoflurane in cerebral ischaemia reperfusion injury, at dose levels that produced similar affects on brain electrical activity." | 7.69 | Propofol neuroprotection in a rat model of ischaemia reperfusion injury. ( Jones, JG; Matta, BF; Menon, DK; Tisavipat, N; Young, Y, 1997) |
| "16 MAC, isoflurane potently inhibits glutamate receptors and delays cellular injury induced by simulated ischemia, and (2) hypothermia does not reduce the intrinsic activity of cortical glutamate receptors but delays calcium accumulation during simulated ischemia." | 7.69 | Effects of isoflurane and hypothermia on glutamate receptor-mediated calcium influx in brain slices. ( Bickler, PE; Buck, LT; Hansen, BM, 1994) |
| " The current investigation was conducted to evaluate the effect of isoflurane and N2O-fentanyl anesthesia on ischemia-induced glutamate release in the rat and to compare it with that of mild hypothermia, an intervention known to reduce glutamate release significantly." | 7.69 | Isoflurane reduces ischemia-induced glutamate release in rats subjected to forebrain ischemia. ( Cole, DJ; Drummond, JC; Goskowicz, RL; Patel, PM, 1995) |
| " We evaluated whether the effect of sevoflurane is similar to that of isoflurane or halothane on brain energy metabolism after cerebral ischemia followed by reperfusion using 31P-magnetic resonance spectroscopy." | 7.69 | The effects of sevoflurane on recovery of brain energy metabolism after cerebral ischemia in the rat: a comparison with isoflurane and halothane. ( Fujise, Y; Ikeda, K; Moriwaki, G; Nakajima, Y, 1997) |
| "Differential effects of isoflurane (ISOF) and N2O on cerebral blood flow, metabolism and electrocorticogram (ECoG) were examined in rats subjected to 15 min-incomplete cerebral ischemia." | 7.67 | [Differential effects of isoflurane and nitrous oxide on cerebral blood flow, metabolism and electrocorticogram after incomplete cerebral ischemia in the rat]. ( Ishikawa, T; Maekawa, T; Sakabe, T; Shinohara, K; Takeshita, H, 1989) |
| "In rats with incomplete cerebral ischemia the effects of 70% N2O alone, isoflurane alone (0." | 7.67 | The interaction of nitrous oxide and isoflurane with incomplete cerebral ischemia in the rat. ( Albrecht, RF; Baughman, VL; Hoffman, WE; Miletich, DJ; Thomas, C, 1989) |
| "Using rats in which incomplete cerebral ischemia was induced, the authors evaluated the effects of halothane (H) and isoflurane (I) on neurologic outcome compared to nitrous oxide (N2O) controls." | 7.67 | Neurologic outcome in rats following incomplete cerebral ischemia during halothane, isoflurane, or N2O. ( Albrecht, RF; Baughman, VL; Hoffman, WE; Miletich, DJ; Thomas, C, 1988) |
| "Isoflurane post-treatment may enhance autophagy by activating the AMPK/ULK1 signaling pathway and further inhibit the release of inflammatory factors from NLRP3 inflammasomes, thereby ameliorating neurological function and cognitive impairment and exerting a protective effect on the brain in CIRI rats." | 5.91 | Isoflurane Enhances Autophagy by Activating AMPK/ULK1, Inhibits NLRP3, and Reduces Cognitive Impairment After Cerebral Ischemia-Reperfusion Injury in Rats. ( Li, N; Li, Y; Ma, K; Qin, X; Wang, R; Wang, S; Yin, J; Zhai, J; Zhang, X, 2023) |
| "Restoration of blood flow after ischaemic stroke leads to cerebral ischaemia-reperfusion injury (CIRI)." | 5.72 | Isoflurane Attenuates Cerebral Ischaemia-Reperfusion Injury via the TLR4-NLRP3 Signalling Pathway in Diabetic Mice. ( Guo, WJ; Hong, P; Huang, XX; Li, FX; Lin, HB; Tang, ZY; Wang, JW; Xu, SY; Zhang, HF; Zhang, YJ, 2022) |
| "Delayed cerebral ischemia (DCI) is identified as one of the significant contributors to poor patient outcome after aneurysmal subarachnoid hemorrhage (SAH)." | 5.62 | Anesthetic and subanesthetic doses of isoflurane conditioning provides strong protection against delayed cerebral ischemia in a mouse model of subarachnoid hemorrhage. ( Athiraman, U; Jayaraman, K; Liu, M; Mehla, J; Yuan, J; Zipfel, GJ, 2021) |
| "Background Delayed cerebral ischemia remains a common and profound risk factor for poor outcome after subarachnoid hemorrhage (SAH)." | 5.56 | Role of Endothelial Nitric Oxide Synthase in Isoflurane Conditioning-Induced Neurovascular Protection in Subarachnoid Hemorrhage. ( Athiraman, U; Giri, T; Jayaraman, K; Liu, M; Yuan, J; Zipfel, GJ, 2020) |
| "Using a middle cerebral artery occlusion (MCAO) model, triphenyltetrazolium chloride staining was utilized to measure the infarct volume and brain edema and immunofluorescence staining was used to detect the MCAO-induced TLR4 expression and localization." | 5.42 | Protective role of isoflurane pretreatment in rats with focal cerebral ischemia and the underlying molecular mechanism. ( Chao, Y; Chen, L; Gao, C; Kuai, J; Lv, M; Ren, P; Sun, X; Wang, Q; Xiao, Z, 2015) |
| "Rats were prepared for temporary middle cerebral artery occlusion (MCAO)." | 5.34 | Isoflurane provides long-term protection against focal cerebral ischemia in the rat. ( Ishida, K; Pearlstein, RD; Sakai, H; Sheng, H; Warner, DS; Yates, RB, 2007) |
| "The volumes of cerebral infarction and selective neuronal necrosis in the animals were determined by image analysis of hematoxylin and eosin-stained coronal brain sections." | 5.31 | Isoflurane delays but does not prevent cerebral infarction in rats subjected to focal ischemia. ( Cole, DJ; Drummond, JC; Kawaguchi, M; Kelly, PJ; Kimbro, JR; Patel, PM, 2000) |
| "Forebrain ischemia was induced by bilateral carotid artery occlusion with simultaneous hypotension for 10 min." | 5.29 | A comparison of the cerebral protective effects of etomidate, thiopental, and isoflurane in a model of forebrain ischemia in the rat. ( Cole, DJ; Drummond, JC; Patel, PM; Sano, T, 1993) |
| "We recently reported that isoflurane conditioning provided multifaceted protection against subarachnoid hemorrhage (SAH)-induced delayed cerebral ischemia (DCI), and this protection was through the upregulation of endothelial nitric oxide synthase (eNOS)." | 4.02 | Role of SIRT1 in Isoflurane Conditioning-Induced Neurovascular Protection against Delayed Cerebral Ischemia Secondary to Subarachnoid Hemorrhage. ( Athiraman, U; Giri, T; Jayaraman, K; Liu, M; Zipfel, GJ, 2021) |
| "The mechanisms of brain protection during ischaemic reperfusion injury induced by isoflurane (ISO) post-conditioning are unclear." | 4.02 | Isoflurane post-conditioning contributes to anti-apoptotic effect after cerebral ischaemia in rats through the ERK5/MEF2D signaling pathway. ( Ge, M; Li, N; Li, Y; Qin, X; Wang, S; Xu, F; Yin, J; Zhai, J; Zhang, Q; Zhou, W, 2021) |
| " In the previous study, the neuroprotection of isoflurane postconditioning (ISPOC) against cerebral ischemia-reperfusion (I/R) injury has been addressed, with particular relevance to the role of BMP7." | 4.02 | Isoflurane post-conditioning attenuates cerebral ischemia/reperfusion injury by reducing apoptotic through activating the BMP7/SMAD signaling pathway in rats. ( Dai, Z; Fan, S; Ge, M; Li, Y; Qin, X; Shao, X; Wang, R; Wang, S; Yin, J; Zhai, J, 2021) |
| "The brain protection effects induced by isoflurane preconditioning after an ischemic injury are mainly mediated by the SPK2 isoform and are somewhat impaired in hypertension." | 3.96 | Isoflurane cerebral preconditioning in a spontaneous hypertension rat model is associated with sphingosine kinases. ( Cheng, X; Ge, J; Kong, K; Liu, D; Lu, G; Peng, L; Shen, Y; Shen, Z; Wu, T, 2020) |
| "Isoflurane postconditioning alleviates cerebral ischemic-reperfusion injury (CIRI), but the underlying mechanism has not been fully clarified." | 3.96 | TGF-β3/Smad3 Contributes to Isoflurane Postconditioning Against Cerebral Ischemia-Reperfusion Injury by Upregulating MEF2C. ( Chen, L; Li, Y; Ma, K; Si, J; Wang, S; Yang, C; Yang, Y; Yin, J, 2020) |
| " This study aimed to investigate the relationship between AQP4, bone morphogenetic protein 4 (BMP4)/Smad1/5/8 signaling pathway and isoflurane post-conditiong, which has effects on brain edema in rats with cerebral ischemia/reperfusion (I/R) injury." | 3.88 | Isoflurane post-conditioning down-regulates expression of aquaporin 4 in rats with cerebral ischemia/reperfusion injury and is possibly related to bone morphogenetic protein 4/Smad1/5/8 signaling pathway. ( Dai, Z; Ge, M; Li, Y; Liu, X; Ma, K; Peng, L; Si, J; Wang, S; Xie, L; Yin, J; Yuan, M; Zhang, G, 2018) |
| " In the present study, we utilized our recently developed photothrombotic model of focal cerebral ischemia in conscious and freely moving rats, and investigated transient hemodynamic changes with or without isoflurane administration." | 3.85 | Hemodynamic effects of intraoperative anesthetics administration in photothrombotic stroke model: a study using laser speckle imaging. ( Bo, B; Li, H; Li, Y; Lu, H; Lu, X; Tong, S; Yuan, L, 2017) |
| " We compared microregional O2 balance in cerebral ischemia-reperfusion during pentobarbital and isoflurane anesthesia." | 3.81 | Local O2 Balance in Cerebral Ischemia-Reperfusion Improved during Pentobarbital Compared with Isoflurane Anesthesia. ( Barsoum, S; Chi, OZ; Liu, X; Rah, KH; Weiss, HR, 2015) |
| "Cerebral blood flow (CBF) and blood-brain barrier (BBB) permeability by arterial spin labeling (ASL)- and dynamic contrast enhanced (DCE)-magnetic resonance imaging (MRI), respectively were repeatedly measured under either halothane (N = 5) or isoflurane (N = 5) anesthesia in a rat stroke model of embolic occlusion of middle cerebral artery (MCA)." | 3.80 | Rate and extent of leakage of a magnetic resonance contrast agent tend to be lower under isoflurane anesthesia in comparison to halothane in a rat model of embolic stroke. ( Alarcon, W; Bezerra, FJ; Brown, M; Karki, K; Keenan, KA; Knight, RA; Nagaraja, TN, 2014) |
| "Application of isoflurane, a volatile anesthetic, after brain ischemia can reduce ischemic brain injury in rodents (isoflurane postconditioning)." | 3.79 | Isoflurane postconditioning reduces ischemia-induced nuclear factor-κB activation and interleukin 1β production to provide neuroprotection in rats and mice. ( Deng, J; Feng, C; Li, H; Li, L; Yin, J; Zuo, Z, 2013) |
| " In the present study, we describe a simple model of mouse forebrain ischemia where the bilateral common carotid artery occlusion (BCCO) is combined with isoflurane-induced hypotension." | 3.78 | Simple model of forebrain ischemia in mouse. ( Berger, S; Kristian, T; Onken, M, 2012) |
| "This study presents our findings on the extent of neuronal damage in the hippocampal CA1-4 subfields following global (forebrain) cerebral ischemia in rats when using different blood pressure levels (37 vs 45 mmHg) and bilateral carotid occlusion durations (8 vs 10 min) under isoflurane anesthesia." | 3.77 | The effect of blood pressure (37 vs 45 mmHg) and carotid occlusion duration (8 vs 10 min) on CA1-4 neuronal damage when using isoflurane in a global cerebral ischemia rat model. ( Campbell, K; Knuckey, NW; Li, LX; Meloni, BP; Zhao, S, 2011) |
| "Isoflurane after treatment worsened physiological and neurological outcomes in this ischemia hyperglycemia-induced hemorrhagic transformation possibly by impairing the antioxidant defense system." | 3.77 | Isoflurane enhanced hemorrhagic transformation by impairing antioxidant enzymes in hyperglycemic rats with middle cerebral artery occlusion. ( He, Z; Hu, Q; Ma, Q; Tang, J; Zhan, Y; Zhang, J; Zhou, C, 2011) |
| "We performed experiments to test whether isoflurane pretreatment produces vascular effects, especially at the levels of arterioles and capillaries affecting regional cerebral blood flow (rCBF), O(2) supply and consumption, or capillary permeability in focal cerebral ischemia." | 3.76 | The effects of isoflurane pretreatment on cerebral blood flow, capillary permeability, and oxygen consumption in focal cerebral ischemia in rats. ( Chi, OZ; Hunter, C; Liu, X; Weiss, HR, 2010) |
| " We compared EEG data before and after clamping of the carotid artery for 2 different anesthesia protocols (isoflurane or propofol) in patients with and without development of cerebral ischemia, making use of SL analysis." | 3.75 | Detection of ischemic electroencephalography changes during carotid endarterectomy using synchronization likelihood analysis. ( Ferrier, C; Kesecioglu, J; Laman, M; Rijsdijk, M; Slooter, A; Stam, K, 2009) |
| "Isoflurane preconditioning improved short-term neurological outcome after focal brain ischemia in adult rats." | 3.75 | Isoflurane preconditioning improves short-term and long-term neurological outcome after focal brain ischemia in adult rats. ( Li, L; Zuo, Z, 2009) |
| "Desflurane shows better preservation of mitochondrial function at 4 h after cerebral ischemia reperfusion injury, indicated by inhibition of mitochondrial swelling, increase of membrane potential, and improvement of functions of mitochondria respiratory complexes I + III and IV when compared with halothane." | 3.74 | Desflurane affords greater protection than halothane in the function of mitochondria against forebrain ischemia reperfusion injury in rats. ( Cui, X; Ding, W; Li, W; Wei, X; Zhang, B; Zhou, H, 2008) |
| "Isoflurane provides protection against severe forebrain ischemia in the rat." | 3.73 | Selective gamma-aminobutyric acid type A receptor antagonism reverses isoflurane ischemic neuroprotection. ( Elsersy, H; Mixco, J; Pearlstein, RD; Sheng, H; Warner, DS, 2006) |
| "To investigate the role of the adenosine A1 receptor in the rapid tolerance to cerebral ischemia induced by isoflurane preconditioning." | 3.73 | Isoflurane tolerance against focal cerebral ischemia is attenuated by adenosine A1 receptor antagonists. ( Chen, S; Liu, Y; Wang, Q; Xiong, L, 2006) |
| "To study the protective effect of volatile anesthetics, isoflurane and sevoflurane, on ischemic neurons after cerebral ischemia-reperfusion in rats and its possible molecular mechanism." | 3.73 | Protective effect of isoflurane and sevoflurane on ischemic neurons and expression of Bcl-2 and ICE genes in rat brain. ( Li, DZ; Wan, H; Zhai, J; Zhang, H; Zhang, SD, 2006) |
| "Isoflurane improves outcome against cerebral ischemia in the rat." | 3.73 | The dose-dependent effects of isoflurane on outcome from severe forebrain ischemia in the rat. ( Hoshikawa, T; Miura, Y; Nasu, I; Okada, M; Takaoka, S; Takata, K; Yokoo, N, 2006) |
| "We compared the postischemic cerebral protective effects of sevoflurane and desflurane in rats with incomplete cerebral ischemia." | 3.73 | Effects of sevoflurane and desflurane in CA1 after incomplete cerebral ischemia in rats. ( Alici, HA; Cesur, M; Dogan, N; Erdem, AF; Erdogan, F; Kursad, H; Yuksek, MS, 2005) |
| "The effect of isoflurane on neuronal apoptosis was investigated in rats subjected to focal cerebral ischemia." | 3.72 | Effect of isoflurane on neuronal apoptosis in rats subjected to focal cerebral ischemia. ( Cole, DJ; Drummond, JC; Kawaguchi, M; Kelly, PJ; Patel, PM; Spurlock, MP, 2004) |
| "This study found no change in the percent alive CA1 hippocampal neurons as a function of duration of recovery from severe forebrain ischemia in isoflurane anesthetized rats." | 3.72 | Effects of isoflurane versus fentanyl-nitrous oxide anesthesia on long-term outcome from severe forebrain ischemia in the rat. ( Elsersy, H; Lynch, JR; Moldovan, M; Pearlstein, RD; Sheng, H; Warner, DS, 2004) |
| "Isoflurane improves outcome from near-complete forebrain ischemia in rats compared with fentanyl-nitrous oxide (N2O)." | 3.70 | Periischemic cerebral blood flow (CBF) does not explain beneficial effects of isoflurane on outcome from near-complete forebrain ischemia in rats. ( Kudo, M; Mackensen, GB; Nellgârd, B; Pearlstein, RD; Sheng, H; Warner, DS, 2000) |
| "Isoflurane-anesthetized rats have better outcome from global cerebral ischemia than rats anesthetized with fentanyl and nitrous oxide." | 3.70 | Sympathetic ganglionic blockade masks beneficial effect of isoflurane on histologic outcome from near-complete forebrain ischemia in the rat. ( Chu, CT; Dexter, F; Mackensen, GB; Miura, Y; Nellgård, B; Pearlstein, RD; Warner, DS, 1999) |
| "Rats exposed to forebrain ischemia have reduced injury when anesthetized with isoflurane versus fentanyl + N(2)O." | 3.70 | The effects of anesthetics on stress responses to forebrain ischemia and reperfusion in the rat. ( Mackensen, GB; Massey, G; Nellgård, B; Pearlstein, RD; Warner, DS, 2000) |
| "A previous study indicated that diaspirin-crosslinked hemoglobin (DCLHb) decreases cerebral ischemia after subarachnoid hemorrhage." | 3.70 | Subarachnoid molecular hemoglobin after subarachnoid hemorrhage in rats: effect on the area of hypoperfusion. ( Cole, DJ; Cross, LM; Drummond, JC; McKay, LD; Patel, PM, 1998) |
| " Isoflurane, sodium pentothal, an N-methyl-D-aspartate receptor antagonist, and mild hypothermia prevented cell death to similar degrees." | 3.70 | Anesthetics and mild hypothermia similarly prevent hippocampal neuron death in an in vitro model of cerebral ischemia. ( Bickler, PE; Liniger, R; Popovic, R, 2000) |
| "This study was designed to test the hypothesis that propofol, which possesses antioxidant properties, would produce greater protection than isoflurane in cerebral ischaemia reperfusion injury, at dose levels that produced similar affects on brain electrical activity." | 3.69 | Propofol neuroprotection in a rat model of ischaemia reperfusion injury. ( Jones, JG; Matta, BF; Menon, DK; Tisavipat, N; Young, Y, 1997) |
| " We evaluated whether the effect of sevoflurane is similar to that of isoflurane or halothane on brain energy metabolism after cerebral ischemia followed by reperfusion using 31P-magnetic resonance spectroscopy." | 3.69 | The effects of sevoflurane on recovery of brain energy metabolism after cerebral ischemia in the rat: a comparison with isoflurane and halothane. ( Fujise, Y; Ikeda, K; Moriwaki, G; Nakajima, Y, 1997) |
| " To determine the degree of anesthetic effect on the collapse of cytoskeletal proteins, we compared the effect of three inhalation anesthetics; isoflurane, halothane, and nitrous oxide (N2O), on MAP2 degradation during 20 min of forebrain ischemia in the rat." | 3.69 | Nitrous oxide attenuates the protective effect of isoflurane on microtubule-associated protein2 degradation during forebrain ischemia in the rat. ( Kitani, Y; Sugaya, T, 1997) |
| " The current investigation was conducted to evaluate the effect of isoflurane and N2O-fentanyl anesthesia on ischemia-induced glutamate release in the rat and to compare it with that of mild hypothermia, an intervention known to reduce glutamate release significantly." | 3.69 | Isoflurane reduces ischemia-induced glutamate release in rats subjected to forebrain ischemia. ( Cole, DJ; Drummond, JC; Goskowicz, RL; Patel, PM, 1995) |
| " In order to select a suitable volatile anaesthetic from the standpoint of cytoskeletal protein breakdown during cerebral ischemia, we compared the effect of isoflurane, halothane and sevoflurane on MAP 2 degradation during 20 min of forebrain ischemia in the rat." | 3.69 | [Effects of volatile anesthetics on microtubule-associated protein 2 degradation during forebrain ischemia in the rat]. ( Fujita, T; Kitani, Y; Morita, T; Saito, S; Sugaya, T; Uehara, K, 1994) |
| "16 MAC, isoflurane potently inhibits glutamate receptors and delays cellular injury induced by simulated ischemia, and (2) hypothermia does not reduce the intrinsic activity of cortical glutamate receptors but delays calcium accumulation during simulated ischemia." | 3.69 | Effects of isoflurane and hypothermia on glutamate receptor-mediated calcium influx in brain slices. ( Bickler, PE; Buck, LT; Hansen, BM, 1994) |
| "Using a rat model of incomplete cerebral ischemia the effects of isoflurane (iso) and methohexital (metho) were compared with those of 70% nitrous oxide controls (N2O)." | 3.68 | Comparison of methohexital and isoflurane on neurologic outcome and histopathology following incomplete ischemia in rats. ( Albrecht, RF; Baughman, VL; Hoffman, WE; Miletich, DJ; Thomas, C, 1990) |
| "In rats with incomplete cerebral ischemia the effects of 70% N2O alone, isoflurane alone (0." | 3.67 | The interaction of nitrous oxide and isoflurane with incomplete cerebral ischemia in the rat. ( Albrecht, RF; Baughman, VL; Hoffman, WE; Miletich, DJ; Thomas, C, 1989) |
| "Differential effects of isoflurane (ISOF) and N2O on cerebral blood flow, metabolism and electrocorticogram (ECoG) were examined in rats subjected to 15 min-incomplete cerebral ischemia." | 3.67 | [Differential effects of isoflurane and nitrous oxide on cerebral blood flow, metabolism and electrocorticogram after incomplete cerebral ischemia in the rat]. ( Ishikawa, T; Maekawa, T; Sakabe, T; Shinohara, K; Takeshita, H, 1989) |
| "Using rats in which incomplete cerebral ischemia was induced, the authors evaluated the effects of halothane (H) and isoflurane (I) on neurologic outcome compared to nitrous oxide (N2O) controls." | 3.67 | Neurologic outcome in rats following incomplete cerebral ischemia during halothane, isoflurane, or N2O. ( Albrecht, RF; Baughman, VL; Hoffman, WE; Miletich, DJ; Thomas, C, 1988) |
| "Thiopental has a metabolically neutral effect on brain tissue gases and pH, even though it is known to decrease cerebral oxygen consumption." | 2.69 | Thiopental and desflurane treatment for brain protection. ( Ausman, JI; Charbel, FT; Edelman, G; Hoffman, WE, 1998) |
| "Therefore, in investigations of cerebral ischemia, the duration of the recovery period should be taken into consideration in the analysis of the neuroprotective effects of anesthetic agents." | 2.43 | Neuroprotective effects of anesthetic agents. ( Furuya, H; Kawaguchi, M; Patel, PM, 2005) |
| "Isoflurane post-treatment may enhance autophagy by activating the AMPK/ULK1 signaling pathway and further inhibit the release of inflammatory factors from NLRP3 inflammasomes, thereby ameliorating neurological function and cognitive impairment and exerting a protective effect on the brain in CIRI rats." | 1.91 | Isoflurane Enhances Autophagy by Activating AMPK/ULK1, Inhibits NLRP3, and Reduces Cognitive Impairment After Cerebral Ischemia-Reperfusion Injury in Rats. ( Li, N; Li, Y; Ma, K; Qin, X; Wang, R; Wang, S; Yin, J; Zhai, J; Zhang, X, 2023) |
| "Restoration of blood flow after ischaemic stroke leads to cerebral ischaemia-reperfusion injury (CIRI)." | 1.72 | Isoflurane Attenuates Cerebral Ischaemia-Reperfusion Injury via the TLR4-NLRP3 Signalling Pathway in Diabetic Mice. ( Guo, WJ; Hong, P; Huang, XX; Li, FX; Lin, HB; Tang, ZY; Wang, JW; Xu, SY; Zhang, HF; Zhang, YJ, 2022) |
| "Delayed cerebral ischemia (DCI) is identified as one of the significant contributors to poor patient outcome after aneurysmal subarachnoid hemorrhage (SAH)." | 1.62 | Anesthetic and subanesthetic doses of isoflurane conditioning provides strong protection against delayed cerebral ischemia in a mouse model of subarachnoid hemorrhage. ( Athiraman, U; Jayaraman, K; Liu, M; Mehla, J; Yuan, J; Zipfel, GJ, 2021) |
| "Background Delayed cerebral ischemia remains a common and profound risk factor for poor outcome after subarachnoid hemorrhage (SAH)." | 1.56 | Role of Endothelial Nitric Oxide Synthase in Isoflurane Conditioning-Induced Neurovascular Protection in Subarachnoid Hemorrhage. ( Athiraman, U; Giri, T; Jayaraman, K; Liu, M; Yuan, J; Zipfel, GJ, 2020) |
| "Because cerebral infarct develops within 24 h after the onset of ischemia, and several therapeutic agents have been shown to reduce the infarct volume when administered at 6 h post-ischemia, we hypothesized that attenuating BBB disruption at its peak (6 h post-ischemia) can also decrease the infarct volume measured at 24 h." | 1.46 | Anesthesia-Induced Hypothermia Attenuates Early-Phase Blood-Brain Barrier Disruption but Not Infarct Volume following Cerebral Ischemia. ( Chen, KB; Lai, TW; Lee, YD; Liao, KH; Liu, YC; Pan, YL; Poon, KS; Wang, HL, 2017) |
| "Using a middle cerebral artery occlusion (MCAO) model, triphenyltetrazolium chloride staining was utilized to measure the infarct volume and brain edema and immunofluorescence staining was used to detect the MCAO-induced TLR4 expression and localization." | 1.42 | Protective role of isoflurane pretreatment in rats with focal cerebral ischemia and the underlying molecular mechanism. ( Chao, Y; Chen, L; Gao, C; Kuai, J; Lv, M; Ren, P; Sun, X; Wang, Q; Xiao, Z, 2015) |
| "Mouse models of global cerebral ischemia are essential tools to study the molecular mechanisms involved in ischemic brain damage." | 1.39 | Guidelines for using mouse global cerebral ischemia models. ( Hu, B; Kristian, T, 2013) |
| "Rats were prepared for temporary middle cerebral artery occlusion (MCAO)." | 1.34 | Isoflurane provides long-term protection against focal cerebral ischemia in the rat. ( Ishida, K; Pearlstein, RD; Sakai, H; Sheng, H; Warner, DS; Yates, RB, 2007) |
| "In the short-duration groups, cerebral infarct volumes were not significantly different between anaesthetics (short-duration halothane: 288 (61) mm(3), mean (SD); short-duration desflurane: 269 (71) mm(3), P>0." | 1.32 | Desflurane affords greater protection than halothane against focal cerebral ischaemia in the rat. ( Ducouret, P; Gérard, JL; Haelewyn, B; Hanouz, JL; MacKenzie, ET; Roussel, S; Yvon, A, 2003) |
| "The volumes of cerebral infarction and selective neuronal necrosis in the animals were determined by image analysis of hematoxylin and eosin-stained coronal brain sections." | 1.31 | Isoflurane delays but does not prevent cerebral infarction in rats subjected to focal ischemia. ( Cole, DJ; Drummond, JC; Kawaguchi, M; Kelly, PJ; Kimbro, JR; Patel, PM, 2000) |
| "Halothane-pretreated animals were subjected to MCAO 24 hours after AP." | 1.31 | Tolerance against ischemic neuronal injury can be induced by volatile anesthetics and is inducible NO synthase dependent. ( Dirnagl, U; Fütterer, C; Isaev, NK; Kapinya, KJ; Löwl, D; Maurer, M; Waschke, KF, 2002) |
| "In a brain slice model of cerebral anoxia, 1 minimum alveolar concentration isoflurane decreases glutamate release to a similar extent that hypothermia (28 degrees C) does." | 1.29 | Hypothermia and isoflurane similarly inhibit glutamate release evoked by chemical anoxia in rat cortical brain slices. ( Bickler, PE; Eilers, H, 1996) |
| "Forebrain ischemia was induced by bilateral carotid artery occlusion with simultaneous hypotension for 10 min." | 1.29 | A comparison of the cerebral protective effects of etomidate, thiopental, and isoflurane in a model of forebrain ischemia in the rat. ( Cole, DJ; Drummond, JC; Patel, PM; Sano, T, 1993) |
| "Hypotension was established before MCAO and was maintained for 10 min, at which time the dimension of the brain areas with zero CBF was determined autoradiographically." | 1.28 | Influence of hypotension and hypotensive technique on the area of profound reduction in cerebral blood flow during focal cerebral ischaemia in the rat. ( Cole, DJ; Drummond, JC; Shapiro, HM; Zornow, MH, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (7.63) | 18.7374 |
| 1990's | 34 (25.95) | 18.2507 |
| 2000's | 39 (29.77) | 29.6817 |
| 2010's | 32 (24.43) | 24.3611 |
| 2020's | 16 (12.21) | 2.80 |
| Authors | Studies |
|---|---|
| Li, N | 4 |
| Zhang, X | 3 |
| Zhai, J | 5 |
| Yin, J | 11 |
| Ma, K | 6 |
| Wang, R | 3 |
| Qin, X | 4 |
| Li, Y | 9 |
| Dong, X | 1 |
| Wang, S | 9 |
| Zhang, YJ | 1 |
| Guo, WJ | 1 |
| Tang, ZY | 1 |
| Lin, HB | 1 |
| Hong, P | 1 |
| Wang, JW | 1 |
| Huang, XX | 1 |
| Li, FX | 1 |
| Xu, SY | 2 |
| Zhang, HF | 1 |
| Zhu, X | 1 |
| Yang, M | 1 |
| Yang, L | 3 |
| Keshavarz, S | 1 |
| Nemati, M | 1 |
| Saied Salehi, M | 1 |
| Naseh, M | 1 |
| Liu, M | 4 |
| Jayaraman, K | 4 |
| Norris, AJ | 1 |
| Hussein, A | 1 |
| Nelson, JW | 1 |
| Mehla, J | 2 |
| Diwan, D | 1 |
| Vellimana, A | 1 |
| Abu-Amer, Y | 1 |
| Zipfel, GJ | 4 |
| Athiraman, U | 4 |
| Chen, G | 1 |
| Kamat, PK | 1 |
| Ahmad, AS | 1 |
| Doré, S | 1 |
| Liu, G | 1 |
| Qiao, S | 1 |
| Yu, Y | 1 |
| Hou, D | 1 |
| Yang, Y | 1 |
| Chen, L | 2 |
| Si, J | 4 |
| Yang, C | 1 |
| Ge, J | 1 |
| Kong, K | 1 |
| Cheng, X | 1 |
| Wu, T | 1 |
| Liu, D | 1 |
| Peng, L | 4 |
| Shen, Z | 1 |
| Lu, G | 1 |
| Shen, Y | 1 |
| Giri, T | 2 |
| Yuan, J | 2 |
| Ge, M | 5 |
| Shao, X | 1 |
| Fan, S | 1 |
| Dai, Z | 4 |
| Liu, XS | 1 |
| Bai, XL | 1 |
| Wang, ZX | 1 |
| Ma, Y | 1 |
| Wang, ZN | 1 |
| Zhang, Q | 2 |
| Xu, F | 2 |
| Zhou, W | 1 |
| Cheon, SY | 1 |
| Kim, SY | 1 |
| Kam, EH | 1 |
| Lee, JH | 1 |
| Kim, JM | 1 |
| Kim, EJ | 1 |
| Kim, TW | 1 |
| Koo, BN | 1 |
| Song, DD | 2 |
| Zhang, TT | 2 |
| Chen, JL | 1 |
| Xia, YF | 2 |
| Qin, ZH | 2 |
| Waeber, C | 1 |
| Sheng, R | 2 |
| Cai, M | 2 |
| Yang, Q | 1 |
| Li, G | 2 |
| Sun, S | 2 |
| Chen, Y | 2 |
| Tian, L | 1 |
| Dong, H | 3 |
| Yuan, M | 1 |
| Xie, L | 2 |
| Liu, X | 3 |
| Zhang, G | 2 |
| Yamamoto, T | 1 |
| Iwamoto, T | 1 |
| Kimura, S | 1 |
| Nakao, S | 1 |
| Zhao, G | 1 |
| Xiong, L | 3 |
| Han, Z | 1 |
| Wise-Faberowski, L | 1 |
| Osorio-Lujan, S | 1 |
| Kristian, T | 2 |
| Hu, B | 1 |
| Ward, JM | 1 |
| Buslov, AM | 1 |
| Vallender, EJ | 1 |
| Bezerra, FJ | 1 |
| Brown, M | 1 |
| Alarcon, W | 1 |
| Karki, K | 1 |
| Knight, RA | 1 |
| Keenan, KA | 1 |
| Nagaraja, TN | 1 |
| Jia, J | 1 |
| Fu, J | 1 |
| Wang, H | 1 |
| Ji, K | 1 |
| Zang, B | 1 |
| Li, H | 3 |
| Feng, C | 2 |
| Zuo, Z | 7 |
| Tong, L | 1 |
| Wu, Z | 1 |
| Ran, M | 1 |
| Zhang, H | 2 |
| Zhang, L | 1 |
| Xiao, Z | 1 |
| Ren, P | 1 |
| Chao, Y | 1 |
| Wang, Q | 2 |
| Kuai, J | 1 |
| Lv, M | 1 |
| Gao, C | 1 |
| Sun, X | 1 |
| Chi, OZ | 2 |
| Barsoum, S | 1 |
| Rah, KH | 1 |
| Weiss, HR | 2 |
| Sun, Y | 2 |
| Li, QF | 1 |
| Yan, J | 1 |
| Hu, R | 2 |
| Jiang, H | 2 |
| Li, L | 5 |
| Yao, S | 1 |
| Kudo, K | 1 |
| Zhao, L | 1 |
| Nowak, TS | 1 |
| Zhou, JH | 1 |
| Lu, H | 2 |
| Bo, B | 1 |
| Yuan, L | 1 |
| Lu, X | 1 |
| Tong, S | 1 |
| Liu, YC | 1 |
| Lee, YD | 1 |
| Wang, HL | 1 |
| Liao, KH | 1 |
| Chen, KB | 1 |
| Poon, KS | 1 |
| Pan, YL | 1 |
| Lai, TW | 1 |
| Wang, L | 1 |
| Kitano, H | 1 |
| Hurn, PD | 1 |
| Murphy, SJ | 2 |
| Zhao, H | 1 |
| Mayhan, WG | 1 |
| Sun, H | 1 |
| Rijsdijk, M | 1 |
| Ferrier, C | 1 |
| Laman, M | 1 |
| Kesecioglu, J | 1 |
| Stam, K | 1 |
| Slooter, A | 1 |
| Hunter, C | 1 |
| Tsuda, K | 1 |
| Hu, Q | 1 |
| Ma, Q | 1 |
| Zhan, Y | 1 |
| He, Z | 1 |
| Tang, J | 1 |
| Zhou, C | 1 |
| Zhang, J | 1 |
| Li, LX | 1 |
| Campbell, K | 1 |
| Zhao, S | 1 |
| Knuckey, NW | 1 |
| Meloni, BP | 1 |
| Johnsen, D | 1 |
| Onken, M | 1 |
| Berger, S | 1 |
| Fang Li, Q | 1 |
| Xu, H | 1 |
| Lückl, J | 2 |
| Dreier, JP | 1 |
| Szabados, T | 1 |
| Wiesenthal, D | 1 |
| Bari, F | 1 |
| Greenberg, JH | 2 |
| Deng, J | 1 |
| Kapinya, KJ | 2 |
| Prass, K | 1 |
| Dirnagl, U | 2 |
| Young, B | 1 |
| Osvath, L | 1 |
| Jones, D | 1 |
| Socha, E | 1 |
| Miura, Y | 4 |
| Amagasa, S | 1 |
| Zheng, S | 2 |
| Haelewyn, B | 1 |
| Yvon, A | 1 |
| Hanouz, JL | 1 |
| MacKenzie, ET | 1 |
| Ducouret, P | 1 |
| Gérard, JL | 1 |
| Roussel, S | 1 |
| Homi, HM | 1 |
| Mixco, JM | 1 |
| Sheng, H | 5 |
| Grocott, HP | 1 |
| Pearlstein, RD | 9 |
| Warner, DS | 18 |
| Kawaguchi, M | 3 |
| Drummond, JC | 11 |
| Cole, DJ | 13 |
| Kelly, PJ | 2 |
| Spurlock, MP | 1 |
| Patel, PM | 10 |
| Elsersy, H | 2 |
| Lynch, JR | 1 |
| Moldovan, M | 1 |
| Inoue, S | 2 |
| Davis, DP | 2 |
| Furuya, H | 1 |
| Yokoo, N | 2 |
| Erdem, AF | 1 |
| Cesur, M | 1 |
| Alici, HA | 1 |
| Erdogan, F | 1 |
| Dogan, N | 1 |
| Kursad, H | 1 |
| Yuksek, MS | 1 |
| Liu, Y | 1 |
| Chen, S | 1 |
| Mixco, J | 1 |
| Zhang, SD | 1 |
| Wan, H | 1 |
| Li, DZ | 1 |
| Nasu, I | 1 |
| Takaoka, S | 1 |
| Takata, K | 1 |
| Hoshikawa, T | 1 |
| Okada, M | 1 |
| Sakai, H | 1 |
| Yates, RB | 1 |
| Ishida, K | 1 |
| Keating, J | 1 |
| Zhang, B | 1 |
| Wei, X | 1 |
| Cui, X | 1 |
| Zhou, H | 1 |
| Ding, W | 1 |
| Li, W | 1 |
| Matsumoto, S | 1 |
| Murozono, M | 1 |
| Nagaoka, D | 1 |
| Matsuoka, S | 1 |
| Takeda, A | 1 |
| Narita, H | 1 |
| Watanabe, S | 1 |
| Isshiki, A | 1 |
| Watanabe, Y | 1 |
| Gelb, AW | 1 |
| Newberg, LA | 1 |
| Michenfelder, JD | 3 |
| Goskowicz, RL | 1 |
| Nakashima, K | 2 |
| Todd, MM | 7 |
| Verhaegen, M | 2 |
| Iaizzo, PA | 1 |
| Sugaya, T | 3 |
| Kitani, Y | 3 |
| Saito, S | 1 |
| Uehara, K | 1 |
| Morita, T | 1 |
| Fujita, T | 1 |
| Bickler, PE | 4 |
| Buck, LT | 1 |
| Hansen, BM | 1 |
| Hoffman, WE | 7 |
| Lingamneni, P | 1 |
| Minshall, R | 1 |
| Miletich, DJ | 4 |
| Albrecht, RF | 5 |
| Thomas, C | 4 |
| Sano, T | 2 |
| Reynolds, LW | 1 |
| Charbel, FT | 2 |
| Edelman, G | 2 |
| Eilers, H | 1 |
| Sessler, DI | 1 |
| Young, Y | 1 |
| Menon, DK | 1 |
| Tisavipat, N | 1 |
| Matta, BF | 1 |
| Jones, JG | 1 |
| Nakajima, Y | 1 |
| Moriwaki, G | 1 |
| Ikeda, K | 1 |
| Fujise, Y | 1 |
| Lavine, SD | 1 |
| Masri, LS | 1 |
| Levy, ML | 1 |
| Giannotta, SL | 1 |
| Linstedt, U | 1 |
| Maier, C | 1 |
| Petry, A | 1 |
| Ashwal, S | 2 |
| Tone, B | 2 |
| Tian, HR | 2 |
| Pearce, WJ | 2 |
| McKay, LD | 1 |
| Cross, LM | 1 |
| Ausman, JI | 1 |
| Mackensen, GB | 5 |
| Nellgård, B | 5 |
| Chu, CT | 1 |
| Dexter, F | 2 |
| Bart, RD | 1 |
| Liwnicz, BH | 1 |
| Kwon, JY | 1 |
| Bacher, A | 1 |
| Deyo, DJ | 1 |
| Disterhoft, JF | 1 |
| Uchida, T | 1 |
| Zornow, MH | 2 |
| Engelhard, K | 1 |
| Werner, C | 1 |
| Reeker, W | 1 |
| Möllenberg, O | 1 |
| Mielke, L | 1 |
| Kochs, E | 1 |
| Kodaka, M | 1 |
| Mori, T | 1 |
| Tanaka, K | 1 |
| Nomura, M | 1 |
| Kawazoe, T | 1 |
| Kimbro, JR | 1 |
| Popovic, R | 1 |
| Liniger, R | 1 |
| Massey, G | 1 |
| Pineda, J | 1 |
| Wellons, JC | 1 |
| Kudo, M | 1 |
| Mortier, E | 1 |
| Struys, M | 1 |
| Herregods, L | 1 |
| Sullivan, BL | 1 |
| Leu, D | 1 |
| Taylor, DM | 1 |
| Fahlman, CS | 1 |
| Löwl, D | 1 |
| Fütterer, C | 1 |
| Maurer, M | 1 |
| Waschke, KF | 1 |
| Isaev, NK | 1 |
| Verhaegen, MJ | 1 |
| Ruta, TS | 1 |
| Grafe, MR | 1 |
| Watson, JC | 1 |
| Zhou, JG | 1 |
| Ramani, R | 1 |
| Baughman, VL | 3 |
| Shapiro, HM | 1 |
| Cottrell, JE | 1 |
| Ishikawa, T | 1 |
| Maekawa, T | 1 |
| Shinohara, K | 1 |
| Sakabe, T | 1 |
| Takeshita, H | 1 |
| Lajoix, M | 1 |
| Cognard, J | 1 |
| Texier, JJ | 1 |
| Tapie, P | 1 |
| Moreau, JJ | 1 |
| Vidal, J | 1 |
| Ravon, R | 1 |
| Feiss, P | 1 |
| Sundt, TM | 1 |
| Fode, N | 1 |
| Sharbrough, FW | 1 |
| Deshpande, JK | 1 |
| Wieloch, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Gut Microbiome and Blood Indices in Patients With AD and Their Spousal Caregivers[NCT05601856] | 104 participants (Anticipated) | Observational | 2022-12-15 | Recruiting | |||
| Inhalatorial Sedation in Patient With SAH Versus Conventional Intravenous Sedation (GAS-SAH)[NCT00830843] | Phase 4 | 13 participants (Actual) | Interventional | 2009-01-31 | Completed | ||
| Pre Warming Protocol Implementation Strategy in the Operation Room Routine[NCT05573152] | 300 participants (Actual) | Interventional | 2015-07-31 | Completed | |||
| Preoperative Active Warming Prevents Postoperative Hypothermia in Patients Undergoing Laparoscopic Gynecologic Surgery. A Randomized Control Trial[NCT02518815] | 42 participants (Actual) | Interventional | 2013-05-31 | Completed | |||
| Delirium Reduction by Volatile Anesthesia in Cardiac Surgery: Prospective, Randomized, Single-blinded Study[NCT03729011] | Phase 4 | 672 participants (Anticipated) | Interventional | 2019-01-09 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for isoflurane and Brain Ischemia
| Article | Year |
|---|---|
[Perioperative cerebral ischemia and the possibility of neuroprotection by inhalational anesthetics].
Topics: Anesthesia, General; Anesthetics, Inhalation; Animals; Brain; Brain Ischemia; Coronary Artery Bypass | 2003 |
Neuroprotective effects of anesthetic agents.
Topics: Anesthetics; Animals; Apoptosis; Barbiturates; Brain Ischemia; Humans; Isoflurane; Neuroprotective A | 2005 |
Perioperative thermoregulation and heat balance.
Topics: Anesthesia, General; Anesthetics, Inhalation; Body Temperature; Body Temperature Regulation; Brain I | 1997 |
Perioperative thermoregulation and heat balance.
Topics: Anesthesia, General; Anesthetics, Inhalation; Body Temperature; Body Temperature Regulation; Brain I | 1997 |
Perioperative thermoregulation and heat balance.
Topics: Anesthesia, General; Anesthetics, Inhalation; Body Temperature; Body Temperature Regulation; Brain I | 1997 |
Perioperative thermoregulation and heat balance.
Topics: Anesthesia, General; Anesthetics, Inhalation; Body Temperature; Body Temperature Regulation; Brain I | 1997 |
Isoflurane neuroprotection: a passing fantasy, again?
Topics: Anesthetics, Inhalation; Animals; Brain; Brain Ischemia; Humans; Isoflurane; Neuroprotective Agents | 2000 |
Therapeutic coma or neuroprotection by anaesthetics.
Topics: Anesthetics; Animals; Barbiturates; Brain; Brain Ischemia; Cardiopulmonary Bypass; Drug Evaluation; | 2000 |
Aspects of brain metabolism during ischemia: intervention.
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Isoflurane; Thiopental | 1989 |
Cerebral preservation for intraoperative focal ischemia.
Topics: Adenosine Triphosphate; Anesthesia; Anesthetics; Aneurysm; Animals; Barbiturates; Brain; Brain Disea | 1985 |
1 trial available for isoflurane and Brain Ischemia
| Article | Year |
|---|---|
Thiopental and desflurane treatment for brain protection.
Topics: Acid-Base Equilibrium; Anesthetics, Inhalation; Brain; Brain Ischemia; Cerebral Revascularization; C | 1998 |
123 other studies available for isoflurane and Brain Ischemia
| Article | Year |
|---|---|
Isoflurane and Netrin-1 combination therapy enhances angiogenesis and neurological recovery by improving the expression of HIF-1α-Netrin-1-UNC5B/VEGF cascade to attenuate cerebral ischemia injury.
Topics: Animals; Brain Injuries; Brain Ischemia; Cerebral Infarction; Disease Models, Animal; Hypoxia-Induci | 2022 |
Isoflurane Attenuates Cerebral Ischaemia-Reperfusion Injury via the TLR4-NLRP3 Signalling Pathway in Diabetic Mice.
Topics: Animals; Brain Ischemia; Diabetes Mellitus, Experimental; Humans; Infarction, Middle Cerebral Artery | 2022 |
Isoflurane Postconditioning Alleviates Ischemic Neuronal Injury Via MiR-384-5p Regulated Autophagy.
Topics: Animals; Apoptosis; Autophagy; Brain Ischemia; Glucose; Isoflurane; Mice; MicroRNAs; Neurons; Rats; | 2023 |
The impact of anesthetic drugs on hemodynamic parameters and neurological outcomes following temporal middle cerebral artery occlusion in rats.
Topics: Anesthetics; Animals; Brain Ischemia; Chloral Hydrate; Halothane; Hemodynamics; Infarction, Middle C | 2023 |
Isoflurane Enhances Autophagy by Activating AMPK/ULK1, Inhibits NLRP3, and Reduces Cognitive Impairment After Cerebral Ischemia-Reperfusion Injury in Rats.
Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Autophagy-Related Protein-1 Homolog; Brain Ischem | 2023 |
Isoflurane Conditioning-Induced Delayed Cerebral Ischemia Protection in Subarachnoid Hemorrhage-Role of Inducible Nitric Oxide Synthase.
Topics: Animals; Brain Ischemia; Cerebral Infarction; Isoflurane; Male; Mice; Mice, Inbred C57BL; Mice, Knoc | 2023 |
Distinctive effect of anesthetics on the effect of limb remote ischemic postconditioning following ischemic stroke.
Topics: Analgesics; Anesthetics; Animals; Brain Infarction; Brain Ischemia; Extremities; Halothane; Infarcti | 2020 |
Isoflurane improves cerebral ischemia-reperfusion injury in rats via activating MAPK signaling pathway.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Isoflurane; MAP Kinase Signaling System; Rats; Repe | 2021 |
TGF-β3/Smad3 Contributes to Isoflurane Postconditioning Against Cerebral Ischemia-Reperfusion Injury by Upregulating MEF2C.
Topics: Animals; Brain Ischemia; Infarction, Middle Cerebral Artery; Isoflurane; Male; MEF2 Transcription Fa | 2020 |
Isoflurane cerebral preconditioning in a spontaneous hypertension rat model is associated with sphingosine kinases.
Topics: Anesthetics, Inhalation; Animals; Brain Ischemia; Humans; Hypertension; Ischemic Preconditioning; Is | 2020 |
Role of Endothelial Nitric Oxide Synthase in Isoflurane Conditioning-Induced Neurovascular Protection in Subarachnoid Hemorrhage.
Topics: Anesthetics, Inhalation; Animals; Brain Ischemia; Disease Models, Animal; Endothelium, Vascular; Isc | 2020 |
Anesthetic and subanesthetic doses of isoflurane conditioning provides strong protection against delayed cerebral ischemia in a mouse model of subarachnoid hemorrhage.
Topics: Animals; Brain Ischemia; Cerebral Infarction; Disease Models, Animal; Isoflurane; Male; Mice; Mice, | 2021 |
Isoflurane post-conditioning attenuates cerebral ischemia/reperfusion injury by reducing apoptotic through activating the BMP7/SMAD signaling pathway in rats.
Topics: Animals; Apoptosis; Bone Morphogenetic Protein 7; Brain Ischemia; Ischemic Postconditioning; Isoflur | 2021 |
Nrf2 mediates the neuroprotective effect of isoflurane preconditioning in cortical neuron injury induced by oxygen-glucose deprivation.
Topics: Anesthetics, Inhalation; Animals; Brain; Brain Ischemia; Cell Survival; Glucose; Humans; Hypoxia; Is | 2021 |
Isoflurane post-conditioning contributes to anti-apoptotic effect after cerebral ischaemia in rats through the ERK5/MEF2D signaling pathway.
Topics: Anesthetics, Inhalation; Animals; Apoptosis; Brain Ischemia; Cell Movement; Cell Proliferation; Gene | 2021 |
Role of SIRT1 in Isoflurane Conditioning-Induced Neurovascular Protection against Delayed Cerebral Ischemia Secondary to Subarachnoid Hemorrhage.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Fluorescent Antibody Technique; Gene Expression; Is | 2021 |
Isoflurane preconditioning inhibits the effects of tissue-type plasminogen activator on brain endothelial cell in an
Topics: Animals; Apoptosis; Brain Injuries; Brain Ischemia; Culture Media, Conditioned; Cyclooxygenase 2; Di | 2017 |
Sphingosine kinase 2 activates autophagy and protects neurons against ischemic injury through interaction with Bcl-2 via its putative BH3 domain.
Topics: Amino Acid Sequence; Animals; Autophagy; Beclin-1; Brain Ischemia; Cerebral Cortex; Gene Expression | 2017 |
Activation of cannabinoid receptor 1 is involved in protection against mitochondrial dysfunction and cerebral ischaemic tolerance induced by isoflurane preconditioning.
Topics: Anesthetics, Inhalation; Animals; Brain Ischemia; Disease Models, Animal; Infarction, Middle Cerebra | 2017 |
Isoflurane post-conditioning down-regulates expression of aquaporin 4 in rats with cerebral ischemia/reperfusion injury and is possibly related to bone morphogenetic protein 4/Smad1/5/8 signaling pathway.
Topics: Animals; Aquaporin 4; Bone Morphogenetic Protein 4; Brain Ischemia; Down-Regulation; Gene Expression | 2018 |
Persistent isoflurane-induced hypotension causes hippocampal neuronal damage in a rat model of chronic cerebral hypoperfusion.
Topics: Animals; Brain Ischemia; CA1 Region, Hippocampal; Disease Models, Animal; Hippocampus; Hypotension; | 2018 |
TREK-2 Mediates the Neuroprotective Effect of Isoflurane Preconditioning Against Acute Cerebral Ischemia in the Rat.
Topics: Acute Disease; Animals; Brain Ischemia; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; | 2019 |
Wnt/β-catenin signaling pathway contributes to isoflurane postconditioning against cerebral ischemia-reperfusion injury and is possibly related to the transforming growth factorβ1/Smad3 signaling pathway.
Topics: Anesthetics, Inhalation; Animals; Brain Ischemia; Ischemic Postconditioning; Isoflurane; Male; Rats; | 2019 |
Acute and sustained isoflurane neuroprotection: the effect of culture age and duration of oxygen and glucose deprivation.
Topics: Analysis of Variance; Animals; Animals, Newborn; Brain Ischemia; Cell Death; Cell Hypoxia; Glucose; | 2013 |
Guidelines for using mouse global cerebral ischemia models.
Topics: Animals; Blood Pressure; Brain; Brain Damage, Chronic; Brain Ischemia; Disease Models, Animal; Heart | 2013 |
Twinning and survivorship of captive common marmosets (Callithrix jacchus) and cotton-top tamarins (Saguinus oedipus).
Topics: Animals; Animals, Laboratory; Brain Ischemia; Bupivacaine; Callithrix; Electroencephalography; Eutha | 2014 |
Rate and extent of leakage of a magnetic resonance contrast agent tend to be lower under isoflurane anesthesia in comparison to halothane in a rat model of embolic stroke.
Topics: Anesthetics, Inhalation; Animals; Blood-Brain Barrier; Brain Ischemia; Cerebrovascular Circulation; | 2014 |
[The effects of preconditioning and postconditioning with isoflurane on focal cerebral ischemi/reperfusion injury in rats].
Topics: Animals; Brain; Brain Ischemia; Disease Models, Animal; Interleukin-1beta; Ischemic Postconditioning | 2014 |
Inhibition of brain ischemia-caused notch activation in microglia may contribute to isoflurane postconditioning-induced neuroprotection in male rats.
Topics: Animals; Brain; Brain Ischemia; Caspase 3; CD11b Antigen; Cell Hypoxia; Cell Line; Cytokines; Diseas | 2014 |
The Role of SUMO-Conjugating Enzyme Ubc9 in the Neuroprotection of Isoflurane Preconditioning Against Ischemic Neuronal Injury.
Topics: Anesthetics, Inhalation; Animals; Brain Ischemia; Disease Models, Animal; Humans; Ischemic Precondit | 2015 |
Protective role of isoflurane pretreatment in rats with focal cerebral ischemia and the underlying molecular mechanism.
Topics: Animals; Astrocytes; Brain Injuries; Brain Ischemia; Disease Models, Animal; Humans; Infarction, Mid | 2015 |
Local O2 Balance in Cerebral Ischemia-Reperfusion Improved during Pentobarbital Compared with Isoflurane Anesthesia.
Topics: Anesthetics, Inhalation; Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Infarction, Mi | 2015 |
Isoflurane Preconditioning Promotes the Survival and Migration of Bone Marrow Stromal Cells.
Topics: Anesthetics, Inhalation; Animals; Brain; Brain Ischemia; Cell Movement; Cell Survival; Cells, Cultur | 2015 |
Transforming growth-beta 1 contributes to isoflurane postconditioning against cerebral ischemia-reperfusion injury by regulating the c-Jun N-terminal kinase signaling pathway.
Topics: Animals; Anthracenes; Behavior, Animal; Brain Ischemia; CA1 Region, Hippocampal; In Situ Nick-End La | 2016 |
Peri-infarct depolarizations during focal ischemia in the awake Spontaneously Hypertensive Rat. Minimizing anesthesia confounds in experimental stroke.
Topics: Anesthetics, Inhalation; Animals; Brain Ischemia; Cerebral Cortex; Disease Models, Animal; Infarctio | 2016 |
TIGAR contributes to ischemic tolerance induced by cerebral preconditioning through scavenging of reactive oxygen species and inhibition of apoptosis.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Brain Ischemia; Cerebral Cortex; Gene Expression | 2016 |
Hemodynamic effects of intraoperative anesthetics administration in photothrombotic stroke model: a study using laser speckle imaging.
Topics: Anesthetics, Inhalation; Animals; Brain; Brain Ischemia; Disease Models, Animal; Hemodynamics; Isofl | 2017 |
Anesthesia-Induced Hypothermia Attenuates Early-Phase Blood-Brain Barrier Disruption but Not Infarct Volume following Cerebral Ischemia.
Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Arterial Occlusive Diseases; Blood-Brain B | 2017 |
Estradiol attenuates neuroprotective benefits of isoflurane preconditioning in ischemic mouse brain.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Drug Implants; Estradiol; Estrogen Receptor alpha; | 2008 |
A modified suture technique produces consistent cerebral infarction in rats.
Topics: Analysis of Variance; Anesthetics; Animals; Brain Ischemia; Cerebrovascular Circulation; Disease Mod | 2008 |
Isoflurane preconditioning improves short-term and long-term neurological outcome after focal brain ischemia in adult rats.
Topics: Animals; Brain Ischemia; Cell Survival; Cerebral Cortex; Desflurane; Infarction, Middle Cerebral Art | 2009 |
Detection of ischemic electroencephalography changes during carotid endarterectomy using synchronization likelihood analysis.
Topics: Adult; Aged; Aged, 80 and over; Algorithms; Anesthesia, General; Anesthetics, Inhalation; Anesthetic | 2009 |
The effects of isoflurane pretreatment on cerebral blood flow, capillary permeability, and oxygen consumption in focal cerebral ischemia in rats.
Topics: Aminoisobutyric Acids; Anesthetics, Inhalation; Animals; Antipyrine; Arterioles; Blood Gas Analysis; | 2010 |
Neuroprotective effect of isoflurane and N-methyl-D-aspartate receptors in ischemic brain injury.
Topics: Animals; Brain; Brain Ischemia; Isoflurane; Neurons; Neuroprotective Agents; Rats; Receptors, N-Meth | 2010 |
Isoflurane enhanced hemorrhagic transformation by impairing antioxidant enzymes in hyperglycemic rats with middle cerebral artery occlusion.
Topics: Anesthetics, Inhalation; Animals; Antioxidants; Brain Ischemia; Catalase; Cerebral Hemorrhage; Hyper | 2011 |
The effect of blood pressure (37 vs 45 mmHg) and carotid occlusion duration (8 vs 10 min) on CA1-4 neuronal damage when using isoflurane in a global cerebral ischemia rat model.
Topics: Anesthetics, Inhalation; Animals; Brain Ischemia; Carotid Arteries; Cell Survival; Disease Models, A | 2011 |
Isoflurane preconditioning protects neurons from male and female mice against oxygen and glucose deprivation and is modulated by estradiol only in neurons from female mice.
Topics: Animals; Brain Ischemia; Cell Survival; Estradiol; Estrogen Antagonists; Female; Glucose; Hypoxia, B | 2011 |
Isoflurane postconditioning induces neuroprotection via Akt activation and attenuation of increased mitochondrial membrane permeability.
Topics: Animals; Blotting, Western; Brain Ischemia; Enzyme Activation; Ischemic Postconditioning; Isoflurane | 2011 |
Simple model of forebrain ischemia in mouse.
Topics: Anesthetics, Inhalation; Animals; Blood Pressure; Brain Ischemia; Cerebrovascular Circulation; Disea | 2012 |
Induction of inducible nitric oxide synthase by isoflurane post-conditioning via hypoxia inducible factor-1α during tolerance against ischemic neuronal injury.
Topics: Anesthetics, Inhalation; Animals; Blood-Brain Barrier; Brain Ischemia; Cells, Cultured; Hypoxia-Indu | 2012 |
Peri-infarct flow transients predict outcome in rat focal brain ischemia.
Topics: Anesthesia; Anesthesia, Inhalation; Animals; Basal Ganglia; Blood Pressure; Brain Ischemia; Carbon D | 2012 |
Isoflurane postconditioning reduces ischemia-induced nuclear factor-κB activation and interleukin 1β production to provide neuroprotection in rats and mice.
Topics: Animals; Blotting, Western; Brain Ischemia; Enzyme-Linked Immunosorbent Assay; In Situ Nick-End Labe | 2013 |
Isoflurane induced prolonged protection against cerebral ischemia in mice: a redox sensitive mechanism?
Topics: Anesthetics, Inhalation; Animals; Blood Pressure; Brain Ischemia; Hypoxia; Isoflurane; Male; Mice; M | 2002 |
A novel EEG artifact in the intensive care unit.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Anesthetics, Inhalation; Artifacts; Brain Ischemia; Electro | 2002 |
Isoflurane preconditioning reduces purkinje cell death in an in vitro model of rat cerebellar ischemia.
Topics: Amino Acid Transport System X-AG; Anesthetics, Inhalation; Animals; Aspartic Acid; Brain Ischemia; C | 2003 |
Desflurane affords greater protection than halothane against focal cerebral ischaemia in the rat.
Topics: Analysis of Variance; Anesthetics, Inhalation; Animals; Blood Pressure; Brain Ischemia; Carbon Dioxi | 2003 |
Severe hypotension is not essential for isoflurane neuroprotection against forebrain ischemia in mice.
Topics: Anesthetics, Inhalation; Animals; Brain; Brain Chemistry; Brain Ischemia; Hypotension, Controlled; I | 2003 |
Perioperative neuroprotection: are we asking the right questions?
Topics: Anesthetics; Animals; Apoptosis; Brain Ischemia; Humans; Isoflurane; Neuroprotective Agents; Postope | 2004 |
Effect of isoflurane on neuronal apoptosis in rats subjected to focal cerebral ischemia.
Topics: Anesthetics, Inhalation; Animals; Apoptosis; Brain Ischemia; Caspase 3; Caspase 9; Caspases; DNA Fra | 2004 |
Isoflurane preconditioning induces neuroprotection against ischemia via activation of P38 mitogen-activated protein kinases.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain Ischemia; Disease Models, Animal; Imidazoles | 2004 |
Effects of isoflurane versus fentanyl-nitrous oxide anesthesia on long-term outcome from severe forebrain ischemia in the rat.
Topics: Anesthesia; Animals; Brain Ischemia; Cell Death; Fentanyl; Isoflurane; Male; Nitrous Oxide; Prosence | 2004 |
Combination of isoflurane and caspase inhibition reduces cerebral injury in rats subjected to focal cerebral ischemia.
Topics: Amino Acid Chloromethyl Ketones; Anesthetics, Inhalation; Animals; Blood Gas Analysis; Brain; Brain | 2004 |
Postischemic nitrous oxide alone versus intraischemic nitrous oxide in the presence of isoflurane: what it may change for neuroprotection against cerebral stroke in the rat.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Brain Ischemia; Drug Interactions; Isoflurane; N | 2005 |
Effects of sevoflurane and desflurane in CA1 after incomplete cerebral ischemia in rats.
Topics: Analysis of Variance; Anesthetics, Inhalation; Animals; Biopsy, Needle; Brain Ischemia; Cerebrovascu | 2005 |
Isoflurane tolerance against focal cerebral ischemia is attenuated by adenosine A1 receptor antagonists.
Topics: Adenosine A1 Receptor Antagonists; Anesthetics, Inhalation; Animals; Brain Ischemia; Ischemic Precon | 2006 |
The combination of isoflurane and caspase 8 inhibition results in sustained neuroprotection in rats subject to focal cerebral ischemia.
Topics: Animals; Brain Ischemia; Caspase 8; Caspase Inhibitors; Caspases; Drug Therapy, Combination; Isoflur | 2006 |
Selective gamma-aminobutyric acid type A receptor antagonism reverses isoflurane ischemic neuroprotection.
Topics: Animals; Brain Ischemia; GABA Antagonists; GABA-A Receptor Antagonists; In Vitro Techniques; Isoflur | 2006 |
Protective effect of isoflurane and sevoflurane on ischemic neurons and expression of Bcl-2 and ICE genes in rat brain.
Topics: Anesthetics, Inhalation; Animals; Apoptosis; Brain Ischemia; Caspase 1; Flow Cytometry; Hippocampus; | 2006 |
The dose-dependent effects of isoflurane on outcome from severe forebrain ischemia in the rat.
Topics: Anesthetics, Inhalation; Animals; Brain Ischemia; Dose-Response Relationship, Drug; Hippocampus; Isc | 2006 |
Isoflurane provides long-term protection against focal cerebral ischemia in the rat.
Topics: Anesthetics, Inhalation; Animals; Blood Pressure; Brain Ischemia; Infarction, Middle Cerebral Artery | 2007 |
Alpha-chloralose is a suitable anesthetic for chronic focal cerebral ischemia studies in the rat: a comparative study.
Topics: Anesthesia; Anesthetics, Intravenous; Animals; Brain; Brain Injuries; Brain Ischemia; Cerebrovascula | 2008 |
Desflurane affords greater protection than halothane in the function of mitochondria against forebrain ischemia reperfusion injury in rats.
Topics: Anesthetics, Inhalation; Animals; Blood Pressure; Brain Ischemia; Cerebrovascular Circulation; Desfl | 2008 |
Isoflurane preconditioning increases B-cell lymphoma-2 expression and reduces cytochrome c release from the mitochondria in the ischemic penumbra of rat brain.
Topics: Anesthetics, Inhalation; Animals; bcl-2-Associated X Protein; BH3 Interacting Domain Death Agonist P | 2008 |
Isoflurane inhibits protein kinase Cgamma and calcium/calmodulin dependent protein kinase ii-alpha translocation to synaptic membranes in ischemic mice brains.
Topics: Anesthetics, Inhalation; Animals; Brain Ischemia; Calcium-Calmodulin-Dependent Protein Kinase Type 2 | 2008 |
Anesthetic considerations for carotid endarterectomy.
Topics: Aged; Anesthesia, General; Anesthesia, Inhalation; Blood Pressure; Brain; Brain Ischemia; Carbon Dio | 1984 |
Cerebral protection by isoflurane during hypoxemia or ischemia.
Topics: Animals; Brain; Brain Ischemia; Dogs; Electroencephalography; Energy Metabolism; Hypoxia; Isoflurane | 1983 |
Isoflurane reduces ischemia-induced glutamate release in rats subjected to forebrain ischemia.
Topics: Anesthesia; Animals; Brain Ischemia; Dialysis; Dose-Response Relationship, Drug; Electroencephalogra | 1995 |
The relation between cerebral metabolic rate and ischemic depolarization. A comparison of the effects of hypothermia, pentobarbital, and isoflurane.
Topics: Animals; Brain; Brain Ischemia; Electroencephalography; Glucose; Hypothermia, Induced; Isoflurane; M | 1995 |
A comparison of the effects of hypothermia, pentobarbital, and isoflurane on cerebral energy stores at the time of ischemic depolarization.
Topics: Adenosine Triphosphate; Animals; Brain; Brain Ischemia; Hypothermia, Induced; Isoflurane; Male; Memb | 1995 |
[Effects of volatile anesthetics on microtubule-associated protein 2 degradation during forebrain ischemia in the rat].
Topics: Anesthetics, Inhalation; Animals; Brain Ischemia; Electroencephalography; Ethers; Halothane; Isoflur | 1994 |
Ischemic depolarization during halothane-nitrous oxide and isoflurane-nitrous oxide anesthesia. An examination of cerebral blood flow threshold and times to depolarization.
Topics: Anesthesia, Inhalation; Animals; Blood Pressure; Brain; Brain Ischemia; Cerebrovascular Circulation; | 1994 |
Effects of isoflurane and hypothermia on glutamate receptor-mediated calcium influx in brain slices.
Topics: Adenosine Triphosphate; Animals; Brain; Brain Ischemia; Calcium; Cytosol; Excitatory Amino Acid Anta | 1994 |
Isoflurane reduces microtubule-associated protein 2 degradation compared with halothane during forebrain ischaemia in the rat.
Topics: Animals; Brain Ischemia; Halothane; Isoflurane; Male; Microtubule-Associated Proteins; Prosencephalo | 1993 |
Brain alpha 2-adrenergic receptor binding during incomplete cerebral ischemia in the rat.
Topics: Anesthesia, Inhalation; Anesthesia, Intravenous; Animals; Blood Pressure; Brain; Brain Ischemia; Car | 1993 |
The effect of halothane and isoflurane on neurologic outcome following incomplete cerebral ischemia in the rat.
Topics: Anesthesia, Inhalation; Animals; Brain Ischemia; Catecholamines; Fentanyl; Halothane; Isoflurane; Ma | 1993 |
A comparison of the cerebral protective effects of etomidate, thiopental, and isoflurane in a model of forebrain ischemia in the rat.
Topics: Animals; Brain; Brain Ischemia; Etomidate; Isoflurane; Male; Prosencephalon; Rats; Rats, Inbred WKY; | 1993 |
Focal cerebral ischemia during anesthesia with etomidate, isoflurane, or thiopental: a comparison of the extent of cerebral injury.
Topics: Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Brain; Brain Damage | 1995 |
Brain tissue oxygen, carbon dioxide, and pH in neurosurgical patients at risk for ischemia.
Topics: Adult; Anesthesia, Inhalation; Anesthetics, Inhalation; Blood Gas Analysis; Brain; Brain Ischemia; C | 1996 |
Effects of hypothermia, pentobarbital, and isoflurane on postdepolarization amino acid release during complete global cerebral ischemia.
Topics: Anesthetics, Inhalation; Animals; Aspartic Acid; Brain Ischemia; Calcium; gamma-Aminobutyric Acid; G | 1996 |
Hypothermia and isoflurane similarly inhibit glutamate release evoked by chemical anoxia in rat cortical brain slices.
Topics: Anesthetics, Inhalation; Animals; Brain Ischemia; Cerebral Cortex; Dose-Response Relationship, Drug; | 1996 |
Propofol neuroprotection in a rat model of ischaemia reperfusion injury.
Topics: Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Antioxidants; Brain; Brain I | 1997 |
The effects of sevoflurane on recovery of brain energy metabolism after cerebral ischemia in the rat: a comparison with isoflurane and halothane.
Topics: Adenosine Triphosphate; Anesthetics, Inhalation; Animals; Brain; Brain Ischemia; Energy Metabolism; | 1997 |
Nitrous oxide attenuates the protective effect of isoflurane on microtubule-associated protein2 degradation during forebrain ischemia in the rat.
Topics: Anesthetics, Inhalation; Animals; Brain Ischemia; Halothane; Isoflurane; Male; Microtubule-Associate | 1997 |
Temporary occlusion of the middle cerebral artery in intracranial aneurysm surgery: time limitation and advantage of brain protection.
Topics: Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, Intravenous; Aneurysm, Ruptured; Brai | 1997 |
Intraoperative monitoring with somatosensory evoked potentials in carotid artery surgery--less reliable in patients with preoperative neurologic deficiency?
Topics: Aged; Anesthetics, Inhalation; Anesthetics, Intravenous; Arteriovenous Shunt, Surgical; Atracurium; | 1998 |
Core and penumbral nitric oxide synthase activity during cerebral ischemia and reperfusion.
Topics: Anesthetics, Inhalation; Animals; Antioxidants; Arterial Occlusive Diseases; Biopterins; Brain Ische | 1998 |
Subarachnoid molecular hemoglobin after subarachnoid hemorrhage in rats: effect on the area of hypoperfusion.
Topics: Analysis of Variance; Anesthetics, Inhalation; Animals; Antipyrine; Aspirin; Blood; Blood Substitute | 1998 |
Sympathetic ganglionic blockade masks beneficial effect of isoflurane on histologic outcome from near-complete forebrain ischemia in the rat.
Topics: Anesthetics, Inhalation; Animals; Brain Ischemia; Ganglia, Sympathetic; Ganglionic Blockers; Injecti | 1999 |
Effects of isoflurane, ketamine, and fentanyl/N2O on concentrations of brain and plasma catecholamines during near-complete cerebral ischemia in the rat.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Brain Ischemia; Catecholamines; Fentanyl | 1999 |
Core and penumbral nitric oxide synthase activity during cerebral ischemia and reperfusion in the rat pup.
Topics: Animals; Brain; Brain Ischemia; Disease Models, Animal; Isoflurane; Male; Nitric Oxide Synthase; Rat | 1999 |
Effects of pentobarbital and isoflurane on conditioned learning after transient global cerebral ischemia in rabbits.
Topics: Adjuvants, Anesthesia; Anesthetics, Inhalation; Animals; Brain Ischemia; Conditioning, Classical; Is | 2000 |
Desflurane and isoflurane improve neurological outcome after incomplete cerebral ischaemia in rats.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Brain Ischemia; Chromatography, High Pre | 1999 |
[Depressive effects of propofol on apoptotic injury and delayed neuronal death after forebrain ischemia in the rat--comparison with nitrous oxide-oxygen-isoflurane].
Topics: Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, Intravenous; | 2000 |
Isoflurane delays but does not prevent cerebral infarction in rats subjected to focal ischemia.
Topics: Anesthetics, Inhalation; Animals; Brain Ischemia; Cerebral Infarction; Hemodynamics; Isoflurane; Neu | 2000 |
Anesthetics and mild hypothermia similarly prevent hippocampal neuron death in an in vitro model of cerebral ischemia.
Topics: Anesthetics; Animals; Brain Ischemia; Cell Death; Hippocampus; Hypothermia; Hypoxia; Isoflurane; Neu | 2000 |
The effects of anesthetics on stress responses to forebrain ischemia and reperfusion in the rat.
Topics: Anesthetics; Animals; Brain Ischemia; Corticosterone; Fentanyl; Interleukin-6; Isoflurane; Metyrapon | 2000 |
Anesthetic effects on cerebral metabolic rate predict histologic outcome from near-complete forebrain ischemia in the rat.
Topics: Anesthetics, Inhalation; Animals; Body Weight; Brain; Brain Ischemia; Halothane; Hemodynamics; Isofl | 2000 |
Periischemic cerebral blood flow (CBF) does not explain beneficial effects of isoflurane on outcome from near-complete forebrain ischemia in rats.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Autonomic Nerve Block; Brain Ischemia; C | 2000 |
Isoflurane prevents delayed cell death in an organotypic slice culture model of cerebral ischemia.
Topics: Anesthetics, Inhalation; Animals; Brain Ischemia; Cell Death; Cell Survival; Dizocilpine Maleate; Gl | 2002 |
Tolerance against ischemic neuronal injury can be induced by volatile anesthetics and is inducible NO synthase dependent.
Topics: Anesthetics, Inhalation; Animals; Body Temperature; Brain; Brain Infarction; Brain Ischemia; Cells, | 2002 |
A comparison of cerebral ischemic flow thresholds during halothane/N2O and isoflurane/N2O anesthesia in rats.
Topics: Anesthesia, Inhalation; Animals; Blood Pressure; Brain; Brain Ischemia; Cerebrovascular Circulation; | 1992 |
A comparison of the area of histochemical dysfunction after focal cerebral ischaemia during anaesthesia with isoflurane and halothane in the rat.
Topics: Anesthesia, Inhalation; Animals; Brain; Brain Ischemia; Halothane; Isoflurane; Male; Rats; Rats, Inb | 1991 |
A comfortable hypothesis reevaluated. Cerebral metabolic depression and brain protection during ischemia.
Topics: Animals; Brain; Brain Ischemia; Depression, Chemical; Dogs; Halothane; Hypothermia, Induced; Isoflur | 1992 |
A comparison of the cerebral protective effects of isoflurane and mild hypothermia in a model of incomplete forebrain ischemia in the rat.
Topics: Animals; Brain Ischemia; Depression, Chemical; Halothane; Hypothermia, Induced; Isoflurane; Male; Pr | 1992 |
Reversible focal ischemia in the rat: effects of halothane, isoflurane, and methohexital anesthesia.
Topics: Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Halothane; Isoflurane; Male; Methohexit | 1991 |
Comparison of methohexital and isoflurane on neurologic outcome and histopathology following incomplete ischemia in rats.
Topics: Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Electroencephalography; Hemodynamics; I | 1990 |
Influence of hypotension and hypotensive technique on the area of profound reduction in cerebral blood flow during focal cerebral ischaemia in the rat.
Topics: Animals; Brain Ischemia; Cerebrovascular Circulation; Hypotension; Hypotension, Controlled; Isoflura | 1990 |
The interaction of nitrous oxide and isoflurane with incomplete cerebral ischemia in the rat.
Topics: Anesthesia, Inhalation; Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Electroencephal | 1989 |
[Differential effects of isoflurane and nitrous oxide on cerebral blood flow, metabolism and electrocorticogram after incomplete cerebral ischemia in the rat].
Topics: Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Electroencephalography; Glucose; Isoflu | 1989 |
Neurologic outcome in rats following incomplete cerebral ischemia during halothane, isoflurane, or N2O.
Topics: Anesthesia, Inhalation; Animals; Blood Gas Analysis; Blood Pressure; Brain; Brain Ischemia; Cerebrov | 1988 |
[Hypometabolism induced by isoflurane and moderate hypothermia in aneurysm surgery with hypotension: evaluation by EEG].
Topics: Brain; Brain Ischemia; Electroencephalography; Humans; Hypotension, Controlled; Hypothermia, Induced | 1987 |
Isoflurane when compared to enflurane and halothane decreases the frequency of cerebral ischemia during carotid endarterectomy.
Topics: Anesthesia, Inhalation; Brain Ischemia; Carotid Arteries; Cerebrovascular Circulation; Endarterectom | 1987 |
The effect of isoflurane on neuronal necrosis following near-complete forebrain ischemia in the rat.
Topics: Animals; Blood Pressure; Brain; Brain Ischemia; Electroencephalography; Isoflurane; Male; Methyl Eth | 1986 |