isoflurane has been researched along with Brain Edema in 25 studies
Isoflurane: A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.
Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of induced hypotension with isoflurane and labetalol on cerebral edema formation were compared following a cryogenic brain injury in dogs." | 9.07 | Cerebral edema formation in dogs following hypotension induced with isoflurane and labetalol. ( Bendo, AA; Capuano, C; Cottrell, JE; Kozlowski, PB; Mendeszoon, MH, 1993) |
| "Isoflurane significantly improved neurobehavioral function and brain edema at 24 hrs but not 72 hrs after subarachnoid hemorrhage." | 7.78 | Isoflurane delays the development of early brain injury after subarachnoid hemorrhage through sphingosine-related pathway activation in mice. ( Altay, O; Hasegawa, Y; Khatibi, NH; Sherchan, P; Suzuki, H; Tang, J; Zhang, JH, 2012) |
| "SAH aggravated neurological scores, brain edema, and blood-brain barrier permeability, which were prevented by 2% but not 1% isoflurane posttreatment." | 7.78 | Isoflurane attenuates blood-brain barrier disruption in ipsilateral hemisphere after subarachnoid hemorrhage in mice. ( Altay, O; Caner, B; Fujii, M; Hasegawa, Y; Krafft, PR; Suzuki, H; Tang, J; Zhang, JH, 2012) |
| "5% isoflurane posttreatment, there was a significant reduction in brain edema, a decrease in apoptotic cell death, and a significant improvement in neurobehavioral deficits." | 7.77 | Isoflurane posttreatment reduces brain injury after an intracerebral hemorrhagic stroke in mice. ( Applegate, R; Fathali, N; Khatibi, NH; Ma, Q; Martin, R; Ostrowski, R; Rolland, W; Stier, G; Tang, J; Zhang, JH, 2011) |
| "24 h prior to intracerebral hemorrhage, C57BL/6J mice were preconditioned with a 4-h exposure to 1% isoflurane gas or room air." | 7.77 | Isoflurane preconditioning affords functional neuroprotection in a murine model of intracerebral hemorrhage. ( Appelboom, G; Connolly, ES; Ducruet, AF; Gigante, PR; Gorski, J; Haque, RM; Hwang, BY; Keesecker, SE; Kellner, CP; Yeh, ML, 2011) |
| " Since volatile anesthetics elevate plasma amino acid concentrations, the influence of isoflurane on arterial plasma glutamate levels and brain edema formation was investigated in brain-injured rats." | 7.70 | Isoflurane doubles plasma glutamate and increases posttraumatic brain edema. ( Kempski, OS; Kroppenstedt, SN; Stover, JF; Thomale, UW; Unterberg, AW, 2000) |
| "To evaluate the impact of anesthetics on the evolution of a cerebral injury, 33 rabbits were subjected to a cryogenic brain lesion, followed by 10 h of anesthesia with 1 MAC halothane or isoflurane (n = 11 each) or with an equipotent dose of pentobarbital (n = 11)." | 7.67 | A comparison of the effects of halothane, isoflurane, and pentobarbital anesthesia on intracranial pressure and cerebral edema formation following brain injury in rabbits. ( Kaieda, R; Todd, MM; Warner, DS; Weeks, JB, 1989) |
| "The first step to treat aneurysmal subarachnoid hemorrhage (SAH) is aneurysmal obliteration under general anesthesia but not treat the SAH itself and the secondary effects." | 5.56 | Isoflurane versus sevoflurane for early brain injury and expression of sphingosine kinase 1 after experimental subarachnoid hemorrhage. ( Altay, BN; Altay, O; Calisir, V; Suzuki, H; Tang, J; Zhang, JH, 2020) |
| "Isoflurane treatment did not reduce brain edema compared with controls in any of the applied isoflurane concentrations." | 5.39 | Lower doses of isoflurane treatment has no beneficial effects in a rat model of intracerebral hemorrhage. ( Esposito, E; Lo, EH; Mandeville, ET, 2013) |
| " Transient MCAO was induced during either isoflurane or ketamine/xylazine (ket/xyl) anesthesia with simultaneously measurement of cerebral blood flow (CBF) in 60 male Wistar rats (380-420 g)." | 5.17 | Effect of anesthesia and cerebral blood flow on neuronal injury in a rat middle cerebral artery occlusion (MCAO) model. ( Bleilevens, C; Dang, J; Goetzenich, A; Hein, M; Kipp, M; Roehl, AB; Rossaint, R; Tolba, R; Zoremba, N, 2013) |
| "The study indicates that before as well as during hyperventilation, subdural ICP and AVDo2 are lower and CPP higher in propofol-anesthetized patients compared with patients anesthetized with isoflurane or sevoflurane." | 5.10 | Intracranial pressure and cerebral hemodynamic in patients with cerebral tumors: a randomized prospective study of patients subjected to craniotomy in propofol-fentanyl, isoflurane-fentanyl, or sevoflurane-fentanyl anesthesia. ( Cold, GE; Hauerberg, J; Holst, P; Landsfeldt, U; Mau, S; Olsen, KS; Petersen, CB; Petersen, KD, 2003) |
| "The effects of induced hypotension with isoflurane and labetalol on cerebral edema formation were compared following a cryogenic brain injury in dogs." | 5.07 | Cerebral edema formation in dogs following hypotension induced with isoflurane and labetalol. ( Bendo, AA; Capuano, C; Cottrell, JE; Kozlowski, PB; Mendeszoon, MH, 1993) |
| "Isoflurane significantly improved neurobehavioral function and brain edema at 24 hrs but not 72 hrs after subarachnoid hemorrhage." | 3.78 | Isoflurane delays the development of early brain injury after subarachnoid hemorrhage through sphingosine-related pathway activation in mice. ( Altay, O; Hasegawa, Y; Khatibi, NH; Sherchan, P; Suzuki, H; Tang, J; Zhang, JH, 2012) |
| "SAH aggravated neurological scores, brain edema, and blood-brain barrier permeability, which were prevented by 2% but not 1% isoflurane posttreatment." | 3.78 | Isoflurane attenuates blood-brain barrier disruption in ipsilateral hemisphere after subarachnoid hemorrhage in mice. ( Altay, O; Caner, B; Fujii, M; Hasegawa, Y; Krafft, PR; Suzuki, H; Tang, J; Zhang, JH, 2012) |
| "5% isoflurane posttreatment, there was a significant reduction in brain edema, a decrease in apoptotic cell death, and a significant improvement in neurobehavioral deficits." | 3.77 | Isoflurane posttreatment reduces brain injury after an intracerebral hemorrhagic stroke in mice. ( Applegate, R; Fathali, N; Khatibi, NH; Ma, Q; Martin, R; Ostrowski, R; Rolland, W; Stier, G; Tang, J; Zhang, JH, 2011) |
| "24 h prior to intracerebral hemorrhage, C57BL/6J mice were preconditioned with a 4-h exposure to 1% isoflurane gas or room air." | 3.77 | Isoflurane preconditioning affords functional neuroprotection in a murine model of intracerebral hemorrhage. ( Appelboom, G; Connolly, ES; Ducruet, AF; Gigante, PR; Gorski, J; Haque, RM; Hwang, BY; Keesecker, SE; Kellner, CP; Yeh, ML, 2011) |
| " Anesthesia was shown to interrupt soman-induced seizures and to attenuate edema and cell change in certain sensitive brain areas." | 3.74 | Cerebral edema induced in mice by a convulsive dose of soman. Evaluation through diffusion-weighted magnetic resonance imaging and histology. ( Bernabé, D; Carpentier, P; Delacour, C; Dorandeu, F; Foquin, A; Lahrech, H; Montigon, O; Segebarth, C; Testylier, G, 2007) |
| " Since volatile anesthetics elevate plasma amino acid concentrations, the influence of isoflurane on arterial plasma glutamate levels and brain edema formation was investigated in brain-injured rats." | 3.70 | Isoflurane doubles plasma glutamate and increases posttraumatic brain edema. ( Kempski, OS; Kroppenstedt, SN; Stover, JF; Thomale, UW; Unterberg, AW, 2000) |
| "To evaluate the impact of anesthetics on the evolution of a cerebral injury, 33 rabbits were subjected to a cryogenic brain lesion, followed by 10 h of anesthesia with 1 MAC halothane or isoflurane (n = 11 each) or with an equipotent dose of pentobarbital (n = 11)." | 3.67 | A comparison of the effects of halothane, isoflurane, and pentobarbital anesthesia on intracranial pressure and cerebral edema formation following brain injury in rabbits. ( Kaieda, R; Todd, MM; Warner, DS; Weeks, JB, 1989) |
| "The first step to treat aneurysmal subarachnoid hemorrhage (SAH) is aneurysmal obliteration under general anesthesia but not treat the SAH itself and the secondary effects." | 1.56 | Isoflurane versus sevoflurane for early brain injury and expression of sphingosine kinase 1 after experimental subarachnoid hemorrhage. ( Altay, BN; Altay, O; Calisir, V; Suzuki, H; Tang, J; Zhang, JH, 2020) |
| "Isoflurane treatment did not reduce brain edema compared with controls in any of the applied isoflurane concentrations." | 1.39 | Lower doses of isoflurane treatment has no beneficial effects in a rat model of intracerebral hemorrhage. ( Esposito, E; Lo, EH; Mandeville, ET, 2013) |
| "The degree of cerebral edema formation was determined by Evans blue dye and coronal magnetic resonance imaging." | 1.28 | Brain retractor edema during induced hypotension: the effect of the rate of return of blood pressure. ( Gelb, AW; Karlik, S; Lownie, S; Wu, X, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (8.00) | 18.7374 |
| 1990's | 5 (20.00) | 18.2507 |
| 2000's | 8 (32.00) | 29.6817 |
| 2010's | 8 (32.00) | 24.3611 |
| 2020's | 2 (8.00) | 2.80 |
| Authors | Studies |
|---|---|
| Poon, KS | 1 |
| Pan, YL | 1 |
| Liao, KH | 1 |
| Wang, HL | 1 |
| Chen, KB | 1 |
| Chen, HY | 1 |
| Liu, YC | 1 |
| Lai, TW | 1 |
| Altay, O | 3 |
| Suzuki, H | 3 |
| Altay, BN | 1 |
| Calisir, V | 1 |
| Tang, J | 4 |
| Zhang, JH | 4 |
| Esposito, E | 1 |
| Mandeville, ET | 1 |
| Lo, EH | 1 |
| Heinemann, U | 1 |
| Tétrault, S | 1 |
| Chever, O | 1 |
| Sik, A | 1 |
| Amzica, F | 1 |
| Bilotta, F | 1 |
| Doronzio, A | 1 |
| Cuzzone, V | 1 |
| Caramia, R | 1 |
| Rosa, G | 1 |
| Khatibi, NH | 2 |
| Ma, Q | 1 |
| Rolland, W | 1 |
| Ostrowski, R | 1 |
| Fathali, N | 1 |
| Martin, R | 1 |
| Applegate, R | 1 |
| Stier, G | 1 |
| Gigante, PR | 1 |
| Appelboom, G | 1 |
| Hwang, BY | 1 |
| Haque, RM | 1 |
| Yeh, ML | 1 |
| Ducruet, AF | 1 |
| Kellner, CP | 1 |
| Gorski, J | 1 |
| Keesecker, SE | 1 |
| Connolly, ES | 1 |
| Hasegawa, Y | 2 |
| Sherchan, P | 1 |
| Caner, B | 1 |
| Krafft, PR | 1 |
| Fujii, M | 1 |
| Bedirli, N | 1 |
| Bagriacik, EU | 1 |
| Emmez, H | 1 |
| Yilmaz, G | 1 |
| Unal, Y | 1 |
| Ozkose, Z | 1 |
| Bleilevens, C | 1 |
| Roehl, AB | 1 |
| Goetzenich, A | 1 |
| Zoremba, N | 1 |
| Kipp, M | 1 |
| Dang, J | 1 |
| Tolba, R | 1 |
| Rossaint, R | 1 |
| Hein, M | 1 |
| Thal, SC | 1 |
| Luh, C | 1 |
| Schaible, EV | 1 |
| Timaru-Kast, R | 1 |
| Hedrich, J | 1 |
| Luhmann, HJ | 1 |
| Engelhard, K | 1 |
| Zehendner, CM | 1 |
| Petersen, KD | 1 |
| Landsfeldt, U | 1 |
| Cold, GE | 1 |
| Petersen, CB | 1 |
| Mau, S | 1 |
| Hauerberg, J | 1 |
| Holst, P | 1 |
| Olsen, KS | 1 |
| Mavroudis, G | 1 |
| Prior, MJ | 1 |
| Lister, T | 1 |
| Nolan, CC | 1 |
| Ray, DE | 1 |
| Ritz, MF | 1 |
| Schmidt, P | 1 |
| Mendelowitsch, A | 1 |
| Testylier, G | 1 |
| Lahrech, H | 1 |
| Montigon, O | 1 |
| Foquin, A | 1 |
| Delacour, C | 1 |
| Bernabé, D | 1 |
| Segebarth, C | 1 |
| Dorandeu, F | 1 |
| Carpentier, P | 1 |
| Murr, R | 1 |
| Berger, S | 1 |
| Schürer, L | 1 |
| Peter, K | 1 |
| Baethmann, A | 1 |
| Bendo, AA | 1 |
| Kozlowski, PB | 1 |
| Capuano, C | 1 |
| Cottrell, JE | 1 |
| Mendeszoon, MH | 1 |
| Hartung, J | 1 |
| Mills, CD | 1 |
| Robertson, CS | 1 |
| Contant, CF | 1 |
| Henley, CM | 1 |
| Stover, JF | 1 |
| Kroppenstedt, SN | 1 |
| Thomale, UW | 1 |
| Kempski, OS | 1 |
| Unterberg, AW | 1 |
| Smith, AL | 1 |
| Marque, JJ | 1 |
| Lownie, S | 1 |
| Wu, X | 1 |
| Karlik, S | 1 |
| Gelb, AW | 1 |
| Kaieda, R | 1 |
| Todd, MM | 1 |
| Weeks, JB | 1 |
| Warner, DS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Influence of Vasopressors on Brain Oxygenation and Microcirculation in Anesthetized Patients With Cerebral Tumors[NCT02713087] | Phase 4 | 48 participants (Actual) | Interventional | 2015-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 trials available for isoflurane and Brain Edema
| Article | Year |
|---|---|
Early postoperative cognitive recovery and gas exchange patterns after balanced anesthesia with sevoflurane or desflurane in overweight and obese patients undergoing craniotomy: a prospective randomized trial.
Topics: Adolescent; Adult; Aged; Anesthesia, Inhalation; Anesthetics, Inhalation; Brain Edema; Cognition; Cr | 2009 |
Effect of anesthesia and cerebral blood flow on neuronal injury in a rat middle cerebral artery occlusion (MCAO) model.
Topics: Anesthesia; Anesthetics; Animals; Blood Pressure; Brain Edema; Brain Injuries; Cerebral Infarction; | 2013 |
Intracranial pressure and cerebral hemodynamic in patients with cerebral tumors: a randomized prospective study of patients subjected to craniotomy in propofol-fentanyl, isoflurane-fentanyl, or sevoflurane-fentanyl anesthesia.
Topics: Adolescent; Adult; Aged; Anesthesia, General; Anesthesia, Inhalation; Anesthetics, Inhalation; Anest | 2003 |
Cerebral edema formation in dogs following hypotension induced with isoflurane and labetalol.
Topics: Animals; Brain; Brain Edema; Brain Injuries; Dogs; Hypotension; Isoflurane; Labetalol; Male | 1993 |
21 other studies available for isoflurane and Brain Edema
| Article | Year |
|---|---|
Isoflurane attenuates carbogen-induced blood-brain barrier disruption independent of body temperature in mice and rats.
Topics: Animals; Blood-Brain Barrier; Body Temperature; Brain; Brain Edema; Capillary Permeability; Carbon D | 2020 |
Isoflurane versus sevoflurane for early brain injury and expression of sphingosine kinase 1 after experimental subarachnoid hemorrhage.
Topics: Animals; Apoptosis; Brain Edema; Disease Models, Animal; Isoflurane; Male; Mice; Neuroprotective Age | 2020 |
Lower doses of isoflurane treatment has no beneficial effects in a rat model of intracerebral hemorrhage.
Topics: Anesthetics, Inhalation; Animals; Brain; Brain Edema; Cerebral Hemorrhage; Disease Models, Animal; D | 2013 |
New dangers of anesthesia: isoflurane induced opening of the blood-brain barrier (Commentary on Tétrault et al.).
Topics: Anesthetics, Inhalation; Blood-Brain Barrier; Brain; Brain Diseases, Metabolic; Brain Edema; Epileps | 2008 |
Opening of the blood-brain barrier during isoflurane anaesthesia.
Topics: Anesthetics, Inhalation; Animals; Blood-Brain Barrier; Brain; Brain Edema; Cats; Cerebral Cortex; Co | 2008 |
Isoflurane posttreatment reduces brain injury after an intracerebral hemorrhagic stroke in mice.
Topics: Anesthetics, Inhalation; Animals; Apoptosis; Basal Ganglia; Behavior, Animal; Body Water; Brain; Bra | 2011 |
Isoflurane preconditioning affords functional neuroprotection in a murine model of intracerebral hemorrhage.
Topics: Albumins; Anesthetics, Inhalation; Animals; Brain; Brain Edema; Cerebral Hemorrhage; Disease Models, | 2011 |
Isoflurane delays the development of early brain injury after subarachnoid hemorrhage through sphingosine-related pathway activation in mice.
Topics: Animals; Apoptosis; Brain Edema; Brain Injuries; Isoflurane; Lysophospholipids; Male; Mice; Neuropro | 2012 |
Isoflurane attenuates blood-brain barrier disruption in ipsilateral hemisphere after subarachnoid hemorrhage in mice.
Topics: Anesthetics, Inhalation; Animals; Biomarkers; Blood-Brain Barrier; Blotting, Western; Brain Edema; C | 2012 |
Sevoflurane and isoflurane preconditioning provides neuroprotection by inhibition of apoptosis-related mRNA expression in a rat model of focal cerebral ischemia.
Topics: Anesthetics, Inhalation; Animals; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Brain Edem | 2012 |
Volatile anesthetics influence blood-brain barrier integrity by modulation of tight junction protein expression in traumatic brain injury.
Topics: Anesthetics, Inhalation; Animals; Blood-Brain Barrier; Brain Edema; Brain Injuries; Cell Line; Claud | 2012 |
Neurochemical and oedematous changes in 1,3-dinitrobenzene-induced astroglial injury in rat brain from a 1H-nuclear magnetic resonance perspective.
Topics: Anesthesia; Anesthetics, Inhalation; Animals; Astrocytes; Brain; Brain Chemistry; Brain Edema; Dinit | 2006 |
Effects of isoflurane on glutamate and taurine releases, brain swelling and injury during transient ischemia and reperfusion.
Topics: Anesthetics; Animals; Brain Edema; Glutamic Acid; Ischemic Attack, Transient; Isoflurane; Male; Neur | 2006 |
Cerebral edema induced in mice by a convulsive dose of soman. Evaluation through diffusion-weighted magnetic resonance imaging and histology.
Topics: Anesthesia; Anesthetics, Inhalation; Animals; Body Water; Brain; Brain Edema; Convulsants; Diffusion | 2007 |
Influence of isoflurane, fentanyl, thiopental, and alpha-chloralose on formation of brain edema resulting from a focal cryogenic lesion.
Topics: Anesthetics; Animals; Brain; Brain Edema; Brain Injuries; Cerebrovascular Circulation; Chloralose; F | 1995 |
Isoflurane, fentanyl, thiopental, and brain edema.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Brain; Brain Edema; Chloralose; Fentanyl | 1996 |
Effects of anesthesia on polyamine metabolism and water content in the rat brain.
Topics: Anesthesia, General; Anesthetics, General; Animals; Biogenic Polyamines; Body Water; Brain Chemistry | 1997 |
Isoflurane doubles plasma glutamate and increases posttraumatic brain edema.
Topics: Animals; Brain Concussion; Brain Edema; Cerebral Cortex; Chloral Hydrate; Glutamic Acid; Intracrania | 2000 |
Anesthetics and cerebral edema.
Topics: Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics; Animals; Brain; Brain Edema; Dogs; Dro | 1976 |
Brain retractor edema during induced hypotension: the effect of the rate of return of blood pressure.
Topics: Animals; Blood Pressure; Blood-Brain Barrier; Brain Edema; Cats; Hypotension; Hypotension, Controlle | 1990 |
A comparison of the effects of halothane, isoflurane, and pentobarbital anesthesia on intracranial pressure and cerebral edema formation following brain injury in rabbits.
Topics: Anesthesia; Anesthesia, Inhalation; Anesthesia, Intravenous; Animals; Brain Edema; Brain Injuries; C | 1989 |