Page last updated: 2024-10-29

isoflurane and Bradycardia

isoflurane has been researched along with Bradycardia in 28 studies

Isoflurane: A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.

Bradycardia: Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. They can be classified broadly into SINOATRIAL NODE dysfunction and ATRIOVENTRICULAR BLOCK.

Research Excerpts

ExcerptRelevanceReference
"To assess cardiopulmonary function in sedated and anesthetized dogs administered intravenous (IV) dexmedetomidine and subsequently administered IV lidocaine to treat dexmedetomidine-induced bradycardia."9.41Use of intravenous lidocaine to treat dexmedetomidine-induced bradycardia in sedated and anesthetized dogs. ( Arroyo, L; Hanna, B; Hopkins, A; O'Sullivan, ML; Tisotti, T; Valverde, A, 2021)
"To compare the cardiopulmonary effects of low and high doses of fentanyl before and after the correction of bradycardia in isoflurane-anesthetized dogs."9.27Cardiovascular and respiratory effects of two doses of fentanyl in the presence or absence of bradycardia in isoflurane-anesthetized dogs. ( Council-Troche, RM; Henao-Guerrero, N; Pavlisko, ND; Soares, JH; Williamson, EJ, 2018)
"This study compared the risk of clinically significant reflex bradycardia during anaesthesia with sevoflurane or desflurane in patients undergoing gastrectomy."9.16Comparison of desflurane and sevoflurane anaesthesia in relation to the risk of vagally mediated reflex bradycardia during gastrectomy. ( Cho, EA; Joo, Y; Kim, DK; Shin, BS, 2012)
" Two dogs that had undergone surgery, under isoflurane anaesthesia, developed a sudden and profound bradycardia when a dopamine infusion was administered."7.79Dopamine-induced bradycardia in two dogs under isoflurane anaesthesia. ( Anagnostou, TL; Kazakos, GM; Tsompanidou, PP, 2013)
"The purpose of the present study was to quantify the inhibitory effect of inhaled halothane and isoflurane on acute hypercapnia-induced responses of capacitance-regulating veins and related cardiovascular variables in response to sequential 40-s periods of 5%, 10%, 15%, and 20% inspired CO2 (FICO2)."7.69Effect of halothane and isoflurane on in situ diameter responses of small mesenteric veins to acute graded hypercapnia. ( Bosnjak, ZJ; Kampine, JP; Stadnicka, A; Stekiel, TA; Stekiel, WJ; Tominaga, M, 1996)
"Remifentanil was started before induction with propofol and succinylcholine."6.73Dosing of remifentanil to prevent movement during craniotomy in the absence of neuromuscular blockade. ( Bakri, MH; Deogaonkar, A; Ebrahim, Z; Foss, J; Lotto, M; Mascha, E; Maurtua, MA; Na, J; Schubert, A; Sessler, DI, 2008)
"For the treatment of bradycardia atropine sulfate should be adjusted at least to lean body weight in order to avoid paradoxical heart rate response in patients with obesity."5.42Atropine sulfate for treatment of bradycardia in a patient with morbid obesity: what may happen when you least expect it. ( Carron, M; Veronese, S, 2015)
"To assess cardiopulmonary function in sedated and anesthetized dogs administered intravenous (IV) dexmedetomidine and subsequently administered IV lidocaine to treat dexmedetomidine-induced bradycardia."5.41Use of intravenous lidocaine to treat dexmedetomidine-induced bradycardia in sedated and anesthetized dogs. ( Arroyo, L; Hanna, B; Hopkins, A; O'Sullivan, ML; Tisotti, T; Valverde, A, 2021)
"To compare the cardiopulmonary effects of low and high doses of fentanyl before and after the correction of bradycardia in isoflurane-anesthetized dogs."5.27Cardiovascular and respiratory effects of two doses of fentanyl in the presence or absence of bradycardia in isoflurane-anesthetized dogs. ( Council-Troche, RM; Henao-Guerrero, N; Pavlisko, ND; Soares, JH; Williamson, EJ, 2018)
"This study compared the risk of clinically significant reflex bradycardia during anaesthesia with sevoflurane or desflurane in patients undergoing gastrectomy."5.16Comparison of desflurane and sevoflurane anaesthesia in relation to the risk of vagally mediated reflex bradycardia during gastrectomy. ( Cho, EA; Joo, Y; Kim, DK; Shin, BS, 2012)
"We compared the effectiveness of atropine, glycopyrrolate, and a transesophageal atrial pacing (TAP) stethoscope for treating intraoperative bradycardia in 64 unpremedicated patients receiving a standardized sufentanil/N2O/vecuronium anesthetic."5.07Comparison of transesophageal atrial pacing with anticholinergic drugs for the treatment of intraoperative bradycardia. ( Monk, TG; Smith, I; White, PF, 1994)
" Time to achieve recumbency, LORR, quiescent electromyograph, isoelectric electrocorticograph, heart rate and apnea were recorded."3.83Assessment of Carbon Dioxide, Carbon Dioxide/Oxygen, Isoflurane and Pentobarbital Killing Methods in Adult Female Sprague-Dawley Rats. ( Chisholm, JM; Pang, DS, 2016)
" Severe bradycardia and asystole were observed on bolus administration of a 3 µg/kg loading dose of fentanyl in two dogs under isoflurane anaesthesia."3.81Fentanyl-induced asystole in two dogs. ( Jang, M; Lee, I; Son, WG, 2015)
" Two dogs that had undergone surgery, under isoflurane anaesthesia, developed a sudden and profound bradycardia when a dopamine infusion was administered."3.79Dopamine-induced bradycardia in two dogs under isoflurane anaesthesia. ( Anagnostou, TL; Kazakos, GM; Tsompanidou, PP, 2013)
"Bradycardia during propofol anesthesia is well known, but bradycardia after propofol anesthesia has not been studied well."3.70[Intra- and postoperative heart rate changes following propofol anesthesia; a comparison with isoflurane anesthesia]. ( Ishida, H; Kawashima, S; Miyawaki, H; Muranaka, K; Seo, K; Shinokuma, T, 2000)
" Ten patients undergoing craniotomy requiring hypotension were anesthetized with nitrous oxide and isoflurane."3.69Are all effects of esmolol equally rapid in onset? ( Diaz, J; Matteo, RS; Ornstein, E; Ostapkovich, N; Young, WL, 1995)
"The purpose of the present study was to quantify the inhibitory effect of inhaled halothane and isoflurane on acute hypercapnia-induced responses of capacitance-regulating veins and related cardiovascular variables in response to sequential 40-s periods of 5%, 10%, 15%, and 20% inspired CO2 (FICO2)."3.69Effect of halothane and isoflurane on in situ diameter responses of small mesenteric veins to acute graded hypercapnia. ( Bosnjak, ZJ; Kampine, JP; Stadnicka, A; Stekiel, TA; Stekiel, WJ; Tominaga, M, 1996)
"Remifentanil was started before induction with propofol and succinylcholine."2.73Dosing of remifentanil to prevent movement during craniotomy in the absence of neuromuscular blockade. ( Bakri, MH; Deogaonkar, A; Ebrahim, Z; Foss, J; Lotto, M; Mascha, E; Maurtua, MA; Na, J; Schubert, A; Sessler, DI, 2008)
"Glycopyrrolate was given to significantly more patients in group III (P < 0."2.68A comparison of propofol and isoflurane anaesthesia: the need for ephedrine and glycopyrrolate. ( Eintrei, C; Granfeldt, H; Jensen, AG; Kalman, SH; Nyström, PO, 1995)
"For the treatment of bradycardia atropine sulfate should be adjusted at least to lean body weight in order to avoid paradoxical heart rate response in patients with obesity."1.42Atropine sulfate for treatment of bradycardia in a patient with morbid obesity: what may happen when you least expect it. ( Carron, M; Veronese, S, 2015)
"Neurogenic pulmonary edema (NPE) is an acute life-threatening complication following an injury of the spinal cord or brain, which is associated with sympathetic hyperactivity."1.35The role of nitric oxide in the development of neurogenic pulmonary edema in spinal cord-injured rats: the effect of preventive interventions. ( Hejcl, A; Kunes, J; Sedy, J; Syková, E; Zicha, J, 2009)

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-19901 (3.57)18.7374
1990's9 (32.14)18.2507
2000's5 (17.86)29.6817
2010's9 (32.14)24.3611
2020's4 (14.29)2.80

Authors

AuthorsStudies
Machado, ML1
Soares, JHN1
Pypendop, BH1
Henao-Guerrero, N2
Oliveira, RLS1
Kamohara, H1
Kamohara, T1
Hikasa, Y1
Loomes, K1
Tisotti, T1
Valverde, A1
Hopkins, A1
O'Sullivan, ML1
Hanna, B1
Arroyo, L1
Stoyek, MR1
Schmidt, MK1
Wilfart, FM1
Croll, RP1
Smith, FM1
Tsukamoto, A1
Niino, N1
Sakamoto, M1
Ohtani, R1
Inomata, T1
Williamson, EJ1
Soares, JH1
Council-Troche, RM1
Pavlisko, ND1
Tsompanidou, PP1
Kazakos, GM1
Anagnostou, TL1
Jang, M1
Son, WG1
Lee, I1
Carron, M1
Veronese, S1
Chisholm, JM1
Pang, DS1
Maurtua, MA1
Deogaonkar, A1
Bakri, MH1
Mascha, E1
Na, J1
Foss, J1
Sessler, DI1
Lotto, M1
Ebrahim, Z1
Schubert, A1
Sedy, J1
Zicha, J1
Kunes, J1
Hejcl, A1
Syková, E1
Yamamoto, T1
Honma, T1
Ikoma, M1
Baba, H1
Kohno, T1
Joo, Y1
Shin, BS1
Cho, EA1
Kim, DK1
Grant, C1
Ludbrook, G1
Hampson, EA1
Semenov, R1
Willis, R1
Sfez, M1
Guérard, A1
Desruelle, P1
Ornstein, E1
Young, WL1
Ostapkovich, N1
Matteo, RS1
Diaz, J1
Jensen, AG1
Granfeldt, H1
Kalman, SH1
Nyström, PO1
Eintrei, C1
Smith, I1
Monk, TG1
White, PF1
Erkola, O1
Korttila, K1
Aho, M1
Haasio, J1
Aantaa, R1
Kallio, A1
Stekiel, TA1
Stekiel, WJ1
Tominaga, M1
Stadnicka, A1
Bosnjak, ZJ1
Kampine, JP1
Jamali, S1
Ravussin, P1
Archer, D1
Goutallier, D1
Parker, F1
Ecoffey, C1
Murray, JM1
Luney, SR1
Rubio González, MV1
Uña Orejón, S1
Cortiñas Sáenz, M1
Peyró García, RS1
Cuesta Tobarra, J1
Torri, G1
Casati, A1
Shinokuma, T1
Seo, K1
Ishida, H1
Kawashima, S1
Muranaka, K1
Miyawaki, H1
Sill, JC1
Schumacher, K1
Southorn, PA1
Reuter, J1
Yaksh, TL1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Comparison of Dexmedetomidine and Midazolam as Intramuscular Premedication for Suspension Laryngoscopy[NCT01937611]Phase 440 participants (Anticipated)Interventional2013-03-31Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

11 trials available for isoflurane and Bradycardia

ArticleYear
Effect of fentanyl, with or without treatment of bradycardia, on the minimum alveolar concentration of isoflurane and cardiovascular function in dogs.
    Veterinary anaesthesia and analgesia, 2022, Volume: 49, Issue:1

    Topics: Anesthetics, Inhalation; Animals; Bradycardia; Dog Diseases; Dogs; Fentanyl; Heart Rate; Isoflurane;

2022
Use of intravenous lidocaine to treat dexmedetomidine-induced bradycardia in sedated and anesthetized dogs.
    Veterinary anaesthesia and analgesia, 2021, Volume: 48, Issue:2

    Topics: Anesthetics, Inhalation; Animals; Bradycardia; Dexmedetomidine; Dog Diseases; Dogs; Female; Heart Ra

2021
Cardiovascular and respiratory effects of two doses of fentanyl in the presence or absence of bradycardia in isoflurane-anesthetized dogs.
    Veterinary anaesthesia and analgesia, 2018, Volume: 45, Issue:4

    Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Bradycardia; Cro

2018
Dosing of remifentanil to prevent movement during craniotomy in the absence of neuromuscular blockade.
    Journal of neurosurgical anesthesiology, 2008, Volume: 20, Issue:4

    Topics: Adult; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Blood Pressure; Brady

2008
Comparison of desflurane and sevoflurane anaesthesia in relation to the risk of vagally mediated reflex bradycardia during gastrectomy.
    The Journal of international medical research, 2012, Volume: 40, Issue:4

    Topics: Aged; Anesthesia, Inhalation; Anesthetics, Inhalation; Anti-Arrhythmia Agents; Atropine; Bradycardia

2012
A comparison of propofol and isoflurane anaesthesia: the need for ephedrine and glycopyrrolate.
    European journal of anaesthesiology, 1995, Volume: 12, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia; Anesthesia, Inhalation; Anesthesia, Intraven

1995
Comparison of transesophageal atrial pacing with anticholinergic drugs for the treatment of intraoperative bradycardia.
    Anesthesia and analgesia, 1994, Volume: 78, Issue:2

    Topics: Aged; Anesthesia, General; Atropine; Bradycardia; Cardiac Pacing, Artificial; Glycopyrrolate; Heart

1994
Comparison of intramuscular dexmedetomidine and midazolam premedication for elective abdominal hysterectomy.
    Anesthesia and analgesia, 1994, Volume: 79, Issue:4

    Topics: Adult; Aged; Analgesics, Non-Narcotic; Analysis of Variance; Bradycardia; Double-Blind Method; Femal

1994
The effects of bolus administration of opioids on cerebrospinal fluid pressure in patients with supratentorial lesions.
    Anesthesia and analgesia, 1996, Volume: 82, Issue:3

    Topics: Adult; Aged; Anesthetics, Inhalation; Anti-Arrhythmia Agents; Atropine; Blood Pressure; Bradycardia;

1996
Cardiovascular homeostasis during inhalational general anesthesia: a clinical comparison between sevoflurane and isoflurane. On behalf of the Italian Research Group on sevoflurane.
    Journal of clinical anesthesia, 2000, Volume: 12, Issue:2

    Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anesthesia Recovery Period; Anesthesia, Inh

2000
Bradycardia and hypotension associated with baclofen used during general anesthesia.
    Anesthesiology, 1986, Volume: 64, Issue:2

    Topics: Adult; Aged; Anesthesia, General; Baclofen; Bradycardia; Clinical Trials as Topic; Double-Blind Meth

1986

Other Studies

17 other studies available for isoflurane and Bradycardia

ArticleYear
Reversal effects of atipamezole, flumazenil, and 4-aminopyridine on bradycardia and increases in blood pressures induced by medetomidine, midazolam, and ketamine in isoflurane-anesthetized cats.
    Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001), 2022, Volume: 32, Issue:2

    Topics: 4-Aminopyridine; Animals; Blood Pressure; Bradycardia; Cat Diseases; Cats; Flumazenil; Heart Rate; I

2022
The use of hyoscine N-butylbromide to treat intraoperative bradycardia during isoflurane anaesthesia in a Thoroughbred horse.
    Veterinary anaesthesia and analgesia, 2020, Volume: 47, Issue:6

    Topics: Anesthesia; Animals; Bradycardia; Butylscopolammonium Bromide; Horse Diseases; Horses; Isoflurane

2020
The in vitro zebrafish heart as a model to investigate the chronotropic effects of vapor anesthetics.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2017, Dec-01, Volume: 313, Issue:6

    Topics: Anesthetics, Inhalation; Animals; Biological Clocks; Bradycardia; Desflurane; Dose-Response Relation

2017
The validity of anesthetic protocols for the surgical procedure of castration in rats.
    Experimental animals, 2018, Jul-30, Volume: 67, Issue:3

    Topics: Administration, Inhalation; Anesthesia; Anesthetics; Animal Experimentation; Animals; Bradycardia; B

2018
Dopamine-induced bradycardia in two dogs under isoflurane anaesthesia.
    The Journal of small animal practice, 2013, Volume: 54, Issue:12

    Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Bradycardia; Dog Diseases; Dogs; Dopamine;

2013
Fentanyl-induced asystole in two dogs.
    The Journal of small animal practice, 2015, Volume: 56, Issue:6

    Topics: Analgesics, Opioid; Anesthesia, Inhalation; Animals; Bradycardia; Dog Diseases; Dogs; Fentanyl; Hear

2015
Atropine sulfate for treatment of bradycardia in a patient with morbid obesity: what may happen when you least expect it.
    BMJ case reports, 2015, Jan-29, Volume: 2015

    Topics: Aged; Anesthesia, General; Anti-Arrhythmia Agents; Atrioventricular Block; Atropine; Bradycardia; De

2015
Assessment of Carbon Dioxide, Carbon Dioxide/Oxygen, Isoflurane and Pentobarbital Killing Methods in Adult Female Sprague-Dawley Rats.
    PloS one, 2016, Volume: 11, Issue:9

    Topics: Adjuvants, Anesthesia; Animals; Apnea; Bradycardia; Carbon Dioxide; Electrocardiography; Electrocort

2016
The role of nitric oxide in the development of neurogenic pulmonary edema in spinal cord-injured rats: the effect of preventive interventions.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2009, Volume: 297, Issue:4

    Topics: Anesthetics, Inhalation; Animals; Atropine; Baroreflex; Blood Pressure; Bradycardia; Disease Models,

2009
[Case of profound bradycardia and cardiac arrest during left upper lobectomy and lymph node dissection].
    Masui. The Japanese journal of anesthesiology, 2010, Volume: 59, Issue:12

    Topics: Anesthesia, Epidural; Anesthesia, General; Bradycardia; Cardiac Pacing, Artificial; Electrocoagulati

2010
Adverse physiological events under anaesthesia and sedation: a pilot audit of electronic patient records.
    Anaesthesia and intensive care, 2008, Volume: 36, Issue:2

    Topics: Adult; Aged; Anesthesia; Anesthetics; Blood Pressure; Bradycardia; Clinical Audit; Colonoscopy; Cons

2008
Cardiorespiratory changes during laparoscopic fundoplication in children.
    Paediatric anaesthesia, 1995, Volume: 5, Issue:2

    Topics: Adolescent; Anesthesia, Inhalation; Anesthetics, Inhalation; Blood Pressure; Bradycardia; Bronchitis

1995
Are all effects of esmolol equally rapid in onset?
    Anesthesia and analgesia, 1995, Volume: 81, Issue:2

    Topics: Adrenergic beta-Antagonists; Anesthesia, Inhalation; Blood Pressure; Bradycardia; Craniotomy; Half-L

1995
Effect of halothane and isoflurane on in situ diameter responses of small mesenteric veins to acute graded hypercapnia.
    Anesthesia and analgesia, 1996, Volume: 82, Issue:2

    Topics: Acute Disease; Anesthetics, Inhalation; Animals; Blood Pressure; Bradycardia; Halothane; Heart Rate;

1996
Fatal cardiac ischaemia associated with prolonged desflurane anaesthesia and administration of exogenous catecholamines.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1998, Volume: 45, Issue:12

    Topics: Aged; Anesthetics, Inhalation; Blood Pressure; Bradycardia; Cardiotonic Agents; Coronary Disease; Cr

1998
[Convulsions after balanced general anesthesia in a newborn infant].
    Revista espanola de anestesiologia y reanimacion, 1999, Volume: 46, Issue:3

    Topics: Anesthesia, General; Anesthetics, General; Apnea; Bradycardia; Epilepsy, Generalized; Epilepsy, Toni

1999
[Intra- and postoperative heart rate changes following propofol anesthesia; a comparison with isoflurane anesthesia].
    Masui. The Japanese journal of anesthesiology, 2000, Volume: 49, Issue:6

    Topics: Anesthesia, Epidural; Anesthesia, General; Bradycardia; Female; Gynecologic Surgical Procedures; Hea

2000