Page last updated: 2024-10-29

isoflurane and Anxiety

isoflurane has been researched along with Anxiety in 17 studies

Isoflurane: A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.

Anxiety: Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.

Research Excerpts

ExcerptRelevanceReference
"5 h exposures of NHPs to isoflurane during infancy are associated with decreased close social behaviour after multiple exposures and more anxiety-related behaviours and increased behavioural inhibition after single exposure, but they do not affect the cognitive domains tested."4.02Infant isoflurane exposure affects social behaviours, but does not impair specific cognitive domains in juvenile non-human primates. ( Bemis, A; Brambrink, AM; Coleman, K; Dissen, GA; Fair, DA; Glickman, B; Martin, LD; Neudecker, V; Neuringer, M; Perez-Zoghbi, JF; Robertson, N; Schenning, KJ, 2021)
"Isoflurane anesthesia was physiologically well tolerated by the dams."3.77Rats exposed to isoflurane in utero during early gestation are behaviorally abnormal as adults. ( Baxter, MG; Crosby, G; Culley, DJ; Keel, PK; Palanisamy, A; Xie, Z, 2011)
"Isoflurane was previously the major clinical anesthetic agent but is now mainly used for veterinary anesthesia."1.42Postanesthetic effects of isoflurane on behavioral phenotypes of adult male C57BL/6J mice. ( Asakura, A; Goto, T; Kobayashi, A; Miyazaki, T; Takase, K; Uchimoto, K; Yonezaki, K, 2015)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (5.88)18.2507
2000's4 (23.53)29.6817
2010's7 (41.18)24.3611
2020's5 (29.41)2.80

Authors

AuthorsStudies
Diana, P1
Joksimovic, SM1
Faisant, A1
Jevtovic-Todorovic, V1
Neudecker, V1
Perez-Zoghbi, JF1
Coleman, K2
Neuringer, M1
Robertson, N1
Bemis, A1
Glickman, B1
Schenning, KJ1
Fair, DA1
Martin, LD2
Dissen, GA2
Brambrink, AM2
Peng, L1
Liu, X1
Yang, Y1
Guo, Q1
Zhong, T1
Pavlovsky, VH1
Corona, D1
Hug, PJ1
Kümmerlen, D1
Graage, R1
Bettschart-Wolfensberger, R1
Herbst, LS1
Gaigher, T1
Siqueira, AA1
Joca, SRL1
Sampaio, KN1
Beijamini, V1
Toyama, K1
Spin, JM1
Abe, Y1
Suzuki, Y1
Deng, AC1
Wagenhäuser, MU1
Yoshino, T1
Mulorz, J1
Liu, S1
Tsao, PS1
Mogi, M1
Liu, T1
Li, Z1
He, J1
Yang, N1
Han, D1
Li, Y1
Tian, X1
Liu, H1
Manyande, A1
Xiang, H1
Xu, F1
Wang, J1
Guo, X1
Yonezaki, K1
Uchimoto, K1
Miyazaki, T1
Asakura, A1
Kobayashi, A1
Takase, K1
Goto, T1
Robertson, ND1
Neuringer, MD1
Cuzon Carlson, VC1
Kroenke, C1
Fair, D1
Terushkin, V1
Brauer, J1
Bernstein, L1
Geronemus, R1
Palanisamy, A1
Baxter, MG1
Keel, PK1
Xie, Z1
Crosby, G1
Culley, DJ1
Hankenson, FC1
Braden-Weiss, GC1
Blendy, JA1
Knight, DJ1
Hardman, JG1
Kerssens, C1
Ouchi, T1
Sebel, PS1
Cruickshank, ME1
Anthony, GB1
Fitzmaurice, A1
McConnell, D1
Graham, W1
Alexander, DA1
Tunstall, M1
Ross, JA1
Sackey, PV1
Martling, CR1
Carlswärd, C1
Sundin, O1
Radell, PJ1
Pollard, BJ1
Bryan, A1
Bennett, D1
Faragher, EB1
Un, EN1
Keegan, M1
Wilson, A1
Burkill, M1
Beatty, PC1
Stollery, BT1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Study of the Effect of Intraoperative Positive Messages on Postoperative Outcomes[NCT02765750]5 participants (Actual)Interventional2016-03-31Terminated (stopped due to The primary investigator was transferred to another hospital)
Evaluation of Mirus™ for Sedation in Resuscitation[NCT02889055]9 participants (Actual)Observational2016-01-17Terminated (stopped due to Safety profile was not satisfying with sevolflurane)
A Phase 3, Multicenter, Randomized, Controlled, Open Label, Assessor-Blinded Study to Evaluate the Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensi[NCT05327296]Phase 3235 participants (Anticipated)Interventional2022-06-30Recruiting
A Phase 3, Multicenter, Randomized, Controlled, Open Label, Assessor-Blinded Study to Evaluate the Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensi[NCT05312385]Phase 3235 participants (Anticipated)Interventional2022-04-28Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

5 trials available for isoflurane and Anxiety

ArticleYear
Butorphanol induces anxiety-like -behaviour and distress in piglets.
    Schweizer Archiv fur Tierheilkunde, 2021, Volume: 163, Issue:7

    Topics: Anesthesia; Animals; Anxiety; Butorphanol; Isoflurane; Male; Orchiectomy; Swine

2021
No evidence of memory function during anesthesia with propofol or isoflurane with close control of hypnotic state.
    Anesthesiology, 2005, Volume: 102, Issue:1

    Topics: Adult; Ambulatory Surgical Procedures; Anesthesia; Anesthetics, Intravenous; Anxiety; Electroencepha

2005
A randomised controlled trial to evaluate the effect of self-administered analgesia on women's experience of outpatient treatment at colposcopy.
    BJOG : an international journal of obstetrics and gynaecology, 2005, Volume: 112, Issue:12

    Topics: Adult; Ambulatory Care; Analgesia, Patient-Controlled; Anesthetics, Inhalation; Anxiety; Colposcopy;

2005
Short- and long-term follow-up of intensive care unit patients after sedation with isoflurane and midazolam--a pilot study.
    Critical care medicine, 2008, Volume: 36, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Anxiety; Cognition Disorders; Conscious Sedation; Delusions; Depress

2008
Short- and long-term follow-up of intensive care unit patients after sedation with isoflurane and midazolam--a pilot study.
    Critical care medicine, 2008, Volume: 36, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Anxiety; Cognition Disorders; Conscious Sedation; Delusions; Depress

2008
Short- and long-term follow-up of intensive care unit patients after sedation with isoflurane and midazolam--a pilot study.
    Critical care medicine, 2008, Volume: 36, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Anxiety; Cognition Disorders; Conscious Sedation; Delusions; Depress

2008
Short- and long-term follow-up of intensive care unit patients after sedation with isoflurane and midazolam--a pilot study.
    Critical care medicine, 2008, Volume: 36, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Anxiety; Cognition Disorders; Conscious Sedation; Delusions; Depress

2008
Short- and long-term follow-up of intensive care unit patients after sedation with isoflurane and midazolam--a pilot study.
    Critical care medicine, 2008, Volume: 36, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Anxiety; Cognition Disorders; Conscious Sedation; Delusions; Depress

2008
Short- and long-term follow-up of intensive care unit patients after sedation with isoflurane and midazolam--a pilot study.
    Critical care medicine, 2008, Volume: 36, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Anxiety; Cognition Disorders; Conscious Sedation; Delusions; Depress

2008
Short- and long-term follow-up of intensive care unit patients after sedation with isoflurane and midazolam--a pilot study.
    Critical care medicine, 2008, Volume: 36, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Anxiety; Cognition Disorders; Conscious Sedation; Delusions; Depress

2008
Short- and long-term follow-up of intensive care unit patients after sedation with isoflurane and midazolam--a pilot study.
    Critical care medicine, 2008, Volume: 36, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Anxiety; Cognition Disorders; Conscious Sedation; Delusions; Depress

2008
Short- and long-term follow-up of intensive care unit patients after sedation with isoflurane and midazolam--a pilot study.
    Critical care medicine, 2008, Volume: 36, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Anxiety; Cognition Disorders; Conscious Sedation; Delusions; Depress

2008
Recovery after oral surgery with halothane, enflurane, isoflurane or propofol anaesthesia.
    British journal of anaesthesia, 1994, Volume: 72, Issue:5

    Topics: Adult; Affect; Ambulatory Surgical Procedures; Anesthesia Recovery Period; Anesthesia, Inhalation; A

1994

Other Studies

12 other studies available for isoflurane and Anxiety

ArticleYear
Early exposure to general anesthesia impairs social and emotional development in rats.
    Molecular neurobiology, 2020, Volume: 57, Issue:1

    Topics: Anesthesia, General; Animals; Animals, Newborn; Anxiety; Behavior, Animal; Emotions; Exploratory Beh

2020
Infant isoflurane exposure affects social behaviours, but does not impair specific cognitive domains in juvenile non-human primates.
    British journal of anaesthesia, 2021, Volume: 126, Issue:2

    Topics: Age Factors; Anesthetics, Inhalation; Animals; Animals, Newborn; Anxiety; Behavior, Animal; Brain; C

2021
Histone Deacetylase 2-Mediated Epigenetic Regulation is Involved in the Early Isoflurane Exposure-Related Increase in Susceptibility to Anxiety-Like Behaviour Evoked by Chronic Variable Stress in Mice.
    Neurochemical research, 2021, Volume: 46, Issue:9

    Topics: Acetylation; Amygdala; Anesthetics, Inhalation; Animals; Animals, Newborn; Anxiety; Brain-Derived Ne

2021
New evidence for refinement of anesthetic choice in procedures preceding the forced swimming test and the elevated plus-maze.
    Behavioural brain research, 2019, 08-05, Volume: 368

    Topics: Anesthetics, General; Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Behavior, Animal

2019
Controlled isoflurane anesthesia exposure is required for reliable behavioral testing in murine surgical models.
    Journal of pharmacological sciences, 2019, Volume: 140, Issue:1

    Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Anxiety; Behavior, Animal; Isoflurane; Mal

2019
Regional Metabolic Patterns of Abnormal Postoperative Behavioral Performance in Aged Mice Assessed by
    Neuroscience bulletin, 2020, Volume: 36, Issue:1

    Topics: Aging; Anesthesia; Animals; Anxiety; Aspartic Acid; Brain; Cerebral Cortex; Cognitive Dysfunction; F

2020
Postanesthetic effects of isoflurane on behavioral phenotypes of adult male C57BL/6J mice.
    PloS one, 2015, Volume: 10, Issue:3

    Topics: Anesthetics, Inhalation; Animals; Anxiety; Attention; Behavior, Animal; Depression; Isoflurane; Male

2015
Isoflurane Anesthesia Has Long-term Consequences on Motor and Behavioral Development in Infant Rhesus Macaques.
    Anesthesiology, 2017, Volume: 126, Issue:1

    Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Anxiety; Behavior, Animal; Isoflurane; Macaca mu

2017
Effect of General Anesthesia on Neurodevelopmental Abnormalities in Children Undergoing Treatment of Vascular Anomalies With Laser Surgery: A Retrospective Review.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2017, Volume: 43, Issue:4

    Topics: Administration, Inhalation; Administration, Intravenous; Anesthesia, General; Anxiety; Attention Def

2017
Rats exposed to isoflurane in utero during early gestation are behaviorally abnormal as adults.
    Anesthesiology, 2011, Volume: 114, Issue:3

    Topics: Anesthesia; Anesthetics, Inhalation; Animals; Anxiety; Behavior, Animal; Blood Pressure; Body Weight

2011
Behavioral and activity assessment of laboratory mice (Mus musculus) after tail biopsy under isoflurane anesthesia.
    Journal of the American Association for Laboratory Animal Science : JAALAS, 2011, Volume: 50, Issue:5

    Topics: Age Factors; Analysis of Variance; Anesthetics, Inhalation; Animals; Animals, Laboratory; Anxiety; B

2011
Recollection of dreams after short general anaesthesia: influence on patient anxiety and satisfaction.
    European journal of anaesthesiology, 2003, Volume: 20, Issue:11

    Topics: Adult; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Anxiety; Dreams; Elec

2003