Page last updated: 2024-10-29

isoflurane and Acute Confusional Senile Dementia

isoflurane has been researched along with Acute Confusional Senile Dementia in 34 studies

Isoflurane: A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.

Research Excerpts

ExcerptRelevanceReference
" Furthermore, the commonly used isoflurane anesthesia induces vasodilation and is thereby inherently a vascular challenge."3.91Longitudinal assessment of cerebral perfusion and vascular response to hypoventilation in a bigenic mouse model of Alzheimer's disease with amyloid and tau pathology. ( Borghgraef, P; Dresselaers, T; Govaerts, K; Himmelreich, U; Kremer, A; Lechat, B; Struys, T; Van Leuven, F, 2019)
"Many in vitro findings suggest that isoflurane exposure might accelerate the process of Alzheimer Disease (AD); however, no behavioral evidence exists to support this theory."3.78Isoflurane exposure during mid-adulthood attenuates age-related spatial memory impairment in APP/PS1 transgenic mice. ( Chen, J; Chen, X; Su, D; Wang, B; Wang, X; Xu, H; Zhao, Y, 2012)
"The incidence of Alzheimer's disease (AD) in individuals >65 years of age is 13% and ~66 million individuals in this age group undergo surgery annually under anesthesia."2.52Effect of the inhaled anesthetics isoflurane, sevoflurane and desflurane on the neuropathogenesis of Alzheimer's disease (review). ( Jiang, H; Jiang, J, 2015)
"Isoflurane exposure may cause potential neurotoxicity, which is tolerated to some extent in Zn-adequate APP/PS1 mice."1.43Isoflurane anesthesia exacerbates learning and memory impairment in zinc-deficient APP/PS1 transgenic mice. ( Cui, W; Feng, C; Liu, Y; Ma, Y; Piao, M; Yuan, Y; Zheng, F, 2016)
"Increasingly more aged people with Alzheimer's disease (AD) must undergo surgery with general anesthesia for various reasons."1.40Smaller sized inhaled anesthetics have more potency on senescence-accelerated prone-8 mice compared with senescence-resistant-1 mice. ( Deng, Y; He, Z; Lu, B; Qi, B; Su, D; Tian, J; Wang, X; Xu, H; Zheng, B, 2014)
"Anaesthesia and genotype Alzheimer's disease had no impact on locomotor activity."1.39Effects of isoflurane-induced anaesthesia on cognitive performance in a mouse model of Alzheimer's disease: A randomised trial in transgenic APP23 mice. ( Blobner, M; Bogdanski, R; Eckel, B; Kochs, E; Ohl, F; Rammes, G; Starker, L, 2013)
"Cotreatment with trehalose reduces the levels of β amyloid peptide aggregates, tau plaques and levels of phospho-tau."1.38Trehalose protects from aggravation of amyloid pathology induced by isoflurane anesthesia in APP(swe) mutant mice. ( Casarejos, MJ; de Yébenes, JG; Gomez, A; Mena, MA; Perucho, J; Solano, RM, 2012)
"Current understanding on Alzheimer's disease (AD) reveals that soluble amyloid beta-peptide (Abeta) oligomeric formation plays an important role in AD pathophysiology."1.35Isoflurane and desflurane at clinically relevant concentrations induce amyloid beta-peptide oligomerization: an NMR study. ( Fodale, V; Mandal, PK, 2009)
"Alzheimer's disease and other tauopathies are characterized by the presence of intracellular neurofibrillary tangles composed of hyperphosphorylated, insoluble tau."1.35Acceleration and persistence of neurofibrillary pathology in a mouse model of tauopathy following anesthesia. ( Bretteville, A; Dickson, DW; Du, AL; Duff, KE; Liu, L; Planel, E; Virag, L; Whittington, RA; Yu, WH, 2009)
"Isoflurane also promotes Abeta aggregation."1.34The inhalation anesthetic isoflurane induces a vicious cycle of apoptosis and amyloid beta-protein accumulation. ( Crosby, G; Culley, DJ; Dong, Y; Maeda, U; Moir, RD; Tanzi, RE; Xia, W; Xie, Z, 2007)

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (17.65)29.6817
2010's23 (67.65)24.3611
2020's5 (14.71)2.80

Authors

AuthorsStudies
Hofmann, C1
Sander, A1
Wang, XX1
Buerge, M1
Jungwirth, B2
Borgstedt, L2
Kreuzer, M1
Kopp, C1
Schorpp, K1
Hadian, K1
Wotjak, CT1
Ebert, T1
Ruitenberg, M1
Parsons, CG1
Rammes, G4
Han, F1
Zhao, J1
Zhao, G1
Shi, D1
Wong, JKY1
Zhu, K1
Noakes, PG1
Joseph, DJ1
Liu, C3
Peng, J1
Liang, G1
Wei, H1
Halim, AA1
Alsayed, B1
Embarak, S1
Yaseen, T1
Dabbous, S1
Fontaine, O1
Dueluzeau, R1
Raibaud, P1
Chabanet, C1
Popoff, MR1
Badoual, J1
Gabilan, JC1
Andremont, A1
Gómez, L1
Andrés, S1
Sánchez, J1
Alonso, JM1
Rey, J1
López, F1
Jiménez, A1
Yan, Z1
Zhou, L1
Zhao, Y4
Wang, J6
Huang, L2
Hu, K1
Liu, H4
Wang, H3
Guo, Z1
Song, Y1
Huang, H4
Yang, R1
Owen, TW1
Al-Kaysi, RO1
Bardeen, CJ1
Cheng, Q1
Wu, S1
Cheng, T1
Zhou, X1
Wang, B5
Zhang, Q4
Wu, X2
Yao, Y3
Ochiai, T1
Ishiguro, H2
Nakano, R2
Kubota, Y2
Hara, M1
Sunada, K1
Hashimoto, K1
Kajioka, J1
Fujishima, A1
Jiao, J3
Gai, QY3
Wang, W2
Zang, YP2
Niu, LL2
Fu, YJ3
Wang, X6
Yao, LP1
Qin, QP1
Wang, ZY1
Liu, J4
Aleksic Sabo, V1
Knezevic, P1
Borges-Argáez, R1
Chan-Balan, R1
Cetina-Montejo, L1
Ayora-Talavera, G1
Sansores-Peraza, P1
Gómez-Carballo, J1
Cáceres-Farfán, M1
Jang, J1
Akin, D1
Bashir, R1
Yu, Z1
Zhu, J2
Jiang, H2
He, C2
Xiao, Z1
Xu, J2
Sun, Q1
Han, D1
Lei, H1
Zhao, K2
Zhu, L1
Li, X4
Fu, H2
Wilson, BK1
Step, DL1
Maxwell, CL1
Gifford, CA1
Richards, CJ1
Krehbiel, CR1
Warner, JM1
Doerr, AJ1
Erickson, GE1
Guretzky, JA1
Rasby, RJ1
Watson, AK1
Klopfenstein, TJ1
Sun, Y4
Liu, Z3
Pham, TD1
Lee, BK1
Yang, FC1
Wu, KH1
Lin, WP1
Hu, MK1
Lin, L3
Shao, J1
Sun, M1
Xu, G1
Zhang, X6
Xu, N1
Wang, R1
Liu, S2
He, H1
Dong, X2
Yang, M2
Yang, Q1
Duan, S1
Yu, Y2
Han, J2
Zhang, C3
Chen, L2
Yang, X1
Li, W3
Wang, T2
Campbell, DA1
Gao, K1
Zager, RA1
Johnson, ACM1
Guillem, A1
Keyser, J1
Singh, B1
Steubl, D1
Schneider, MP1
Meiselbach, H1
Nadal, J1
Schmid, MC1
Saritas, T1
Krane, V1
Sommerer, C1
Baid-Agrawal, S1
Voelkl, J1
Kotsis, F1
Köttgen, A1
Eckardt, KU1
Scherberich, JE1
Li, H4
Yao, L2
Sun, L3
Zhu, Z1
Naren, N1
Zhang, XX2
Gentile, GL1
Rupert, AS1
Carrasco, LI1
Garcia, EM1
Kumar, NG1
Walsh, SW1
Jefferson, KK1
Guest, RL1
Samé Guerra, D1
Wissler, M1
Grimm, J1
Silhavy, TJ1
Lee, JH2
Yoo, JS1
Kim, Y1
Kim, JS2
Lee, EJ1
Roe, JH1
Delorme, M1
Bouchard, PA1
Simon, M1
Simard, S1
Lellouche, F1
D'Urzo, KA1
Mok, F1
D'Urzo, AD1
Koneru, B1
Lopez, G1
Farooqi, A1
Conkrite, KL1
Nguyen, TH1
Macha, SJ1
Modi, A1
Rokita, JL1
Urias, E1
Hindle, A1
Davidson, H1
Mccoy, K1
Nance, J1
Yazdani, V1
Irwin, MS1
Yang, S1
Wheeler, DA1
Maris, JM1
Diskin, SJ1
Reynolds, CP1
Abhilash, L1
Kalliyil, A1
Sheeba, V1
Hartley, AM2
Meunier, B2
Pinotsis, N1
Maréchal, A2
Xu, JY1
Genko, N1
Haraux, F1
Rich, PR1
Kamalanathan, M1
Doyle, SM1
Xu, C1
Achberger, AM1
Wade, TL1
Schwehr, K1
Santschi, PH1
Sylvan, JB1
Quigg, A1
Leong, W1
Xu, W2
Gao, S1
Zhai, X1
Wang, C2
Gilson, E1
Ye, J1
Lu, Y1
Yan, R1
Zhang, Y7
Hu, Z1
You, Q1
Cai, Q1
Yang, D1
Gu, S1
Dai, H1
Zhao, X1
Gui, C1
Gui, J1
Wu, PK1
Hong, SK1
Starenki, D1
Oshima, K1
Shao, H1
Gestwicki, JE1
Tsai, S1
Park, JI1
Wang, Y7
Zhao, R1
Gu, Z1
Dong, C2
Guo, G1
Li, L4
Barrett, HE1
Meester, EJ1
van Gaalen, K1
van der Heiden, K1
Krenning, BJ1
Beekman, FJ1
de Blois, E1
de Swart, J1
Verhagen, HJ1
Maina, T1
Nock, BA1
Norenberg, JP1
de Jong, M1
Gijsen, FJH1
Bernsen, MR1
Martínez-Milla, J1
Galán-Arriola, C1
Carnero, M1
Cobiella, J1
Pérez-Camargo, D1
Bautista-Hernández, V1
Rigol, M1
Solanes, N1
Villena-Gutierrez, R1
Lobo, M1
Mateo, J1
Vilchez-Tschischke, JP1
Salinas, B1
Cussó, L1
López, GJ1
Fuster, V1
Desco, M1
Sanchez-González, J1
Ibanez, B1
van den Berg, P1
Schweitzer, DH1
van Haard, PMM1
Geusens, PP1
van den Bergh, JP1
Zhu, X1
Huang, X2
Xu, H4
Yang, G2
Lin, Z1
Salem, HF1
Nafady, MM1
Kharshoum, RM1
Abd El-Ghafar, OA1
Farouk, HO1
Domiciano, D1
Nery, FC1
de Carvalho, PA1
Prudente, DO1
de Souza, LB1
Chalfun-Júnior, A1
Paiva, R1
Marchiori, PER1
Lu, M2
An, Z1
Jiang, J3
Li, J7
Du, S1
Zhou, H1
Cui, J1
Wu, W1
Liu, Y8
Song, J1
Lian, Q2
Uddin Ahmad, Z1
Gang, DD1
Konggidinata, MI1
Gallo, AA1
Zappi, ME1
Yang, TWW1
Johari, Y1
Burton, PR1
Earnest, A1
Shaw, K1
Hare, JL1
Brown, WA1
Kim, GA1
Han, S1
Choi, GH1
Choi, J1
Lim, YS1
Gallo, A1
Cancelli, C1
Ceron, E1
Covino, M1
Capoluongo, E1
Pocino, K1
Ianiro, G1
Cammarota, G1
Gasbarrini, A1
Montalto, M1
Somasundar, Y1
Lu, IC1
Mills, MR1
Qian, LY1
Olivares, X1
Ryabov, AD1
Collins, TJ1
Zhao, L1
Doddipatla, S1
Thomas, AM1
Nikolayev, AA1
Galimova, GR1
Azyazov, VN1
Mebel, AM1
Kaiser, RI1
Guo, S1
Yang, P1
Yu, X2
Wu, Y2
Zhang, H1
Yu, B2
Han, B1
George, MW1
Moor, MB1
Bonny, O1
Langenberg, E1
Paik, H1
Smith, EH1
Nair, HP1
Hanke, I1
Ganschow, S1
Catalan, G1
Domingo, N1
Schlom, DG1
Assefa, MK1
Wu, G2
Hayton, TW1
Becker, B1
Enikeev, D1
Netsch, C1
Gross, AJ1
Laukhtina, E1
Glybochko, P1
Rapoport, L1
Herrmann, TRW1
Taratkin, M1
Dai, W1
Shi, J2
Carreno, J1
Kloner, RA1
Pickersgill, NA1
Vetter, JM1
Kim, EH1
Cope, SJ1
Du, K1
Venkatesh, R1
Giardina, JD1
Saad, NES1
Bhayani, SB1
Figenshau, RS1
Eriksson, J1
Landfeldt, E1
Ireland, S1
Jackson, C1
Wyatt, E1
Gaudig, M1
Stancill, JS1
Happ, JT1
Broniowska, KA1
Hogg, N1
Corbett, JA1
Tang, LF1
Bi, YL1
Fan, Y2
Sun, YB1
Wang, AL1
Xiao, BH1
Wang, LF1
Qiu, SW1
Guo, SW1
Wáng, YXJ1
Sun, J2
Chu, S1
Pan, Q1
Li, D2
Zheng, S2
Ma, L1
Wang, L3
Hu, T1
Wang, F1
Han, Z1
Yin, Z1
Ge, X1
Xie, K1
Lei, P1
Dias-Santagata, D1
Lennerz, JK1
Sadow, PM1
Frazier, RP1
Govinda Raju, S1
Henry, D1
Chung, T1
Kherani, J1
Rothenberg, SM1
Wirth, LJ1
Marti, CN1
Choi, NG1
Bae, SJ1
Ni, L1
Luo, X2
Dai, T1
Yang, Y3
Lee, R1
Fleischer, AS1
Wemhoff, AP1
Ford, CR1
Kleppinger, EL1
Helms, K1
Bush, AA1
Luna-Abanto, J1
García Ruiz, L1
Laura Martinez, J1
Álvarez Larraondo, M1
Villoslada Terrones, V1
Dukic, L1
Maric, N1
Simundic, AM1
Chogtu, B1
Ommurugan, B1
Thomson, SR1
Kalthur, SG1
Benidir, M1
El Massoudi, S1
El Ghadraoui, L1
Lazraq, A1
Benjelloun, M1
Errachidi, F1
Cassar, M1
Law, AD1
Chow, ES1
Giebultowicz, JM1
Kretzschmar, D1
Salonurmi, T1
Nabil, H1
Ronkainen, J1
Hyötyläinen, T1
Hautajärvi, H1
Savolainen, MJ1
Tolonen, A1
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Känsäkoski, P1
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Barb, J1
Collado, CJ1
Elloumi, F1
Palmieri, EM1
Boelte, K1
Kolodgie, FD1
Finn, AV1
Biesecker, LG1
McVicar, DW1
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Xiong, D1
Zhao, D1
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Liu, T2
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Park, DJ1
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Kim, HB1
Song, M1
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Nigam, K1
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Millar, JE1
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Ki, KK1
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Boyle, AJ1
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Fraser, JF1
Settles, JA1
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Kraemer, US1
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Pourmand, A1
Ghassemi, M1
Sumon, K1
Amini, SB1
Hood, C1
Sikka, N1
Duan, H1
Chen, WP1
Fan, M1
Wang, WP1
Yu, L1
Tan, SJ1
Xin, S1
Wan, LJ1
Guo, YG1
Tanda, S1
Gingl, K1
Ličbinský, R1
Hegrová, J1
Goessler, W1
Li, ZL1
Zhou, YL1
Yan, W1
Luo, L1
Su, ZZ1
Fan, MZ1
Wang, SR1
Zhao, WG1
Xu, D1
Hassan, HM1
Jiang, Z1
Bachmann, KF1
Haenggi, M1
Jakob, SM1
Takala, J1
Gattinoni, L1
Berger, D1
Bentley, RF1
Vecchiarelli, E1
Banks, L1
Gonçalves, PEO1
Thomas, SG1
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Mather, K1
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Panahi, S1
Anderson, GH1
Luhovyy, BL1
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Arafa, K1
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Alakhdar, AA1
Arafa, RK1
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Chu, Q1
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Yao, M1
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Kulich, P1
Zeman, T1
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Tvrdoňová, M1
Mikuška, P1
Večeřa, Z1
Stráská, J1
Moravec, P1
Balcar, VJ1
Šerý, O1
Qiao, L1
Xiong, X1
Peng, X1
Zheng, J1
Duan, J1
Xiao, W1
Zhou, HY1
Sui, ZY1
Zhao, FL1
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Wang, HY1
Han, BH1
Jintao, X1
Shasha, Y1
Jincai, W1
Chunyan, L1
Mengya, Y1
Yongli, S1
Rasoanirina, BNV1
Lassoued, MA1
Miladi, K1
Razafindrakoto, Z1
Chaâbane-Banaoues, R1
Ramanitrahasimbola, D1
Cornet, M1
Sfar, S1
Liang, C1
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Tang, SJ1
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Peng, M1
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Lyu, J1
Yu, CQ1
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Pang, ZC1
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Dong, Z1
Wu, F1
Wu, XP1
Jiang, GH1
Wang, XJ1
Wang, BY1
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Yong, ZP1
Shan, GL1
Weng, TT1
Yan, SQ1
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Dong, S1
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Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effect of Isoflurane Versus Propofol Anesthesia on Alzheimers Disease CSF Markers[NCT01640275]Phase 1105 participants (Actual)Interventional2012-03-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for isoflurane and Acute Confusional Senile Dementia

ArticleYear
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016
Effect of the inhaled anesthetics isoflurane, sevoflurane and desflurane on the neuropathogenesis of Alzheimer's disease (review).
    Molecular medicine reports, 2015, Volume: 12, Issue:1

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Anesthetics, Inhalation; Caspases; Cognition; Desflurane;

2015
[Therapeutic effect of clioquinol for Alzheimer disease].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2008, Volume: 131, Issue:3

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Anesthetics, Inhalation; Animals; Brain; Caspase 3; Choles

2008

Trials

2 trials available for isoflurane and Acute Confusional Senile Dementia

ArticleYear
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016
The Effect of Propofol Versus Isoflurane Anesthesia on Human Cerebrospinal Fluid Markers of Alzheimer's Disease: Results of a Randomized Trial.
    Journal of Alzheimer's disease : JAD, 2016, 04-15, Volume: 52, Issue:4

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Anesthesia, Intravenous; Anesthetics, Intravenous; Biomark

2016

Other Studies

30 other studies available for isoflurane and Acute Confusional Senile Dementia

ArticleYear
Inhalational Anesthetics Do Not Deteriorate Amyloid-β-Derived Pathophysiology in Alzheimer's Disease: Investigations on the Molecular, Neuronal, and Behavioral Level.
    Journal of Alzheimer's disease : JAD, 2021, Volume: 84, Issue:3

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Anesthetics, Inhalation; Animals; Disease Models, Animal;

2021
Prolonged Volatile Anesthetic Exposure Exacerbates Cognitive Impairment and Neuropathology in the 5xFAD Mouse Model of Alzheimer's Disease.
    Journal of Alzheimer's disease : JAD, 2021, Volume: 84, Issue:4

    Topics: Alzheimer Disease; Anesthetics, Inhalation; Animals; Cognitive Dysfunction; Disease Models, Animal;

2021
The Anaesthetics Isoflurane and Xenon Reverse the Synaptotoxic Effects of Aβ
    International journal of molecular sciences, 2023, Jan-04, Volume: 24, Issue:2

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Anesthetics, Inhalation; Animals; Astrocytes; Brain; Hippo

2023
Isoflurane mediated neuropathological and cognitive impairments in the triple transgenic Alzheimer's mouse model are associated with hippocampal synaptic deficits in an age-dependent manner.
    PloS one, 2019, Volume: 14, Issue:10

    Topics: Aging; Alzheimer Disease; Amyloid; Animals; Animals, Newborn; Apoptosis; Biomarkers; Cognitive Dysfu

2019
Long Non-Coding RNA BACE1-AS Modulates Isoflurane-Induced Neurotoxicity to Alzheimer's Disease Through Sponging miR-214-3p.
    Neurochemical research, 2020, Volume: 45, Issue:10

    Topics: Alzheimer Disease; Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Gene

2020
Neurotoxicity of different amyloid beta subspecies in mice and their interaction with isoflurane anaesthesia.
    PloS one, 2020, Volume: 15, Issue:12

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Anesthetics, Inhalation; Animals; Behavior, Animal; Brain;

2020
Longitudinal assessment of cerebral perfusion and vascular response to hypoventilation in a bigenic mouse model of Alzheimer's disease with amyloid and tau pathology.
    NMR in biomedicine, 2019, Volume: 32, Issue:2

    Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Anesthesia; Animals; Brain; Carbon Dioxide; Disea

2019
Smaller sized inhaled anesthetics have more potency on senescence-accelerated prone-8 mice compared with senescence-resistant-1 mice.
    Journal of Alzheimer's disease : JAD, 2014, Volume: 39, Issue:1

    Topics: Aging; Alzheimer Disease; Analysis of Variance; Anesthetics, Inhalation; Animals; Desflurane; Diseas

2014
Tau hyperphosphorylation: a downstream effector of isoflurane-induced neuroinflammation in aged rodents.
    Medical hypotheses, 2014, Volume: 82, Issue:1

    Topics: Age Factors; Alzheimer Disease; Anesthetics, Inhalation; Animals; Cognition Disorders; Cytokines; In

2014
Effects of repetitive exposure to anesthetics and analgesics in the Tg2576 mouse Alzheimer's model.
    Neurotoxicity research, 2014, Volume: 26, Issue:4

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analgesics; Anesthetics; A

2014
The role of hippocampal tau protein phosphorylation in isoflurane-induced cognitive dysfunction in transgenic APP695 mice.
    Anesthesia and analgesia, 2014, Volume: 119, Issue:2

    Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Behavior, Animal; Cognition; Cognition D

2014
[Electroacupuncture Intervention Inhibits the Decline of Learning-memory Ability and Overex- pression of Cleaved Caspase-3 and Bax in Hippocampus Induced by Isoflurane in APPswe/PS 1].
    Zhen ci yan jiu = Acupuncture research, 2016, Volume: 41, Issue:1

    Topics: Alzheimer Disease; Animals; bcl-2-Associated X Protein; Caspase 3; Disease Models, Animal; Electroac

2016
Isoflurane anesthesia exacerbates learning and memory impairment in zinc-deficient APP/PS1 transgenic mice.
    Neuropharmacology, 2016, Volume: 111

    Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Anesthetics, Inhalation; Animals; Apoptosis; Cere

2016
Alzheimer's disease and anesthesia: out of body, out of mind...or not?
    Annals of neurology, 2008, Volume: 64, Issue:6

    Topics: Alzheimer Disease; Anesthesia, General; Animals; Humans; Isoflurane; Sensation Disorders

2008
Isoflurane and desflurane at clinically relevant concentrations induce amyloid beta-peptide oligomerization: an NMR study.
    Biochemical and biophysical research communications, 2009, Feb-13, Volume: 379, Issue:3

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Anesthetics, Inhalation; Desflurane; Humans; Isoflurane; M

2009
Acceleration and persistence of neurofibrillary pathology in a mouse model of tauopathy following anesthesia.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2009, Volume: 23, Issue:8

    Topics: Alzheimer Disease; Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Calcium-Calmodulin-Depe

2009
Transgenic Alzheimer mice have a larger minimum alveolar anesthetic concentration of isoflurane than their nontransgenic littermates.
    Anesthesia and analgesia, 2010, Feb-01, Volume: 110, Issue:2

    Topics: Aging; Alzheimer Disease; Anesthetics, Inhalation; Animals; Isoflurane; Male; Mice; Mice, Transgenic

2010
Inhaled anesthetic potency in aged Alzheimer mice.
    Anesthesia and analgesia, 2010, Feb-01, Volume: 110, Issue:2

    Topics: Alzheimer Disease; Anesthesia Recovery Period; Anesthetics, Inhalation; Animals; Dose-Response Relat

2010
A smoking gun but still no victim.
    Journal of Alzheimer's disease : JAD, 2010, Volume: 19, Issue:4

    Topics: Alzheimer Disease; Anesthetics, Inhalation; Humans; Isoflurane; Neurodegenerative Diseases

2010
Isoflurane anesthesia elicits protein pattern changes in rat hippocampus.
    Journal of neurosurgical anesthesiology, 2010, Volume: 22, Issue:2

    Topics: Alzheimer Disease; Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Brain Mapping; Carbon D

2010
Anesthesia with isoflurane increases amyloid pathology in mice models of Alzheimer's disease.
    Journal of Alzheimer's disease : JAD, 2010, Volume: 19, Issue:4

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Anesthesia, General; Anesthetics, Inhalation; Animals; Apo

2010
Anesthesia in presymptomatic Alzheimer's disease: a study using the triple-transgenic mouse model.
    Alzheimer's & dementia : the journal of the Alzheimer's Association, 2011, Volume: 7, Issue:5

    Topics: Alzheimer Disease; Anesthetics, Inhalation; Animals; Brain; Cognition Disorders; Disease Models, Ani

2011
Anesthetic propofol attenuates the isoflurane-induced caspase-3 activation and Aβ oligomerization.
    PloS one, 2011, Volume: 6, Issue:11

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Anesthetics, Inhalation; A

2011
Trehalose protects from aggravation of amyloid pathology induced by isoflurane anesthesia in APP(swe) mutant mice.
    Current Alzheimer research, 2012, Volume: 9, Issue:3

    Topics: Alzheimer Disease; Anesthetics, Inhalation; Animals; Disease Models, Animal; Female; Humans; Isoflur

2012
Isoflurane anesthesia precipitates tauopathy and upper airways dysfunction in pre-symptomatic Tau.P301L mice: possible implication for neurodegenerative diseases.
    Neurobiology of disease, 2012, Volume: 46, Issue:1

    Topics: Alzheimer Disease; Anesthetics, Inhalation; Animals; Brain Stem; Disease Models, Animal; Isoflurane;

2012
Isoflurane exposure during mid-adulthood attenuates age-related spatial memory impairment in APP/PS1 transgenic mice.
    PloS one, 2012, Volume: 7, Issue:11

    Topics: Age Factors; Alzheimer Disease; Amyloid beta-Protein Precursor; Anesthetics, Inhalation; Animals; Di

2012
Effects of isoflurane-induced anaesthesia on cognitive performance in a mouse model of Alzheimer's disease: A randomised trial in transgenic APP23 mice.
    European journal of anaesthesiology, 2013, Volume: 30, Issue:10

    Topics: Age Factors; Alzheimer Disease; Amyloid beta-Protein Precursor; Anesthetics, Inhalation; Animals; Be

2013
Differential general anesthetic effects on microglial cytokine expression.
    PloS one, 2013, Volume: 8, Issue:1

    Topics: Alzheimer Disease; Anesthetics; Cells, Cultured; Cytokines; Gene Expression Regulation; Humans; Infl

2013
The inhalation anesthetic isoflurane induces a vicious cycle of apoptosis and amyloid beta-protein accumulation.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007, Feb-07, Volume: 27, Issue:6

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Anesthetics, Inhalat

2007
Anesthesia-Alzheimer disease link probed.
    JAMA, 2007, Apr-25, Volume: 297, Issue:16

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Anesthesia; Anesthetics; Animals; Cognition; Halothane; Hu

2007