isoflurane has been researched along with Academic Disorder, Developmental in 17 studies
Isoflurane: A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The isoflurane-exposed rats were further divided into a learning/memory-impaired subgroup and a non-learning/memory-impaired subgroup according to their behavioral performance, which was measured using Morris water maze." | 1.39 | Hippocampal glutamate level and glutamate aspartate transporter (GLAST) are up-regulated in senior rat associated with isoflurane-induced spatial learning/memory impairment. ( Ji, C; Jia, X; Liu, W; Qu, X; Wang, H; Wang, Y; Wu, A; Xie, Z; Xu, C; Xu, J; Xu, Z; Yue, Y, 2013) |
| "The isoflurane anaesthesia treatment increased the escape latency contrast to propofol anaesthesia group." | 1.38 | Changes of learning and memory in aged rats after isoflurane inhalational anaesthesia correlated with hippocampal acetylcholine level. ( Feng, C; Jia, X; Wang, H; Wang, Y; Wu, A; Xu, Z; Yue, Y, 2012) |
| "This isoflurane effect was attenuated by lidocaine, a local anesthetic with anti-inflammatory property." | 1.38 | Isoflurane induces learning impairment that is mediated by interleukin 1β in rodents. ( Cao, L; Li, L; Lin, D; Zuo, Z, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (5.88) | 18.2507 |
| 2000's | 2 (11.76) | 29.6817 |
| 2010's | 11 (64.71) | 24.3611 |
| 2020's | 3 (17.65) | 2.80 |
| Authors | Studies |
|---|---|
| Mineshima, H | 1 |
| Kimoto, H | 1 |
| Hitomi, M | 1 |
| Akizawa, F | 1 |
| Terayama, Y | 1 |
| Yoshikawa, T | 1 |
| Wen, J | 1 |
| Li, Z | 1 |
| Zuo, Z | 4 |
| Aksenov, DP | 1 |
| Venkatasubramanian, PN | 1 |
| Miller, MJ | 1 |
| Dixon, CJ | 1 |
| Li, L | 2 |
| Wyrwicz, AM | 1 |
| Tan, H | 2 |
| Cao, J | 1 |
| Zhang, J | 2 |
| Yang, B | 1 |
| Liang, G | 1 |
| Khojasteh, S | 1 |
| Wu, Z | 1 |
| Yang, W | 1 |
| Joseph, D | 1 |
| Wei, H | 1 |
| Li, G | 1 |
| Xue, Q | 1 |
| Luo, Y | 1 |
| Hu, X | 1 |
| Yu, B | 1 |
| Jiang, W | 1 |
| Luo, T | 1 |
| Yin, S | 1 |
| Shi, R | 1 |
| Xu, C | 2 |
| Wang, Y | 3 |
| Cai, J | 1 |
| Yue, Y | 3 |
| Wu, A | 3 |
| Walters, JL | 1 |
| Chelonis, JJ | 1 |
| Fogle, CM | 1 |
| Orser, BA | 1 |
| Paule, MG | 1 |
| Chai, D | 1 |
| Jiang, H | 2 |
| Li, Q | 1 |
| Huang, Y | 1 |
| Xu, H | 1 |
| Sun, Y | 1 |
| Han, N | 1 |
| Li, QF | 1 |
| Wang, H | 2 |
| Xu, Z | 2 |
| Feng, C | 1 |
| Jia, X | 2 |
| Qu, X | 1 |
| Xu, J | 1 |
| Liu, W | 1 |
| Xie, Z | 1 |
| Ji, C | 1 |
| Cao, L | 1 |
| Lin, D | 1 |
| Jevtovic-Todorovic, V | 1 |
| Hartman, RE | 1 |
| Izumi, Y | 1 |
| Benshoff, ND | 1 |
| Dikranian, K | 1 |
| Zorumski, CF | 1 |
| Olney, JW | 1 |
| Wozniak, DF | 1 |
| Baxter, MG | 1 |
| Murphy, KL | 1 |
| Crosby, G | 1 |
| Culley, DJ | 1 |
| Chortkoff, BS | 1 |
| Bennett, HL | 1 |
| Eger, EI | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Gut Microbiome and Blood Indices in Patients With AD and Their Spousal Caregivers[NCT05601856] | 104 participants (Anticipated) | Observational | 2022-12-15 | Recruiting | |||
| The EPigenetic Consequences in Children of Intravenous vs Volatile Anaesthesia for Surgery (EPIVA) - A Randomised, Feasibility Trial[NCT05936853] | 16 participants (Anticipated) | Interventional | 2023-07-31 | Not yet recruiting | |||
| Anesthesia Exposure and Neurodevelopment in Infants and Children: Pediatric Anesthesia & NeuroDevelopment (PANDA) Study[NCT00881764] | 369 participants (Actual) | Observational | 2009-05-31 | Completed | |||
| Dexmedetomidine Sedation Versus General Anaesthesia for Inguinal Hernia Surgery on Peri-operative Outcomes and Neurocognitive Development in Infants: A Randomized Controlled Trial[NCT02559102] | Phase 3 | 104 participants (Actual) | Interventional | 2015-07-31 | Completed | ||
| Randomized Controlled Trial of Nitrous Oxide Analgesia in External Cephalic Version (ECV)[NCT03502915] | Phase 3 | 48 participants (Actual) | Interventional | 2017-01-30 | Completed | ||
| Appendectomy During Pregnancy in General Anesthesia With Perioperative Management Does Not Influence Normal Child Development: 10-year Study[NCT05759351] | 30 participants (Actual) | Observational | 2006-01-01 | Completed | |||
| A Comparison of Functional Magnetic Resonance Imaging (fMRI) Findings in Children With and Without a History of Early Exposure to General Anesthetics[NCT01229514] | 30 participants (Actual) | Observational | 2008-10-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Anxiety scores will be collected following each version attempt using an 11 point scale (0 being not at all anxious; 10 being extremely anxious), ranging from 0 to 10. Higher scores indicate more anxiety, lower scores indicate less anxiety. If more than one attempt, anxiety scores will be averaged to obtain a single score for the entire procedure. (NCT03502915)
Timeframe: During each version procedure, a total average of up to approximately 30 minutes
| Intervention | score on a scale (Mean) |
|---|---|
| Nitrous Oxide | 4.696 |
| Oxygen | 4.253 |
Pain scores will be collected following each version attempt using an 11 point scale (with 0 being no pain at all; 10 being worst pain imaginable), ranging from 0 to 10. Higher scores indicate more pain, lower scores indicate less pain. If more than one attempt, pain scores will be averaged to obtain a single score for the entire procedure. (NCT03502915)
Timeframe: During each version procedure, a total average of up to approximately 30 minutes
| Intervention | score on a scale (Mean) |
|---|---|
| Nitrous Oxide | 5.486 |
| Oxygen | 5.433 |
Pain scores will be collected following completion of the version using an 11 point scale (0 being no pain at all; 10 being worst pain imaginable), ranging from 0 to 10. Higher scores indicate more pain, lower scores indicate less pain. (NCT03502915)
Timeframe: Immediately Post-procedure, within approximately 15 minutes of final version attempt
| Intervention | score on a scale (Mean) |
|---|---|
| Nitrous Oxide | 1 |
| Oxygen | 0.88 |
Satisfaction will be assessed following the procedure using an 11 point scale (0 being not at all satisfied; 10 being extremely satisfied), ranging from 0 to 10. Higher scores indicate more satisfaction, lower scores indicate less satisfaction. (NCT03502915)
Timeframe: Immediately Post-procedure, within approximately 15 minutes of final version attempt
| Intervention | score on a scale (Mean) |
|---|---|
| Nitrous Oxide | 4.286 |
| Oxygen | 6.920 |
Following the procedure, the obstetric provider performing the procedure will rate the ease of procedure on a 1-10 scale (1 being very easy and 10 being extremely difficult), ranging from 1 to 10. Higher scores indicate more difficulty, lower scores indicate less difficulty. A 10 point scale was used for this outcome, while an 11 point scale was used for the other 4 outcome measures (pain, anxiety, post-procedure pain and satisfaction). (NCT03502915)
Timeframe: Immediately Post-procedure, within approximately 15 minutes of final version attempt
| Intervention | score on a scale (Mean) |
|---|---|
| Nitrous Oxide | 6.136 |
| Oxygen | 6.080 |
17 other studies available for isoflurane and Academic Disorder, Developmental
| Article | Year |
|---|---|
Comparative study on detectability of learning and memory disorder between two water maze tests commonly used in juvenile rat toxicity studies using isoflurane inhaled rat model.
Topics: Animals; Brain; Female; Isoflurane; Learning Disabilities; Male; Maze Learning; Memory Disorders; Ra | 2022 |
Postoperative Learning and Memory Dysfunction Is More Severe in Males But Is Not Persistent and Transmittable to Next Generation in Young Adult Rats.
Topics: Animals; Fear; Female; Hippocampus; Isoflurane; Learning Disabilities; Male; Maze Learning; Rats; Ra | 2023 |
Effects of neonatal isoflurane anesthesia exposure on learning-specific and sensory systems in adults.
Topics: Adolescent; Anesthesia, General; Animals; Animals, Newborn; Blinking; Conditioning, Classical; Femal | 2020 |
Critical role of inflammatory cytokines in impairing biochemical processes for learning and memory after surgery in rats.
Topics: Animals; Carotid Arteries; Cytokines; Disease Models, Animal; Gene Expression Regulation; Hippocampu | 2014 |
Comparison of neurodegeneration and cognitive impairment in neonatal mice exposed to propofol or isoflurane.
Topics: Administration, Inhalation; Anesthetics; Animals; Animals, Newborn; Apoptosis; Brain Damage, Chronic | 2014 |
S6 inhibition contributes to isoflurane neurotoxicity in the developing brain.
Topics: Anesthetics, Inhalation; Animals; Apoptosis; Brain; Hippocampus; Isoflurane; Learning Disabilities; | 2015 |
The choice of general anesthetics may not affect neuroinflammation and impairment of learning and memory after surgery in elderly rats.
Topics: Anesthetics, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Buprenorphine; Cal | 2015 |
miRNA expression profile and involvement of Let-7d-APP in aged rats with isoflurane-induced learning and memory impairment.
Topics: Amyloid beta-Protein Precursor; Animals; Down-Regulation; Gene Expression Profiling; Gene Expression | 2015 |
Single and repeated exposures to the volatile anesthetic isoflurane do not impair operant performance in aged rats.
Topics: Aging; Anesthetics, Inhalation; Animals; Conditioning, Operant; Disease Models, Animal; Drug Adminis | 2016 |
Isoflurane neurotoxicity involves activation of hypoxia inducible factor-1α via intracellular calcium in neonatal rodents.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Apoptosis; Calcium; Calcium Signaling; Cells, Cu | 2016 |
Hypoxia inducible factor-1α is involved in the neurodegeneration induced by isoflurane in the brain of neonatal rats.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Apoptosis; Brain; Calcium; Cell Survival; Cells, | 2012 |
Changes of learning and memory in aged rats after isoflurane inhalational anaesthesia correlated with hippocampal acetylcholine level.
Topics: Acetylcholine; Aging; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Brain; Brain Chemi | 2012 |
Hippocampal glutamate level and glutamate aspartate transporter (GLAST) are up-regulated in senior rat associated with isoflurane-induced spatial learning/memory impairment.
Topics: Aging; Anesthetics, Inhalation; Animals; Blotting, Western; Excitatory Amino Acid Transporter 1; Exc | 2013 |
Isoflurane induces learning impairment that is mediated by interleukin 1β in rodents.
Topics: Animals; Antigens, Nuclear; Caspase 3; CD11b Antigen; Cognition; Conditioning, Psychological; Enzyme | 2012 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Different behavioral effects of neurotoxic dorsal hippocampal lesions placed under either isoflurane or propofol anesthesia.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Behavior, Animal; Denervation; Hippocamp | 2008 |
Does nitrous oxide antagonize isoflurane-induced suppression of learning?
Topics: Adult; Behavior; Dose-Response Relationship, Drug; Drug Interactions; Humans; Isoflurane; Learning; | 1993 |