Page last updated: 2024-10-29

isocarboxazid and Depression

isocarboxazid has been researched along with Depression in 70 studies

Isocarboxazid: An MAO inhibitor that is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in the treatment of panic disorder and the phobic disorders. (From AMA, Drug Evaluations Annual, 1994, p311)

Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.

Research Excerpts

Excerpt	Relevance	Reference
"There have been numerous case reports of adverse reactions involving monoamine oxidase inhibitors (MAOIs), including reactions that developed when one MAOI was substituted for another."	1.28	Central nervous system toxicity after abrupt monoamine oxidase inhibitor switch: a case report. ( Masiar, SJ; Safferman, AZ, 1992)
"Depression is common in Huntington's disease."	1.27	Treatment of depression in Huntington's disease with monoamine oxidase inhibitors. ( Ford, MF, 1986)

Research

Studies (70)

Timeframe	Studies, this research(%)	All Research%
pre-1990	69 (98.57)	18.7374
1990's	1 (1.43)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
DARLING, HF	3
KRUSE, W	1
HESS, GF	1
HOERMANN, MG	1
FOURNIAL, P	2
DEMAY-LAULAN, M	2
DEMAY, J	2
ABRAHAM, A	2
ROUDIERE, JJ	2
GOASGUEN, J	2
SCHOCRON, G	2
HOHEISEL, HP	1
D'AGOSTINI, N	1
CURRO' DOSSI, B	1
ROTHMAN, T	1
GRAYSON, H	1
FERGUSON, J	1
MEUSERT, W	1
MOCK, JE	1
PANERO, C	1
ROBINSON, N	1
VASSILIOU, V	1
HIMWICH, HE	1
JOSHI, VG	1
BURGERMEISTER, JJ	1
DICK, P	1
GARRONE, G	1
TISSOT, R	1
FREEMAN, H	2
KENEFICK, DP	1
RIVERA, MR	1
GATTUSO, R	1
LANTERI, G	1
PARE, CM	3
REES, L	1
SAINSBURY, MJ	1
HONIGFELD, G	1
LASKY, JJ	1
RAVN, J	1
SCHIELE, BC	1
WIEHLER, H	1
HASTINGS, GE	1
JACKSON, D	1
BERNARD, LA	1
BENTLIF, P	1
ANDREONI, M	1
INVERNIZZI, G	1
BEERMAN, HM	1
GREENBLATT, M	3
GROSSER, GH	2
WECHSLER, H	2
SIEGLER, PE	1
LEIJNSE, B	4
KLINE, NS	1
RICHMOND, PW	1
ROBERTS, AH	1
MANS, J	1
SENES, M	1
DESTOUNIS, N	2
PINTO, A	2
JOHNSON, C	1
COOPER, M	1
KIMBELL, I	1
POKORNY, AD	1
LATHBURY, VT	1
OLTMAN, JE	1
FRIEDMAN, S	1
SAKURAI, T	1
NISHISONO, M	1
HOLLISTER, LE	1
PRUSMACK, JJ	1
Young, JP	1
Lader, MH	1
Hughes, WC	1
Cohen, R	1
Pickar, D	1
Spiker, DG	1
Pugh, DD	1
Youdim, MB	2
Abdala, EN	1
Johnson, WC	1
Safferman, AZ	1
Masiar, SJ	1
Ford, MF	1
Green, MD	1
Locke, SE	1
Wyatt, RJ	1
Kupfer, DJ	1
Scott, J	1
Robinson, DS	1
Snyder, F	1
Kurland, AA	1
Shaffer, JW	1
Snowdon, J	1
Braithwaite, R	1
Collins, GG	1
Sandler, M	1
Bevan Jones, AB	1
Nicholson, WJ	1
Nias, DK	1
Shapiro, MB	1
Vann, D	1
Van Renynghe, G	1
Morris, JB	1
Beck, AT	1
Davidson, J	1
Hays, P	1
Steinert, J	1
Lipman, RS	1
Uhlenhuth, EH	1
Rickels, K	1
Covi, L	1
Feldstein, A	1
Hoagland, H	1
Rivera Oktem, M	1
Bartonícek, VJ	1
Pollitt, J	1
Young, J	1
Winston, F	1
Schuckit, M	1
Robins, E	1
Feighner, J	1
Lippincott, RC	1
van Praag, HM	1
Sargant, W	1
Walter, CJ	1
Wright, N	1
Schorer, CE	1
Lowinger, P	1
Dobie, S	1

Reviews

4 reviews available for isocarboxazid and Depression

Article	Year
MONOAMINE OXIDASE INHIBITORS: A REVIEW. The Journal of the Kansas Medical Society, 1963, Volume: 64 Topics: Angina Pectoris; Colitis; Colitis, Ulcerative; Collagen Diseases; Depression; Depressive Disorder; D	1963
CURRENT STATUS OF DRUG TREATMENT IN THE DEPRESSIVE STATE. The Medical clinics of North America, 1964, Volume: 48 Topics: Amitriptyline; Amphetamine; Amphetamines; Antidepressive Agents; Aspartic Acid; Benactyzine; Classif	1964
Efficacy of ECT in affective and schizophrenic illness. The American journal of psychiatry, 1977, Volume: 134, Issue:9 Topics: Amitriptyline; Chlorpromazine; Depression; Electroconvulsive Therapy; Evaluation Studies as Topic; H	1977
Monoamine oxidase. Its inhibition. Modern problems of pharmacopsychiatry, 1975, Volume: 10 Topics: Bipolar Disorder; Brain; Clorgyline; Depression; Humans; Isocarboxazid; Mitochondria; Monoamine Oxid	1975

Trials

6 trials available for isocarboxazid and Depression

Article	Year
Controlled trial of trimipramine, monoamine oxidase inhibitors, and combined treatment in depressed outpatients. British medical journal, 1979, Nov-24, Volume: 2, Issue:6201 Topics: Adult; Aged; Clinical Trials as Topic; Depression; Dibenzazepines; Drug Therapy, Combination; Humans	1979
A critical study of isocarboxazid (Marplan) in the treatment of depressed patients. The Journal of nervous and mental disease, 1967, Volume: 145, Issue:4 Topics: Adolescent; Adult; Aged; Behavior; Clinical Trials as Topic; Depression; Environment; Female; Humans	1967
The effects of small electrical currents upon depressive symptoms. The British journal of psychiatry : the journal of mental science, 1974, Volume: 125, Issue:0 Topics: Adult; Awareness; Brain; Chlordiazepoxide; Chlorpromazine; Clinical Trials as Topic; Depression; Ele	1974
A blind comparative trial of nortriptyline and isocarboxazid in depressed outpatients. Canadian Psychiatric Association journal, 1969, Volume: 14, Issue:3 Topics: Clinical Trials as Topic; Depression; Humans; Isocarboxazid; Nortriptyline; Outpatient Clinics, Hosp	1969
Medication attitudes and drug response. Diseases of the nervous system, 1969, Volume: 30, Issue:7 Topics: Anorexia Nervosa; Anxiety; Atropine; Attitude; Attitude of Health Personnel; Clinical Trials as Topi	1969
MAO inhibition and antidepressant activity. International journal of neuropsychiatry, 1965, Volume: 1, Issue:4 Topics: Adult; Antidepressive Agents; Bipolar Disorder; Clinical Trials as Topic; Depression; Humans; Isocar	1965

Other Studies

60 other studies available for isocarboxazid and Depression

Article	Year
Preliminary study of isocarboxazid, an iproniazid analog. Diseases of the nervous system, 1959, Volume: 20, Issue:6 Topics: Depression; Depressive Disorder; Hydrazines; Iproniazid; Isocarboxazid; Organic Chemicals; Oxazoles	1959
[Preliminary note on the use of a new iproniazid derivative, Ro 5-0831 in depressive states]. Journal de medecine de Bordeaux et du Sud-Ouest, 1960, Volume: 137 Topics: Depression; Depressive Disorder; Hydrazines; Iproniazid; Isocarboxazid	1960
[On the therapy of psychomotor depression with Marplan]. Medizinische Monatsschrift, 1960, Volume: 14 Topics: Depression; Depressive Disorder; Hydrazines; Isocarboxazid	1960
[On the antidepressive action of 1-benzyl-2-(5-methyl-3-isoxazolylcarbonyl-hydrazine (Marplan)]. L' Arcispedale S. Anna di Ferrara, 1960, Volume: 13(Suppl 6) Topics: Antidepressive Agents; Depression; Depressive Disorder; Isocarboxazid; Monomethylhydrazine; Psychoph	1960
Chlorprothixine (Taractan) and isocarboxazid (Marplan) in psychotic depressions. The American journal of psychiatry, 1961, Volume: 117 Topics: Bipolar Disorder; Chlorprothixene; Depression; Depressive Disorder, Major; Hydrazines; Isocarboxazid	1961
An evaluation of the effectiveness of isocarboxazid (Marplan) in the depressive syndromes. Comprehensive psychiatry, 1961, Volume: 2 Topics: Depression; Depressive Disorder; Humans; Hydrazines; Iproniazid; Isocarboxazid; Psychopharmacology	1961
[The use of a new monoamine oxidase (marplan) in neurological practice]. Die Medizinische Welt, 1960, Nov-26, Volume: 48 Topics: Databases, Genetic; Depression; Depressive Disorder; Hydrazines; Isocarboxazid; Monoamine Oxidase	1960
Marplan in the treatment of depression. (A preliminary study). Diseases of the nervous system, 1961, Volume: 22 Topics: Depression; Depressive Disorder; Hydrazines; Isocarboxazid; Psychopharmacology	1961
Psychological effects of isocarboxazid and nialamide on a group of depressed patients. Journal of clinical psychology, 1961, Volume: 17 Topics: Depression; Depressive Disorder; Humans; Hydrazines; Iproniazid; Isocarboxazid; Mental Disorders; Ni	1961
Controlled clinical trial of isocarboxazid ("Marplan") in hospital psychiatry. The Journal of mental science, 1961, Volume: 107 Topics: Depression; Depressive Disorder; Hospitals, Psychiatric; Hydrazines; Isocarboxazid; Oxidoreductases;	1961
[Preliminary study of the therapeutic action of a new monoamine oxidase inhibitor. Ro 5-0831]. Praxis, 1960, Jan-21, Volume: 49 Topics: Depression; Depressive Disorder; Isocarboxazid; Monoamine Oxidase Inhibitors; Psychopharmacology	1960
Isocarboxazid (marplan) in ambulatory psychiatric patients. The American journal of psychiatry, 1959, Volume: 116 Topics: Depression; Depressive Disorder; Hydrazines; Isocarboxazid; Patients; Schizophrenia	1959
[First results with a new iproniazid derivative, Ro 5-0831 (marplan), in depressive syndromes]. Annales medico-psychologiques, 1960, Volume: 118(1) Topics: Depression; Depressive Disorder; Hydrazines; Iproniazid; Isocarboxazid	1960
A clinical evaluation of marplan in depressed patients. Diseases of the nervous system, 1960, Volume: 21(3)Suppl Topics: Depression; Depressive Disorder; Isocarboxazid; Oxidoreductases; Parasympatholytics	1960
[Clinical observations on a drug with antimonoaminoxidase action (Ro 5-0831) in psychiatric therapy]. Gazzetta medica italiana, 1961, Volume: 120 Topics: Depression; Depressive Disorder; Isocarboxazid; Oxidoreductases; Psychopharmacology; Psychotherapy	1961
Differentiation of two genetically specific types of depression by the response to anti-depressants. Lancet (London, England), 1962, Dec-29, Volume: 2, Issue:7270 Topics: Antidepressive Agents; Depression; Depressive Disorder; Imipramine; Iproniazid; Isocarboxazid; Monoa	1962
One year follow-up of depressed patients treated in a multi-hospital drug study. I. Social workers' evaluations. Diseases of the nervous system, 1962, Volume: 23 Topics: Amobarbital; Depression; Depressive Disorder; Dextroamphetamine; Drug Evaluation; Follow-Up Studies;	1962
[Patients with endogenous depressions treated with Marplan]. Nordisk psykiatrisk tidsskrift. Nordic journal of psychiatry, 1962, Volume: 16 Topics: Depression; Depressive Disorder; Humans; Isocarboxazid	1962
Antidepressants: comparison of clinical effects in anergic schizophrenia and the depressed states. Annals of the New York Academy of Sciences, 1963, Jul-08, Volume: 107 Topics: Antidepressive Agents; Depression; Imipramine; Iproniazid; Isocarboxazid; Monoamine Oxidase Inhibito	1963
[On the treatment of depression with monoamine oxidase inhibitors]. Der Nervenarzt, 1962, Volume: 33 Topics: Depression; Depressive Disorder; Isocarboxazid; Monoamine Oxidase Inhibitors	1962
ANTI-DEPRESSANT DRUGS. Medical record and annals, 1963, Volume: 56 Topics: Amitriptyline; Antidepressive Agents; Depression; Depressive Disorder; Geriatrics; Headache; Imipram	1963
[ON A CASE OF ATTEMPTED SUICIDE WITH A DRUG WITH MONOAMINE OXIDASE INHIBITING ACTIVITY]. Giornale di psichiatria e di neuropatologia, 1963, Volume: 91 Topics: Depression; Depressive Disorder; Isocarboxazid; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Sui	1963
ACONTROLLED STUDY OF DIAZEPAM IN PSYCHIATRIC OUTPATIENTS. The American journal of psychiatry, 1964, Volume: 120 Topics: Adolescent; Anxiety; Anxiety Disorders; Depression; Diazepam; Geriatrics; Humans; Isocarboxazid; Neu	1964
DIFFERENTIAL RESPONSE OF HOSPITALIZED DEPRESSED PATIENTS TO SOMATIC THERAPY. The American journal of psychiatry, 1964, Volume: 120 Topics: Bipolar Disorder; Depression; Depressive Disorder; Depressive Disorder, Major; Electroconvulsive The	1964
[SIGNIFICANCE OF MONOAMINE OXIDASE INHIBITION AS AN ANTIDEPRESSIVE PRINCIPLE]. Nederlands tijdschrift voor geneeskunde, 1964, May-09, Volume: 108 Topics: Antidepressive Agents; Depression; Depressive Disorder; Iproniazid; Isocarboxazid; Monoamine Oxidase	1964
THE PRACTICAL MANAGEMENT OF DEPRESSION. JAMA, 1964, Nov-23, Volume: 190 Topics: Amitriptyline; Antidepressive Agents; Benzoates; Classification; Depression; Depressive Disorder; Dr	1964
A COMPARATIVE TRIAL OF IMIPRAMINE, AMITRIPTYLINE, ISOCARBOXAZID AND TRANYLCYPROMINE IN OUT-PATIENT DEPRESSIVE ILLNESS. The British journal of psychiatry : the journal of mental science, 1964, Volume: 110 Topics: Amitriptyline; Biomedical Research; Depression; Depressive Disorder; Drug Therapy; Humans; Imipramin	1964
[THE EFFECT OF ANTIDEPRESSIVE AGENTS OF THE HYDRAZINE TYPE ON CARBOHYDRATE METABOLISM IN DEPRESSIVE PATIENTS]. Nederlands tijdschrift voor geneeskunde, 1964, Oct-10, Volume: 108 Topics: Antidepressive Agents; Carbohydrate Metabolism; Depression; Depressive Disorder; Glucose Tolerance T	1964
[ISOCARBOXAZIDE; RO 5-0690 OR CHLORDIAZEPOXIDE; RO 4-0403, DERIVATIVE OF THIOXANTHENES. STUDY ON THEIR INDIVIDUAL EFFECTS AND THEIR POSSIBILITIES OF COMBINATION]. Journal de medecine de Bordeaux et du Sud-Ouest, 1964, Volume: 141 Topics: Biomedical Research; Chlordiazepoxide; Chlorprothixene; Depression; Depressive Disorder; Drug Therap	1964
TREATMENT OF DEPRESSION. Lancet (London, England), 1965, May-01, Volume: 1, Issue:7392 Topics: Amphetamine; Amphetamines; Antidepressive Agents; Catecholamines; Depression; Depressive Disorder; D	1965
CLINICAL TRIAL OF ISOCARBOXAZID. Current therapeutic research, clinical and experimental, 1965, Volume: 7 Topics: Biomedical Research; Depression; Depressive Disorder; Drug Therapy; Isocarboxazid; Mental Disorders;	1965
CHOICE OF SOMATIC THERAPIES IN DEPRESSION. Current psychiatric therapies, 1964, Volume: 4 Topics: Biomedical Research; Depression; Depressive Disorder; Drug Therapy; Electroconvulsive Therapy; Imipr	1964
THE XYLOSE METABOLISM IN DEPRESSED PATIENTS AND ITS ALTERATIONS UNDER THE INFLUENCE OF ANTIDEPRESSIVE HYDRAZINES. Clinica chimica acta; international journal of clinical chemistry, 1965, Volume: 11 Topics: Biological Transport; Blood; Body Fluids; Carbohydrate Metabolism; Depression; Depressive Disorder;	1965
The use of marplan in chronically depressed patients. Diseases of the nervous system, 1960, Volume: 21(3)Suppl Topics: Depression; Depressive Disorder; Isocarboxazid; Parasympatholytics	1960
A note on eleven months of clinical experience with isocarboxazid, a new antidepressant. Medical times, 1960, Volume: 88 Topics: Antidepressive Agents; Depression; Depressive Disorder; Hydrazines; Isocarboxazid	1960
Use of marplan in depressive states. (A preliminary report). Diseases of the nervous system, 1960, Volume: 21(3)Suppl Topics: Depression; Depressive Disorder; Isocarboxazid; Parasympatholytics	1960
[Combined use of chlordiazepoxide (Contol) and isocarboxazid (Enerzer) in depressive states]. No to shinkei = Brain and nerve, 1962, Volume: 14 Topics: Antidepressive Agents; Chlordiazepoxide; Depression; Depressive Disorder; Hydrazines; Isocarboxazid;	1962
PSYCHOTHERAPEUTIC DRUGS IN THE TREATMENT OF DEPRESSIONS. Clinical medicine (Northfield, Ill.), 1963, Volume: 70 Topics: Amitriptyline; Amphetamine; Amphetamines; Antidepressive Agents; Depression; Electroconvulsive Thera	1963
Implications of monoamine oxidase inhibitor-induced hypomania. Archives of general psychiatry, 1978, Volume: 35, Issue:11 Topics: Adult; Bipolar Disorder; Depression; Humans; Isocarboxazid; Male; Phenelzine	1978
Combining tricyclic and monoamine oxidase inhibitor antidepressants. Archives of general psychiatry, 1976, Volume: 33, Issue:7 Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Depression; Drug Therapy, Combination; Humans; Hype	1976
[Combination of tricyclic antidepressants and MAOI in the depressions]. Acta psiquiatrica y psicologica de America latina, 1975, Volume: 21, Issue:1 Topics: Administration, Oral; Adult; Aged; Depression; Dibenzazepines; Drug Evaluation; Drug Therapy, Combin	1975
A neglected modality in psychiatric treatment--the monoamine oxidase inhibitors. Diseases of the nervous system, 1975, Volume: 36, Issue:9 Topics: Depression; Humans; Hypertension; Iproniazid; Isocarboxazid; Jaundice; Mental Disorders; Monoamine O	1975
Central nervous system toxicity after abrupt monoamine oxidase inhibitor switch: a case report. The Annals of pharmacotherapy, 1992, Volume: 26, Issue:3 Topics: Brain; Depression; Female; Humans; Isocarboxazid; Middle Aged; Monoamine Oxidase Inhibitors; Phenelz	1992
Treatment of depression in Huntington's disease with monoamine oxidase inhibitors. The British journal of psychiatry : the journal of mental science, 1986, Volume: 149 Topics: Adult; Aged; Depression; Female; Humans; Huntington Disease; Isocarboxazid; Middle Aged; Monoamine O	1986
The immune system and its control: a possible model in herpes virus infections. Journal of clinical psychopharmacology, 1988, Volume: 8, Issue:1 Topics: Adult; Depression; Herpes Genitalis; Humans; Immunity, Cellular; Isocarboxazid; Male; Recurrence	1988
Longitudinal studies of the effect of monoamine oxidase inhibitors on sleep in man. Psychopharmacologia, 1969, Volume: 15, Issue:3 Topics: Blood Platelets; Depression; Female; Humans; Hydrazines; Isocarboxazid; Isoniazid; Male; Monoamine O	1969
Letter: Combined antidepressant medication. The British journal of psychiatry : the journal of mental science, 1974, Volume: 125 Topics: Amitriptyline; Depression; Drug Synergism; Drug Therapy, Combination; Humans; Isocarboxazid; Norepin	1974
Human brain monoamine oxidase: multiple forms and selective inhibitors. Nature, 1972, Mar-31, Volume: 236, Issue:5344 Topics: Aged; Amines; Basal Ganglia; Brain; Carbon Isotopes; Cerebellum; Cerebral Cortex; Depression; Dopami	1972
"Endogenous" depression: some suggestions. The Medical journal of Australia, 1972, Nov-18, Volume: 2, Issue:21 Topics: Antidepressive Agents; Depression; Humans; Isocarboxazid; Tranylcypromine	1972
[Are the MAOIs outmoded?]. Acta psychiatrica Belgica, 1972, Volume: 72, Issue:6 Topics: Adjustment Disorders; Adult; Aged; Antidepressive Agents; Anxiety Disorders; Delusions; Depression;	1972
The efficacy of antidepressant drugs. A review of research (1958-1972). Archives of general psychiatry, 1974, Volume: 30, Issue:5 Topics: Adolescent; Adult; Aged; Amitriptyline; Antidepressive Agents; Bipolar Disorder; Depression; Dibenza	1974
The management of resistant depression. The British journal of psychiatry : the journal of mental science, 1974, Volume: 124, Issue:579 Topics: Amitriptyline; Anesthesia; Depression; Dose-Response Relationship, Drug; Drug Therapy, Combination;	1974
Monoamine oxidase inhibitors, combined with thymoleptics: Are they really unusable for human beings? Pharmacology, 1970, Volume: 4, Issue:2 Topics: Animals; Behavior, Animal; Brain Chemistry; Brain Stem; Butyrophenones; Depression; Fluorescence; Hu	1970
Anxiety state or masked depression? A study based on the action of monoamine oxidase inhibitors. The British journal of psychiatry : the journal of mental science, 1971, Volume: 119, Issue:549 Topics: Adult; Age Factors; Aged; Anxiety; Appetite; Body Weight; Circadian Rhythm; Depression; Female; Huma	1971
Combined antidepressant therapy. The British journal of psychiatry : the journal of mental science, 1971, Volume: 118, Issue:544 Topics: Adjustment Disorders; Adult; Amitriptyline; Depression; Electroconvulsive Therapy; Female; Humans; I	1971
Tricyclic antidepressants and monoamine oxidase inhibitors. Archives of general psychiatry, 1971, Volume: 24, Issue:6 Topics: Administration, Oral; Adolescent; Adult; Aged; Amitriptyline; Animals; Depression; Desipramine; Drug	1971
Depressive illness. Identification and treatment in the elderly. Geriatrics, 1968, Volume: 23, Issue:11 Topics: Aged; Depression; Electroconvulsive Therapy; Humans; Isocarboxazid; Phenelzine; Social Isolation; Su	1968
Depression, glucose tolerance, peripheral glucose uptake and their alterations under the influence of anti-depressive drugs of the hydrazine type. Psychopharmacologia, 1965, Jun-01, Volume: 8, Issue:1 Topics: Adult; Aged; Depression; Glucagon; Glucose; Glucose Tolerance Test; Humans; Hunger; Isocarboxazid; L	1965
New treatment of some chronic tension states. British medical journal, 1966, Feb-05, Volume: 1, Issue:5483 Topics: Adult; Aged; Amitriptyline; Antidepressive Agents; Anxiety; Chlorpromazine; Depression; Electroconvu	1966
The real effect of imipramine, isocarboxazid and nialamide. Michigan medicine, 1966, Volume: 65, Issue:12 Topics: Adult; Depression; Humans; Imipramine; Isocarboxazid; Nialamide	1966