isepamicin and Prostatitis

To assess the efficacy of a combined regimen of levofloxacin (LVFX) plus isepamicin (ISP) as prophylaxis for transrectal ultrasound-guided needle biopsy of the prostate (TRUSP-Bx).. Overall, 562 patients undergoing TRUSP-Bx were included in the present study. All patients were administered a single-dose of oral LVFX (500 mg) in the morning and intravenous ISP (400 mg) 60 min before biopsy. All biopsies were performed via TRUSP-Bx with an 18-gauge needle, and 12-core specimens were routinely obtained. Before initiating antibiotic treatment, urine and blood bacterial cultures were tested to determine the causative microorganisms in the patients with acute bacterial prostatitis.. Acute bacterial prostatitis developed in three (0.53%) participants. The incidence rates of acute bacterial prostatitis in the low- and high-risk groups were 0.79% and 0.46%, respectively. These patients showed clinical symptoms of acute bacterial prostatitis 12-24 h after their biopsy. Escherichia coli (E. coli) was isolated in the urine or bladder cultures of all of patients. All three isolates were determined to be LVFX-resistant E. coli, although they had good sensitivity to aminoglycosides, cephalosporins, and carbapenems. All patients were administered antibiotic treatment (cephalosporin or carbapenem) immediately and were treated successfully with no evidence of further disease progression.. Antibiotic prophylaxis with LVFX plus ISP was effective, resulting in a lower incidence of acute bacterial prostatitis after TRUSP-Bx in both low- and high-risk patients.

Topics: Acute Disease; Administration, Intravenous; Administration, Oral; Aged; Antibiotic Prophylaxis; Bacteria; Biopsy, Large-Core Needle; Drug Therapy, Combination; Gentamicins; Humans; Incidence; Levofloxacin; Male; Postoperative Complications; Prostate; Prostatic Neoplasms; Prostatitis; Rectum; Retrospective Studies; Ultrasonography, Interventional

To evaluate the combination of isepamicin and levofloxacin in the prophylaxis of infectious complications associated with prostate biopsy (PBX).. A total of 586 patients who underwent transrectal PBX in a single center were included in this retrospective analysis. They received 400 mg isepamicin once just before PBX plus 300 mg oral levofloxacin each day for three days as a rule. Clinical and laboratory data were evaluated.. A total of three (0.51%) patients presented a febrile complication after PBX. All of them were diagnosed as acute prostatitis. Serum white blood cell count and C-reactive protein in the 131 patients whose laboratory data were available for statistical analyses did not rise significantly after PBX.. Isepamicin plus fluoroquinolone can be considered a valuable regimen for antibiotic prophylaxis of PBX.

Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Antibiotic Prophylaxis; Bacterial Infections; Biopsy; Drug Therapy, Combination; Gentamicins; Humans; Levofloxacin; Male; Ofloxacin; Prostate; Prostatitis; Rectum; Retrospective Studies; Risk Factors; Ultrasound, High-Intensity Focused, Transrectal