isbogrel has been researched along with Acute-Kidney-Injury* in 1 studies
1 other study(ies) available for isbogrel and Acute-Kidney-Injury
| Article | Year |
|---|---|
Dibenzoxepin derivatives: thromboxane A2 synthase inhibition and thromboxane A2 receptor antagonism combined in one molecule.
A new series of 6,11-dihydrodibenz[b,e]oxepin derivatives exerting both thromboxane synthase inhibitory (TXS-I) and thromboxane receptor antagonist (TXRA) activities is described. (-)-11-[(3-Pyridylmethyl)thio]-6,11-dihydrodibenz[b,e]oxepin -2- carboxylic acid [(-)-3] and (E)-11-[2-(3-pyridyl)ethylidene]-6,11-dihydrodibenz[b,e]oxepin+ ++-2- carboxylic acid methanesulfonate (11E) exhibited potent inhibitory effects on bovine platelet thromboxane synthase with IC50 values of 4.0 and 14 nM, respectively, and these derivatives also antagonized guinea pig platelet TXA2/PGH2 receptors with Ki values of 85 and 180 nM, respectively. Compound 11E exhibited the dual inhibitory activity in ex vivo experiments and demonstrated a significant protective effect in a rat acute renal failure model. Topics: Acute Kidney Injury; Animals; Blood Platelets; Cattle; Dibenzoxepins; Guinea Pigs; Humans; In Vitro Techniques; Male; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Thromboxane; Structure-Activity Relationship; Thromboxane-A Synthase | 1993 |