isavuconazole has been researched along with Meningitis--Cryptococcal* in 2 studies
2 other study(ies) available for isavuconazole and Meningitis--Cryptococcal
| Article | Year |
|---|---|
Pharmacodynamics of Isavuconazole in a Rabbit Model of Cryptococcal Meningoencephalitis.
Topics: Animals; Antifungal Agents; Area Under Curve; Brain; Cryptococcus neoformans; Disease Models, Animal; Male; Meningitis, Cryptococcal; Meningoencephalitis; Microbial Sensitivity Tests; Models, Theoretical; Nitriles; Pyridines; Rabbits; Triazoles | 2019 |
Isavuconazole Is Effective for the Treatment of Experimental Cryptococcal Meningitis.
We evaluated the efficacy of isavuconazole against cryptococcal meningitis. Treatment with either oral isavuconazole (120 mg/kg and 240 mg/kg twice a day [BID]) or fluconazole as the positive control significantly improved survival in mice infected intracranially with either Cryptococcus neoformans USC1597 or H99 and significantly reduced brain fungal burdens for both isolates. Concentrations of isavuconazole in plasma and brain tissue also demonstrated that the greatest improvements in survival and fungal burden were associated with elevated exposures. Topics: Animals; Antifungal Agents; Brain; Cryptococcus neoformans; Disease Models, Animal; Meningitis, Cryptococcal; Mice; Microbial Sensitivity Tests; Nitriles; Pyridines; Triazoles | 2016 |