isavuconazole and Arrhythmias--Cardiac

isavuconazole has been researched along with Arrhythmias--Cardiac* in 1 studies

Trials

1 trial(s) available for isavuconazole and Arrhythmias--Cardiac

Article	Year
QT Interval Shortening With Isavuconazole: In Vitro and In Vivo Effects on Cardiac Repolarization. Clinical pharmacology and therapeutics, 2017, Volume: 101, Issue:6 The effects of isavuconazole (active moiety of isavuconazonium sulfate) on cardiac ion channels in vitro and cardiac repolarization clinically were assessed in a phase I, randomized, double-blind study in healthy individuals who received isavuconazole (after 2-day loading dose), at therapeutic or supratherapeutic doses daily for 11 days, moxifloxacin (400 mg q.d.), or placebo. A post-hoc analysis of the phase III SECURE trial assessed effects on cardiac safety. L-type Ca Topics: Action Potentials; Adult; Antifungal Agents; Arrhythmias, Cardiac; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Female; Heart Conduction System; Heart Rate; Humans; Male; Models, Biological; Nitriles; Pyridines; Risk Assessment; Time Factors; Transfection; Triazoles; Young Adult	2017

Article

Year

QT Interval Shortening With Isavuconazole: In Vitro and In Vivo Effects on Cardiac Repolarization.

Clinical pharmacology and therapeutics, 2017, Volume: 101, Issue:6

The effects of isavuconazole (active moiety of isavuconazonium sulfate) on cardiac ion channels in vitro and cardiac repolarization clinically were assessed in a phase I, randomized, double-blind study in healthy individuals who received isavuconazole (after 2-day loading dose), at therapeutic or supratherapeutic doses daily for 11 days, moxifloxacin (400 mg q.d.), or placebo. A post-hoc analysis of the phase III SECURE trial assessed effects on cardiac safety. L-type Ca

Topics: Action Potentials; Adult; Antifungal Agents; Arrhythmias, Cardiac; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Female; Heart Conduction System; Heart Rate; Humans; Male; Models, Biological; Nitriles; Pyridines; Risk Assessment; Time Factors; Transfection; Triazoles; Young Adult

2017