irsogladine has been researched along with Disease Models, Animal in 8 studies
irsogladine: RN given refers to parent cpd; MN 1695 refers to maleate salt
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " To investigate the therapeutic approach to intestinal fibrosis, we have developed a mouse model of intestinal fibrosis by administering dextran sulfate sodium (DSS) and examining the effects of irsogladine maleate (IM) [2,4-diamino-6-(2,5-dichlorophenyl)-s-triazine maleate], which has been widely used as an antiulcer drug for gastric mucosa in Japan, on DDS-induced chronic colitis." | 7.78 | Irsogladine maleate ameliorates inflammation and fibrosis in mice with chronic colitis induced by dextran sulfate sodium. ( Asakura, H; Kawachi, H; Kawase, T; Kawauchi, Y; Nagata, M; Sukumaran, V; Suzuki, K; Takagi, R; Thandavarayan, RA; Tomita, M; Watanabe, K; Yamaguchi, H; Yokoyama, J; Yoneyama, H, 2012) |
| " To investigate the therapeutic approach to intestinal fibrosis, we have developed a mouse model of intestinal fibrosis by administering dextran sulfate sodium (DSS) and examining the effects of irsogladine maleate (IM) [2,4-diamino-6-(2,5-dichlorophenyl)-s-triazine maleate], which has been widely used as an antiulcer drug for gastric mucosa in Japan, on DDS-induced chronic colitis." | 3.78 | Irsogladine maleate ameliorates inflammation and fibrosis in mice with chronic colitis induced by dextran sulfate sodium. ( Asakura, H; Kawachi, H; Kawase, T; Kawauchi, Y; Nagata, M; Sukumaran, V; Suzuki, K; Takagi, R; Thandavarayan, RA; Tomita, M; Watanabe, K; Yamaguchi, H; Yokoyama, J; Yoneyama, H, 2012) |
| "The effect of irsogladine maleate, a widely used antiulcer drug in Japan, on indomethacin-induced small intestinal lesions was examined in rats." | 3.74 | Prophylactic effect of irsogladine maleate against indomethacin-induced small intestinal lesions in rats. ( Amagase, K; Hatazawa, R; Kamei, K; Kato, N; Kubo, Y; Takeuchi, K, 2008) |
| "Irsogladine maleate (IM) is a drug with gastric mucosal protective properties." | 1.48 | [Development of "Patient Friendly Formulations" to Counter the Side Effects of Cancer Chemotherapy]. ( Hanawa, T; Kawano, Y; Satoh, M, 2018) |
| "Treatment with irsogladine maleate at doses of 5 and 50 ppm significantly reduced the number of intestinal polyps to 69% and 66% of the untreated control value, respectively." | 1.43 | Irsogladine maleate, a gastric mucosal protectant, suppresses intestinal polyp development in Apc-mutant mice. ( Fujii, G; Fujimoto, K; Fukai, F; Hamoya, T; Miyamoto, S; Miyoshi, N; Mutoh, M; Onuma, W; Tomono, S; Wakabayashi, K, 2016) |
| "Pretreatment with irsogladine maleate markedly reduced the number and severity of these lesions in a dose-dependent manner." | 1.35 | Irsogladine maleate suppresses indomethacin-induced elevation of proinflammatory cytokines and gastric injury in rats. ( Kageyama, K; Kyoi, T; Tajima, K; Zhang, X, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Hanawa, T | 2 |
| Kawano, Y | 2 |
| Satoh, M | 2 |
| Onuma, W | 1 |
| Tomono, S | 1 |
| Miyamoto, S | 1 |
| Fujii, G | 1 |
| Hamoya, T | 1 |
| Fujimoto, K | 1 |
| Miyoshi, N | 1 |
| Fukai, F | 1 |
| Wakabayashi, K | 1 |
| Mutoh, M | 1 |
| Imamura, A | 1 |
| Nakamura, T | 1 |
| Akaishi, M | 1 |
| Zhang, X | 1 |
| Tajima, K | 1 |
| Kageyama, K | 1 |
| Kyoi, T | 1 |
| Yamaguchi, H | 1 |
| Suzuki, K | 1 |
| Nagata, M | 1 |
| Kawase, T | 1 |
| Sukumaran, V | 1 |
| Thandavarayan, RA | 1 |
| Kawauchi, Y | 1 |
| Yokoyama, J | 1 |
| Tomita, M | 1 |
| Kawachi, H | 1 |
| Watanabe, K | 1 |
| Yoneyama, H | 1 |
| Asakura, H | 1 |
| Takagi, R | 1 |
| Kamei, K | 1 |
| Kubo, Y | 1 |
| Kato, N | 1 |
| Hatazawa, R | 1 |
| Amagase, K | 1 |
| Takeuchi, K | 1 |
| Mizoguchi, Y | 1 |
| Kawada, N | 1 |
| Ichikawa, Y | 1 |
| Kobayashi, K | 1 |
| Morisawa, S | 1 |
8 other studies available for irsogladine and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
[Development of "Patient Friendly Formulations" to Counter the Side Effects of Cancer Chemotherapy].
Topics: Administration, Oral; Alanine; Animals; Antineoplastic Agents; Cell Communication; Cyclic AMP; Disea | 2018 |
Irsogladine maleate, a gastric mucosal protectant, suppresses intestinal polyp development in Apc-mutant mice.
Topics: Animals; Anti-Ulcer Agents; Apoptosis; Blotting, Western; Cell Proliferation; Cells, Cultured; Disea | 2016 |
Development and Characterization of Oral Spray for Stomatitis Containing Irsogladine Maleate.
Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Male; Mesocricetus; Oral Sprays; Stomatitis; | 2016 |
Irsogladine maleate suppresses indomethacin-induced elevation of proinflammatory cytokines and gastric injury in rats.
Topics: Animals; Anti-Ulcer Agents; Cyclic Nucleotide Phosphodiesterases, Type 4; Cytokines; Disease Models, | 2008 |
Irsogladine maleate ameliorates inflammation and fibrosis in mice with chronic colitis induced by dextran sulfate sodium.
Topics: Animals; Anti-Ulcer Agents; Chronic Disease; Colitis; Dextran Sulfate; Disease Models, Animal; Femal | 2012 |
Prophylactic effect of irsogladine maleate against indomethacin-induced small intestinal lesions in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cyclic Nucleotide Phosphodieste | 2008 |
Effects of irsoglandine maleate in an experimentally-induced acute hepatic failure model using mice.
Topics: Animals; Anti-Ulcer Agents; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Lipopoly | 1991 |