iron-tetraphenylporphyrin and Hypertension

iron-tetraphenylporphyrin has been researched along with Hypertension* in 1 studies

Other Studies

1 other study(ies) available for iron-tetraphenylporphyrin and Hypertension

Article	Year
Human serum albumin incorporating synthetic heme: red blood cell substitute without hypertension by nitric oxide scavenging. Journal of biomedical materials research. Part A, 2003, Feb-01, Volume: 64, Issue:2 The administration of extracellular, hemoglobin-based oxygen carriers often elicits an acute increase in blood pressure by vasoconstriction. This side effect is now recognized to be due to the depletion of nitric oxide (endothelial-derived relaxing factor) by the extravasuated hemoglobins. We have recently found that the administration of a recombinant human serum albumin (rHSA)-based oxygen carrier involving synthetic tetraphenyporphinatoiron(II) derivative (FeP) (rHSA-FeP) does not induce such hypertensive action, because of its low permeability through the vascular endothelium. The heart rate responses after the rHSA-FeP injection were also negligibly small. Visualization of the intestinal microcirculatory changes clearly revealed the widths of the venule and arteriole to be fairly constant. The entirely synthetic rHSA-FeP becomes a promising material as a new type of red blood cell substitute. Topics: Anesthesia; Animals; Blood Pressure; Blood Substitutes; Capillary Permeability; Endothelium, Vascular; Erythrocytes; Heart Rate; Heme; Hypertension; Intestines; Male; Metalloporphyrins; Microcirculation; Muscle, Smooth, Vascular; Nitric Oxide; Rats; Rats, Wistar; Recombinant Proteins; Regional Blood Flow; Serum Albumin	2003

Article

Year

Human serum albumin incorporating synthetic heme: red blood cell substitute without hypertension by nitric oxide scavenging.

Journal of biomedical materials research. Part A, 2003, Feb-01, Volume: 64, Issue:2

The administration of extracellular, hemoglobin-based oxygen carriers often elicits an acute increase in blood pressure by vasoconstriction. This side effect is now recognized to be due to the depletion of nitric oxide (endothelial-derived relaxing factor) by the extravasuated hemoglobins. We have recently found that the administration of a recombinant human serum albumin (rHSA)-based oxygen carrier involving synthetic tetraphenyporphinatoiron(II) derivative (FeP) (rHSA-FeP) does not induce such hypertensive action, because of its low permeability through the vascular endothelium. The heart rate responses after the rHSA-FeP injection were also negligibly small. Visualization of the intestinal microcirculatory changes clearly revealed the widths of the venule and arteriole to be fairly constant. The entirely synthetic rHSA-FeP becomes a promising material as a new type of red blood cell substitute.

Topics: Anesthesia; Animals; Blood Pressure; Blood Substitutes; Capillary Permeability; Endothelium, Vascular; Erythrocytes; Heart Rate; Heme; Hypertension; Intestines; Male; Metalloporphyrins; Microcirculation; Muscle, Smooth, Vascular; Nitric Oxide; Rats; Rats, Wistar; Recombinant Proteins; Regional Blood Flow; Serum Albumin

2003