Page last updated: 2024-09-04

irofulven and Lung Neoplasms

irofulven has been researched along with Lung Neoplasms in 13 studies

*Lung Neoplasms: Tumors or cancer of the LUNG. [MeSH]

Research

Studies (13)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	4 (30.77)	18.2507
2000's	8 (61.54)	29.6817
2010's	1 (7.69)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Estes, LA; Kelner, MJ; McMorris, TC; Taetle, R; Wang, W; Yu, J	1
Alisala, K; Banda, G; Chimmani, R; Kelner, MJ; McMorris, TC; Staake, MD	1
Green, MR; Herndon, JE; Sherman, CA; Watson, DM	1
Estes, LA; Kelner, MJ; McMorris, TC; Rojas, RJ; Suthipinijtham, P	2
Estes, L; Kelner, MJ; McMorris, TC; Samson, KM; Taetle, R; Wang, W	1
Chen, SF; Dexter, DL; Kelner, MJ; MacDonald, JR; Mangold, GL; McMorris, TC; Muscoplat, CC; Von Hoff, DD	1
Bagnell, RD; Estes, L; Kelner, MJ; McMorris, TC; Samson, KM; Taetle, R	1
Estes, LA; Kelner, MJ; Lanham, KA; Lynn, JR; McMorris, TC; Oval, MY; Rojas, RJ; Samson, KM	1
Eckhardt, SG; Hammond, LA; Hilsenbeck, SG; MacDonald, JR; Mangold, G; Marty, J; Rowinsky, EK; Von Hoff, DD; Weitman, S	1
DeVore, RF; Dowell, JE; Johnson, DH; Krozely, P; McCullough, N; Rogers, JS; Shyr, Y	1
Kashimoto, S; MacDonald, JR; Nakano, K; Sato, Y	1
Estes, L; Kelner, MJ; McMorris, TC; Rojas, RJ; Trani, NA	1

Trials

2 trial(s) available for irofulven and Lung Neoplasms

Article	Year
A phase II trial of 6-hydroxymethylacylfulvene (MGI-114, irofulven) in patients with relapsed or refractory non-small cell lung cancer. Lung cancer (Amsterdam, Netherlands), 2004, Volume: 45, Issue:3 Topics: Aged; Antineoplastic Agents, Alkylating; Carcinoma, Non-Small-Cell Lung; Female; Humans; Infusions, Intravenous; Lung Neoplasms; Male; Middle Aged; Salvage Therapy; Sesquiterpenes; Treatment Outcome	2004
A phase II trial of 6-hydroxymethylacylfulvene (MGI-114, irofulven) in patients with advanced non-small cell cancer previously treated with chemotherapy. Investigational new drugs, 2001, Volume: 19, Issue:1 Topics: Aged; Aged, 80 and over; Anemia; Antineoplastic Agents, Alkylating; Carcinoma, Non-Small-Cell Lung; Drug Evaluation; Fatigue; Female; Humans; Lung Neoplasms; Male; Middle Aged; Nausea; Neutropenia; Sesquiterpenes; Thrombocytopenia; Toxicity Tests; Treatment Outcome; Vomiting	2001

Article

Year

A phase II trial of 6-hydroxymethylacylfulvene (MGI-114, irofulven) in patients with relapsed or refractory non-small cell lung cancer.

Lung cancer (Amsterdam, Netherlands), 2004, Volume: 45, Issue:3

Topics: Aged; Antineoplastic Agents, Alkylating; Carcinoma, Non-Small-Cell Lung; Female; Humans; Infusions, Intravenous; Lung Neoplasms; Male; Middle Aged; Salvage Therapy; Sesquiterpenes; Treatment Outcome

2004

A phase II trial of 6-hydroxymethylacylfulvene (MGI-114, irofulven) in patients with advanced non-small cell cancer previously treated with chemotherapy.

Investigational new drugs, 2001, Volume: 19, Issue:1

Topics: Aged; Aged, 80 and over; Anemia; Antineoplastic Agents, Alkylating; Carcinoma, Non-Small-Cell Lung; Drug Evaluation; Fatigue; Female; Humans; Lung Neoplasms; Male; Middle Aged; Nausea; Neutropenia; Sesquiterpenes; Thrombocytopenia; Toxicity Tests; Treatment Outcome; Vomiting

2001

Other Studies

11 other study(ies) available for irofulven and Lung Neoplasms

Article	Year
(Hydroxymethyl)acylfulvene: an illudin derivative with superior antitumor properties. Journal of natural products, 1996, Volume: 59, Issue:9 Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Basidiomycota; Chromatography, Thin Layer; Crystallography, X-Ray; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; Lung Neoplasms; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Polycyclic Sesquiterpenes; Sesquiterpenes	1996
Structure-activity studies of urea, carbamate, and sulfonamide derivatives of acylfulvene. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Adenocarcinoma; Animals; B-Lymphocytes; Carbamates; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Lung Neoplasms; Mice; Sesquiterpenes; Spiro Compounds; Structure-Activity Relationship; Sulfonamides; Urea	2010
Synergy of Irofulven in combination with various anti-metabolites, enzyme inhibitors, and miscellaneous agents in MV522 lung carcinoma cells: marked interaction with gemcitabine and 5-fluorouracil. Investigational new drugs, 2008, Volume: 26, Issue:5 Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Deoxycytidine; Drug Synergism; Enzyme Inhibitors; Female; Fluorouracil; Gemcitabine; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Random Allocation; Sesquiterpenes; Xenograft Model Antitumor Assays	2008
Synergy of irofulven in combination with other DNA damaging agents: synergistic interaction with altretamine, alkylating, and platinum-derived agents in the MV522 lung tumor model. Cancer chemotherapy and pharmacology, 2008, Volume: 63, Issue:1 Topics: Altretamine; Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma; DNA Damage; DNA, Neoplasm; Drug Synergism; Female; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Organoplatinum Compounds; Random Allocation; Sesquiterpenes; Transcription, Genetic; Xenograft Model Antitumor Assays	2008
Efficacy of HMAF (MGI-114) in the MV522 metastatic lung carcinoma xenograft model nonresponsive to traditional anticancer agents. Investigational new drugs, 1996, Volume: 14, Issue:2 Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Disease Models, Animal; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Female; Lung Neoplasms; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Sesquiterpenes; Transplantation, Heterologous	1996
Preclinical antitumor activity of 6-hydroxymethylacylfulvene, a semisynthetic derivative of the mushroom toxin illudin S. Cancer research, 1997, Jan-15, Volume: 57, Issue:2 Topics: Animals; Antibiotics, Antineoplastic; Breast Neoplasms; Drug Screening Assays, Antitumor; Female; HT29 Cells; Humans; Leukemia P388; Lung Neoplasms; Melanoma, Experimental; Mice; Mice, Nude; Sesquiterpenes; Transplantation, Heterologous	1997
Efficacy of MGI 114 (6-hydroxymethylacylfulvene, HMAF) against the mdr1/gp170 metastatic MV522 lung carcinoma xenograft. European journal of cancer (Oxford, England : 1990), 1998, Volume: 34, Issue:6 Topics: Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Drug Resistance, Neoplasm; Female; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mitomycin; Neoplasm Transplantation; Paclitaxel; Sesquiterpenes; Transplantation, Heterologous; Tumor Cells, Cultured	1998
Efficacy of MGI 114 (HMAF) against the MRP+ metastatic MV522 lung carcinoma xenograft. Anti-cancer drugs, 2000, Volume: 11, Issue:3 Topics: Animals; Antineoplastic Agents; Drug Resistance, Neoplasm; Female; Genes, MDR; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Sesquiterpenes; Transplantation, Heterologous; Tumor Cells, Cultured; Vinblastine	2000
Enhanced antitumour activity of 6-hydroxymethylacylfulvene in combination with topotecan or paclitaxel in the MV522 lung carcinoma xenograft model. European journal of cancer (Oxford, England : 1990), 2000, Volume: 36, Issue:18 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Dose-Response Relationship, Drug; Humans; Lung Neoplasms; Mice; Mice, Nude; Neoplasm Transplantation; Paclitaxel; Sesquiterpenes; Topotecan; Transplantation, Heterologous	2000
In vivo antitumour efficacy of MGI-114 (6-hydroxymethylacylfulvene, HMAF) in various human tumour xenograft models including several lung and gastric tumours. European journal of cancer (Oxford, England : 1990), 2001, Volume: 37, Issue:11 Topics: Adenocarcinoma; Animals; Antineoplastic Agents, Alkylating; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Colonic Neoplasms; Humans; Lung Neoplasms; Melanoma; Mice; Mice, Nude; Sesquiterpenes; Stomach Neoplasms; Xenograft Model Antitumor Assays	2001
Enhanced antitumor activity of irofulven in combination with thiotepa or mitomycin C. Cancer chemotherapy and pharmacology, 2002, Volume: 49, Issue:5 Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Aziridines; Drug Resistance, Neoplasm; Drug Synergism; Female; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mitomycin; Neoplasm Transplantation; Sesquiterpenes; Thiotepa; Transplantation, Heterologous; Tumor Cells, Cultured	2002