irinotecan has been researched along with Mucositis in 55 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 15 (27.27) | 29.6817 |
| 2010's | 24 (43.64) | 24.3611 |
| 2020's | 16 (29.09) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, Q; Zhao, W | 1 |
| Arifa, RDN; Barcelos, LS; Brito, CB; Cassini-Vieira, P; da Silva, JM; da Silva, TA; de Paula, TP; Fagundes, CT; Lima, RL; Menezes-Garcia, Z; Queiroz-Junior, CM; Souza, DG; Teixeira, MM; Vilas Boas, FA | 1 |
| Ávila, TV; do Nascimento Arifa, RD; Fagundes, CT; Machado, AMV; Menezes-Garcia, Z; Soriani, FM; Souza, DG; Teixeira, MM | 1 |
| Cano-Cebrián, MJ; Dahlgren, D; Kullenberg, F; Lennernäs, H; Olander, T; Peters, K; Sjöblom, M | 1 |
| Bowen, JM; Coller, JK; Prestidge, CA; Tam, JSY | 1 |
| Bowen, JM; Coller, JK; Crame, EE; Elz, AS; Prestidge, CA; Tam, JSY; Wignall, A | 1 |
| Dahlgren, D; Hellström, PM; Kullenberg, F; Lennernäs, H; Nygren, P; Peters, K; Rosenqvist, E; Sjöblom, M | 1 |
| Marsh, DT; Smid, SD | 1 |
| Cirillo, N; Huang, J; Hwang, AYM; Iskandar, M; Jia, Y; Kim, B; Mohammed, AI | 1 |
| Cai, K; Chen, H; Chen, Y; Gong, J; Li, P; Liang, R; Liao, Q; Wang, D; Xiao, X; Xie, Z; Zhang, X | 1 |
| Boeing, T; Cury, BJ; da Silva, LM; de Andrade, SF; de Souza, P; Desreumax, P; Dubuqoy, L; Ferreira Dos Anjos, M; Mariano, LNB; Quintão, NLM; Somensi, LB; Speca, S | 1 |
| Du, GH; Wang, L; Wang, R; Wang, SM; Wei, GY | 1 |
| Al Thaalibi, M; McQuade, RM; Nurgali, K | 1 |
| Boeing, T; da Silva, LM; de Souza, P; Gois, MB; Sant Ana, DMG; Somensi, LB | 1 |
| Almeida, PRC; Amorim, JO; Arruda, LM; Bandeira, AM; Cajado, AG; Carvalho, RF; Chaves, FF; Cunha, FQ; Ferreira, LMM; Holanda, RBF; Lima-Júnior, RCP; Lopes, MHS; Oliveira, RTG; Pereira, AF; Pereira, JFB; Pinheiro, RF; Ribeiro-Júnior, HL; Rocha-Filho, DR; Sant'Ana, RO; Torres, CS; Wong, DVT | 1 |
| Alvarenga, EM; Araújo, AR; Brito, GAC; de Araújo, S; Iles, B; Júnior, JLP; Medeiros, JVR; Pacífico, DM; Sousa, DP; Sousa, NA; Souza, EP | 1 |
| Almeida, PRC; Câmara, LMC; Cândido, AGF; Falcão, RB; Fernandes, C; Lima-Júnior, RCP; Muniz, HA; Silva, CMS; Souza, MHLP; Souza, NRP; Teixeira, MA; Wanderley, CWS | 1 |
| Bowen, JM; Coller, JK; Fakiha, K; Gibson, RJ; Logan, RM | 1 |
| Stringer, A; Sultani, M; Thorpe, D | 1 |
| Butler, R; Stringer, A; Sultani, M; Thorpe, D; Vanhoecke, B | 1 |
| Amaral, SS; Besnard, AG; Beyaert, R; Braun, H; Cunha, FQ; Graham, GJ; Guabiraba, R; Jabir, MS; Liew, FY; Lima-Junior, RC; Menezes, GB; Ribeiro, RA; Secher, T; Teixeira, MM | 1 |
| Brito, GA; Cunha, FQ; Freitas, HC; Leite, LL; Lima-Júnior, RC; Magalhães, PJ; Miranda, SP; Nunes, LG; Ribeiro, RA; Souza, MH; Teixeira, MM; Wanderley, CW; Wong, DV | 1 |
| Chan, GL; Gao, J; Han, W; Qian, L; Wang, X; Wu, M; Yu, Y; Zhang, Y; Zhu, S | 1 |
| Doherty, GA; Lee, CS; Ryan, EJ | 1 |
| Arifa, RD; de Paula, TP; Fagundes, CT; Lima, RL; Madeira, MF; Menezes-Garcia, Z; Rachid, MA; Ryffel, B; Souza, DG; Tavares, LD; Teixeira, MM; Zamboni, DS | 1 |
| Bateman, E; Keefe, D; Mayo, B; Stringer, A; Thorpe, D; Vanhoecke, B; Vanlancker, E | 1 |
| Bateman, E; Keefe, D; Klein, G; Mayo, B; Plews, E; Weaver, E; White, I; Wignall, A; Wozniak, B | 1 |
| Arantes, RME; Bastos, RW; Cardoso, VN; Cartelle, CT; Generoso, SV; Martins, FS; Nicoli, JR; Oliveira, JS; Pedroso, SHSP; Soares, PMG; Teixeira, MM; Vieira, AT | 1 |
| Almeida, PR; Batista, GL; Bem, AX; Borges, VF; Brito, GA; Carvalho, CB; Cunha, FQ; Cunha, TM; Leite, CA; Lima-Júnior, RC; Ribeiro, RA; Silva, RL; Teixeira, MA; Wanderley, CW; Wong, DV | 1 |
| Almeida, PR; Assis-Júnior, EM; Brito, GA; Lima-Júnior, RC; Melo, AT; Pereira, VB; Ribeiro, RA; Wong, DV | 1 |
| Arifa, RDN; Barcelos, LS; Garcia, ZM; Krambrock, K; Ladeira, LO; Lima, RL; Madeira, MFM; Paula, TP; Pinheiro, MVB; Pinho, V; Souza, DG; Teixeira, MM; Ÿvila, TV | 1 |
| Arantes, RM; Bastos, RW; Cardoso, VN; Cartelle, CT; França, CS; Generoso, SV; Martins, FS; Moreira, LM; Neves, MJ; Nicoli, JR; Pedroso, SH; Vieira, AT | 1 |
| Cunha, FQ; Leite, CA; Lima-Júnior, RC; Mota, JM; Ribeiro, RA; Souza, MH; Wanderley, CW; Wong, DV | 1 |
| Al-Dasooqi, N; Bennett, C; Bowen, J; Finnie, J; Gibson, R; Keefe, D | 1 |
| Bateman, EH; Bowen, JM; Keefe, DM; Mayo, BJ; Stringer, AM | 1 |
| Alvarenga, EM; Araújo, AR; Araújo, TS; de C Brito, GA; Martins, CS; Medeiros, JV; Nogueira, KM; Pacífico, DM; Sousa, DP; Sousa, FB; Souza, EP; Souza, LK | 1 |
| Bajetta, E; Bajetta, R; Buzzoni, R; Di Bartolomeo, M; Dotti, KF; Ferrario, E; Galassi, M; Gevorgyan, A; Mariani, L; Venturino, P | 1 |
| Bowen, JM; Gibson, RJ; Keefe, DM; Laurence, J; Logan, RM; Stringer, AM; Yeoh, AS | 1 |
| Cicin, I; Sezer, A; Usta, U | 1 |
| Al-Dasooqi, N; Ashton, K; Bowen, JM; Gibson, RJ; Keefe, DM; Logan, RM; Stringer, AM; Yeoh, AS | 1 |
| Al-Dasooqi, N; Bowen, JM; Gibson, RJ; Keefe, DM; Logan, RM; Stringer, AM | 2 |
| Brito, GA; Cunha, FQ; Figueiredo, AA; Freitas, HC; Leite, CA; Lima-Júnior, RC; Marques-Neto, RD; Medeiros, RP; Melo, ML; Oriá, RB; Ribeiro, RA; Souza, MH; Vale, ML; Wong, DV | 1 |
| Aoki, D; Chiyoda, T; Kataoka, F; Nomura, H; Susumu, N; Tominaga, E; Tsuda, H; Yamagami, W | 1 |
| Bowen, JM; Cummins, AG; Gibson, RJ; Keefe, DM; Tyskin, A | 1 |
| Butler, RN; Davidson, GP; Howarth, GS; Tooley, KL | 1 |
| Cao, S; Creaven, PJ; Durrani, FA; Iyer, RV; Javle, MM; Lawrence, DD; Noel, DC; Pendyala, L; Rustum, YM; Smith, PF | 1 |
| Alvarez, E; Bowen, JM; Burns, J; Gibson, RJ; Keefe, DM; Logan, RM; Stringer, AM; Yeoh, AS | 1 |
| Bowen, JM; Gibson, RJ; Keefe, DM; Logan, RM; Stringer, AM; Tsykin, A | 1 |
| Benson, A; Wisinski, K | 1 |
| Brito, GA; Carvalho, SB; Cunha, FQ; Melo, ML; Ribeiro, RA; Silva, JV; Soares, PM; Soares, RC; Souza, MH; Vale, ML | 1 |
| Arena, MG; Di Lauro, L; Foggi, P; Lopez, M; Nunziata, C; Sperduti, I | 1 |
| Bowen, JM; Gibson, RJ; Keefe, DM; Logan, RM; Sonis, ST; Stringer, AM | 2 |
| Alvarez, E; Bowen, JM; Finnie, J; Gibson, RJ; Keefe, DM | 1 |
6 review(s) available for irinotecan and Mucositis
| Article | Year |
|---|---|
Experimental Chemotherapy-Induced Mucositis: A Scoping Review Guiding the Design of Suitable Preclinical Models.
Topics: Animals; Antineoplastic Agents; Fluorouracil; Humans; Irinotecan; Methotrexate; Mice; Mucositis; Rabbits; Rats; Reproducibility of Results; Stomatitis; Swine; Zebrafish | 2022 |
Impact of chemotherapy-induced enteric nervous system toxicity on gastrointestinal mucositis.
Topics: Animals; Antineoplastic Agents; Cisplatin; Enteric Nervous System; Fluorouracil; Gastrointestinal Diseases; Humans; Inflammation; Irinotecan; Mucositis; Oxaliplatin; Vincristine | 2020 |
Gastro-intestinal toxicity of chemotherapeutics in colorectal cancer: the role of inflammation.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Camptothecin; Cell Death; Colorectal Neoplasms; Diarrhea; Disease Models, Animal; Fluorouracil; Gastrointestinal Diseases; Gastrointestinal Tract; Humans; Inflammation; Intestinal Mucosa; Irinotecan; Mucositis; Neoplasm Recurrence, Local; Organoplatinum Compounds; Oxaliplatin | 2014 |
Dark Agouti rat model of chemotherapy-induced mucositis: establishment and current state of the art.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Female; Fluorouracil; Humans; Irinotecan; Mammary Neoplasms, Experimental; Methotrexate; Mice; Mucositis; Rats | 2015 |
Irinotecan- and 5-fluorouracil-induced intestinal mucositis: insights into pathogenesis and therapeutic perspectives.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Camptothecin; Cytokines; Fluorouracil; Humans; Intestinal Diseases; Irinotecan; Mucositis; Receptors, Cytokine | 2016 |
Irinotecan-induced mucositis: the interactions and potential role of GLP-2 analogues.
Topics: Anti-Bacterial Agents; Antidiarrheals; Apoptosis; Camptothecin; Cholinergic Antagonists; Gastrointestinal Microbiome; Glucagon-Like Peptide 2; Humans; Irinotecan; Mucositis | 2017 |
3 trial(s) available for irinotecan and Mucositis
| Article | Year |
|---|---|
Dose finding study of erlotinib combined to capecitabine and irinotecan in pretreated advanced colorectal cancer patients.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Cohort Studies; Colorectal Neoplasms; Deoxycytidine; Dose-Response Relationship, Drug; Drug Eruptions; Erlotinib Hydrochloride; Female; Fever; Fluorouracil; Humans; Irinotecan; Male; Maximum Tolerated Dose; Middle Aged; Mucositis; Neoplasm Metastasis; Neutropenia; Quinazolines | 2009 |
Celecoxib and mucosal protection: translation from an animal model to a phase I clinical trial of celecoxib, irinotecan, and 5-fluorouracil.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Celecoxib; Colorectal Neoplasms; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Fluorouracil; Glucuronates; Humans; Intestinal Mucosa; Irinotecan; Leucovorin; Male; Maximum Tolerated Dose; Mucositis; Neoplasm Transplantation; Neoplasms, Experimental; Pyrazoles; Rats; Rats, Inbred F344; Sulfonamides | 2007 |
Irinotecan, docetaxel and oxaliplatin combination in metastatic gastric or gastroesophageal junction adenocarcinoma.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Diarrhea; Disease Progression; Docetaxel; Esophagogastric Junction; Female; Fever; Humans; Irinotecan; Kaplan-Meier Estimate; Male; Middle Aged; Mucositis; Neoplasm Metastasis; Neutropenia; Organoplatinum Compounds; Oxaliplatin; Stomach Neoplasms; Taxoids; Treatment Outcome; Vomiting | 2007 |
46 other study(ies) available for irinotecan and Mucositis
| Article | Year |
|---|---|
Knockdown of TRIM9 attenuates irinotecan‑induced intestinal mucositis in IEC‑6 cells by regulating DUSP6 expression via the P38 pathway.
Topics: Animals; Apoptosis; Carrier Proteins; Cell Line; Cell Proliferation; Dual Specificity Phosphatase 6; Epithelial Cells; Intestinal Mucosa; Intestines; Irinotecan; Mucositis; Nerve Tissue Proteins; Rats; Tripartite Motif Proteins; Ubiquitin-Protein Ligases | 2021 |
Eosinophil plays a crucial role in intestinal mucositis induced by antineoplastic chemotherapy.
Topics: Animals; Antineoplastic Agents; Camptothecin; Eosinophils; Humans; Intestinal Mucosa; Irinotecan; Mice; Mucositis | 2022 |
Mitochondrial DNA as a Possible Ligand for TLR9 in Irinotecan-induced Small Intestinal Mucositis.
Topics: Animals; DNA, Mitochondrial; Inflammation; Irinotecan; Ligands; Mice; Mice, Knockout; Mucositis; NLR Family, Pyrin Domain-Containing 3 Protein; Toll-Like Receptor 9 | 2022 |
Chemotherapeutics Combined with Luminal Irritants: Effects on Small-Intestinal Mannitol Permeability and Villus Length in Rats.
Topics: Animals; Doxycycline; Ethanol; Fluorouracil; Injections, Intraperitoneal; Intestinal Mucosa; Irinotecan; Irritants; Male; Mannitol; Mucositis; Organ Size; Permeability; Rats; Sodium Dodecyl Sulfate | 2022 |
Investigation of TLR4 Antagonists for Prevention of Intestinal Inflammation.
Topics: Animals; Humans; Inflammation; Interleukin-6; Interleukin-8; Irinotecan; Lipopolysaccharides; Mice; Mucositis; Toll-Like Receptor 4; U937 Cells | 2023 |
Effects of a novel toll-like receptor 4 antagonist IAXO-102 in a murine model of chemotherapy-induced gastrointestinal toxicity.
Topics: Amino Sugars; Animals; Antineoplastic Agents; Disease Models, Animal; Glycolipids; Irinotecan; Mice; Mice, Inbred C57BL; Mucositis; Toll-Like Receptor 4 | 2022 |
Evaluation and validation of chemotherapy-specific diarrhoea and histopathology in rats.
Topics: Animals; Antineoplastic Agents; Atrophy; Body Weight; Diarrhea; Doxorubicin; Fluorouracil; Idarubicin; Intestinal Mucosa; Irinotecan; Male; Methotrexate; Mucositis; Rats; Rats, Wistar | 2022 |
The semi-synthetic flavonoid 2',3',4'-trihydroxyflavone (2-D08) inhibits both SN-38- and cytokine-evoked increases in epithelial barrier permeability in an
Topics: Antioxidants; Caco-2 Cells; Cytokines; Flavonoids; Humans; Inflammation; Intestinal Mucosa; Irinotecan; Mucositis; Permeability; Quercetin | 2022 |
Pogostemon cablin (Blanco) Benth granule revealed a positive effect on improving intestinal barrier function and fecal microbiota in mice with irinotecan-induced intestinal mucositis.
Topics: Animals; Gastrointestinal Microbiome; Intestinal Mucosa; Intestines; Irinotecan; Mice; Mucositis; Pogostemon | 2023 |
Luteolin prevents irinotecan-induced intestinal mucositis in mice through antioxidant and anti-inflammatory properties.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Camptothecin; Intestinal Mucosa; Irinotecan; Luteolin; Mice; Mucositis | 2020 |
Dihydrotanshinone attenuates chemotherapy-induced intestinal mucositis and alters fecal microbiota in mice.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Bacteria; Colon; Diglycerides; Disease Models, Animal; Feces; Fluorouracil; Furans; Gastrointestinal Microbiome; Interleukin-6; Intestinal Mucosa; Irinotecan; Male; Mice, Inbred C57BL; Mucositis; Phenanthrenes; Quinones; Triglycerides; Tumor Necrosis Factor-alpha | 2020 |
Irinotecan-induced intestinal mucositis in mice: a histopathological study.
Topics: Animals; Colon; Female; Intestinal Mucosa; Intestine, Small; Irinotecan; Mice; Mucositis; Topoisomerase I Inhibitors | 2021 |
TLR4 deficiency upregulates TLR9 expression and enhances irinotecan-related intestinal mucositis and late-onset diarrhoea.
Topics: Animals; Diarrhea; Humans; Irinotecan; Mice; Mucositis; Toll-Like Receptor 4; Toll-Like Receptor 9 | 2021 |
Carvacryl acetate, a novel semisynthetic monoterpene ester, binds to the TRPA1 receptor and is effective in attenuating irinotecan-induced intestinal mucositis in mice.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic; Antioxidants; Bacteremia; Camptothecin; Cytokines; Female; Intestinal Mucosa; Irinotecan; Jejunum; Mice; Molecular Docking Simulation; Monoterpenes; Mucositis; Neutropenia; TRPA1 Cation Channel | 2017 |
Role of regulatory T cells in irinotecan-induced intestinal mucositis.
Topics: Animals; Camptothecin; Cyclophosphamide; Cytokines; Diarrhea; Ileum; Inflammation; Intestinal Mucosa; Irinotecan; Mice; Mice, Inbred C57BL; Mucositis; Neutrophil Infiltration; Peroxidase; T-Lymphocytes, Regulatory; Th17 Cells | 2018 |
Amitriptyline prevents CPT-11-induced early-onset diarrhea and colonic apoptosis without reducing overall gastrointestinal damage in a rat model of mucositis.
Topics: Amitriptyline; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Colon; Diarrhea; Disease Models, Animal; Irinotecan; Male; Mucositis; Rats; Rats, Wistar | 2019 |
Irinotecan induces enterocyte cell death and changes to muc2 and muc4 composition during mucositis in a tumour-bearing DA rat model.
Topics: Adenocarcinoma; Animals; Colon; Enterocytes; Female; Goblet Cells; Irinotecan; Jejunum; Mammary Neoplasms, Experimental; Mucin-2; Mucin-4; Mucositis; Rats, Inbred Strains | 2019 |
Irinotecan-Induced Mucositis Is Associated with Goblet Cell Dysregulation and Neural Cell Damage in a Tumour Bearing DA Rat Model.
Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Enteric Nervous System; Female; Goblet Cells; Intestinal Mucosa; Irinotecan; Mucositis; Neoplasms, Experimental; Neurons; Rats | 2020 |
IL-33 targeting attenuates intestinal mucositis and enhances effective tumor chemotherapy in mice.
Topics: Animals; Antineoplastic Agents, Phytogenic; Blotting, Western; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; Drug Synergism; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Humans; Interleukin-1 Receptor-Like 1 Protein; Interleukin-33; Irinotecan; Mice; Mice, Inbred BALB C; Mucositis; Receptors, Interleukin; Recombinant Proteins | 2014 |
Targeted inhibition of IL-18 attenuates irinotecan-induced intestinal mucositis in mice.
Topics: Animals; Camptothecin; Drug Delivery Systems; Intercellular Signaling Peptides and Proteins; Interleukin-18; Intestinal Mucosa; Irinotecan; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Mucositis; Organ Culture Techniques | 2014 |
IL-1Ra selectively protects intestinal crypt epithelial cells, but not tumor cells, from chemotoxicity via p53-mediated upregulation of p21(WAF1) and p27(KIP1.).
Topics: Animals; Antimetabolites, Antineoplastic; Camptothecin; Cell Line; Cell Line, Tumor; Colon; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Epithelial Cells; Fluorouracil; Humans; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Irinotecan; Jejunum; Liver Neoplasms; Male; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Mucositis; Protective Agents; Recombinant Proteins; Tumor Suppressor Protein p53; Up-Regulation | 2014 |
Inflammasome activation is reactive oxygen species dependent and mediates irinotecan-induced mucositis through IL-1β and IL-18 in mice.
Topics: Animals; Camptothecin; Caspase 1; Ileum; Inflammasomes; Interleukin-18; Interleukin-1beta; Irinotecan; Male; Membrane Glycoproteins; Mice, Inbred C57BL; Mice, Knockout; Mucositis; NADPH Oxidase 2; NADPH Oxidases; Oxidative Stress; Reactive Oxygen Species | 2014 |
Serum-derived bovine immunoglobulin/protein isolate in the alleviation of chemotherapy-induced mucositis.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic; Blood Proteins; Body Weight; Camptothecin; Cattle; Colitis; Diarrhea; Enteritis; Female; Immunoglobulins; Injections, Intraperitoneal; Irinotecan; Jejunal Diseases; Mucositis; Random Allocation; Rats | 2016 |
Evaluation of mucositis induced by irinotecan after microbial colonization in germ-free mice.
Topics: Animals; Antineoplastic Agents; Bacteria; Camptothecin; Gastrointestinal Microbiome; Germ-Free Life; Intestinal Mucosa; Irinotecan; Mice; Mucositis | 2015 |
The Adaptor Protein Myd88 Is a Key Signaling Molecule in the Pathogenesis of Irinotecan-Induced Intestinal Mucositis.
Topics: Animals; Bacteremia; Camptothecin; Diarrhea; Intestinal Diseases; Intestinal Mucosa; Irinotecan; Mice; Mice, Knockout; Mucositis; Myeloid Differentiation Factor 88; Peroxidase; Signal Transduction; Toll-Like Receptor 2; Toll-Like Receptor 9 | 2015 |
A new animal model of intestinal mucositis induced by the combination of irinotecan and 5-fluorouracil in mice.
Topics: Animals; Antineoplastic Agents; Camptothecin; Diarrhea; Dose-Response Relationship, Drug; Drug Administration Schedule; Fluorouracil; Interleukin-6; Intestinal Mucosa; Irinotecan; Male; Mice; Mice, Inbred C57BL; Models, Animal; Mucositis; Peroxidase; Tumor Necrosis Factor-alpha | 2016 |
The reduction of oxidative stress by nanocomposite Fullerol decreases mucositis severity and reverts leukopenia induced by Irinotecan.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Fullerenes; Glutathione; Ileum; Interleukin-1beta; Intestinal Mucosa; Irinotecan; Leukopenia; Male; Melanoma; Mice, Inbred C57BL; Mice, Transgenic; Mucositis; Nanocomposites; Oxidative Stress; Peroxidase; Thiobarbituric Acid Reactive Substances; Tumor Burden | 2016 |
Saccharomyces cerevisiae UFMG A-905 treatment reduces intestinal damage in a murine model of irinotecan-induced mucositis.
Topics: Animals; Camptothecin; Disease Models, Animal; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Irinotecan; Jejunum; Lipid Peroxidation; Male; Mice; Mucositis; Oxidative Stress; Probiotics; Saccharomyces cerevisiae; Weight Loss | 2016 |
Cell adhesion molecules are altered during irinotecan-induced mucositis: a qualitative histopathological study.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Adhesion Molecules; Female; Immunohistochemistry; Intestinal Mucosa; Irinotecan; Jejunum; Mucositis; Rats | 2017 |
Carvacrol reduces irinotecan-induced intestinal mucositis through inhibition of inflammation and oxidative damage via TRPA1 receptor activation.
Topics: Animals; Antioxidants; Body Weight; Camptothecin; Cyclooxygenase 2; Cymenes; Female; Immunohistochemistry; Inflammation; Intestines; Irinotecan; Leukocyte Count; Mice; Molecular Docking Simulation; Monoterpenes; Mucositis; NF-kappa B; Oxidative Stress; Peroxidase; Survival Analysis; Transient Receptor Potential Channels; TRPA1 Cation Channel | 2016 |
Irinotecan-induced mucositis is associated with changes in intestinal mucins.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Female; Gene Expression Regulation; Goblet Cells; Immunohistochemistry; Intestinal Mucosa; Irinotecan; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Mucin-2; Mucin-4; Mucins; Mucositis; Rats; Statistics, Nonparametric; Time Factors | 2009 |
The effect of Saccharomyces boulardii on reducing irinotecan-induced intestinal mucositis and diarrhea.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Diarrhea; Histocytochemistry; Irinotecan; Leukocytes; Mucositis; Rats; Saccharomyces; Weight Loss | 2009 |
Irinotecan-induced mucositis manifesting as diarrhoea corresponds with an amended intestinal flora and mucin profile.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Colon; Diarrhea; Feces; Female; Glucuronidase; Goblet Cells; Intestinal Mucosa; Irinotecan; Jejunum; Mucins; Mucositis; Rats | 2009 |
Matrix metalloproteinases are possible mediators for the development of alimentary tract mucositis in the dark agouti rat.
Topics: Animals; Antineoplastic Agents, Phytogenic; Base Sequence; Camptothecin; Colon; DNA Primers; Female; Gastroenteritis; Gene Expression; Inflammation Mediators; Intestinal Mucosa; Irinotecan; Jejunum; Matrix Metalloproteinases; Mucositis; Plasminogen; Rats; RNA, Messenger; Tissue Inhibitor of Metalloproteinases | 2010 |
Selection of housekeeping genes for gene expression studies in a rat model of irinotecan-induced mucositis.
Topics: 14-3-3 Proteins; Actins; Animals; Camptothecin; Colon; Disease Models, Animal; Gene Expression Regulation; Glyceraldehyde-3-Phosphate Dehydrogenases; Irinotecan; Jejunum; Male; Matrix Metalloproteinase 2; Molecular Chaperones; Mucositis; Rats; Succinate Dehydrogenase; Ubiquitin C; Up-Regulation | 2011 |
Involvement of nitric oxide on the pathogenesis of irinotecan-induced intestinal mucositis: role of cytokines on inducible nitric oxide synthase activation.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cytokines; Disease Models, Animal; Enzyme Activation; Immunohistochemistry; Intestinal Mucosa; Irinotecan; Mice; Mice, Inbred C57BL; Mice, Knockout; Mucositis; Nitric Oxide; Nitric Oxide Synthase Type II | 2012 |
Retrospective study comparing irinotecan and pegylated liposomal doxorubicin in treatment of recurrent platinum-refractory/resistant epithelial ovarian cancer.
Topics: Adult; Aged; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Camptothecin; Carcinoma, Ovarian Epithelial; Disease-Free Survival; Doxorubicin; Drug Resistance, Neoplasm; Female; Hand-Foot Syndrome; Humans; Irinotecan; Kaplan-Meier Estimate; Middle Aged; Mucositis; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Platinum; Polyethylene Glycols; Retrospective Studies; Salvage Therapy | 2012 |
Irinotecan changes gene expression in the small intestine of the rat with breast cancer.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Caspase 1; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Irinotecan; Jejunum; Mammary Neoplasms, Experimental; Mitogen-Activated Protein Kinase Kinases; Mucositis; Oligonucleotide Array Sequence Analysis; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Up-Regulation | 2007 |
A non-invasive method for detection of intestinal mucositis induced by different classes of chemotherapy drugs in the rat.
Topics: Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Breath Tests; Camptothecin; Cyclophosphamide; Disease Models, Animal; DNA Topoisomerases, Type I; Doxorubicin; Etoposide; Female; Intestine, Small; Irinotecan; Mucositis; Rats; Sucrase; Sucrose; Topoisomerase I Inhibitors | 2006 |
Velafermin improves gastrointestinal mucositis following irinotecan treatment in tumor-bearing DA rats.
Topics: Animals; Antineoplastic Agents, Phytogenic; Body Weight; Camptothecin; Diarrhea; Fibroblast Growth Factors; Gastroenteritis; Irinotecan; Mucositis; Rats; Rats, Inbred Strains | 2007 |
Gene expression analysis of multiple gastrointestinal regions reveals activation of common cell regulatory pathways following cytotoxic chemotherapy.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Cycle Proteins; Colon; Female; Gastric Mucosa; Gastrointestinal Tract; Gene Expression Profiling; Gene Expression Regulation; Irinotecan; Jejunum; Mucositis; Oligonucleotide Array Sequence Analysis; Rats; Signal Transduction; Stomach; Time Factors; Transcription Factors | 2007 |
Chemotherapy-induced mucositis: focusing on diarrhea.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Budesonide; Camptothecin; Dehydration; Diarrhea; Fluorouracil; Gastric Mucosa; Gastrointestinal Tract; Humans; Infusions, Intravenous; Intestinal Absorption; Intestinal Mucosa; Irinotecan; Leucovorin; Loperamide; Mice; Mucositis; Organoplatinum Compounds; Rats | 2007 |
Role of cytokines (TNF-alpha, IL-1beta and KC) in the pathogenesis of CPT-11-induced intestinal mucositis in mice: effect of pentoxifylline and thalidomide.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Chemokines; Diarrhea; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Injections, Intraperitoneal; Interleukin-1beta; Intestine, Small; Irinotecan; Male; Mice; Mucositis; Pentoxifylline; Peroxidase; Thalidomide; Tumor Necrosis Factor-alpha | 2008 |
Characterisation of mucosal changes in the alimentary tract following administration of irinotecan: implications for the pathobiology of mucositis.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Colon; Coloring Agents; Cytokines; Diarrhea; Digestive System; Eosine Yellowish-(YS); Female; Fluorescent Dyes; Gastric Mucosa; Hematoxylin; Immunohistochemistry; Intestinal Mucosa; Irinotecan; Jejunum; Mouth Mucosa; Mucositis; NF-kappa B; Rats | 2008 |
Establishment of a single-dose irinotecan model of gastrointestinal mucositis.
Topics: Animals; Body Weight; Camptothecin; Diarrhea; Disease Models, Animal; Female; Irinotecan; Mucositis; Neoplasm Transplantation; Organ Size; Rats; Survival Rate | 2007 |
Is the pathobiology of chemotherapy-induced alimentary tract mucositis influenced by the type of mucotoxic drug administered?
Topics: Animals; Antineoplastic Agents; Camptothecin; Colon; Female; Fluorouracil; Immunohistochemistry; Interleukin-1; Interleukin-6; Intestinal Mucosa; Irinotecan; Jejunum; Methotrexate; Mouth Mucosa; Mucositis; NF-kappa B; Rats; Rats, Inbred Strains; Tumor Necrosis Factor-alpha | 2009 |