Compounds > irinotecan
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irinotecan and Invasiveness, Neoplasm

irinotecan has been researched along with Invasiveness, Neoplasm in 55 studies

Research

Studies (55)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (3.64)18.2507
2000's23 (41.82)29.6817
2010's26 (47.27)24.3611
2020's4 (7.27)2.80

Authors

AuthorsStudies
Artemiyev, AI; Bashkov, AN; Bogoevich, Z; Kolyshev, IY; Kucherov, NN; Naydenov, EV; Shabalin, MV; Voskanyan, SE1
Igarashi, H; Imai, K; Ishigami, K; Koide, H; Mitsuhashi, K; Nakase, H; Nosho, K; Okita, K; Takemasa, I; Taniguchi, H1
An, H; Heo, JS; Hong, CP; Hong, E; Kang, JM; Kim, SJ; Lee, S; Ooshima, A; Park, J; Park, JO; Park, S; Park, SH1
Endo, I; Kumamoto, T; Matsuyama, R; Murakami, T; Sawada, Y; Tsuchiya, N; Yabushita, Y1
Abdel Moneim, R; Aldaly, M; Elsherbiny, M; Sakr, A; Shaaban, S1
Ames, MM; Foster, NR; Goetz, MP; Hobday, TJ; Horvath, LE; Jatoi, A; Mahoney, MR; McWilliams, RR; Meyers, JP; Murray, JA; Schneider, DJ; Smyrk, TC1
Chang, GJ1
Abdel-Rahman, WM; Al-Khayyal, NA; Aravind, SR; Nair, VA; Saber-Ayad, M1
Chen, X; Huang, Y; Luo, Y; Su, P; Wang, G; Wang, Q; Yang, Y; Zhu, D1
Berger, MD; Cao, S; Falcone, A; Heinemann, V; Lenz, HJ; Loupakis, F; Matsusaka, S; Miyamoto, Y; Ning, Y; Okazaki, S; Schirripa, M; Soni, S; Stintzing, S; Suenaga, M; Sunakawa, Y; Yang, D; Zhang, W1
Liu, B; Liu, S1
Bähr, O; Belka, C; Braun, C; Gerlach, R; Glas, M; Goldbrunner, R; Hänel, M; Hattingen, E; Hau, P; Herrlinger, U; Junold, N; Kebir, S; Kortmann, RD; Krex, D; Mack, F; Niessen, M; Proescholdt, M; Rohde, V; Sabel, M; Schäfer, N; Schaub, C; Schlegel, U; Schmidt-Graf, F; Steinbach, JP; Stuplich, M; Tzaridis, T; Vatter, H; Weyerbrock, A1
Kralova, V; Krbal, L; Matouskova, P; Rudolf, E; Skarkova, V; Soukup, J1
Barenboim, A; Brazowski, E; Geva, R; Goykhman, Y; Isakov, O; Klausner, JM; Lahat, G; Lubezky, N; Nachmany, I; Nakache, R; Rosen, G; Wolf, I1
Barbier, E; Blanc, JF; Bourgeois, V; Desrame, J; Edeline, J; Malka, D; Manfredi, S; Michel, P; Neuzillet, C; Phelip, JM1
Büchler, MW; Hackert, T; Heckler, M; Heger, U; Klaiber, U; Mihaljevic, AL; Sun, H; Tanaka, M1
Capussotti, L; De Rosa, G; De Saussure, WO; Mentha, G; Rubbia-Brandt, L; Viganò, L1
Bachet, JB; Blanc, JF; Carbonnel, F; Coriat, R; Cueff, A; De La Fouchardière, C; Francois, E; Gauthier, M; Lécaille, C; Malka, D; Manfredi, S; Marthey, L; Sa-Cunha, A; Solub, D; Taieb, J; Terrebonne, E; Thirot Bidault, A; Trouilloud, I1
Ba, Y; Chen, Y; Deng, T; He, Y; Li, W; Liu, R; Ren, L; Wang, X; Ying, G; Zhou, L; Zuo, D1
Bernard, AC; Coqueret, O; De Carné Trécesson, S; Gamelin, E; Guette, C; Henry, C; Jonchère, B; Juin, P; Lam, D; Toutain, B; Vétillard, A1
Hassan, AS; Naicker, M; Wan Ishak, WZ; Yusof, KH1
Delestre, L; Dewitte, A; Lansiaux, A; Lepretre, F; Pham, MH; Wattez, N1
Higashida, M; Hirai, T; Kubota, H; Matsumoto, H; Murakami, H; Okumura, H; Tohyama, K; Tsuruta, A1
Chen, MC; Chen, RJ; Ho, TJ; Hsu, HH; Huang, CY; Kuo, WW; Lee, NH; Lin, YM; Tu, CC; Viswanadha, VP1
Chen, Q; Cheng, M; Wang, Z; Zhao, S1
Akamatsu, H; Furukawa, K; Ikehara, M; Kishi, K; Koh, M; Masuzawa, T; Suzuki, Y; Tanemura, M; Tei, M; Tsukada, R1
Bolognese, A; Caputo, M; Di Cello, P; Izzo, L; Izzo, P; Meloni, P; Pietrasanta, D1
Chang, MH; Jun, HJ; Kang, WK; Kim, HS; Kim, KH; Lee, J; Lee, JK; Lee, KT; Lim, HY; Park, JO; Park, MJ; Park, SH; Park, YS; Uhm, JE; Yi, SY1
Blumgart, LH; D'Angelica, M; DeMatteo, RP; Fahy, BN; Gonen, M; Jarnagin, WR; Ostrovnaya, I; Weiser, MR1
Ahn, KD; Cho, YB; Choi, SH; Chun, HK; Kim, HC; Lee, JM; Lee, WY; Shin, HJ; Song, SY; Yun, SH1
Erben, P; Hochhaus, A; Hofheinz, RD; Horisberger, K; Kaehler, G; Muessle, B; Post, S; Stroebel, P; Wenz, F; Willeke, F; Woernle, C1
Adlard, JW; Allan, JM; Braun, MS; Daly, CL; Meade, AM; Parmar, MK; Quirke, P; Richman, SD; Seymour, MT; Thompson, L1
Ng, RC; Tantisattamo, E1
Aboody, KS; Annala, AJ; Garcia, E; Gilchrist, M; Glackin, CA; Gutova, M; Kim, SU; Metz, MZ; Najbauer, J; Polewski, MD; Zhao, D1
Cakar, B; Karabulut, B; Karaca, B; Sezgin, C; Uslu, R; Varol, U1
Akimoto, Y; Hamasaki, A; Honda, H; Kaneko, M; Okamoto, K; Oshita, T; Takao, Y; Tanimoto, H; Teramoto, H; Teramoto, M1
Hazama, S; Hinoda, Y; Oka, M1
Saiki, I1
Abad, A; Antón, A; Aranda, E; Carrato, A; Díaz-Rubio, E; Gil, S; Maestu, I; Marcuello, E; Masutti, B; Maurel, J; Navarro, M; Sastre, J; Valladares, M; Vicent, JM1
Hasegawa, Y; Hayashi, N; Kato, Y; Wakita, T1
Hayashi, Y; Ishida, H; Nakada, H; Ohsawa, T; Okada, N; Shirakawa, K; Yokoyama, M1
Kato, T; Masuoka, HO; Sato, K; Tamahashi, N; Yano, H1
Aggarwal, BB; Ajani, JA; Chao, KS; Ensor, J; Hittelman, WN; Izzo, JG; Lee, JH; Liao, Z; Luthra, R; Malhotra, U; Swisher, SG; Wu, TT1
Chaudhury, P; Hayashi, S; Horton, PJ; Jass, JR; Marcus, VA; Martinie, JB; Metrakos, P; Znajda, TL1
Goi, T; Hirono, Y; Iida, A; Ishida, M; Katayama, K; Maeda, H; Murakami, M; Obata, S; Yamaguchi, A1
Cummings, K; Gao, F; Govindan, R; Hennenfent, KL; Marsh, S; McLeod, HL; Pillot, GA; Read, WL; Viswanathan, A1
Shoji, Y; Toyooka, M1
Bajetta, E; Bajetta, R; Celio, L; Colombo, A; Denaro, A; Di Bartolomeo, M; Dotti, K; Ferrario, E; Mancin, M; Pusceddu, S1
Gotoh, M; Hashimoto, Y; Hoshino, Y; Kashimura, S; Kogure, M; Odashima, Y; Osuka, F; Otani, S; Saito, T; Saze, Z; Soeta, N; Terashima, M; Watanabe, K1
Han, I; Hatori, S; Iwasaki, H; Murakami, H; Suzuki, M; Takanashi, Y; Yamakawa, M1
Hayakawa, S; Sato, S; Takano, T; Wagazuma, S; Yajima, A1
Hashimoto, A; Matsuura, T; Murakami, K; Saiki, I; Sakukawa, R; Sano, M; Yamada, Y; Yonekura, K1
Fujiyoshi, K; Hasuo, Y; Hirai, N; Kamura, T; Kumagai, S; Nishida, T; Nishio, S; Oota, S; Sugiyama, T; Tomioka, Y1
Ikeda, T; Mitani, N; Murakami, K; Saiki, I; Yamaura, T1
Chang, W; Kondo, Y; Kosaka, H; Maeda, S; Matsusaka, S; Okada, T; Oriyama, T1

Reviews

4 review(s) available for irinotecan and Invasiveness, Neoplasm

ArticleYear
The efficacy and safety of panitumumab plus irrinotecan-based chemotherapy in the treatment of metastatic colorectal cancer: A meta-analysis.
    Medicine, 2016, Volume: 95, Issue:50

    Topics: Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Disease-Free Survival; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Irinotecan; Male; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Staging; Panitumumab; Prognosis; Survival Rate; Treatment Outcome

2016
Dual paraneoplastic syndromes: small cell lung carcinoma-related oncogenic osteomalacia, and syndrome of inappropriate antidiuretic hormone secretion: report of a case and review of the literature.
    Hawaii medical journal, 2011, Volume: 70, Issue:7

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cisplatin; Diabetes Mellitus, Type 2; Fatal Outcome; Gout; Humans; Hyperlipidemias; Hypertension; Hypophosphatemia; Inappropriate ADH Syndrome; Irinotecan; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Osteomalacia; Paraneoplastic Syndromes; Risk Factors; Small Cell Lung Carcinoma

2011
[Polymorphism in colorectal cancer].
    Nihon rinsho. Japanese journal of clinical medicine, 2003, Volume: 61 Suppl 7

    Topics: Antineoplastic Agents; Camptothecin; Colorectal Neoplasms; Fluorouracil; Genetic Predisposition to Disease; Humans; Irinotecan; Life Style; Matrix Metalloproteinase 1; Matrix Metalloproteinase 3; Neoplasm Invasiveness; Neoplasm Metastasis; Organoplatinum Compounds; Oxaliplatin; Pharmacogenetics; Polymorphism, Single Nucleotide; Prodrugs; Prognosis; Risk Factors

2003
[Chemotherapy of uterine endometrial cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1995, Volume: 22, Issue:9

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemotherapy, Adjuvant; Cisplatin; Doxorubicin; Endometrial Neoplasms; Female; Humans; Irinotecan; Lymphatic Metastasis; Neoplasm Invasiveness; Paclitaxel

1995

Trials

14 trial(s) available for irinotecan and Invasiveness, Neoplasm

ArticleYear
Neoadjuvant FOLFIRINOX followed by Chemoradiotherapy for Middle and Lower Rectal Cancer.
    Asian Pacific journal of cancer prevention : APJCP, 2020, Jun-01, Volume: 21, Issue:6

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Chemoradiotherapy; Deoxycytidine; Female; Fluorouracil; Follow-Up Studies; Humans; Irinotecan; Leucovorin; Lymphatic Metastasis; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Oxaliplatin; Prognosis; Prospective Studies; Rectal Neoplasms; Survival Rate; Young Adult

2020
North Central Cancer Treatment Group N0543 (Alliance): A phase 2 trial of pharmacogenetic-based dosing of irinotecan, oxaliplatin, and capecitabine as first-line therapy for patients with advanced small bowel adenocarcinoma.
    Cancer, 2017, Sep-15, Volume: 123, Issue:18

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cancer Care Facilities; Capecitabine; Databases, Factual; Disease-Free Survival; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Genotype; Glucuronosyltransferase; Humans; Intestinal Neoplasms; Intestine, Small; Irinotecan; Kaplan-Meier Estimate; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Pharmacogenetics; Prognosis; Proportional Hazards Models; Retrospective Studies; Survival Analysis

2017
Treatment of Locally Advanced Rectal Cancer: Turning Good Rationale Into Good Evidence?
    Diseases of the colon and rectum, 2017, Volume: 60, Issue:7

    Topics: Antineoplastic Agents; Camptothecin; Chemoradiotherapy; Colectomy; Dose-Response Relationship, Drug; Female; Fluorouracil; Humans; Induction Chemotherapy; Irinotecan; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Patient Care Management; Patient Selection; Rectal Neoplasms

2017
Impact of genetic variations in the MAPK signaling pathway on outcome in metastatic colorectal cancer patients treated with first-line FOLFIRI and bevacizumab: data from FIRE-3 and TRIBE trials.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2017, Nov-01, Volume: 28, Issue:11

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Biomarkers, Tumor; Camptothecin; Colorectal Neoplasms; Fluorouracil; Follow-Up Studies; Genotype; Humans; Intracellular Signaling Peptides and Proteins; Irinotecan; Leucovorin; Lymphatic Metastasis; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Polymorphism, Single Nucleotide; Population Groups; Prognosis; Protein Serine-Threonine Kinases; Survival Rate

2017
Tumor growth patterns of MGMT-non-methylated glioblastoma in the randomized GLARIUS trial.
    Journal of cancer research and clinical oncology, 2018, Volume: 144, Issue:8

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Cell Growth Processes; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Irinotecan; Magnetic Resonance Imaging; Male; Methylation; Middle Aged; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Radiotherapy; Temozolomide; Tumor Suppressor Proteins

2018
Modified FOLFIRINOX versus CisGem first-line chemotherapy for locally advanced non resectable or metastatic biliary tract cancer (AMEBICA)-PRODIGE 38: Study protocol for a randomized controlled multicenter phase II/III study.
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2019, Volume: 51, Issue:2

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bile Duct Neoplasms; Carcinoma; Cisplatin; Deoxycytidine; Drug Monitoring; Female; Fluorouracil; France; Gemcitabine; Humans; Irinotecan; Leucovorin; Male; Neoplasm Invasiveness; Neoplasm Staging; Oxaliplatin

2019
Irinotecan monotherapy as second-line treatment in advanced pancreatic cancer.
    Cancer chemotherapy and pharmacology, 2009, Volume: 63, Issue:6

    Topics: Adult; Aged; Antineoplastic Agents, Phytogenic; Camptothecin; Disease-Free Survival; Female; Humans; Irinotecan; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Invasiveness; Pancreatic Neoplasms

2009
Topoisomerase I expression correlates to response to neoadjuvant irinotecan-based chemoradiation in rectal cancer.
    Anti-cancer drugs, 2009, Volume: 20, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Biopsy; Camptothecin; DNA Topoisomerases, Type I; Humans; Intestinal Mucosa; Irinotecan; Neoadjuvant Therapy; Neoplasm Invasiveness; Prospective Studies; Rectal Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; Thymidylate Synthase

2009
Association of molecular markers with toxicity outcomes in a randomized trial of chemotherapy for advanced colorectal cancer: the FOCUS trial.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009, Nov-20, Volume: 27, Issue:33

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Camptothecin; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fluorouracil; Follow-Up Studies; Glutathione Transferase; Humans; Irinotecan; Leucovorin; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Polymorphism, Genetic; Predictive Value of Tests; Probability; Survival Analysis; Thymidylate Synthase; Time Factors; Treatment Outcome

2009
Irinotecan in combination with fluorouracil in a 48-hour continuous infusion as first-line chemotherapy for elderly patients with metastatic colorectal cancer: a Spanish Cooperative Group for the Treatment of Digestive Tumors study.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005, May-20, Volume: 23, Issue:15

    Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Confidence Intervals; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fluorouracil; Follow-Up Studies; Geriatric Assessment; Humans; Infusions, Intravenous; Irinotecan; Male; Neoplasm Invasiveness; Neoplasm Staging; Probability; Risk Assessment; Survival Analysis; Treatment Outcome

2005
Association of activated transcription factor nuclear factor kappab with chemoradiation resistance and poor outcome in esophageal carcinoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2006, Feb-10, Volume: 24, Issue:5

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoma; Combined Modality Therapy; Disease-Free Survival; Docetaxel; Esophageal Neoplasms; Female; Fluorouracil; Gene Expression Profiling; Humans; Immunohistochemistry; Infusions, Intravenous; Injections, Intravenous; Irinotecan; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; NF-kappa B; Prognosis; Taxoids; Treatment Outcome

2006
A phase II study of irinotecan and carboplatin in advanced non-small cell lung cancer with pharmacogenomic analysis: final report.
    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2006, Volume: 1, Issue:9

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Camptothecin; Carboplatin; Carcinoma, Non-Small-Cell Lung; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Infusions, Intravenous; Irinotecan; Lung Neoplasms; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Pharmacogenetics; Probability; Survival Analysis; Treatment Outcome

2006
Capecitabine plus oxaliplatin and irinotecan regimen every other week: a phase I/II study in first-line treatment of metastatic colorectal cancer.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2007, Volume: 18, Issue:11

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biopsy, Needle; Camptothecin; Capecitabine; Colorectal Neoplasms; Confidence Intervals; Deoxycytidine; Disease-Free Survival; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fluorouracil; Follow-Up Studies; Humans; Immunohistochemistry; Irinotecan; Liver Neoplasms; Male; Maximum Tolerated Dose; Neoplasm Invasiveness; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Risk Assessment; Survival Analysis; Treatment Outcome

2007
[Neoadjuvant chemotherapy with cisplatin and CPT-11 for advanced cervical cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2000, Volume: 27, Issue:3

    Topics: Adult; Aged; Anemia; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cisplatin; Drug Administration Schedule; Female; Humans; Irinotecan; Leukopenia; Middle Aged; Neoadjuvant Therapy; Neoplasm Invasiveness; Neoplasm Staging; Neutropenia; Uterine Cervical Neoplasms

2000

Other Studies

37 other study(ies) available for irinotecan and Invasiveness, Neoplasm

ArticleYear
[Pure laparoscopic DP-CAR procedure with portal vein resection].
    Khirurgiia, 2019, Issue:9

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Celiac Artery; Fluorouracil; Humans; Irinotecan; Laparoscopy; Leucovorin; Middle Aged; Neoplasm Invasiveness; Oxaliplatin; Pancreatectomy; Pancreatic Fistula; Pancreatic Neoplasms; Portal Vein

2019
PRDM14 promotes malignant phenotype and correlates with poor prognosis in colorectal cancer.
    Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2020, Volume: 22, Issue:7

    Topics: Adenocarcinoma; Adenoma; Aged; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colorectal Neoplasms; DNA-Binding Proteins; Drug Resistance, Neoplasm; Female; Fluorouracil; Humans; Immunohistochemistry; Irinotecan; Lymph Nodes; Lymphatic Metastasis; Male; Mice, Nude; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Neoplasm Transplantation; Oxaliplatin; Prognosis; Reverse Transcriptase Polymerase Chain Reaction; RNA-Binding Proteins; RNA, Messenger; Transcription Factors; Tumor Burden

2020
Inhibition of TGF-β signalling in combination with nal-IRI plus 5-Fluorouracil/Leucovorin suppresses invasion and prolongs survival in pancreatic tumour mouse models.
    Scientific reports, 2020, 02-19, Volume: 10, Issue:1

    Topics: Aniline Compounds; Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinogenesis; Cell Line, Tumor; Cell Movement; Disease Models, Animal; Drug Synergism; Epithelial-Mesenchymal Transition; Fluorouracil; Gene Expression Regulation, Neoplastic; Irinotecan; Leucovorin; Liposomes; Mice, Inbred C57BL; Nanoparticles; Neoplasm Invasiveness; Pancreatic Neoplasms; Signal Transduction; Survival Analysis; Transcriptome; Transforming Growth Factor beta; Triazoles; Tumor Stem Cell Assay; Up-Regulation

2020
Role of Conversion Surgery for Unresectable Pancreatic Cancer After Long-Term Chemotherapy.
    World journal of surgery, 2020, Volume: 44, Issue:8

    Topics: Aged; Albumins; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Deoxycytidine; Drug Combinations; Female; Fluorouracil; Gemcitabine; Humans; Irinotecan; Kaplan-Meier Estimate; Leucovorin; Lymph Node Excision; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Oxaliplatin; Oxonic Acid; Paclitaxel; Pancreatectomy; Pancreatic Neoplasms; Pancreaticoduodenectomy; Prognosis; Pyridines; Radiotherapy; Retrospective Studies; Tegafur; Time Factors

2020
Role of AXL in invasion and drug resistance of colon and breast cancer cells and its association with p53 alterations.
    World journal of gastroenterology, 2017, May-21, Volume: 23, Issue:19

    Topics: Animals; Axl Receptor Tyrosine Kinase; Breast Neoplasms; Camptothecin; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Doxorubicin; Fluorouracil; Gene Expression Regulation, Neoplastic; Gene Silencing; HCT116 Cells; HeLa Cells; Humans; Irinotecan; MCF-7 Cells; Mice, Knockout; Mutation; Neoplasm Invasiveness; Oligonucleotide Array Sequence Analysis; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; RNA, Small Interfering; Signal Transduction; Treatment Outcome; Tumor Suppressor Protein p53

2017
Epithelial-mesenchymal transition and cancer stem cell-like phenotype induced by Twist1 contribute to acquired resistance to irinotecan in colon cancer.
    International journal of oncology, 2017, Volume: 51, Issue:2

    Topics: Camptothecin; Cell Movement; Cell Proliferation; Colonic Neoplasms; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Humans; Irinotecan; Neoplasm Invasiveness; Neoplastic Stem Cells; Nuclear Proteins; RNA, Small Interfering; Transfection; Twist-Related Protein 1

2017
Overexpression of Nitrogen Permease Regulator Like-2 (NPRL2) Enhances Sensitivity to Irinotecan (CPT-11) in Colon Cancer Cells by Activating the DNA Damage Checkpoint Pathway.
    Medical science monitor : international medical journal of experimental and clinical research, 2018, Mar-09, Volume: 24

    Topics: Apoptosis; Camptothecin; Cell Cycle Checkpoints; Cell Movement; Colonic Neoplasms; DNA Damage; Down-Regulation; G2 Phase; Gene Expression Regulation, Neoplastic; HCT116 Cells; Histones; Humans; Irinotecan; Lentivirus; Membrane Potential, Mitochondrial; Mitosis; Neoplasm Invasiveness; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Transduction, Genetic; Tumor Suppressor Proteins

2018
Oxaliplatin and irinotecan induce heterogenous changes in the EMT markers of metastasizing colorectal carcinoma cells.
    Experimental cell research, 2018, 08-15, Volume: 369, Issue:2

    Topics: Adenocarcinoma; Antineoplastic Agents; Biomarkers, Tumor; Cell Line, Tumor; Colorectal Neoplasms; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Humans; Irinotecan; Lymphatic Metastasis; Neoplasm Invasiveness; Neovascularization, Pathologic; Oxaliplatin

2018
Neoadjuvant FOLFIRINOX for locally advanced and borderline resectable pancreatic cancer: An intention to treat analysis.
    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 2018, Volume: 44, Issue:10

    Topics: Adenocarcinoma; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Drug Combinations; Female; Fluorouracil; Humans; Intention to Treat Analysis; Irinotecan; Leucovorin; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Invasiveness; Neoplasm Staging; Organometallic Compounds; Oxaliplatin; Pancreatectomy; Pancreatic Ducts; Pancreatic Neoplasms; Pancreaticoduodenectomy; Portal Vein; Postoperative Complications; Survival Rate

2018
CT response of primary tumor and CA19-9 predict resectability of metastasized pancreatic cancer after FOLFIRINOX.
    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 2019, Volume: 45, Issue:8

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; CA-19-9 Antigen; Carcinoma, Pancreatic Ductal; Cohort Studies; Databases, Factual; Disease-Free Survival; Female; Fluorouracil; Germany; Humans; Induction Chemotherapy; Irinotecan; Kaplan-Meier Estimate; Leucovorin; Male; Metastasectomy; Middle Aged; Multivariate Analysis; Neoadjuvant Therapy; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Staging; Oxaliplatin; Pancreatic Neoplasms; Patient Selection; Prognosis; Proportional Hazards Models; Retrospective Studies; Survival Analysis; Tomography, X-Ray Computed

2019
Liver resection for colorectal metastases after chemotherapy: impact of chemotherapy-related liver injuries, pathological tumor response, and micrometastases on long-term survival.
    Annals of surgery, 2013, Volume: 258, Issue:5

    Topics: Aged; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Bevacizumab; Camptothecin; Chemotherapy, Adjuvant; Colorectal Neoplasms; Combined Modality Therapy; Fatty Liver; Female; Hepatectomy; Hepatic Veno-Occlusive Disease; Humans; Irinotecan; Liver Neoplasms; Male; Neoplasm Invasiveness; Neoplasm Micrometastasis; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Prognosis; Survival Rate; Treatment Outcome

2013
FOLFIRINOX for locally advanced pancreatic adenocarcinoma: results of an AGEO multicenter prospective observational cohort.
    Annals of surgical oncology, 2015, Volume: 22, Issue:1

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cisplatin; Deoxycytidine; Female; Fluorouracil; Follow-Up Studies; Gemcitabine; Humans; Irinotecan; Leucovorin; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Neoplasm Staging; Pancreatic Neoplasms; Prognosis; Prospective Studies; Survival Rate

2015
Shed Syndecan-1 is involved in chemotherapy resistance via the EGFR pathway in colorectal cancer.
    British journal of cancer, 2014, Nov-11, Volume: 111, Issue:10

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Biomarkers, Tumor; Blotting, Western; Camptothecin; Case-Control Studies; Cell Proliferation; Cisplatin; Colorectal Neoplasms; Drug Resistance, Neoplasm; ErbB Receptors; Female; Flow Cytometry; Fluorescent Antibody Technique; Fluorouracil; Humans; Immunoenzyme Techniques; Irinotecan; Male; Matrix Metalloproteinase 7; Neoplasm Grading; Neoplasm Invasiveness; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Syndecan-1; Tumor Cells, Cultured

2014
Irinotecan treatment and senescence failure promote the emergence of more transformed and invasive cells that depend on anti-apoptotic Mcl-1.
    Oncotarget, 2015, Jan-01, Volume: 6, Issue:1

    Topics: Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Camptothecin; Cell Line, Tumor; Cell Transformation, Neoplastic; Cellular Senescence; Colorectal Neoplasms; Drug Resistance, Neoplasm; Flow Cytometry; Heterografts; Humans; Irinotecan; Male; Mice; Mice, Inbred BALB C; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Invasiveness; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Transfection

2015
Prognostic factors and the role of adjuvant chemotherapy in post-curative surgery for Dukes B and C colon cancers and survival outcomes: a Malaysian experience.
    Asian Pacific journal of cancer prevention : APJCP, 2015, Volume: 16, Issue:6

    Topics: Adenocarcinoma; Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Chemotherapy, Adjuvant; Colonic Neoplasms; Female; Fluorouracil; Follow-Up Studies; Humans; Irinotecan; Leucovorin; Lymphatic Metastasis; Malaysia; Male; Middle Aged; Neoplasm Grading; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Organoplatinum Compounds; Oxaliplatin; Postoperative Period; Prognosis; Retrospective Studies; Survival Rate; Young Adult

2015
Synergistic Effect of SN-38 in Combination with Cetuximab on Angiogenesis and Cancer Cell Invasion.
    Anticancer research, 2015, Volume: 35, Issue:11

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Camptothecin; Cell Adhesion; Cell Cycle; Cell Movement; Cell Proliferation; Cells, Cultured; Cetuximab; Colonic Neoplasms; Drug Synergism; Flow Cytometry; Human Umbilical Vein Endothelial Cells; Humans; Irinotecan; Neoplasm Invasiveness; Neovascularization, Pathologic; Phosphorylation; Signal Transduction

2015
Fluctuation in Plasma 5-Fluorouracil Concentration During Continuous 5-Fluorouracil Infusion for Colorectal Cancer.
    Anticancer research, 2015, Volume: 35, Issue:11

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Female; Fluorouracil; Follow-Up Studies; Gas Chromatography-Mass Spectrometry; Humans; Immunoassay; Infusions, Intravenous; Irinotecan; Leucovorin; Liver Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Prognosis; Prospective Studies; Survival Rate

2015
Inhibition of NF-κB and metastasis in irinotecan (CPT-11)-resistant LoVo colon cancer cells by thymoquinone via JNK and p38.
    Environmental toxicology, 2017, Volume: 32, Issue:2

    Topics: Antineoplastic Agents, Phytogenic; Benzoquinones; Camptothecin; Cell Line, Tumor; Cell Movement; Colonic Neoplasms; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Humans; Irinotecan; JNK Mitogen-Activated Protein Kinases; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Metastasis; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Transcription Factor RelA

2017
[Curative Resection for Chemorefractory Advanced Gastric Cancer with Pancreatic Invasion by Pancreatoduodenectomy - A Case Report].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2016, Volume: 43, Issue:12

    Topics: Adult; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cisplatin; Disease Progression; Drug Combinations; Female; Humans; Irinotecan; Neoplasm Invasiveness; Oxonic Acid; Pancreas; Pancreaticoduodenectomy; Stomach Neoplasms; Tegafur; Treatment Outcome

2016
A case of relapsing secondary bladder adenocarcinoma after right colonic cancer.
    Nature clinical practice. Urology, 2008, Volume: 5, Issue:7

    Topics: Adenocarcinoma; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cecal Neoplasms; Cetuximab; Chemotherapy, Adjuvant; Colectomy; Female; Fluorouracil; Humans; Immunohistochemistry; Irinotecan; Leucovorin; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Organoplatinum Compounds; Quinazolines; Retroperitoneal Neoplasms; Sacrum; Thiophenes; Tomography, X-Ray Computed; Urinary Bladder Neoplasms

2008
Synchronous hepatic metastases from colon cancer: changing treatment strategies and results of surgical intervention.
    Annals of surgical oncology, 2009, Volume: 16, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Camptothecin; Carcinoembryonic Antigen; Colonic Neoplasms; Combined Modality Therapy; Female; Humans; Irinotecan; Liver Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Prognosis; Retrospective Studies; Survival Rate; Treatment Outcome

2009
In vitro chemosensitivity based on depth of invasion in advanced colorectal cancer using ATP-based chemotherapy response assay (ATP-CRA).
    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 2009, Volume: 35, Issue:9

    Topics: Adult; Aged; Antineoplastic Agents; Camptothecin; Colorectal Neoplasms; Drug Screening Assays, Antitumor; Female; Fluorouracil; Humans; Irinotecan; Male; Middle Aged; Mitomycin; Neoplasm Invasiveness; Organoplatinum Compounds; Pyridines; Regression Analysis; Tumor Cells, Cultured

2009
Human neural stem cell tropism to metastatic breast cancer.
    Stem cells (Dayton, Ohio), 2012, Volume: 30, Issue:2

    Topics: Animals; Antineoplastic Agents, Phytogenic; Biotransformation; Camptothecin; Carboxylesterase; Cell Line, Tumor; Cell Movement; Cell Survival; Drug Delivery Systems; Female; Humans; Interleukin-6; Irinotecan; Lung Neoplasms; Lymphatic Metastasis; Mammary Neoplasms, Experimental; Mice; Mice, Nude; Neoplasm Invasiveness; Neural Stem Cells; Prodrugs; Rabbits; Xenograft Model Antitumor Assays

2012
Comparing time to disease progression of irinotecan and oxaliplatin-based chemotherapies in colorectal cancer patients with liver only metastasis.
    American journal of clinical oncology, 2013, Volume: 36, Issue:4

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cohort Studies; Colorectal Neoplasms; Databases, Factual; Disease Progression; Disease-Free Survival; Female; Fluorouracil; Follow-Up Studies; Humans; Infusions, Intravenous; Irinotecan; Leucovorin; Liver Neoplasms; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Retrospective Studies; Risk Assessment; Survival Analysis; Time Factors; Treatment Outcome

2013
[A case of large cell neuroendocrine carcinoma (LCNEC) of the uterine cervix successfully treated by postoperative CPT-11+CDDP chemotherapy after non-curative surgery].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2012, Volume: 39, Issue:9

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoma, Large Cell; Carcinoma, Neuroendocrine; Cisplatin; Combined Modality Therapy; Female; Humans; Irinotecan; Neoplasm Invasiveness; Tomography, X-Ray Computed; Uterine Cervical Neoplasms

2012
[Screening for inhibitors of tumor invasion into basement membranes].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2004, Volume: 31, Issue:4

    Topics: Animals; Basement Membrane; Berberine; Camptothecin; Carcinoma, Lewis Lung; Cell Movement; Drug Screening Assays, Antitumor; Humans; Irinotecan; Lymphatic Metastasis; Mice; Neoplasm Invasiveness; Neoplastic Cells, Circulating; Saponins; Tumor Cells, Cultured

2004
[A young patient with invasive small cell carcinoma of the urinary bladder: a case report].
    Hinyokika kiyo. Acta urologica Japonica, 2005, Volume: 51, Issue:4

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoma, Small Cell; Chemotherapy, Adjuvant; Cisplatin; Cystoscopy; Drug Administration Schedule; Female; Humans; Hysterectomy; Irinotecan; Neoplasm Invasiveness; Urinary Bladder Neoplasms

2005
[Clinical significant of semiquantificating DNA topoisomerase- I mRNA in colorectal cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2005, Volume: 32, Issue:9

    Topics: Aged; Antineoplastic Agents, Phytogenic; Camptothecin; Colorectal Neoplasms; DNA Topoisomerases, Type I; Female; Humans; Irinotecan; Male; Middle Aged; Neoplasm Invasiveness; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thymidylate Synthase

2005
[A case of small cell carcinoma of the stomach].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2005, Volume: 32, Issue:10

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoma, Small Cell; Cisplatin; Combined Modality Therapy; Drug Administration Schedule; Gastrectomy; Humans; Irinotecan; Liver Neoplasms; Male; Middle Aged; Neoplasm Invasiveness; Pancreatic Neoplasms; Rupture, Spontaneous; Stomach Neoplasms; Stomach Rupture

2005
Postchemotherapy characteristics of hepatic colorectal metastases: remnants of uncertain malignant potential.
    Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2006, Volume: 10, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Camptothecin; Colonic Neoplasms; DNA Repair; Follow-Up Studies; Gene Silencing; Hepatectomy; Humans; Irinotecan; Liver; Liver Neoplasms; Middle Aged; Neoadjuvant Therapy; Neoplasm Invasiveness; O(6)-Methylguanine-DNA Methyltransferase; Organoplatinum Compounds; Oxaliplatin; Preoperative Care; Rectal Neoplasms; Remission Induction; Retrospective Studies; Topoisomerase I Inhibitors

2006
[A case of recurrent colon cancer with urinary bladder, para-aortic lymph nodes, and spleen metastases successfully treated with CPT-11].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2007, Volume: 34, Issue:1

    Topics: Adenocarcinoma; Aged; Antineoplastic Agents, Phytogenic; Aorta; Camptothecin; Combined Modality Therapy; Drug Administration Schedule; Female; Humans; Irinotecan; Lymph Nodes; Lymphatic Metastasis; Neoplasm Invasiveness; Quality of Life; Remission Induction; Sigmoid Neoplasms; Splenic Neoplasms; Urinary Bladder Neoplasms

2007
[A case of effective regimen of tegafur and uracil (UFT)/leucovorin (LV) plus irinotecan (CPT-11) for advanced rectal carcinoma with severe pelvic infiltration to be performed curative resection].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2007, Volume: 34, Issue:4

    Topics: Adenocarcinoma; Administration, Oral; Aged; Ambulatory Care; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemotherapy, Adjuvant; Drug Administration Schedule; Drug Combinations; Humans; Irinotecan; Leucovorin; Male; Neoadjuvant Therapy; Neoplasm Invasiveness; Pelvic Neoplasms; Quality of Life; Rectal Neoplasms; Tegafur; Uracil

2007
[A case of advanced gastric cancer responding remarkably to neo-adjuvant combination chemotherapy using CPT-11 plus S-1].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2007, Volume: 34, Issue:9

    Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Drug Combinations; Female; Humans; Irinotecan; Lymphatic Metastasis; Neoadjuvant Therapy; Neoplasm Invasiveness; Oxonic Acid; Stomach Neoplasms; Tegafur; Tomography, X-Ray Computed

2007
[Neoadjuvant chemotherapy with combination of S-1 and CPT-11 in advanced rectal cancer - a case report].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2007, Volume: 34, Issue:10

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemotherapy, Adjuvant; Drug Combinations; Humans; Irinotecan; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Invasiveness; Oxonic Acid; Rectal Neoplasms; Tegafur

2007
4-[3,5-Bis(trimethylsilyl)benzamido] benzoic acid (TAC-101) inhibits the intrahepatic spread of hepatocellular carcinoma and prolongs the life-span of tumor-bearing animals.
    Clinical & experimental metastasis, 1998, Volume: 16, Issue:7

    Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Benzoates; Body Weight; Camptothecin; Carcinoma, Hepatocellular; Fluorouracil; Humans; Irinotecan; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Mice; Mice, Nude; Molecular Structure; Neoplasm Invasiveness; Proto-Oncogene Proteins c-met; Receptors, Retinoic Acid; Reverse Transcriptase Polymerase Chain Reaction; Specific Pathogen-Free Organisms; Survival Rate; Trimethylsilyl Compounds; Tumor Cells, Cultured

1998
Inhibitory effect of berberine on the mediastinal lymph node metastasis produced by orthotopic implantation of Lewis lung carcinoma.
    Cancer letters, 2001, Apr-10, Volume: 165, Issue:1

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Berberine; Camptothecin; Carcinoma, Lewis Lung; Disease Models, Animal; Female; Irinotecan; Lung Neoplasms; Lymphatic Metastasis; Mediastinal Neoplasms; Mice; Mice, Inbred C57BL; Neoplasm Invasiveness; Neoplasm Transplantation; Transcription Factor AP-1

2001
[A case of hepatic metastasis from rectal carcinoma successfully treated with pharmacokinetic modulating chemotherapy (PMC)-CPT-11 therapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2002, Volume: 29, Issue:3

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Camptothecin; Combined Modality Therapy; Drug Administration Schedule; Female; Fluorouracil; Hepatic Artery; Humans; Hysterectomy; Infusions, Intra-Arterial; Infusions, Intravenous; Irinotecan; Liver Neoplasms; Middle Aged; Neoplasm Invasiveness; Rectal Neoplasms; Sigmoid Neoplasms

2002