irinotecan has been researched along with Innate Inflammatory Response in 29 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (13.79) | 29.6817 |
| 2010's | 13 (44.83) | 24.3611 |
| 2020's | 12 (41.38) | 2.80 |
| Authors | Studies |
|---|---|
| Ávila, TV; do Nascimento Arifa, RD; Fagundes, CT; Machado, AMV; Menezes-Garcia, Z; Soriani, FM; Souza, DG; Teixeira, MM | 1 |
| Ahmad, U; Anthoney, A; Appleyard, J; Collinson, F; Damyanova, I; Dawood, M; Hubner, RA; Kamposioras, K; Lamarca, A; McNamara, MG; Papaxoinis, G; Pihlak, R; Razzaq, B; Valle, JW; Wright, F | 1 |
| Chityala, PK; Ghose, R; Li, L; Lin, Z; Tao, G | 1 |
| Bowen, JM; Coller, JK; Prestidge, CA; Tam, JSY | 1 |
| Marsh, DT; Smid, SD | 1 |
| Huang, K; Huang, Y; Jin, H; Li, M; Tan, B; Wang, J; Yin, Y; Yuan, D | 1 |
| Chen, X; Han, W; Li, Y; Shi, L; Wan, J; Wang, H; Xie, B | 1 |
| Huang, H; Jiang, W; Jinbo, M; Wang, H; Wang, X; Yu, P; Zhang, G; Zhang, X | 1 |
| Chityala, PK; Chow, DS; Ghose, R; Wu, L | 1 |
| Al Thaalibi, M; McQuade, RM; Nurgali, K | 1 |
| Cheng, Y; Fu, C; Hu, Y; Wang, D; Wu, Y; Yang, X; Yang, Y; Zhang, J | 1 |
| Dobi, A; Gasque, P; Guiraud, P; Selambarom, J | 1 |
| Bharali, MK; Borah, G | 1 |
| Collado, MC; Forsgård, RA; Frias, R; Korpela, K; Korpela, R; Marrachelli, VG; Monleon, D; Österlund, P; Spillmann, T | 1 |
| Almeida, PRC; Câmara, LMC; Cândido, AGF; Falcão, RB; Fernandes, C; Lima-Júnior, RCP; Muniz, HA; Silva, CMS; Souza, MHLP; Souza, NRP; Teixeira, MA; Wanderley, CWS | 1 |
| Alencar, NMN; Assef, ANB; Batista, GLP; Borges, LPC; Cajado, AG; Cunha, FQ; Cunha, TM; Figueira, ACM; González, RH; Leite, CAVG; Lima, JB; Lima-Júnior, RCP; Ribeiro-Filho, HV; Silva, KO; Wanderley, CWS; Wilke, DV; Wong, DVT | 1 |
| Doherty, GA; Lee, CS; Ryan, EJ | 1 |
| Cereda, V; Cunningham, D; Ferroni, P; Formica, V; Guadagni, F; Luccchetti, J; Nardecchia, A; Roselli, M; Smyth, EC; Tesauro, M | 1 |
| Matsui, H; Nagasaki, Y; Vong, LB; Yoshitomi, T | 1 |
| Alvarenga, EM; Araújo, AR; Araújo, TS; de C Brito, GA; Martins, CS; Medeiros, JV; Nogueira, KM; Pacífico, DM; Sousa, DP; Sousa, FB; Souza, EP; Souza, LK | 1 |
| Hazama, S; Iida, M; Inoue, Y; Kanekiyo, S; Nagano, H; Sakamoto, K; Suzuki, N; Takeda, S; Tokuhisa, Y; Tokumitsu, Y; Tomochika, S; Tsunedomi, R; Ueno, T; Yoshino, S | 1 |
| Bowen, JM; Gibson, RJ; Keefe, DM; Logan, RM; Sonis, ST; Stringer, AM | 1 |
| Bussom, S; Cheng, YC; Guan, F; Gullen, EA; Jiang, Z; Lam, W; Liu, SH; Zhang, W | 1 |
| Bedognetti, D; Bussom, S; Chen, J; Cheng, YC; Guan, F; Jiang, Z; Lam, W; Marincola, FM; Mark, Y; Quinn, C; Stroncek, DF; Wang, E; White, J; Zhao, Y | 1 |
| Arlt, A; Bauer, I; Ehlers, S; Geismann, C; Grage-Griebenow, E; Kruse, ML; Schäfer, H; Sebens, S | 1 |
| Gleyzer, N; Scarpulla, RC | 1 |
| Berrocal, DH; Gelpi, RJ; González, GE; Grinfeld, LR; Morales, C | 1 |
| Beale, PJ; Childs, A; Clarke, SJ; Read, JA; Smith, N; Volker, DH | 1 |
| Koitz, N; Roth, E; Schmuckenschlager, C; Strasser, EM; Unger-Manhart, N; Wessner, B | 1 |
2 review(s) available for irinotecan and Innate Inflammatory Response
| Article | Year |
|---|---|
Impact of chemotherapy-induced enteric nervous system toxicity on gastrointestinal mucositis.
Topics: Animals; Antineoplastic Agents; Cisplatin; Enteric Nervous System; Fluorouracil; Gastrointestinal Diseases; Humans; Inflammation; Irinotecan; Mucositis; Oxaliplatin; Vincristine | 2020 |
Gastro-intestinal toxicity of chemotherapeutics in colorectal cancer: the role of inflammation.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Camptothecin; Cell Death; Colorectal Neoplasms; Diarrhea; Disease Models, Animal; Fluorouracil; Gastrointestinal Diseases; Gastrointestinal Tract; Humans; Inflammation; Intestinal Mucosa; Irinotecan; Mucositis; Neoplasm Recurrence, Local; Organoplatinum Compounds; Oxaliplatin | 2014 |
1 trial(s) available for irinotecan and Innate Inflammatory Response
| Article | Year |
|---|---|
Nutrition intervention using an eicosapentaenoic acid (EPA)-containing supplement in patients with advanced colorectal cancer. Effects on nutritional and inflammatory status: a phase II trial.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Australia; Biomarkers; Body Composition; Camptothecin; Colorectal Neoplasms; Cytokines; Dietary Proteins; Dietary Supplements; Eicosapentaenoic Acid; Energy Intake; Female; Fluorouracil; Humans; Inflammation; Irinotecan; Leucovorin; Male; Malnutrition; Middle Aged; Nutritional Status; Nutritional Support; Phospholipids; Quality of Life; Treatment Outcome; Vitamin B Complex | 2007 |
26 other study(ies) available for irinotecan and Innate Inflammatory Response
| Article | Year |
|---|---|
Mitochondrial DNA as a Possible Ligand for TLR9 in Irinotecan-induced Small Intestinal Mucositis.
Topics: Animals; DNA, Mitochondrial; Inflammation; Irinotecan; Ligands; Mice; Mice, Knockout; Mucositis; NLR Family, Pyrin Domain-Containing 3 Protein; Toll-Like Receptor 9 | 2022 |
Markers of tumor inflammation as prognostic factors for overall survival in patients with advanced pancreatic cancer receiving first-line FOLFIRINOX chemotherapy.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Biomarkers; Fluorouracil; Humans; Inflammation; Irinotecan; Leucovorin; Oxaliplatin; Pancreatic Neoplasms; Prognosis; Retrospective Studies | 2022 |
Development of a physiologically based pharmacokinetic model to predict irinotecan disposition during inflammation.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Diarrhea; Glucuronosyltransferase; Inflammation; Irinotecan; Mice | 2022 |
Investigation of TLR4 Antagonists for Prevention of Intestinal Inflammation.
Topics: Animals; Humans; Inflammation; Interleukin-6; Interleukin-8; Irinotecan; Lipopolysaccharides; Mice; Mucositis; Toll-Like Receptor 4; U937 Cells | 2023 |
The semi-synthetic flavonoid 2',3',4'-trihydroxyflavone (2-D08) inhibits both SN-38- and cytokine-evoked increases in epithelial barrier permeability in an
Topics: Antioxidants; Caco-2 Cells; Cytokines; Flavonoids; Humans; Inflammation; Intestinal Mucosa; Irinotecan; Mucositis; Permeability; Quercetin | 2022 |
Vitamin A Ameliorated Irinotecan-Induced Diarrhea in a Piglet Model Involving Enteric Glia Modulation and Immune Cells Infiltration.
Topics: Animals; Diarrhea; Enteric Nervous System; Gliosis; Inflammation; Intestine, Small; Irinotecan; Neuroglia; Swine; Vitamin A | 2022 |
Orally Deliverable Nanotherapeutics for the Synergistic Treatment of Colitis-Associated Colorectal Cancer.
Topics: Administration, Oral; Animals; Apoptosis; Azoxymethane; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Colitis; Colorectal Neoplasms; Curcumin; Cytokines; Dextran Sulfate; Disease Models, Animal; Disease Progression; Drug Synergism; Female; Inflammation; Inflammation Mediators; Intestines; Irinotecan; Macrophages; Mice; Mice, Inbred C57BL; Nanoparticles; RAW 264.7 Cells | 2019 |
Ganciclovir reduces irinotecan-induced intestinal toxicity by inhibiting NLRP3 activation.
Topics: Animals; Antiviral Agents; Apoptosis; Biomarkers; Cell Proliferation; Colonic Neoplasms; Diarrhea; Ganciclovir; Gene Expression Regulation; Humans; Inflammation; Intestinal Diseases; Irinotecan; Male; Mice; Mice, Inbred BALB C; Mice, Nude; NLR Family, Pyrin Domain-Containing 3 Protein; Topoisomerase I Inhibitors; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2020 |
Effects of inflammation on irinotecan pharmacokinetics and development of a best-fit PK model.
Topics: Administration, Oral; Animals; Area Under Curve; Chromatography, High Pressure Liquid; Half-Life; Inflammation; Irinotecan; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Models, Theoretical; ROC Curve; Tandem Mass Spectrometry | 2020 |
Mechanisms of Gegen Qinlian Pill to ameliorate irinotecan-induced diarrhea investigated by the combination of serum pharmacochemistry and network pharmacology.
Topics: Animals; Body Weight; Diarrhea; Disease Models, Animal; Drugs, Chinese Herbal; Gastrointestinal Diseases; Gene Expression Regulation; Heme Oxygenase-1; Inflammation; Intestines; Irinotecan; Kelch-Like ECH-Associated Protein 1; Membrane Proteins; Metabolic Networks and Pathways; Mice; NF-E2-Related Factor 2; Oxidative Stress; Protective Agents; Tablets | 2021 |
Irinotecan (CPT-11) Canonical Anti-Cancer Drug Can also Modulate Antiviral and Pro-Inflammatory Responses of Primary Human Synovial Fibroblasts.
Topics: Alphavirus Infections; Antiviral Agents; Arthritis, Rheumatoid; Cytokines; Fibroblasts; Humans; Inflammation; Irinotecan; Primary Cell Culture; Synovial Membrane | 2021 |
Green tea catechins in combination with irinotecan attenuates tumorigenesis and treatment-associated toxicity in an inflammation-associated colon cancer mice model.
Topics: Animals; Carcinogenesis; Catechin; Colonic Neoplasms; Humans; Inflammation; Irinotecan; Mice; Tea | 2021 |
Chemotherapy-induced gastrointestinal toxicity is associated with changes in serum and urine metabolome and fecal microbiota in male Sprague-Dawley rats.
Topics: Animals; Antineoplastic Agents; Camptothecin; Feces; Fluorouracil; Gastrointestinal Diseases; Inflammation; Intestinal Mucosa; Irinotecan; Magnetic Resonance Spectroscopy; Male; Metabolome; Microbiota; Organoplatinum Compounds; Oxaliplatin; Permeability; Rats; Rats, Sprague-Dawley; RNA, Ribosomal, 16S; Severity of Illness Index | 2017 |
Role of regulatory T cells in irinotecan-induced intestinal mucositis.
Topics: Animals; Camptothecin; Cyclophosphamide; Cytokines; Diarrhea; Ileum; Inflammation; Intestinal Mucosa; Irinotecan; Mice; Mice, Inbred C57BL; Mucositis; Neutrophil Infiltration; Peroxidase; T-Lymphocytes, Regulatory; Th17 Cells | 2018 |
SN-38, the active metabolite of irinotecan, inhibits the acute inflammatory response by targeting toll-like receptor 4.
Topics: Animals; Humans; Inflammation; Irinotecan; Male; Mice; Toll-Like Receptor 4; Topoisomerase I Inhibitors | 2019 |
Systemic inflammation, as measured by the neutrophil/lymphocyte ratio, may have differential prognostic impact before and during treatment with fluorouracil, irinotecan and bevacizumab in metastatic colorectal cancer patients.
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Bevacizumab; Camptothecin; Colorectal Neoplasms; Female; Fluorouracil; Humans; Inflammation; Irinotecan; Kaplan-Meier Estimate; Leukocyte Count; Lymphocytes; Male; Middle Aged; Neutrophils; Prognosis; Retrospective Studies; ROC Curve | 2014 |
Development of an oral nanotherapeutics using redox nanoparticles for treatment of colitis-associated colon cancer.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Azoxymethane; Camptothecin; Cell Line, Tumor; Colitis; Colonic Neoplasms; Dextrans; Drug Delivery Systems; Drug Screening Assays, Antitumor; Endoscopy; Free Radical Scavengers; Inflammation; Irinotecan; Male; Mice; Mice, Inbred ICR; Nanomedicine; Nanoparticles; Neoplasms, Experimental; Nitrogen Oxides; Oxidation-Reduction; Reactive Oxygen Species; Sulfates | 2015 |
Carvacrol reduces irinotecan-induced intestinal mucositis through inhibition of inflammation and oxidative damage via TRPA1 receptor activation.
Topics: Animals; Antioxidants; Body Weight; Camptothecin; Cyclooxygenase 2; Cymenes; Female; Immunohistochemistry; Inflammation; Intestines; Irinotecan; Leukocyte Count; Mice; Molecular Docking Simulation; Monoterpenes; Mucositis; NF-kappa B; Oxidative Stress; Peroxidase; Survival Analysis; Transient Receptor Potential Channels; TRPA1 Cation Channel | 2016 |
Cetuximab strongly enhances immune cell infiltration into liver metastatic sites in colorectal cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Capecitabine; CD3 Complex; CD56 Antigen; CD8 Antigens; Cetuximab; Colorectal Neoplasms; Deoxycytidine; Female; Fluorouracil; Humans; Inflammation; Irinotecan; Leucovorin; Liver Neoplasms; Male; Middle Aged; Organoplatinum Compounds; Oxaloacetates | 2017 |
Serum levels of NFkappaB and pro-inflammatory cytokines following administration of mucotoxic drugs.
Topics: Animals; Antineoplastic Agents; Camptothecin; Cytokines; Epithelium; Female; Fluorouracil; Gastrointestinal Tract; Gene Expression Regulation; Inflammation; Interleukin-1beta; Interleukin-6; Irinotecan; Methotrexate; NF-kappa B; Rats; Tumor Necrosis Factor-alpha | 2008 |
The four-herb Chinese medicine PHY906 reduces chemotherapy-induced gastrointestinal toxicity.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; beta Catenin; Biomarkers, Tumor; Bromodeoxyuridine; Camptothecin; Cell Proliferation; DNA Damage; Drugs, Chinese Herbal; Gastrointestinal Tract; Glucuronidase; Humans; Inflammation; Irinotecan; Medicine, Chinese Traditional; Mice; Proliferating Cell Nuclear Antigen; Recovery of Function; Signal Transduction; Stem Cells; Transplantation, Homologous; Weight Loss; Wnt Proteins; Wnt3 Protein; Wnt3A Protein | 2010 |
Interaction of a traditional Chinese Medicine (PHY906) and CPT-11 on the inflammatory process in the tumor microenvironment.
Topics: Animals; Camptothecin; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Drug Interactions; Drugs, Chinese Herbal; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Immunity; Immunohistochemistry; Inflammation; Irinotecan; Liver; Macrophages; Medicine, Chinese Traditional; Mice; Organ Size; Polymerase Chain Reaction; Reproducibility of Results; RNA, Messenger; Signal Transduction; Spleen; Tumor Microenvironment | 2011 |
Inflammatory macrophages induce Nrf2 transcription factor-dependent proteasome activity in colonic NCM460 cells and thereby confer anti-apoptotic protection.
Topics: Apoptosis; Camptothecin; Cell Line; Coculture Techniques; Colon; Gene Expression Regulation, Enzymologic; Humans; Inflammation; Intracellular Space; Irinotecan; Macrophages; NF-E2-Related Factor 2; Proteasome Endopeptidase Complex; Reactive Oxygen Species; TNF-Related Apoptosis-Inducing Ligand | 2011 |
Activation of a PGC-1-related coactivator (PRC)-dependent inflammatory stress program linked to apoptosis and premature senescence.
Topics: Acetylcysteine; Antioxidants; Apoptosis; Camptothecin; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Line, Tumor; Cell Survival; Cellular Senescence; Cornified Envelope Proline-Rich Proteins; Gene Expression; Gene Knockdown Techniques; Histamine H1 Antagonists; Humans; Inflammation; Irinotecan; Kinetics; Meclizine; Oxidants; Oxidative Stress; Proto-Oncogene Proteins c-myc; Proton Ionophores; RNA, Small Interfering; Topoisomerase I Inhibitors; Transcription Factors; Transcriptional Activation; Vitamin K 3 | 2013 |
Irinotecan-eluting stents inhibited neointimal proliferation in hypercholesterolemic rabbit aortas.
Topics: Animals; Aorta, Abdominal; Atherosclerosis; Camptothecin; Cell Proliferation; Dietary Fats; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Carriers; Hypercholesterolemia; Inflammation; Irinotecan; Necrosis; Phosphorylcholine; Rabbits; Research Design; Stents; Tunica Intima | 2006 |
Green tea polyphenol administration partly ameliorates chemotherapy-induced side effects in the small intestine of mice.
Topics: Animals; Antineoplastic Agents; Camptothecin; Female; Flavonoids; Inflammation; Intestinal Mucosa; Intestine, Small; Irinotecan; Mice; Mice, Inbred BALB C; Oxidative Stress; Phenols; Polyphenols; Tea | 2007 |