Page last updated: 2024-08-24

irinotecan and Genetic Predisposition

irinotecan has been researched along with Genetic Predisposition in 43 studies

Research

Studies (43)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	17 (39.53)	29.6817
2010's	24 (55.81)	24.3611
2020's	2 (4.65)	2.80

Authors

Authors	Studies
Chen, W; Li, M; Sun, X; Wang, Z; Wei, H; Zou, X	1
Chovanec, M; Janega, P; Macák, D; Makovník, M; Mardiak, J; Mego, M; Pazderová, N; Rejleková, K; Urbán, V	1
Ma, R; Ma, X; Yang, G; Zhu, X	1
Hazama, S; Nagano, H; Oka, M; Okayama, N; Tsunedomi, R	1
Barnadas, A; Gallano, P; Páez, D; Riera, P; Salazar, J; Sebio, A; Tobeña, M; Virgili, AC	1
Cui, Y; Hu, M; Huang, F; Liang, L; Yang, Y; Zhong, Q; Zhou, M	1
Anon, B; Barin-le Guellec, C; Caulet, M; Godart, B; Guyetant, S; Lecomte, T; Orain, I; Ouaissi, M; Pages, JC; Perray, C; Regnault, D; Tallet, A	1
Jiménez Gordo, AM; López Gómez, M	1
De Marchis, ML; Ferroni, P; Formica, V; Guadagni, F; La Farina, F; Laudisi, A; Ludovici, G; Palmirotta, R; Peeters, M; Rolfo, C; Roselli, M; Russo, A	1
Chen, YJ; Chu, L; Fang, JM; Hu, F; Li, CY; Xu, Q; Zhang, X	1
Gillmore, R; Suarez Martinez-Falero, B	1
Ando, Y; Fujita, K; Ichikawa, W; Minamimura, K; Miyauchi, H; Morita, S; Moriwaki, T; Nakamura, M; Ohashi, Y; Okutani, Y; Sadahiro, S; Sakata, Y; Shinozaki, K; Sugihara, M; Sugiyama, T; Takahashi, T; Takii, Y; Tanaka, C; Tsuji, A; Uehara, K	1
Atasilp, C; Chamnanphon, M; Chansriwong, P; Puangpetch, A; Reungwetwattana, T; Sirachainan, E; Sukasem, C; Wongwaisayawan, S	1
Bateman, E; Bowen, JM; Campbell, JM; Keefe, DM; Peters, MD; Stephenson, MD	1
Akahane, T; Aoki, D; Hirasawa, A; Kataoka, F; Mushiroda, T; Nanki, Y; Nomura, H; Susumu, N; Tominaga, E; Yamagami, W; Yoshihama, T	1
Anthony, L	1
Akiyama, Y; Ando, Y; Araki, K; Endo, H; Fujita, K; Hirose, T; Ichikawa, W; Ishida, H; Kawara, K; Miya, T; Mizuno, K; Nagashima, F; Narabayashi, M; Sasaki, Y; Sugiyama, M; Sunakawa, Y; Yamamoto, W; Yamashita, K	1
Bradley, LA; Dotson, WD; Douglas, MP; Kolor, K; Palomaki, GE	1
Gurney, H; Mathijssen, RH	1
Chen, P; Das, S; Dolan, ME; Innocenti, F; Kroetz, DL; Ramírez, J; Ratain, MJ; Relling, M; Rosner, GL; Schuetz, E	1
Bellanger, A; Carpentier, C; Dehais, C; Delattre, JY; Granger, B; Guillevin, R; Hoang-Xuan, K; Laigle-Donadey, F; Marie, Y; Meng, Y; Mokhtari, K; Psimaras, D; Rousseau, A; Sanson, M; Sierra del Rio, M; Taillibert, S; Vincent, LA	1
James, E; Saif, MW; Waldron-Lynch, MG	1
Garcia-Bournissen, F; Ito, S; Kim, R; Nathan, PC; Sakaguchi, S; Schwarz, UI	1
Akcan, S; Artac, M; Bozcuk, H; Ozdogan, M; Pehlivan, M; Pehlivan, S; Savas, B; Sever, T	1
Chamberlain, MC	1
Furuya, K; Goto, T; Kato, M; Kikuchi, Y; Takano, M; Yoshikawa, T	1
de Jong, FA; Mathijssen, RH; Sleijfer, S; Sparreboom, A; van Daele, PL; van de Geijn, FE; van der Bol, JM; van Fessem, MA; van Schaik, RH; Verweij, J	1
Strassburg, CP	1
Fujikawa, K; Hazama, S; Kato, T; Kimura, H; Kobayashi, M; Mishima, H; Nagata, N; Nozawa, H; Oba, K; Okuyama, Y; Sakamoto, J; Takahashi, K	1
Arbitrio, M; Cannataro, M; Caraglia, M; Ciliberto, D; Di Martino, MT; Doldo, P; Fabiani, F; Guzzi, PH; Leone, E; Rotundo, MS; Sperlongano, P; Tagliaferri, P; Talarico, D; Tassone, P; Tomaino, V	1
Crea, F; Cremolini, C; Danesi, R; Falcone, A; Farrar, WL; Fornaro, L; Frumento, P; Graziano, F; Loupakis, F; Masi, G; Paolicchi, E; Ricci, V; Ronzoni, M; Salvatore, L; Schirripa, M	1
Lee, PL; Sung, C; Tan, LL; Toh, DS	1
Albanes, D; Baris, D; Black, A; Burdett, L; Carrato, A; Chanock, SJ; Chatterjee, N; De Vivo, I; Diver, WR; Figueroa, JD; Fraumeni, JF; Fu, YP; Gapstur, SM; Garcia-Closas, M; Garcia-Closas, R; Hall, JL; Hunter, DJ; Hutchinson, A; Jacobs, EJ; Johnson, A; Karagas, MR; Kogevinas, M; Liu, L; Lloreta, J; Malats, N; Myers, T; Porter-Gill, P; Prokunina-Olsson, L; Purdue, MP; Rothman, N; Schned, A; Schwenn, M; Serra, C; Silverman, DT; Tang, W; Tardón, A; Thun, M; Virtamo, J	1
Etoh, T; Hayashi, H; Inoue, K; Itoh, K; Kawamura, Y; Kikuyama, M; Kimura, M; Matsumura, T; Minami, S; Sonobe, M; Suzuki, T; Takagi, M; Tsuji, D; Utsuki, H; Yamazaki, T	1
Hazama, S; Hinoda, Y; Oka, M	1
Du, J; Feng, G; He, L; Li, X; Qin, S; Wang, L; Xing, Q; Xu, L; Xu, M; Yu, L; Zhang, A	1
Hahn, KK; Kolesar, JM; Wolff, JJ	1
Higa, GM	1
Albritton, K; Crews, KR; Furman, WL; McNall-Knapp, RY; Pappo, AS; Rodriguez-Galindo, C; Stewart, CF; Wagner, LM	1
Chowbay, B; Goh, BC; Jada, SR; Lee, SC; Lim, R; Shu, X; Wong, CI; Zhou, Q	1
Erichsen, TJ; Heinemann, V; Lankisch, TO; Manns, MP; Schulz, C; Strassburg, CP; Zwingers, T	1
Bao, HY; Jiao, SC; Li, F; Li, J; Shen, L; Song, ST; Wang, JW; Wang, Y; Xu, JM; Xu, N; Yang, L; Zhang, JS	1

Reviews

12 review(s) available for irinotecan and Genetic Predisposition

Article	Year
Association of UGT1A16 polymorphism with irinotecan-based chemotherapy reaction in colorectal cancer patients: a systematic review and a meta-analysis. Bioscience reports, 2020, 10-30, Volume: 40, Issue:10* Topics: Colorectal Neoplasms; Diarrhea; Genetic Predisposition to Disease; Glucuronosyltransferase; Humans; Irinotecan; Neutropenia; Pharmacogenetics; Pharmacogenomic Variants; Polymorphism, Genetic; Risk Assessment; Risk Factors; Topoisomerase I Inhibitors; Treatment Outcome	2020
UGT1A16 and UGT1A128 polymorphisms are correlated with irinotecan-induced toxicity: A meta-analysis. Asia-Pacific journal of clinical oncology, 2018, Volume: 14, Issue:5 Topics: Antineoplastic Agents; Diarrhea; Female; Genetic Predisposition to Disease; Genotype; Glucuronosyltransferase; Humans; Irinotecan; Male; Middle Aged; Neoplasms; Neutropenia; Polymorphism, Single Nucleotide	2018
Nowadays pancreatic cancer prognosis. Medicina clinica, 2019, 05-17, Volume: 152, Issue:10 Topics: Aged; Aged, 80 and over; Albumin-Bound Paclitaxel; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Comorbidity; Deoxycytidine; Diabetes Mellitus; Diet; Drug Resistance, Neoplasm; Early Detection of Cancer; Fluorouracil; Gemcitabine; Genetic Predisposition to Disease; Humans; Irinotecan; Leucovorin; Neoadjuvant Therapy; Neoplasm Metastasis; Oxaliplatin; Palliative Care; Pancreatectomy; Pancreatic Neoplasms; Poly(ADP-ribose) Polymerase Inhibitors; Prognosis; Radiosurgery; Risk Factors; Spain	2019
The association of UGT1A16 and UGT1A128 with irinotecan-induced neutropenia in Asians: a meta-analysis. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 2014, Volume: 19, Issue:1 Topics: Antineoplastic Agents, Phytogenic; Asian People; Camptothecin; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Glucuronosyltransferase; Humans; Irinotecan; Neutropenia; Polymorphism, Genetic; Risk	2014
Irinotecan-induced toxicity pharmacogenetics: an umbrella review of systematic reviews and meta-analyses. The pharmacogenomics journal, 2017, Volume: 17, Issue:1 Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Diarrhea; Genetic Predisposition to Disease; Glucuronosyltransferase; Heterozygote; Homozygote; Humans; Irinotecan; Meta-Analysis as Topic; Neutropenia; Odds Ratio; Pharmacogenetics; Pharmacogenomic Testing; Pharmacogenomic Variants; Phenotype; Polymorphism, Single Nucleotide; Predictive Value of Tests; Reproducibility of Results; Risk Assessment; Risk Factors; Systematic Reviews as Topic; Treatment Outcome	2017
Irinotecan toxicity. Current opinion in supportive and palliative care, 2007, Volume: 1, Issue:1 Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Diarrhea; ErbB Receptors; Genetic Predisposition to Disease; Humans; Irinotecan; Neutropenia	2007
Can UGT1A1 genotyping reduce morbidity and mortality in patients with metastatic colorectal cancer treated with irinotecan? An evidence-based review. Genetics in medicine : official journal of the American College of Medical Genetics, 2009, Volume: 11, Issue:1 Topics: Camptothecin; Colorectal Neoplasms; Genetic Predisposition to Disease; Genetic Testing; Genotype; Glucuronosyltransferase; Humans; Irinotecan; Neoplasm Metastasis; Polymorphism, Single Nucleotide	2009
Prolonged survival in a patient with BRCA2 associated metastatic pancreatic cancer after exposure to camptothecin: a case report and review of literature. Anti-cancer drugs, 2009, Volume: 20, Issue:7 Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Drug Resistance, Neoplasm; Genes, BRCA2; Genetic Predisposition to Disease; Humans; Irinotecan; Male; Neoplasm Metastasis; Pancreatic Neoplasms; Survival Rate	2009
Hyperbilirubinemia syndromes (Gilbert-Meulengracht, Crigler-Najjar, Dubin-Johnson, and Rotor syndrome). Best practice & research. Clinical gastroenterology, 2010, Volume: 24, Issue:5 Topics: Animals; Antineoplastic Agents, Phytogenic; Bilirubin; Camptothecin; Crigler-Najjar Syndrome; Diagnosis, Differential; Genetic Predisposition to Disease; Genetic Variation; Gilbert Disease; Glucuronosyltransferase; Humans; Hyperbilirubinemia, Hereditary; Irinotecan; Jaundice, Chronic Idiopathic; Neoplasms	2010
[Polymorphism in colorectal cancer]. Nihon rinsho. Japanese journal of clinical medicine, 2003, Volume: 61 Suppl 7 Topics: Antineoplastic Agents; Camptothecin; Colorectal Neoplasms; Fluorouracil; Genetic Predisposition to Disease; Humans; Irinotecan; Life Style; Matrix Metalloproteinase 1; Matrix Metalloproteinase 3; Neoplasm Invasiveness; Neoplasm Metastasis; Organoplatinum Compounds; Oxaliplatin; Pharmacogenetics; Polymorphism, Single Nucleotide; Prodrugs; Prognosis; Risk Factors	2003
Pharmacogenetics and irinotecan therapy. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2006, Nov-15, Volume: 63, Issue:22 Topics: Antineoplastic Agents; Bilirubin; Biomarkers; Camptothecin; Clinical Trials as Topic; Colorectal Neoplasms; Diarrhea; Drug Labeling; Genetic Predisposition to Disease; Genetic Testing; Genotype; Glucuronosyltransferase; Humans; Irinotecan; Neutropenia; Pharmacogenetics; Polymorphism, Genetic; Practice Guidelines as Topic; Risk Assessment	2006
Reducing irinotecan-associated diarrhea in children. Pediatric blood & cancer, 2008, Volume: 50, Issue:2 Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Cephalosporins; Child; Diarrhea; Genetic Predisposition to Disease; Humans; Irinotecan	2008

Trials

1 trial(s) available for irinotecan and Genetic Predisposition

Article	Year
Prospective phase II study of FOLFIRI for mCRC in Japan, including the analysis of UGT1A1 28/6 polymorphisms. Japanese journal of clinical oncology, 2011, Volume: 41, Issue:4 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Asian People; Camptothecin; Colorectal Neoplasms; Disease-Free Survival; Drug Administration Schedule; Female; Fluorouracil; Genetic Predisposition to Disease; Glucuronosyltransferase; Heterozygote; Homozygote; Humans; Irinotecan; Japan; Leucovorin; Male; Middle Aged; Neoplasm Staging; Neutropenia; Polymorphism, Single Nucleotide; Prospective Studies; Severity of Illness Index; Topoisomerase I Inhibitors; Treatment Outcome	2011

Article

Year

Prospective phase II study of FOLFIRI for mCRC in Japan, including the analysis of UGT1A1 28/6 polymorphisms.

Japanese journal of clinical oncology, 2011, Volume: 41, Issue:4

Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Asian People; Camptothecin; Colorectal Neoplasms; Disease-Free Survival; Drug Administration Schedule; Female; Fluorouracil; Genetic Predisposition to Disease; Glucuronosyltransferase; Heterozygote; Homozygote; Humans; Irinotecan; Japan; Leucovorin; Male; Middle Aged; Neoplasm Staging; Neutropenia; Polymorphism, Single Nucleotide; Prospective Studies; Severity of Illness Index; Topoisomerase I Inhibitors; Treatment Outcome

2011

Other Studies

30 other study(ies) available for irinotecan and Genetic Predisposition

Article	Year
Metastatic colorectal cancer and severe hypocalcemia following irinotecan administration in a patient with X-linked agammaglobulinemia: a case report. BMC medical genetics, 2019, 09-12, Volume: 20, Issue:1 Topics: Adult; Agammaglobulinaemia Tyrosine Kinase; Agammaglobulinemia; Asian People; ATP-Binding Cassette Transporters; B-Lymphocytes; Calcium Channels, L-Type; Capecitabine; Colorectal Neoplasms; Complement C6; Drug Monitoring; Drug Therapy; Exome Sequencing; Genetic Association Studies; Genetic Diseases, X-Linked; Genetic Predisposition to Disease; Humans; Hypocalcemia; Immunoglobulins; Irinotecan; Male; Mutation; Oxaliplatin; PAX3 Transcription Factor; Young Adult	2019
Complete Response to Chemotherapy in Metastatic Pancreatic Carcinoma Associated with Double Heterozygous Germline Mutation in BRCA2 and CHEK2 Genes - a Case Report. Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti, 2020,Spring, Volume: 33, Issue:3 Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; BRCA2 Protein; Checkpoint Kinase 2; Female; Fluorouracil; Genes, BRCA2; Genetic Predisposition to Disease; Germ-Line Mutation; Humans; Irinotecan; Leucovorin; Male; Middle Aged; Oxaliplatin; Pancreatic Neoplasms; Pedigree	2020
Rapid and sensitive detection of UGT1A1 polymorphisms associated with irinotecan toxicity by a novel DNA microarray. Cancer science, 2017, Volume: 108, Issue:7 Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Colorectal Neoplasms; Genetic Predisposition to Disease; Genetic Testing; Genotype; Glucuronosyltransferase; Humans; Irinotecan; Oligonucleotide Array Sequence Analysis; Polymorphism, Single Nucleotide	2017
Relevance of CYP3A420, UGT1A137 and UGT1A128 variants in irinotecan-induced severe toxicity. British journal of clinical pharmacology, 2018, Volume: 84, Issue:6* Topics: Aged; Asthenia; Colorectal Neoplasms; Cytochrome P-450 CYP3A; Diarrhea; Female; Gene Frequency; Genetic Predisposition to Disease; Glucuronosyltransferase; Heterozygote; Humans; Irinotecan; Male; Neutropenia; Pharmacogenomic Variants; Phenotype; Risk Factors; Severity of Illness Index; Topoisomerase I Inhibitors	2018
A study of the association between UGT1A128 variant allele of UGT1A1 gene and colonic phenotype of sporadic colorectal cancer. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2019, Volume: 51, Issue:4* Topics: Adult; Aged; Aged, 80 and over; Alleles; Colorectal Neoplasms; Female; France; Genetic Predisposition to Disease; Glucuronosyltransferase; Heterozygote; Homozygote; Humans; Irinotecan; Male; Middle Aged; Phenotype; Polymorphism, Genetic; Promoter Regions, Genetic; Retrospective Studies; Tertiary Care Centers	2019
TNF-α gene promoter polymorphisms and risk of venous thromboembolism in gastrointestinal cancer patients undergoing chemotherapy. Annals of oncology : official journal of the European Society for Medical Oncology, 2013, Volume: 24, Issue:10 Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Camptothecin; Case-Control Studies; Female; Fluorouracil; Gastrointestinal Neoplasms; Genetic Predisposition to Disease; Haplotypes; Humans; Irinotecan; Male; Middle Aged; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Retrospective Studies; Risk; Tumor Necrosis Factor-alpha; Venous Thromboembolism	2013
A rare cause of susceptibility to neutropenic sepsis in a patient with metastatic pancreas cancer. BMJ case reports, 2014, Apr-03, Volume: 2014 Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemotherapy-Induced Febrile Neutropenia; Dihydrouracil Dehydrogenase (NADP); Female; Fluorouracil; Genetic Predisposition to Disease; Humans; Irinotecan; Mutation; Organoplatinum Compounds; Oxaliplatin; Pancreatic Neoplasms; Peritoneal Neoplasms; Sepsis	2014
An internally and externally validated nomogram for predicting the risk of irinotecan-induced severe neutropenia in advanced colorectal cancer patients. British journal of cancer, 2015, May-12, Volume: 112, Issue:10 Topics: Aged; Alleles; Asian People; Bilirubin; Camptothecin; Colorectal Neoplasms; Female; Genetic Predisposition to Disease; Genotype; Glucuronosyltransferase; Humans; Irinotecan; Male; Middle Aged; Neutropenia; Neutrophils; Nomograms; Prospective Studies	2015
Correlation of UGT1A1()28 and ()6 polymorphisms with irinotecan-induced neutropenia in Thai colorectal cancer patients. Drug metabolism and pharmacokinetics, 2016, Volume: 31, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Asian People; Camptothecin; Colorectal Neoplasms; Female; Genetic Predisposition to Disease; Genotype; Glucuronosyltransferase; Humans; Irinotecan; Male; Middle Aged; Neutropenia; Polymorphism, Genetic; Risk; Thailand	2016
UGT1A1 polymorphism as a prognostic indicator of stage I ovarian clear cell carcinoma patients treated with irinotecan. Japanese journal of clinical oncology, 2017, 02-04, Volume: 47, Issue:2 Topics: Adult; Antineoplastic Agents, Phytogenic; Camptothecin; Disease-Free Survival; Female; Genetic Predisposition to Disease; Glucuronosyltransferase; Humans; Irinotecan; Middle Aged; Neoplasm Staging; Ovarian Neoplasms; Polymorphism, Genetic; Prognosis	2017
Genetic testing for UGT1A128 and 6 in Japanese patients who receive irinotecan chemotherapy. Annals of oncology : official journal of the European Society for Medical Oncology, 2008, Volume: 19, Issue:12 Topics: Antineoplastic Agents, Phytogenic; Asian People; Camptothecin; Female; Genetic Predisposition to Disease; Glucuronosyltransferase; Humans; Irinotecan; Male; Neoplasms; Polymorphism, Genetic	2008
Recommendations from the EGAPP Working Group: can UGT1A1 genotyping reduce morbidity and mortality in patients with metastatic colorectal cancer treated with irinotecan? Genetics in medicine : official journal of the American College of Medical Genetics, 2009, Volume: 11, Issue:1 Topics: Camptothecin; Colorectal Neoplasms; Genetic Predisposition to Disease; Genetic Testing; Genotype; Glucuronosyltransferase; Humans; Irinotecan; Models, Biological; Neoplasm Metastasis; Neutropenia	2009
Irinogenetics: how many stars are there in the sky? Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009, Jun-01, Volume: 27, Issue:16 Topics: Antineoplastic Agents, Phytogenic; Biotransformation; Camptothecin; Colorectal Neoplasms; Drug Administration Schedule; Genetic Predisposition to Disease; Glucuronosyltransferase; Hepatocyte Nuclear Factor 1-alpha; Humans; Irinotecan; Liver-Specific Organic Anion Transporter 1; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neutropenia; Organic Anion Transporters; Patient Selection; Phenotype; Polymorphism, Genetic; Risk Assessment; Risk Factors; Treatment Outcome	2009
Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009, Jun-01, Volume: 27, Issue:16 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Phytogenic; Bilirubin; Biotransformation; Camptothecin; Colorectal Neoplasms; Drug Administration Schedule; Female; Genetic Predisposition to Disease; Glucuronides; Glucuronosyltransferase; Hepatocyte Nuclear Factor 1-alpha; Humans; Irinotecan; Liver-Specific Organic Anion Transporter 1; Male; Middle Aged; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Multivariate Analysis; Neutropenia; Organic Anion Transporters; Patient Selection; Phenotype; Polymorphism, Genetic; Risk Assessment; Risk Factors; Treatment Outcome	2009
Bevacizumab and irinotecan for recurrent oligodendroglial tumors. Neurology, 2009, May-05, Volume: 72, Issue:18 Topics: Adult; Aged; Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Phytogenic; Bevacizumab; Brain Neoplasms; Camptothecin; Cerebral Hemorrhage; DNA Mutational Analysis; Female; Genetic Predisposition to Disease; Genetic Testing; Humans; Irinotecan; Male; Middle Aged; Neoplasm Recurrence, Local; Oligodendroglioma; Patient Compliance; Retrospective Studies; Survival Rate; Treatment Outcome; Young Adult	2009
Prolonged neutropenia after irinotecan-based chemotherapy in a child with polymorphisms of UGT1A1 and SLCO1B1. Archives of disease in childhood, 2009, Volume: 94, Issue:12 Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Child; Female; Genetic Predisposition to Disease; Glucuronosyltransferase; Humans; Irinotecan; Liver-Specific Organic Anion Transporter 1; Nasopharyngeal Neoplasms; Neutropenia; Organic Anion Transporters; Polymorphism, Single Nucleotide; Rhabdomyosarcoma, Alveolar	2009
The value of XPD and XRCC1 genotype polymorphisms to predict clinical outcome in metastatic colorectal carcinoma patients with irinotecan-based regimens. Journal of cancer research and clinical oncology, 2010, Volume: 136, Issue:6 Topics: Adenocarcinoma; Adult; Aged; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Camptothecin; Colorectal Neoplasms; DNA Repair; DNA-Binding Proteins; Female; Follow-Up Studies; Genetic Predisposition to Disease; Genotype; Humans; Irinotecan; Male; Middle Aged; Neoplasm Staging; Polymorphism, Single Nucleotide; Predictive Value of Tests; Prospective Studies; Survival Analysis; Treatment Outcome; X-ray Repair Cross Complementing Protein 1; Xeroderma Pigmentosum Group D Protein	2010
Bevacizumab and irinotecan for recurrent oligodendroglial tumors. Neurology, 2010, Jan-12, Volume: 74, Issue:2 Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Camptothecin; Chromosomes, Human, Pair 1; Genetic Predisposition to Disease; Genotype; Humans; Irinotecan; Mutation; Neoplasm Recurrence, Local; Oligodendroglioma; Survival Rate; Treatment Outcome	2010
Indispensability of UGT1A16 genotyping in Japanese cancer patients treated with irinotecan. International journal of clinical oncology, 2010, Volume: 15, Issue:2* Topics: Antineoplastic Agents, Phytogenic; Asian People; Camptothecin; Genetic Predisposition to Disease; Genotype; Glucuronosyltransferase; Humans; Irinotecan; Japan; Neoplasms; Neutropenia; Phenotype; Polymorphism, Genetic; Risk Assessment; Risk Factors; Severity of Illness Index	2010
Effects of mannose-binding lectin polymorphisms on irinotecan-induced febrile neutropenia. The oncologist, 2010, Volume: 15, Issue:10 Topics: Adult; Aged; Antineoplastic Agents, Phytogenic; Camptothecin; Female; Fever; Genetic Predisposition to Disease; Genotype; Haplotypes; Humans; Irinotecan; Male; Mannose-Binding Lectin; Middle Aged; Neoplasms; Neutropenia; Polymorphism, Genetic; Promoter Regions, Genetic	2010
Single nucleotide polymorphisms of ABCC5 and ABCG1 transporter genes correlate to irinotecan-associated gastrointestinal toxicity in colorectal cancer patients: a DMET microarray profiling study. Cancer biology & therapy, 2011, Nov-01, Volume: 12, Issue:9 Topics: Aged; Alleles; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily G, Member 1; ATP-Binding Cassette Transporters; Camptothecin; Colorectal Neoplasms; Female; Gastrointestinal Diseases; Genetic Predisposition to Disease; Genotype; Humans; Irinotecan; Male; Middle Aged; Multidrug Resistance-Associated Proteins; Oligonucleotide Array Sequence Analysis; Polymorphism, Single Nucleotide	2011
An EZH2 polymorphism is associated with clinical outcome in metastatic colorectal cancer patients. Annals of oncology : official journal of the European Society for Medical Oncology, 2012, Volume: 23, Issue:5 Topics: Adenocarcinoma; Adult; Aged; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colorectal Neoplasms; Disease-Free Survival; DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; Female; Fluorouracil; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Irinotecan; Leucovorin; Male; Middle Aged; Neoplasm Metastasis; Polycomb Repressive Complex 2; Polymorphism, Single Nucleotide; Prognosis; Retrospective Studies; Transcription Factors; Treatment Outcome	2012
Pharmacogenetic risk for adverse reactions to irinotecan in the major ethnic populations of Singapore: regulatory evaluation by the health sciences authority. Drug safety, 2011, Dec-01, Volume: 34, Issue:12 Topics: Alleles; Antineoplastic Agents, Phytogenic; Camptothecin; Ethnicity; Genetic Predisposition to Disease; Genetic Variation; Genotype; Humans; Irinotecan; Neutropenia; Pharmacogenetics; Risk Factors; Singapore	2011
Mapping of the UGT1A locus identifies an uncommon coding variant that affects mRNA expression and protects from bladder cancer. Human molecular genetics, 2012, Apr-15, Volume: 21, Issue:8 Topics: Camptothecin; Carcinogens; Case-Control Studies; Chromosome Mapping; Genetic Predisposition to Disease; Genome-Wide Association Study; Glucuronosyltransferase; Humans; Irinotecan; Liver; Phenotype; Polymorphism, Single Nucleotide; Protein Isoforms; Risk Factors; RNA, Messenger; Urinary Bladder; Urinary Bladder Neoplasms	2012
Polymorphisms of the UDP-glucuronosyl transferase 1A genes are associated with adverse events in cancer patients receiving irinotecan-based chemotherapy. The Tohoku journal of experimental medicine, 2013, Volume: 229, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Phytogenic; Camptothecin; Colonic Neoplasms; Diarrhea; Drug-Related Side Effects and Adverse Reactions; Female; Genetic Predisposition to Disease; Glucuronosyltransferase; Humans; Irinotecan; Isoenzymes; Lung Neoplasms; Male; Middle Aged; Neoplasms; Neutropenia; Pharmacogenetics; Polymorphism, Genetic; Stomach Neoplasms	2013
Intra-ethnic differences in genetic variants of the UGT-glucuronosyltransferase 1A1 gene in Chinese populations. The pharmacogenomics journal, 2007, Volume: 7, Issue:5 Topics: Adult; Antineoplastic Agents, Phytogenic; Asian People; Bilirubin; Bone Marrow Diseases; Camptothecin; China; Ethnicity; Exons; Female; Gastrointestinal Diseases; Gene Frequency; Genetic Predisposition to Disease; Glucuronosyltransferase; Haplotypes; Heterozygote; Homozygote; Humans; Hyperbilirubinemia; Irinotecan; Linkage Disequilibrium; Male; Middle Aged; Phenotype; Polymorphism, Genetic; Reference Values; TATA Box	2007
Searching for the Holy Grail of oncology. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2006, Nov-15, Volume: 63, Issue:22 Topics: Antineoplastic Agents; Camptothecin; Colonic Neoplasms; Diarrhea; Genetic Predisposition to Disease; Glucuronosyltransferase; Humans; Irinotecan; Neutropenia; Pharmacogenetics; Polymorphism, Single Nucleotide; Risk Assessment	2006
Role of UGT1A16, UGT1A128 and ABCG2 c.421C>A polymorphisms in irinotecan-induced neutropenia in Asian cancer patients. Cancer science, 2007, Volume: 98, Issue:9 Topics: Adult; Aged; Alleles; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Camptothecin; Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Female; Genetic Predisposition to Disease; Glucuronosyltransferase; Humans; India; Irinotecan; Lung Neoplasms; Malaysia; Male; Middle Aged; Neoplasm Proteins; Neutropenia; Polymorphism, Genetic; Singapore; Urogenital Neoplasms	2007
Gilbert's Syndrome and irinotecan toxicity: combination with UDP-glucuronosyltransferase 1A7 variants increases risk. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2008, Volume: 17, Issue:3 Topics: Alleles; Antineoplastic Agents, Phytogenic; Camptothecin; Chi-Square Distribution; Female; Genetic Predisposition to Disease; Genotype; Gilbert Disease; Glucuronosyltransferase; Haplotypes; Humans; Irinotecan; Male; Middle Aged; Polymorphism, Single Nucleotide; Risk; Statistics, Nonparametric	2008
[Polymorphisms of UGT1A gene and irinotecan toxicity in Chinese colorectal cancer patients]. Zhonghua zhong liu za zhi [Chinese journal of oncology], 2007, Volume: 29, Issue:12 Topics: Adult; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Asian People; Camptothecin; Case-Control Studies; China; Colorectal Neoplasms; Diarrhea; Fluorouracil; Genetic Predisposition to Disease; Genotype; Glucuronosyltransferase; Humans; Irinotecan; Neutropenia; Polymorphism, Genetic; Young Adult	2007