Page last updated: 2024-08-24

irinotecan and Disease Models, Animal

irinotecan has been researched along with Disease Models, Animal in 131 studies

Research

Studies (131)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	5 (3.82)	18.2507
2000's	29 (22.14)	29.6817
2010's	67 (51.15)	24.3611
2020's	30 (22.90)	2.80

Authors

Authors	Studies
Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV	1
Chen, D; Gao, F; Kan, S; Lu, C; Qian, Z; Yin, Y; Zhu, H	1
Bathe, O; Jacobs, R; Mazurak, VC; Monirujjaman, M; Nelson, R; Pant, A	1
Luo, D; Mackenzie, GG; Rodriguez Lanzi, C; Wei, R	1
Abi Jaoude, J; Delahoussaye, AM; Feng, N; Fowlkes, N; Fujimoto, TN; Garcia Garcia, CJ; Gay, JP; Green, M; Marszalek, J; Molkentine, J; Taniguchi, CM	1
Aoki, Y; Han, Q; Hoffman, RM; Hozumi, C; Kubota, Y; Masaki, N; Tsunoda, T; Yamamoto, J	1
Chen, G; Dan, M; Gao, X; Hu, X; Hui, X; Liu, B; Ouyang, P; Sun, Z; Yao, B; Yuan, C	1
Bowen, JM; Coller, JK; Crame, EE; Elz, AS; Prestidge, CA; Tam, JSY; Wignall, A	1
Abu, YF; Chen, C; Meng, J; Ramakrishnan, S; Roy, S; Tao, J; Xie, Y; Yan, Y; Zhang, Y; Zhou, Y	1
Chen, Y; Du, C; Jiang, X; Li, S; Luo, Y; Wang, Y; Wu, L; Xie, Y; Zhang, R	1
Chen, L; Chen, X; Feng, M; He, H; Lan, S; Wang, K; Zhu, Y; Zuo, D	1
Carrabotta, M; Cristalli, C; Donati, DM; Ferracin, M; Giusti, V; Ianzano, ML; Landuzzi, L; Lollini, PL; Magnani, M; Manara, MC; Nanni, P; Nicoletti, G; Palladini, A; Parra, A; Pasello, M; Picci, P; Righi, A; Ruzzi, F; Scotlandi, K	1
Durbin, AD; Ki, DH; Look, AT; Oppel, F	1
Abdul-Hadi, K; Brown, A; Guan, E; Wagoner, M; Yoneyama, T; Zhu, AZX	1
Chen, X; Han, W; Li, Y; Shi, L; Wan, J; Wang, H; Xie, B	1
Brenner, AJ; Chiou, J; Gruslova, A; Pandey, R; Tiziani, S	1
Fontaine, SD; Ghilu, S; Houghton, PJ; Kurmasheva, RT; Li, Q; Santi, DV; Zheng, S	1
Cong, Z; Lam, KS; Liao, YH; Ma, SQ; Yang, FF; Zhang, L	1
Abe, S; Hatano, A; Ikeda, Y; Izumi, T; Miyamoto, L; Okuno, H; Tsuchihashi, Y; Tsuchiya, K; Tsunematsu, H; Yamane, M; Yasuoka, T	1
An, H; Heo, JS; Hong, CP; Hong, E; Kang, JM; Kim, SJ; Lee, S; Ooshima, A; Park, J; Park, JO; Park, S; Park, SH	1
Azcarate-Peril, MA; Bailey, ST; Bhatt, AP; Biernat, KA; Bultman, SJ; Creekmore, BC; Darr, DB; Gharaibeh, RZ; Letertre, MM; Montgomery, SA; Pellock, SJ; Redinbo, MR; Roach, JM; Roques, JR; Sartor, RB; Swann, JR; Wallace, BD; Walton, WG; Wilson, ID	1
Gong, L; Gong, X; Hu, M; Liu, Z; Ruan, Y; Zhang, Q	1
Du, GH; Wang, L; Wang, R; Wang, SM; Wei, GY	1
Dreher, MR; Gates, VL; Gordon, AC; Harris, KR; Huang, X; Larson, AC; Lewandowski, RJ; Lyu, T; Omary, RA; Procissi, D; Salem, R; White, SB; Yang, Y; Zhang, Z	1
Eberle, KC; Hollingsworth, MA; Mehla, K; Mundry, CS; Singh, PK	1
Bhutiani, N; Chen, Y; Li, Y; Martin, RCG; Pandit, H; Pulliam, ZR; Shi, X; Tan, M; Yu, Y; Zheng, Q	1
Chen, L; Gu, Y; He, X; Hu, L; Li, Y; Liu, WT; Liu, X; Wang, C; Yang, X; Yu, Q; Zhang, C; Zhang, X	1
Belli, A; Fusco, R; Granata, V; Izzo, F; Palaia, R; Petrillo, A	1
Burnouf, PA; Chen, BM; Chen, CY; Dashnyam, P; Gao, S; Hsieh, TJ; Hsieh, WC; Kuo, YH; Lin, CH; Lin, HY; Lin, TC; Roffler, SR; Tu, Z; Yeh, LF	1
Balaguer-Lluna, L; Baulenas-Farres, M; Burgueño, V; Carcaboso, AM; Carrasco, R; Castañeda, A; Castillo-Ecija, H; Celis, V; Cruz, O; Cuadrado-Vilanova, M; Garraus, M; Gorostegui, M; Jimenez-Cabaco, A; Krauel, L; Lavarino, C; Manzanares, A; Monterrubio, C; Mora, J; Morales La Madrid, A; Muñoz-Aznar, O; Olaciregui, NG; Pascual-Pasto, G; Perez-Jaume, S; Resa-Pares, C; Salvador, N; Santa-Maria, V; Suñol, M; Torner, F; Vancells, M; Vicario, FJ; Vila-Ubach, M	1
Dai, XM; Hou, XY; Li, DT; Lv, B; Qin, SY; Wan, JB; Wang, D; Wang, O; Xu, DD; Xu, FG; Zhang, ZJ	1
Cheng, Y; Fu, C; Hu, Y; Wang, D; Wu, Y; Yang, X; Yang, Y; Zhang, J	1
Chen, YY; Duan, JA; Jiang, JQ; Kang, A; Qin, YF; Tang, YP; Tao, HJ; Yue, SJ; Zhou, GS	1
Allan, S; Byrne, JA; Cheung, L; Eden, GL; Flemming, CL; Fletcher, JI; Gamble, LD; Gifford, AJ; Haber, M; Hanssen, KM; Henderson, MJ; Murray, J; Norris, MD; Ruhle, M; Saletta, F; Schuetz, JD; Tan, A; Tivnan, A; Truong, AM; Valli, E; Yu, DMT	1
Ebadi, M; Field, CJ; Lehner, R; Mazurak, VC	1
Alferiev, I; Brodeur, GM; Chorny, M; Guan, P; Guerrero, DT; Kolla, V; Moorthy, GS; Nguyen, F	1
Bardeesy, N; Caravan, P; Erstad, DJ; Ferrone, CR; Fuchs, BC; Ghoshal, S; Graham-O'Regan, KA; Lanuti, M; Razavi, AA; Sojoodi, M; Tanabe, KK; Taylor, MS	1
Hatefi, A; Malekshah, OM; Nomani, A; Patel, N; Sarkar, S	1
Anbil, S; Hasan, T; Huang, HC; Liu, J; Mai, Z; Mallidi, S; Pigula, M	1
Dudenkova, VV; Lukina, MM; Shimolina, LE; Shirmanova, MV; Snopova, LB; Zagaynova, EV	1
Bowen, JM; Coller, JK; Fakiha, K; Gibson, RJ; Logan, RM	1
Bohnenberger, H; Farin, HF; Gerlach, K; Godavarthy, PS; Hoang, VT; Krause, DS; Llavona, P; Michels, BE; Müller-Kuller, U; Oehler, VG; Oellerich, T; Steiner, M; Verma, D; Voutsinas, JM; Wachter, A; Weissenberger, E; Zörnig, M	1
Hui, SC; Kang, C; Lang, HD; Mi, MT; Wang, XL; Yi, L; Zhang, Y; Zhou, M; Zhu, XH	1
Butler, R; Stringer, A; Sultani, M; Thorpe, D; Vanhoecke, B	1
Bouvet, M; Chawla, SP; Hayashi, K; Higuchi, T; Hoffman, RM; Igarashi, K; Kimura, H; Miwa, S; Miyake, K; Oshiro, H; Singh, SR; Sugisawa, N; Tsuchiya, H; Yamamoto, N	1
Gao, Y; Hao, K; Huang, W; Huang, Y; Jiao, Y; Liu, Y; Tian, Y; Wan, JB; Xu, F; Zhang, P; Zhang, Z	1
Lu, Y; Luo, Z; Ouyang, M; Wu, J; Yao, X; Zhang, W; Zhu, D	1
Chen, KW; Cheng, SX; Dong, X; Fan, JX; Pan, P; Zhang, XZ; Zheng, DW	1
Allen, TM; Anantha, M; Bally, MB; Dos Santos, N; Harasym, N; Hare, JI; Neijzen, RW; Waterhouse, DN; Webb, MS	1
Ebara, K; Ichimura, E; Miyakawa, Y; Miyazaki, O; Morino, T; Nagai, D; Nakajima, N; Okamoto, K; Onda, T; Sekine, K	1
Hasegawa, M; Hattori, S; Ide, H; Kikuchi, E; Miyajima, A; Oya, M; Yasumizu, Y	1
Boelsterli, UA; Mani, S; Redinbo, MR	1
D'Incalci, M; Grohar, PJ; Helman, LJ; Mendoza, A; Pommier, Y; Segars, LE; Yeung, C	1
Benković, V; Blažević, AS; Knežević, AH; Lisičić, D; Mihaljević, J; Oršolić, N; Ðikić, D	1
Chen, YL; Chiang, JH; Chueh, FS; Chung, JG; Hsueh, SC; Lee, CS; Lu, CC; Lu, HF; Yang, JS	1
Fujii, H; Horie, H; Inoue, T; Kotake, K; Miyakura, Y; Sato, F; Sugano, K; Tahara, M; Yasuda, Y	1
Doherty, GA; Lee, CS; Ryan, EJ	1
Ahmad, S; Kong, R; Liu, T; Phan, AT; Scott, JE; Williams, AL; Wong, ST; Yeh, LA; Zhao, H; Zhu, X	1
Hongeng, S; Manaspon, C; Nasongkla, N; Nittayacharn, P	1
Anantha, M; Bally, MB; Harasym, N; Manisali, I; Masin, D; Osooly, M; Ostlund, C; Santos, ND; Strutt, D; Sutherland, BW; Waterhouse, DN; Webb, MS; Wehbe, M	1
Aragão, KS; Costa, ML; de Almeida, PR; de Castro Brito, GA; de Mesquita Neto, JW; de Sá Grassi, L; de Souza, MH; Leite, LL; Lima-Júnior, RC; Marques-Neto, RD; Medeiros, RP; Nunes, LG; Ribeiro, RA	1
Al-Azri, AR; Bowen, JM; Gibson, RJ; Keefe, DM; Logan, RM; Stringer, AM	1
Hayashi, A; Higashi, Y; Hori, Y; Kishimoto, K; Maeda, N; Morii, E; Ohashi, F; Osuga, K; Tanaka, K; Tomiyama, N	1
Choi, KC; Kim, SU; Yi, BR	1
Alferiev, IS; Brodeur, GM; Chorny, M; Croucher, JL; Iyer, R; Kolla, V; Levy, RJ; Mangino, JL	1
Bellemann, N; Gnutzmann, DM; Gockner, TL; Kauczor, HU; Köhler, K; Kortes, N; Krone, D; Mechel, J; Mokry, T; Radeleff, BA; Schmitz, A; Sommer, CM; Stampfl, U	1
Hakamada, K; Hui, FM; Kijima, H; Kudo, D; Miura, T; Morohashi, S; Nanashima, N; Sawano, T; Shimizu, T; Tsuchida, S; Yamada, T	1
Chen, TC; Golden, EB; Gong, A; Hofman, FM; Howard, A; Jhaveri, N; Louie, SG; Schönthal, AH; Sivakumar, W; Torres, S; Vaikari, VP; Wang, W	1
Calderon, RI; Cruz, RE; Drummond, DC; Fitzgerald, JB; Hall, CP; Hindle, A; Kang, MH; Ko, W; Lee, JS; Makena, MR; Paz, N; Reynolds, CP; Song, MM; Triche, TJ; Wang, J	1
Frese, S; Frese-Schaper, M; Keil, A; Körner, M; Schmid, RA; Steiner, SK	1
Atyabi, F; Dinarvand, M; Dinarvand, R; Esmaeili, A; Kiani, M; Mirzaie, Z; Mirzazadeh, F; Soleimani, M	1
Bijman-Lagcher, W; de Bruin, RW; Huisman, SA; IJzermans, JN; Smits, R	1
Guo, GL; Schumacher, JD	1
Adkins, CE; Eldon, MA; Hoch, U; Hye, T; Lockman, PR; Mohammad, AS; Mohan, NK; Nounou, MI; Terrell-Hall, T	1
Arantes, RM; Bastos, RW; Cardoso, VN; Cartelle, CT; França, CS; Generoso, SV; Martins, FS; Moreira, LM; Neves, MJ; Nicoli, JR; Pedroso, SH; Vieira, AT	1
Bardelli, A; Bonaldi, T; Cancelliere, C; Conte, A; Cuomo, A; Di Fiore, PP; Magni, E; Penna, G; Pozzi, C; Ravenda, PS; Rescigno, M; Sigismund, S; Silvola, A; Spadoni, I; Zampino, MG	1
Cardillo, TM; Chang, CH; Goldenberg, DM; Liu, D; Wang, Y; Zalath, M	1
Dai, B; Fleming, JB; Kang, Y; Li, X; Perez, MVR; Pratt, M; Roife, D	1
Guo, B; Qian, SY; Sun, M; Yang, X; Zhang, Q	1
Huang, YC; Lee, WH; Liu, SC; Liu, SJ; Su, CH; Tseng, YY; Wang, YC; Yang, ST	1
Baumgart, JT; Edessa, LD; Helman, LJ; Heske, CM; Lee, S; Mendoza, A; Neckers, L; Proia, DA; Trepel, J	1
Krishnan, V; Liem, N; Peethala, PC; Subhash, VV; Tan, SH; Yan, FL; Yeo, MS; Yong, WP	1
Frese, S; Hall, SR; Herrmann, M; Keil, A; Körner, M; Schmid, RA	1
Carter, KA; Geng, J; Lovell, JF; Luo, D; Ortega, J; Razi, A; Shao, S	1
Aragão, KS; da Silveira Bitencourt, F; de Alencar, NM; de Castro Brito, GA; de Figueiredo, IS; de Freitas, AP; Lima-Júnior, RC; Luz, PB; Magalhães, PJ; Ramos, MV; Ribeiro, RA	1
Bosserhoff, A; Dietrich, P; Hellerbrand, C; Koch, A; Lee, S; Luehrmann, A; Mahli, A; Müller, M; Saugspier, M; Schulze-Luehrmann, J; Sommer, J; Thasler, R; Thasler, WE	1
Bernheim, J; Buchbut, D; Goldiner, I; Inbar, M; Ish-Shalom, M; Keizman, D; Klein, B; Konikoff, F; Leikin-Frenkel, A; Maimon, N	1
Baltes, S; Brinker, T; Freund, I; Lewis, AL; Nolte, I	1
Bankiewicz, KS; Berger, MS; Bringas, JR; Dickinson, PJ; Drummond, DC; Forsayeth, J; Higgins, RJ; Kirpotin, DB; Krauze, MT; Larson, RF; LeCouteur, RA; Noble, CO; Park, JW; Yamashita, Y	1
Becherini, P; Cilli, M; Emionite, L; Greenberger, LM; Horak, ID; Loi, M; Pastorino, F; Ponzoni, M; Ribatti, D; Sapra, P	1
Kenmotsu, H; Kinoshita, T; Koga, Y; Kuroda, J; Matsumura, Y; Ohkohchi, N; Takahashi, A; Yasunaga, M	1
Adachi, S; Hiraumi, Y; Itoh, K; Matsubara, H; Naka, N; Nakahata, T; Sano, K; Watanabe, K; Watanabe, M; Yoshioka, K; Yui, Y	1
Nirmala, P; Ramanathan, M	1
Al-Dasooqi, N; Bowen, JM; Gibson, RJ; Keefe, DM; Logan, RM; Stringer, AM	1
Cardillo, TM; Goldenberg, DM; Govindan, SV; Sharkey, RM; Trisal, P	1
Brito, GA; Cunha, FQ; Figueiredo, AA; Freitas, HC; Leite, CA; Lima-Júnior, RC; Marques-Neto, RD; Medeiros, RP; Melo, ML; Oriá, RB; Ribeiro, RA; Souza, MH; Vale, ML; Wong, DV	1
Balivada, S; Basel, MT; Bossmann, SH; Pyle, MM; Seo, GM; Shrestha, TB; Tamura, M; Troyer, DL	1
Hojo, K; Maekawa, R; Maki, H; Sawada, TY; Tanaka, H; Yoshioka, T	1
McLeod, HL; Watters, JW	1
Carano, RA; Koeppen, H; Ross, AL; Ross, J; Schwall, RH; Van Bruggen, N; Williams, SP	1
Morotomi, M; Nomoto, K; Takahashi, T	1
D'Haene, N; Darro, F; Gaussin, JF; Kiss, R; Mathieu, A; Penant, S; Remmelink, M; Salmon, I; Van Ginckel, R	1
Ahmad, I; Ali, S; Chien, PY; Lei, S; Sheikh, S; Zhang, A	1
Fujiwara, Y; Fukushima, S; Hirohashi, K; Lee, S; Morimura, K; Osugi, H; Suehiro, S; Takemura, M	1
Akbulut, H; Deisseroth, A; Maynard, J; Pizzorno, G; Tang, Y; Zhang, L	1
Cai, SR; Church, RD; Culverhouse, R; Garbow, JR; McLeod, HL; Shannon, WD; Zhang, W	1
Handa, O; Higashihara, H; Ishikawa, T; Kokura, S; Naito, Y; Nakabe, N; Sakamoto, N; Takagi, T; Yoshida, N; Yoshikawa, T	1
Kiselyov, A	1
Beck, S; Bourquin, C; Endres, S; Hartmann, G; Schreiber, S	1
Berrocal, DH; Gelpi, RJ; González, GE; Grinfeld, LR; Morales, C	1
Liang, H	1
Hasegawa, F; Komatsu, T; Nishio, K; Ochiya, T; Takeshita, F; Takigahira, M; Yanagihara, K	1
Butler, RN; Davidson, GP; Howarth, GS; Tooley, KL	1
Boelsterli, UA; Chan, E; Chan, SY; Duan, W; Ee, PL; Hu, ZP; Huang, M; Koh, HL; Sheu, FS; Wang, JC; Xu, AL; Yang, XX; Zhang, Q; Zhou, SF; Zhu, YZ	1
Gupta, AA; Pappo, AS	1
Aoyagi, Y; Enomoto, T; Nakajima, M; Noguchi, M; Oda, T; Ohkohchi, N; Satake, M; Sugiura, S	1
Azrak, RG; Cao, S; Combs, GF; Durrani, FA; Fakih, M; Pendyala, L; Prey, J; Rustum, YM; Smith, PF	1
Cao, S; Creaven, PJ; Durrani, FA; Iyer, RV; Javle, MM; Lawrence, DD; Noel, DC; Pendyala, L; Rustum, YM; Smith, PF	1
Chamberlain, MC; Chen, TC; Gupta, V; Hofman, FM; Liebes, LF; Samuelson, CG; Schönthal, AH; Su, YS	1
Brito, GA; Carvalho, SB; Cunha, FQ; Melo, ML; Ribeiro, RA; Silva, JV; Soares, PM; Soares, RC; Souza, MH; Vale, ML	1
Alvarez, E; Bowen, JM; Finnie, J; Gibson, RJ; Keefe, DM	1
Hamaguchi, T; Kano, Y; Kato, K; Koizumi, F; Matsumura, Y; Nakajima, TE; Shimada, Y; Shirao, K; Yamada, Y; Yasunaga, M	1
Greenberger, LM; Horak, ID; Kraft, P; Longley, C; Malaby, J; Mehlig, M; Sapra, P; Zhao, H	1
Tanaka, T; Umesaki, N; Utsunomiya, H; Utsunomiya, T	1
Danks, MK; Houghton, JA; Houghton, PJ; Luo, X; Stewart, CF; Thompson, J; Zamboni, WC	1
Cheshire, PJ; Houghton, JA; Houghton, PJ; Luo, X; Richmond, L; Stewart, CF; Thompson, J; Zamboni, WC	1
Black, JD; Cao, S; Rustum, YM; Troutt, AB	1
Chuang, N; Cohen, HW; O'Leary, JJ; Potmesil, M; Ren, CJ; Shapiro, RL	1
Gliniak, B; Le, T	1
Ikeda, T; Mitani, N; Murakami, K; Saiki, I; Yamaura, T	1
Blumenthal, RD; Goldenberg, DM; Lew, W; Modrak, DE; Rodriguez, MD	1

Reviews

6 review(s) available for irinotecan and Disease Models, Animal

Article	Year
Local and systemic immunosuppression in pancreatic cancer: Targeting the stalwarts in tumor's arsenal. Biochimica et biophysica acta. Reviews on cancer, 2020, Volume: 1874, Issue:1 Topics: Adaptive Immunity; Animals; Antineoplastic Agents, Immunological; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Cancer Vaccines; Carcinoma, Pancreatic Ductal; Chemotherapy, Adjuvant; Clinical Trials as Topic; Combined Modality Therapy; Disease Models, Animal; Disease-Free Survival; Fluorouracil; Humans; Immunity, Innate; Immunotherapy; Irinotecan; Leucovorin; Lymph Node Excision; Lymph Nodes; Mice; Mice, Transgenic; Neoadjuvant Therapy; Oxaliplatin; Pancreas; Pancreatectomy; Pancreatic Neoplasms; Spleen; Splenectomy; T-Lymphocytes; Transplantation, Autologous; Tumor Escape; Tumor Microenvironment; United States	2020
Understanding and modulating mammalian-microbial communication for improved human health. Annual review of pharmacology and toxicology, 2014, Volume: 54 Topics: Animals; Anti-Inflammatory Agents; Camptothecin; Disease Models, Animal; Enteritis; Eosinophilia; Gastritis; Gastrointestinal Tract; Glucuronidase; Humans; Irinotecan; Lipopolysaccharides; Mammals; Microbiota	2014
Gastro-intestinal toxicity of chemotherapeutics in colorectal cancer: the role of inflammation. World journal of gastroenterology, 2014, Apr-14, Volume: 20, Issue:14 Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Camptothecin; Cell Death; Colorectal Neoplasms; Diarrhea; Disease Models, Animal; Fluorouracil; Gastrointestinal Diseases; Gastrointestinal Tract; Humans; Inflammation; Intestinal Mucosa; Irinotecan; Mucositis; Neoplasm Recurrence, Local; Organoplatinum Compounds; Oxaliplatin	2014
Mechanistic review of drug-induced steatohepatitis. Toxicology and applied pharmacology, 2015, Nov-15, Volume: 289, Issue:1 Topics: Amiodarone; Animals; Camptothecin; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Fatty Liver; Hepatocytes; Humans; Irinotecan; Lipid Metabolism; Liver; Methotrexate; Mitochondria, Liver; Organoplatinum Compounds; Oxaliplatin; Perhexiline; Tamoxifen; Tetracycline; Valproic Acid	2015
Cancer pharmacogenomics: current and future applications. Biochimica et biophysica acta, 2003, Mar-17, Volume: 1603, Issue:2 Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Camptothecin; Dihydrouracil Dehydrogenase (NADP); Disease Models, Animal; DNA Adducts; DNA Repair; Fluorouracil; Glucuronosyltransferase; Glutathione Transferase; Humans; Irinotecan; Mercaptopurine; Methyltransferases; Neoplasms; Organoplatinum Compounds; Oxidoreductases; Pharmacogenetics; Polymorphism, Genetic; Thymidylate Synthase	2003
New drugs for the treatment of metastatic or refractory soft tissue sarcomas in children. Future oncology (London, England), 2006, Volume: 2, Issue:5 Topics: Animals; Camptothecin; Child; Disease Models, Animal; Drug Design; Enzyme Inhibitors; Humans; Irinotecan; Rhabdomyosarcoma; Sarcoma; Survival Rate; Topoisomerase I Inhibitors; Topotecan	2006

Trials

2 trial(s) available for irinotecan and Disease Models, Animal

Article	Year
Electrochemotherapy with Irreversible Electroporation and FOLFIRINOX Improves Survival in Murine Models of Pancreatic Adenocarcinoma. Annals of surgical oncology, 2020, Volume: 27, Issue:11 Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Deoxycytidine; Disease Models, Animal; Electrochemotherapy; Fluorouracil; Gemcitabine; Humans; Irinotecan; Leucovorin; Mice; Oxaliplatin; Pancreatic Neoplasms; Treatment Outcome	2020
Celecoxib and mucosal protection: translation from an animal model to a phase I clinical trial of celecoxib, irinotecan, and 5-fluorouracil. Clinical cancer research : an official journal of the American Association for Cancer Research, 2007, Feb-01, Volume: 13, Issue:3 Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Celecoxib; Colorectal Neoplasms; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Fluorouracil; Glucuronates; Humans; Intestinal Mucosa; Irinotecan; Leucovorin; Male; Maximum Tolerated Dose; Mucositis; Neoplasm Transplantation; Neoplasms, Experimental; Pyrazoles; Rats; Rats, Inbred F344; Sulfonamides	2007

Article

Year

Electrochemotherapy with Irreversible Electroporation and FOLFIRINOX Improves Survival in Murine Models of Pancreatic Adenocarcinoma.

Annals of surgical oncology, 2020, Volume: 27, Issue:11

Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Deoxycytidine; Disease Models, Animal; Electrochemotherapy; Fluorouracil; Gemcitabine; Humans; Irinotecan; Leucovorin; Mice; Oxaliplatin; Pancreatic Neoplasms; Treatment Outcome

2020

Celecoxib and mucosal protection: translation from an animal model to a phase I clinical trial of celecoxib, irinotecan, and 5-fluorouracil.

Clinical cancer research : an official journal of the American Association for Cancer Research, 2007, Feb-01, Volume: 13, Issue:3

Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Celecoxib; Colorectal Neoplasms; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Fluorouracil; Glucuronates; Humans; Intestinal Mucosa; Irinotecan; Leucovorin; Male; Maximum Tolerated Dose; Mucositis; Neoplasm Transplantation; Neoplasms, Experimental; Pyrazoles; Rats; Rats, Inbred F344; Sulfonamides

2007

Other Studies

123 other study(ies) available for irinotecan and Disease Models, Animal

Article	Year
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. Proceedings of the National Academy of Sciences of the United States of America, 2020, 12-08, Volume: 117, Issue:49 Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection	2020
Selenium-enriched Bifidobacterium longum DD98 attenuates irinotecan-induced intestinal and hepatic toxicity in vitro and in vivo. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 143 Topics: Animals; Bifidobacterium longum; Cell Line; Chemical and Drug Induced Liver Injury; Cytokines; Diarrhea; Disease Models, Animal; Feces; Gastrointestinal Microbiome; Inflammation Mediators; Intestines; Irinotecan; Liver; Mice, Inbred BALB C; Oxidative Stress; Probiotics; Rats; Selenium; Tight Junction Proteins; Weight Loss	2021
Alterations in hepatic fatty acids reveal depletion of total polyunsaturated fatty acids following irinotecan plus 5-fluorouracil treatment in an animal model of colorectal cancer. Prostaglandins, leukotrienes, and essential fatty acids, 2021, Volume: 174 Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Disease Models, Animal; Docosahexaenoic Acids; Fatty Acids, Omega-6; Fatty Liver; Female; Fluorouracil; Gene Expression; Irinotecan; Lipid Metabolism; Liver; Rats; Rats, Inbred F344; Signal Transduction; Topoisomerase I Inhibitors; Treatment Outcome; Triglycerides	2021
Phospho-Aspirin (MDC-22) inhibits pancreatic cancer growth in patient-derived tumor xenografts and KPC mice by targeting EGFR: Enhanced efficacy in combination with irinotecan. Neoplasia (New York, N.Y.), 2022, Volume: 24, Issue:2 Topics: Animals; Antineoplastic Agents; Aspirin; Disease Models, Animal; Drug Therapy, Combination; ErbB Receptors; Humans; Irinotecan; Mice; Pancreatic Neoplasms; Treatment Outcome; Xenograft Model Antitumor Assays	2022
Feasibility of administering human pancreatic cancer chemotherapy in a spontaneous pancreatic cancer mouse model. BMC cancer, 2022, Feb-16, Volume: 22, Issue:1 Topics: Albumins; Animals; Antineoplastic Combined Chemotherapy Protocols; Deoxycytidine; Disease Models, Animal; Feasibility Studies; Fluorouracil; Gemcitabine; Humans; Irinotecan; Leucovorin; Mice; Oxaliplatin; Paclitaxel; Pancreatic Neoplasms	2022
Stage IV Pancreatic Cancer Patient Treated With FOLFIRINOX Combined With Oral Methioninase: A Highly-Rare Case With Long-term Stable Disease. Anticancer research, 2022, Volume: 42, Issue:5 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; CA-19-9 Antigen; Carbon-Sulfur Lyases; Disease Models, Animal; Female; Fluorouracil; Humans; Irinotecan; Leucovorin; Methionine; Mice; Mice, Nude; Oxaliplatin; Pancreatic Neoplasms; Xenograft Model Antitumor Assays	2022
Selection of Payloads for Antibody-Drug Conjugates Targeting Ubiquitously Expressed Tumor-Associated Antigens: a Case Study. The AAPS journal, 2022, 05-27, Volume: 24, Issue:4 Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Humans; Immunoconjugates; Irinotecan; Pancreatic Neoplasms; Xenograft Model Antitumor Assays	2022
Effects of a novel toll-like receptor 4 antagonist IAXO-102 in a murine model of chemotherapy-induced gastrointestinal toxicity. Cancer chemotherapy and pharmacology, 2022, Volume: 90, Issue:3 Topics: Amino Sugars; Animals; Antineoplastic Agents; Disease Models, Animal; Glycolipids; Irinotecan; Mice; Mice, Inbred C57BL; Mucositis; Toll-Like Receptor 4	2022
Opioid-induced microbial dysbiosis disrupts irinotecan (CPT-11) metabolism and increases gastrointestinal toxicity in a murine model. British journal of pharmacology, 2023, Volume: 180, Issue:10 Topics: Analgesics, Opioid; Animals; Antineoplastic Agents, Phytogenic; Bacteria; Camptothecin; Disease Models, Animal; Dysbiosis; Glucuronidase; Humans; Irinotecan; Male; Mice; Mice, Inbred C57BL; Morphine Derivatives; Neoplasms; RNA, Ribosomal, 16S	2023
Synthesis and biological evaluation of novel SN38-glucose conjugate for colorectal cancer treatment. Bioorganic & medicinal chemistry letters, 2023, 02-01, Volume: 81 Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Colorectal Neoplasms; Disease Models, Animal; Drug Delivery Systems; Humans; Irinotecan	2023
Mesothelin-targeted CAR-T therapy combined with irinotecan for the treatment of solid cancer. Journal of cancer research and clinical oncology, 2023, Volume: 149, Issue:16 Topics: Animals; Cell Line, Tumor; Disease Models, Animal; GPI-Linked Proteins; Humans; Immunotherapy, Adoptive; Irinotecan; Mesothelin; Mice; Neoplasms; Receptors, Chimeric Antigen	2023
Bone sarcoma patient-derived xenografts are faithful and stable preclinical models for molecular and therapeutic investigations. Scientific reports, 2019, 08-21, Volume: 9, Issue:1 Topics: 12E7 Antigen; Animals; Antibodies; Antineoplastic Agents; Bone Neoplasms; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Humans; Irinotecan; Mice; Mice, Inbred NOD; Mice, SCID; Osteosarcoma; Sarcoma, Ewing; Transplantation, Heterologous; Tumor Cells, Cultured; Tumor Suppressor Protein p53	2019
Mechanisms underlying synergy between DNA topoisomerase I-targeted drugs and mTOR kinase inhibitors in NF1-associated malignant peripheral nerve sheath tumors. Oncogene, 2019, Volume: 38, Issue:39 Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Benzamides; Cell Cycle Proteins; Disease Models, Animal; Humans; Irinotecan; Morpholines; Nerve Sheath Neoplasms; Neurofibromatosis 1; Peripheral Nerves; Phosphorylation; Protein Kinase Inhibitors; Pyrimidines; Topoisomerase I Inhibitors; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays; Zebrafish	2019
A Citrulline-Based Translational Population System Toxicology Model for Gastrointestinal-Related Adverse Events Associated With Anticancer Treatments. CPT: pharmacometrics & systems pharmacology, 2019, Volume: 8, Issue:12 Topics: Animals; Antineoplastic Agents; Citrulline; Disease Models, Animal; Gastrointestinal Tract; Humans; Irinotecan; Rats; Toxicity Tests; Translational Research, Biomedical	2019
Orally Deliverable Nanotherapeutics for the Synergistic Treatment of Colitis-Associated Colorectal Cancer. Theranostics, 2019, Volume: 9, Issue:24 Topics: Administration, Oral; Animals; Apoptosis; Azoxymethane; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Colitis; Colorectal Neoplasms; Curcumin; Cytokines; Dextran Sulfate; Disease Models, Animal; Disease Progression; Drug Synergism; Female; Inflammation; Inflammation Mediators; Intestines; Irinotecan; Macrophages; Mice; Mice, Inbred C57BL; Nanoparticles; RAW 264.7 Cells	2019
Stable Isotope Dilution LC-HRMS Assay To Determine Free SN-38, Total SN-38, and SN-38G in a Tumor Xenograft Model after Intravenous Administration of Antibody-Drug Conjugate (Sacituzumab Govitecan). Analytical chemistry, 2020, 01-07, Volume: 92, Issue:1 Topics: Administration, Intravenous; Animals; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Chromatography, High Pressure Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Immunoconjugates; Indicator Dilution Techniques; Irinotecan; Mass Spectrometry; Mice; Mice, SCID; Molecular Structure; Neoplasms, Experimental	2020
Prospective use of the single-mouse experimental design for the evaluation of PLX038A. Cancer chemotherapy and pharmacology, 2020, Volume: 85, Issue:2 Topics: Animals; Antineoplastic Agents; Biomarkers, Tumor; Cell Line, Tumor; Disease Models, Animal; DNA Damage; Female; Irinotecan; Mice; Mice, SCID; Neoplasms; Prospective Studies; Research Design; Tumor Burden; Xenograft Model Antitumor Assays	2020
Size-Transformable Hyaluronan Stacked Self-Assembling Peptide Nanoparticles for Improved Transcellular Tumor Penetration and Photo-Chemo Combination Therapy. ACS nano, 2020, 02-25, Volume: 14, Issue:2 Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Survival; Combined Modality Therapy; Disease Models, Animal; Dopamine; Female; Folic Acid; Hyaluronic Acid; Indocyanine Green; Injections, Intravenous; Irinotecan; Male; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Nanoparticles; Optical Imaging; Particle Size; Peptides; Rats; Rats, Wistar; Surface Properties	2020
Novel Hydrophilic Camptothecin Derivatives Conjugated to Branched Glycerol Trimer Suppress Tumor Growth without Causing Diarrhea in Murine Xenograft Models of Human Lung Cancer. Molecular pharmaceutics, 2020, 04-06, Volume: 17, Issue:4 Topics: A549 Cells; Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Diarrhea; Disease Models, Animal; Glycerol; Heterografts; Humans; Hydrophobic and Hydrophilic Interactions; Irinotecan; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Microsomes, Liver; Rats, Sprague-Dawley; Xenograft Model Antitumor Assays	2020
Inhibition of TGF-β signalling in combination with nal-IRI plus 5-Fluorouracil/Leucovorin suppresses invasion and prolongs survival in pancreatic tumour mouse models. Scientific reports, 2020, 02-19, Volume: 10, Issue:1 Topics: Aniline Compounds; Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinogenesis; Cell Line, Tumor; Cell Movement; Disease Models, Animal; Drug Synergism; Epithelial-Mesenchymal Transition; Fluorouracil; Gene Expression Regulation, Neoplastic; Irinotecan; Leucovorin; Liposomes; Mice, Inbred C57BL; Nanoparticles; Neoplasm Invasiveness; Pancreatic Neoplasms; Signal Transduction; Survival Analysis; Transcriptome; Transforming Growth Factor beta; Triazoles; Tumor Stem Cell Assay; Up-Regulation	2020
Targeted inhibition of gut bacterial β-glucuronidase activity enhances anticancer drug efficacy. Proceedings of the National Academy of Sciences of the United States of America, 2020, 03-31, Volume: 117, Issue:13 Topics: Animals; Antineoplastic Agents, Phytogenic; Bacteria; Disease Models, Animal; Dysbiosis; Enzyme Inhibitors; Female; Gastrointestinal Microbiome; Glucuronidase; Humans; Irinotecan; Mice; Mice, Nude; Neoplasms	2020
Chronic Alcohol Consumption Increased Bile Acid Levels in Enterohepatic Circulation and Reduced Efficacy of Irinotecan. Alcohol and alcoholism (Oxford, Oxfordshire), 2020, Apr-16, Volume: 55, Issue:3 Topics: Alcohol Drinking; Animals; Antineoplastic Agents; Bile Acids and Salts; Blotting, Western; Colon; Disease Models, Animal; Enterohepatic Circulation; Gallbladder; Irinotecan; Liver; Male; Mice	2020
Dihydrotanshinone attenuates chemotherapy-induced intestinal mucositis and alters fecal microbiota in mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020, Volume: 128 Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Bacteria; Colon; Diglycerides; Disease Models, Animal; Feces; Fluorouracil; Furans; Gastrointestinal Microbiome; Interleukin-6; Intestinal Mucosa; Irinotecan; Male; Mice, Inbred C57BL; Mucositis; Phenanthrenes; Quinones; Triglycerides; Tumor Necrosis Factor-alpha	2020
Feasibility of Combination Intra-arterial Yttrium-90 and Irinotecan Microspheres in the VX2 Rabbit Model. Cardiovascular and interventional radiology, 2020, Volume: 43, Issue:10 Topics: Animals; Antineoplastic Agents; Chemoembolization, Therapeutic; Disease Models, Animal; Dose-Response Relationship, Drug; Feasibility Studies; Irinotecan; Liver Neoplasms, Experimental; Magnetic Resonance Imaging; Microspheres; Necrosis; Rabbits; Yttrium Radioisotopes	2020
AMPK activation by ozone therapy inhibits tissue factor-triggered intestinal ischemia and ameliorates chemotherapeutic enteritis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2020, Volume: 34, Issue:9 Topics: Aged; AMP-Activated Protein Kinases; Animals; Disease Models, Animal; Enteritis; Female; Humans; Intestinal Mucosa; Irinotecan; Male; Mice; Middle Aged; Ozone; Reperfusion Injury; Thromboplastin	2020
Comments on "Electrochemotherapy with Irreversible Electroporation and FOLFIRINOX Improves Survival in Murine Models of Pancreatic Adenocarcinoma". Annals of surgical oncology, 2020, Volume: 27, Issue:Suppl 3 Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Disease Models, Animal; Electrochemotherapy; Electroporation; Fluorouracil; Humans; Irinotecan; Leucovorin; Mice; Oxaliplatin; Pancreatic Neoplasms	2020
Entropy-driven binding of gut bacterial β-glucuronidase inhibitors ameliorates irinotecan-induced toxicity. Communications biology, 2021, 03-04, Volume: 4, Issue:1 Topics: Animals; Bacteria; Cell Line; Colon; Diarrhea; Disease Models, Animal; Enzyme Inhibitors; Female; Gastrointestinal Microbiome; Glucuronidase; Humans; Imino Pyranoses; Irinotecan; Mice, Inbred BALB C; Uronic Acids	2021
Prognostic value of patient-derived xenograft engraftment in pediatric sarcomas. The journal of pathology. Clinical research, 2021, Volume: 7, Issue:4 Topics: Adolescent; Animals; Child; Child, Preschool; Disease Models, Animal; Female; Heterografts; Humans; Irinotecan; Male; Mice; Osteosarcoma; Prognosis; Rhabdomyosarcoma; Sarcoma; Sarcoma, Ewing; Treatment Outcome; Xenograft Model Antitumor Assays	2021
A four-component combination derived from Huang-Qin Decoction significantly enhances anticancer activity of irinotecan. Chinese journal of natural medicines, 2021, Volume: 19, Issue:5 Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Proliferation; Disease Models, Animal; Drugs, Chinese Herbal; HCT116 Cells; Humans; Irinotecan; Scutellaria baicalensis; Xenograft Model Antitumor Assays	2021
Mechanisms of Gegen Qinlian Pill to ameliorate irinotecan-induced diarrhea investigated by the combination of serum pharmacochemistry and network pharmacology. Journal of ethnopharmacology, 2021, Aug-10, Volume: 276 Topics: Animals; Body Weight; Diarrhea; Disease Models, Animal; Drugs, Chinese Herbal; Gastrointestinal Diseases; Gene Expression Regulation; Heme Oxygenase-1; Inflammation; Intestines; Irinotecan; Kelch-Like ECH-Associated Protein 1; Membrane Proteins; Metabolic Networks and Pathways; Mice; NF-E2-Related Factor 2; Oxidative Stress; Protective Agents; Tablets	2021
Total Flavonoids of Frontiers in immunology, 2021, Volume: 12 Topics: Animals; Anti-Inflammatory Agents; Bacteria; Colitis; Colon; Cytokines; Disease Models, Animal; Dysbiosis; Feces; Flavonoids; Gastrointestinal Microbiome; Glycyrrhiza uralensis; Inflammasomes; Inflammation Mediators; Irinotecan; Male; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein; Plant Extracts	2021
Suppression of the ATP-binding cassette transporter ABCC4 impairs neuroblastoma tumour growth and sensitises to irinotecan in vivo. European journal of cancer (Oxford, England : 1990), 2017, Volume: 83 Topics: Animals; Antineoplastic Agents, Phytogenic; Blotting, Western; Camptothecin; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Doxycycline; Heterografts; Irinotecan; Mice; Mice, Knockout; Multidrug Resistance-Associated Proteins; Neuroblastoma; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2017
Chemotherapy diminishes lipid storage capacity of adipose tissue in a preclinical model of colon cancer. Lipids in health and disease, 2017, Dec-19, Volume: 16, Issue:1 Topics: Adipocytes; Adipose Tissue; Animals; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Size; Colonic Neoplasms; Disease Models, Animal; Fatty Acids; Fatty Acids, Monounsaturated; Fatty Acids, Omega-3; Female; Fluorouracil; Humans; Irinotecan; Lipogenesis; Mitochondria; Mitochondrial Proteins; Phospholipids; Proteome; Rats; Rats, Inbred F344; Triglycerides	2017
Enhanced Intratumoral Delivery of SN38 as a Tocopherol Oxyacetate Prodrug Using Nanoparticles in a Neuroblastoma Xenograft Model. Clinical cancer research : an official journal of the American Association for Cancer Research, 2018, 06-01, Volume: 24, Issue:11 Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Disease Models, Animal; Drug Delivery Systems; Humans; Injections, Intralesional; Irinotecan; Mice; Nanoparticles; Neuroblastoma; Prodrugs; Recurrence; Retreatment; Survival Rate; Tissue Distribution; Tocopherols; Treatment Outcome; Tumor Burden; Xenograft Model Antitumor Assays	2018
Orthotopic and heterotopic murine models of pancreatic cancer and their different responses to FOLFIRINOX chemotherapy. Disease models & mechanisms, 2018, 07-30, Volume: 11, Issue:7 Topics: Adenocarcinoma; Allografts; Animals; Antineoplastic Combined Chemotherapy Protocols; Autografts; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Drug Combinations; Fluorouracil; Humans; Irinotecan; Kinetics; Leucovorin; Male; Mice, Inbred C57BL; Organometallic Compounds; Oxaliplatin; Pancreatic Neoplasms; Phenotype; Transplantation, Heterotopic	2018
A novel chemotherapeutic protocol for peritoneal metastasis and inhibition of relapse in drug resistant ovarian cancer. Cancer medicine, 2018, Volume: 7, Issue:8 Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Irinotecan; Mice; Neoplastic Stem Cells; Oligopeptides; Ovarian Neoplasms; Peritoneal Neoplasms; Spheroids, Cellular; Treatment Outcome; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2018
Size-dependent Tumor Response to Photodynamic Therapy and Irinotecan Monotherapies Revealed by Longitudinal Ultrasound Monitoring in an Orthotopic Pancreatic Cancer Model. Photochemistry and photobiology, 2019, Volume: 95, Issue:1 Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Disease Models, Animal; Humans; Irinotecan; Male; Mice; Mice, Nude; Pancreatic Neoplasms; Photochemotherapy; Reproducibility of Results; Topoisomerase I Inhibitors; Ultrasonography; Xenograft Model Antitumor Assays	2019
In vivo metabolic and SHG imaging for monitoring of tumor response to chemotherapy. Cytometry. Part A : the journal of the International Society for Analytical Cytology, 2019, Volume: 95, Issue:1 Topics: Animals; Antineoplastic Agents; Biomarkers, Tumor; Cell Line, Tumor; Cisplatin; Collagen; Colorectal Neoplasms; Disease Models, Animal; Female; Irinotecan; Mice; Mice, Inbred BALB C; Microscopy, Fluorescence, Multiphoton; NADP; Paclitaxel; Second Harmonic Generation Microscopy	2019
Amitriptyline prevents CPT-11-induced early-onset diarrhea and colonic apoptosis without reducing overall gastrointestinal damage in a rat model of mucositis. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2019, Volume: 27, Issue:6 Topics: Amitriptyline; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Colon; Diarrhea; Disease Models, Animal; Irinotecan; Male; Mucositis; Rats; Rats, Wistar	2019
The transcriptional regulator FUBP1 influences disease outcome in murine and human myeloid leukemia. Leukemia, 2019, Volume: 33, Issue:7 Topics: Animals; Apoptosis; Bone Marrow Transplantation; Cell Cycle; Disease Models, Animal; DNA Damage; DNA-Binding Proteins; Humans; Irinotecan; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Mice; Mice, Inbred C57BL; RNA-Binding Proteins; Topoisomerase I Inhibitors; Tumor Cells, Cultured	2019
Synergy between dihydromyricetin intervention and irinotecan chemotherapy delays the progression of colon cancer in mouse models. Food & function, 2019, Apr-17, Volume: 10, Issue:4 Topics: Animals; Chloride Channels; Colonic Neoplasms; Disease Models, Animal; Disease Progression; Drug Synergism; Flavonols; Humans; Irinotecan; Male; Mice; Mice, Inbred C57BL; Mitochondrial Proteins	2019
Irinotecan-Induced Mucositis Is Associated with Goblet Cell Dysregulation and Neural Cell Damage in a Tumour Bearing DA Rat Model. Pathology oncology research : POR, 2020, Volume: 26, Issue:2 Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Enteric Nervous System; Female; Goblet Cells; Intestinal Mucosa; Irinotecan; Mucositis; Neoplasms, Experimental; Neurons; Rats	2020
Trabectedin and irinotecan combination regresses a cisplatinum-resistant osteosarcoma in a patient-derived orthotopic xenograft nude-mouse model. Biochemical and biophysical research communications, 2019, May-28, Volume: 513, Issue:2 Topics: Adolescent; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Disease Models, Animal; Drug Resistance, Neoplasm; Drug Synergism; Humans; Irinotecan; Male; Mice, Nude; Osteosarcoma; Topoisomerase I Inhibitors; Trabectedin	2019
An extendable all-in-one injection twin derivatization LC-MS/MS strategy for the absolute quantification of multiple chemical-group-based submetabolomes. Analytica chimica acta, 2019, Jul-31, Volume: 1063 Topics: Amino Acids; Animals; Bile Acids and Salts; Chromatography, Liquid; Disease Models, Animal; Fatty Acids, Nonesterified; Gastrointestinal Tract; Indoles; Irinotecan; Metabolomics; Polyamines; Rats; Tandem Mass Spectrometry	2019
Protective effect of curcumin against irinotecan‑induced intestinal mucosal injury via attenuation of NF‑κB activation, oxidative stress and endoplasmic reticulum stress. International journal of oncology, 2019, Volume: 54, Issue:4 Topics: Animals; Apoptosis; Cell Line; Colorectal Neoplasms; Curcumin; Diarrhea; Disease Models, Animal; Drug Evaluation, Preclinical; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Epithelial Cells; Humans; Injections, Intraperitoneal; Intestinal Mucosa; Irinotecan; Male; Mice; Mice, Inbred BALB C; Mice, Nude; NF-kappa B; Oxidative Stress; Rats; Signal Transduction; Topoisomerase I Inhibitors; Treatment Outcome	2019
Phage-guided modulation of the gut microbiota of mouse models of colorectal cancer augments their responses to chemotherapy. Nature biomedical engineering, 2019, Volume: 3, Issue:9 Topics: Animals; Antineoplastic Agents; Bacteria; Bacteriophages; Butyrates; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Colorectal Neoplasms; Dextrans; Disease Models, Animal; Drug Therapy; Fusobacterium nucleatum; Gastrointestinal Microbiome; Immunoglobulins; Irinotecan; Male; Mice; Mice, Inbred C57BL; Nanoparticles	2019
Treatment of colorectal cancer using a combination of liposomal irinotecan (Irinophore C™) and 5-fluorouracil. PloS one, 2013, Volume: 8, Issue:4 Topics: Animals; Camptothecin; Cell Line, Tumor; Colorectal Neoplasms; Disease Models, Animal; Drug Combinations; Female; Fluorouracil; HT29 Cells; Humans; Irinotecan; Liposomes; Male; Mice; Tumor Burden	2013
Antimyeloma activity of NK012, a micelle-forming macromolecular prodrug of SN-38, in an orthotopic model. International journal of cancer, 2014, Jan-01, Volume: 134, Issue:1 Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Humans; Irinotecan; Mice; Mice, Inbred NOD; Mice, SCID; Micelles; Multiple Myeloma; Prodrugs; Xenograft Model Antitumor Assays	2014
Therapeutic enhancement of S-1 with CPT-11 through down-regulation of thymidylate synthase in bladder cancer. Cancer medicine, 2013, Volume: 2, Issue:4 Topics: Animals; Camptothecin; Cell Line, Tumor; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Drug Combinations; Drug Resistance, Neoplasm; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; Humans; Irinotecan; Mice; Mice, Nude; Oxonic Acid; RNA Interference; RNA, Small Interfering; Tegafur; Thymidylate Synthase; Urinary Bladder Neoplasms; Xenograft Model Antitumor Assays	2013
Dual targeting of EWS-FLI1 activity and the associated DNA damage response with trabectedin and SN38 synergistically inhibits Ewing sarcoma cell growth. Clinical cancer research : an official journal of the American Association for Cancer Research, 2014, Mar-01, Volume: 20, Issue:5 Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Dioxoles; Disease Models, Animal; DNA Breaks, Double-Stranded; DNA Damage; Doxorubicin; Drug Resistance, Neoplasm; Drug Synergism; Exodeoxyribonucleases; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Irinotecan; Mice; Oncogene Proteins, Fusion; Phenotype; Proto-Oncogene Protein c-fli-1; RecQ Helicases; RNA Interference; RNA-Binding Protein EWS; RNA, Small Interfering; Sarcoma, Ewing; Tetrahydroisoquinolines; Trabectedin; Werner Syndrome Helicase; Xenograft Model Antitumor Assays	2014
Addition of propolis to irinotecan therapy prolongs survival in ehrlich ascites tumor-bearing mice. Cancer biotherapy & radiopharmaceuticals, 2014, Volume: 29, Issue:2 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoma, Ehrlich Tumor; Cell Growth Processes; Disease Models, Animal; Drug Synergism; Irinotecan; Male; Mice; Propolis; Survival Analysis	2014
Antitumor effects with apoptotic death in human promyelocytic leukemia HL-60 cells and suppression of leukemia xenograft tumor growth by irinotecan HCl. Environmental toxicology, 2015, Volume: 30, Issue:7 Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; Camptothecin; Caspase 3; Cell Cycle Proteins; Disease Models, Animal; DNA Damage; Endoplasmic Reticulum Chaperone BiP; G1 Phase Cell Cycle Checkpoints; HL-60 Cells; Humans; Irinotecan; Leukemia, Promyelocytic, Acute; Male; Membrane Potential, Mitochondrial; Mice; Mice, Inbred BALB C; Mice, Nude; Microscopy, Confocal; Transplantation, Heterologous	2015
The use of Olaparib (AZD2281) potentiates SN-38 cytotoxicity in colon cancer cells by indirect inhibition of Rad51-mediated repair of DNA double-strand breaks. Molecular cancer therapeutics, 2014, Volume: 13, Issue:5 Topics: Animals; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; Disease Models, Animal; DNA Breaks, Double-Stranded; DNA Mismatch Repair; DNA Repair; Drug Resistance, Neoplasm; Drug Synergism; Gene Expression Profiling; Gene Knockdown Techniques; Humans; Irinotecan; Mice; Phthalazines; Piperazines; Poly(ADP-ribose) Polymerases; Rad51 Recombinase; Tumor Burden; Xenograft Model Antitumor Assays	2014
Old drug new use--amoxapine and its metabolites as potent bacterial β-glucuronidase inhibitors for alleviating cancer drug toxicity. Clinical cancer research : an official journal of the American Association for Cancer Research, 2014, Jul-01, Volume: 20, Issue:13 Topics: Amoxapine; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Female; Glycoproteins; Irinotecan; Mice; Molecular Conformation; Molecular Docking Simulation; Molecular Dynamics Simulation; Neoplasms; Protective Agents; Protein Binding; Xenograft Model Antitumor Assays	2014
HPLC analysis and extraction method of SN-38 in brain tumor model after injected by polymeric drug delivery system. Experimental biology and medicine (Maywood, N.J.), 2014, Volume: 239, Issue:12 Topics: Animals; Antineoplastic Agents, Phytogenic; Brain Neoplasms; Camptothecin; Chromatography, High Pressure Liquid; Disease Models, Animal; Drug Delivery Systems; Irinotecan; Mice, Nude; Polymers	2014
Irinophore C™, a lipid nanoparticle formulation of irinotecan, abrogates the gastrointestinal effects of irinotecan in a rat model of clinical toxicities. Investigational new drugs, 2014, Volume: 32, Issue:6 Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Camptothecin; Cholesterol; Colon; Diarrhea; Disease Models, Animal; Drug Therapy, Combination; Female; Fluorouracil; Intestine, Small; Irinotecan; Liposomes; Nanoparticles; Phosphatidylcholines; Rats, Sprague-Dawley	2014
Chemotherapy-associated steatohepatitis induced by irinotecan: a novel animal model. Cancer chemotherapy and pharmacology, 2014, Volume: 74, Issue:4 Topics: Alanine Transaminase; Animals; Antineoplastic Agents, Phytogenic; Aspartate Aminotransferases; Camptothecin; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Fatty Liver; Humans; Interleukin-1beta; Irinotecan; Liver; Male; Mice; Peroxidase; Time Factors; Tumor Necrosis Factor-alpha; Weight Loss	2014
Involvement of matrix metalloproteinases (MMP-3 and MMP-9) in the pathogenesis of irinotecan-induced oral mucositis. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2015, Volume: 44, Issue:6 Topics: Analysis of Variance; Animals; Atrophy; Camptothecin; Disease Models, Animal; Female; Immunohistochemistry; Irinotecan; Matrix Metalloproteinase 3; Matrix Metalloproteinase 9; Mouth Mucosa; Random Allocation; Rats; Stomatitis; Tongue	2015
In vivo evaluation of irinotecan-loaded QuadraSphere microspheres for use in chemoembolization of VX2 liver tumors. Journal of vascular and interventional radiology : JVIR, 2014, Volume: 25, Issue:11 Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Chemoembolization, Therapeutic; Disease Models, Animal; Female; Irinotecan; Liver Neoplasms, Experimental; Microspheres; Rabbits; Tomography, X-Ray Computed; Treatment Outcome	2014
Co-treatment with therapeutic neural stem cells expressing carboxyl esterase and CPT-11 inhibit growth of primary and metastatic lung cancers in mice. Oncotarget, 2014, Dec-30, Volume: 5, Issue:24 Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Carboxylesterase; Cell Growth Processes; Cell Line, Tumor; Disease Models, Animal; Humans; Irinotecan; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Metastasis; Neural Stem Cells; Random Allocation; Xenograft Model Antitumor Assays	2014
Nanoparticle delivery of an SN38 conjugate is more effective than irinotecan in a mouse model of neuroblastoma. Cancer letters, 2015, May-01, Volume: 360, Issue:2 Topics: Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Line, Tumor; Disease Models, Animal; Humans; Irinotecan; Mice; Mice, Nude; Nanoparticles; Neuroblastoma; Prodrugs; Tissue Distribution; Xenograft Model Antitumor Assays	2015
Evaluation of the plasmatic and parenchymal elution kinetics of two different irinotecan-loaded drug-eluting embolics in a pig model. Journal of vascular and interventional radiology : JVIR, 2015, Volume: 26, Issue:5 Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Chemoembolization, Therapeutic; Disease Models, Animal; Female; Irinotecan; Liver Neoplasms; Swine	2015
Fatty acid synthase-positive hepatocytes and subsequent steatosis in rat livers by irinotecan. Oncology reports, 2015, Volume: 33, Issue:5 Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Disease Models, Animal; Fatty Acid Synthases; Fatty Liver; Hepatocytes; Immunohistochemistry; Irinotecan; Liver; Male; Oligonucleotide Array Sequence Analysis; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction	2015
Effects of convection-enhanced delivery of bevacizumab on survival of glioma-bearing animals. Neurosurgical focus, 2015, Volume: 38, Issue:3 Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents, Phytogenic; Bevacizumab; Brain Neoplasms; Camptothecin; Cell Line, Tumor; Dendritic Cells; Disease Models, Animal; Drug Delivery Systems; Drug Therapy, Combination; Glioma; Humans; Irinotecan; Mice; Platelet Endothelial Cell Adhesion Molecule-1; Time Factors; Xenograft Model Antitumor Assays	2015
Activity of MM-398, nanoliposomal irinotecan (nal-IRI), in Ewing's family tumor xenografts is associated with high exposure of tumor to drug and high SLFN11 expression. Clinical cancer research : an official journal of the American Association for Cancer Research, 2015, Mar-01, Volume: 21, Issue:5 Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Disease Models, Animal; Drug Combinations; Female; Gene Expression; Humans; Irinotecan; Liposomes; Macrophages; Mice; Nuclear Proteins; Sarcoma, Ewing; Sucrose; Tissue Distribution; Tumor Burden; Xenograft Model Antitumor Assays	2015
The Topoisomerase I Inhibitor Irinotecan and the Tyrosyl-DNA Phosphodiesterase 1 Inhibitor Furamidine Synergistically Suppress Murine Lupus Nephritis. Arthritis & rheumatology (Hoboken, N.J.), 2015, Volume: 67, Issue:7 Topics: Animals; Benzamidines; Camptothecin; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Enzyme Inhibitors; Female; Immunomodulation; Irinotecan; Lupus Nephritis; Mice; Mice, Inbred NZB; Phosphoric Diester Hydrolases; Topoisomerase I Inhibitors; Treatment Outcome	2015
Oral delivery of nanoparticles containing anticancer SN38 and hSET1 antisense for dual therapy of colon cancer. International journal of biological macromolecules, 2015, Volume: 78 Topics: Administration, Oral; Animals; Camptothecin; Cell Line, Tumor; Chitosan; Colonic Neoplasms; Disease Models, Animal; Drug Carriers; Drug Liberation; Drug Stability; Histone-Lysine N-Methyltransferase; Humans; Irinotecan; Mice; Nanoparticles; Oligonucleotides, Antisense; Spectroscopy, Fourier Transform Infrared; Xenograft Model Antitumor Assays	2015
Fasting protects against the side effects of irinotecan but preserves its anti-tumor effect in Apc15lox mutant mice. Cell cycle (Georgetown, Tex.), 2015, Volume: 14, Issue:14 Topics: Adenomatous Polyposis Coli Protein; Animals; Camptothecin; Cell Proliferation; Colorectal Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Disease Models, Animal; Fasting; G2 Phase Cell Cycle Checkpoints; Irinotecan; Mice; Mice, Inbred C57BL; Mice, Knockout; S Phase Cell Cycle Checkpoints; Topoisomerase I Inhibitors	2015
NKTR-102 Efficacy versus irinotecan in a mouse model of brain metastases of breast cancer. BMC cancer, 2015, Oct-13, Volume: 15 Topics: Animals; Antineoplastic Agents, Phytogenic; Blood-Brain Barrier; Brain; Brain Neoplasms; Breast Neoplasms; Camptothecin; Cell Line, Tumor; Disease Models, Animal; Drug Monitoring; Female; Humans; Irinotecan; Luminescent Measurements; Mice; Molecular Structure; Permeability; Tumor Burden; Xenograft Model Antitumor Assays	2015
Saccharomyces cerevisiae UFMG A-905 treatment reduces intestinal damage in a murine model of irinotecan-induced mucositis. Beneficial microbes, 2016, Volume: 7, Issue:4 Topics: Animals; Camptothecin; Disease Models, Animal; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Irinotecan; Jejunum; Lipid Peroxidation; Male; Mice; Mucositis; Oxidative Stress; Probiotics; Saccharomyces cerevisiae; Weight Loss	2016
The EGFR-specific antibody cetuximab combined with chemotherapy triggers immunogenic cell death. Nature medicine, 2016, Volume: 22, Issue:6 Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Calreticulin; Camptothecin; Cell Death; Cell Line, Tumor; Cetuximab; Colorectal Neoplasms; Dendritic Cells; Disease Models, Animal; Endoplasmic Reticulum Stress; Fluorouracil; HCT116 Cells; HT29 Cells; Humans; Indoles; Irinotecan; Leucovorin; Mice; Panitumumab; Phagocytosis; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins p21(ras); Pyridones; Pyrimidinones; Sulfonamides; Unfolded Protein Response; Vemurafenib; X-Box Binding Protein 1	2016
Combining ABCG2 Inhibitors with IMMU-132, an Anti-Trop-2 Antibody Conjugate of SN-38, Overcomes Resistance to SN-38 in Breast and Gastric Cancers. Molecular cancer therapeutics, 2016, Volume: 15, Issue:8 Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antigens, Neoplasm; ATP Binding Cassette Transporter, Subfamily G, Member 2; Breast Neoplasms; Camptothecin; Cell Adhesion Molecules; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Female; Flow Cytometry; Gene Expression; Humans; Immunoconjugates; Inhibitory Concentration 50; Irinotecan; Mice; Stomach Neoplasms; Xenograft Model Antitumor Assays	2016
Ex Vivo Testing of Patient-Derived Xenografts Mirrors the Clinical Outcome of Patients with Pancreatic Ductal Adenocarcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research, 2016, Dec-15, Volume: 22, Issue:24 Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Camptothecin; Carcinoma, Pancreatic Ductal; Deoxycytidine; Disease Models, Animal; Disease-Free Survival; Female; Gemcitabine; Heterografts; Humans; Irinotecan; Mice; Mice, Inbred NOD; Mice, Nude; Mice, SCID; Pancreatic Neoplasms; Retrospective Studies; Xenograft Model Antitumor Assays	2016
Vitamin D Enhances the Efficacy of Irinotecan through miR-627-Mediated Inhibition of Intratumoral Drug Metabolism. Molecular cancer therapeutics, 2016, Volume: 15, Issue:9 Topics: Animals; Camptothecin; Cell Line, Tumor; Cytochrome P-450 CYP3A; Disease Models, Animal; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; Irinotecan; Male; Mice; MicroRNAs; Neoplasms; Pharmacogenetics; RNA Interference; Vitamin D; Xenograft Model Antitumor Assays	2016
Advanced interstitial chemotherapy combined with targeted treatment of malignant glioma in rats by using drug-loaded nanofibrous membranes. Oncotarget, 2016, Sep-13, Volume: 7, Issue:37 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bibenzyls; Brain; Brain Neoplasms; Camptothecin; Cisplatin; Disease Models, Animal; Drug Delivery Systems; Ethylnitrosourea; Glioblastoma; Glioma; Humans; Irinotecan; Lactic Acid; Male; Nanofibers; Neurosurgical Procedures; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Rats, Wistar; Tumor Burden	2016
STA-8666, a novel HSP90 inhibitor/SN-38 drug conjugate, causes complete tumor regression in preclinical mouse models of pediatric sarcoma. Oncotarget, 2016, Oct-04, Volume: 7, Issue:40 Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Child; Disease Models, Animal; DNA Damage; Drug Evaluation, Preclinical; Female; HSP90 Heat-Shock Proteins; Humans; Irinotecan; Mice; Mice, Knockout; Mice, SCID; Resorcinols; Rhabdomyosarcoma; Sarcoma, Ewing; Topoisomerase I Inhibitors; Tumor Burden; Xenograft Model Antitumor Assays	2016
ATM Expression Predicts Veliparib and Irinotecan Sensitivity in Gastric Cancer by Mediating P53-Independent Regulation of Cell Cycle and Apoptosis. Molecular cancer therapeutics, 2016, Volume: 15, Issue:12 Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Ataxia Telangiectasia Mutated Proteins; Benzimidazoles; Camptothecin; Cell Cycle; Cell Line, Tumor; Disease Models, Animal; Drug Resistance, Neoplasm; Drug Synergism; Gene Expression; Histones; Humans; Inhibitory Concentration 50; Irinotecan; Oncogene Protein p21(ras); Phosphorylation; Proto-Oncogene Proteins; Stomach Neoplasms; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays	2016
Suppression of lupus nephritis and skin lesions in MRL/lpr mice by administration of the topoisomerase I inhibitor irinotecan. Arthritis research & therapy, 2016, 10-22, Volume: 18, Issue:1 Topics: Animals; Antibodies, Antinuclear; Camptothecin; Disease Models, Animal; DNA; Enzyme-Linked Immunosorbent Assay; Enzyme-Linked Immunospot Assay; Female; Flow Cytometry; Irinotecan; Kidney; Lupus Nephritis; Mice; Mice, Inbred MRL lpr; Random Allocation; Skin; Topoisomerase I Inhibitors	2016
Sphingomyelin Liposomes Containing Porphyrin-phospholipid for Irinotecan Chemophototherapy. Theranostics, 2016, Volume: 6, Issue:13 Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Disease Models, Animal; Drug Carriers; Heterografts; Infrared Rays; Irinotecan; Liposomes; Mice; Pancreatic Neoplasms; Phospholipids; Porphyrins; Sphingomyelins; Treatment Outcome	2016
Side-Effects of Irinotecan (CPT-11), the Clinically Used Drug for Colon Cancer Therapy, Are Eliminated in Experimental Animals Treated with Latex Proteins from Calotropis procera (Apocynaceae). Phytotherapy research : PTR, 2017, Volume: 31, Issue:2 Topics: Animals; Apocynaceae; Calotropis; Camptothecin; Colonic Neoplasms; Disease Models, Animal; Irinotecan; Latex; Male; Mice	2017
ERK activation and autophagy impairment are central mediators of irinotecan-induced steatohepatitis. Gut, 2018, Volume: 67, Issue:4 Topics: Animals; Antineoplastic Agents, Phytogenic; Autophagy; Camptothecin; Disease Models, Animal; Fatty Liver; Hepatocytes; Humans; In Vitro Techniques; Irinotecan; Liver Neoplasms; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Preoperative Care	2018
An animal model for chemotherapy-associated steatohepatitis and its prevention by the oral administration of fatty acid bile acid conjugate. Cancer, 2010, Jan-01, Volume: 116, Issue:1 Topics: Animals; Bile Acids and Salts; Camptothecin; Disease Models, Animal; Fatty Acids; Fatty Liver; Irinotecan; Mice; Mice, Inbred C57BL; Organoplatinum Compounds; Oxaliplatin	2010
Doxorubicin and irinotecan drug-eluting beads for treatment of glioma: a pilot study in a rat model. Journal of materials science. Materials in medicine, 2010, Volume: 21, Issue:4 Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Camptothecin; Disease Models, Animal; Doxorubicin; Drug Carriers; Drug Delivery Systems; Female; Glioma; Injections, Intralesional; Irinotecan; Male; Microspheres; Pilot Projects; Rats; Survival Analysis	2010
Canine spontaneous glioma: a translational model system for convection-enhanced delivery. Neuro-oncology, 2010, Volume: 12, Issue:9 Topics: Animals; Antineoplastic Agents, Phytogenic; Brain Neoplasms; Camptothecin; Convection; Disease Models, Animal; Dogs; Drug Delivery Systems; Glioma; Irinotecan; Liposomes; Magnetic Resonance Imaging; Nanoparticles	2010
Tumor regression and curability of preclinical neuroblastoma models by PEGylated SN38 (EZN-2208), a novel topoisomerase I inhibitor. Clinical cancer research : an official journal of the American Association for Cancer Research, 2010, Oct-01, Volume: 16, Issue:19 Topics: Animals; Antineoplastic Agents; Apoptosis; Camptothecin; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; DNA Topoisomerases, Type I; Drug Screening Assays, Antitumor; Female; Humans; Irinotecan; Mice; Mice, Nude; Neoplasms, Experimental; Neovascularization, Pathologic; Neuroblastoma; Polyethylene Glycols; Survival Rate; Topoisomerase I Inhibitors	2010
Detailed distribution of NK012, an SN-38-incorporating micelle, in the liver and its potent antitumor effects in mice bearing liver metastases. Clinical cancer research : an official journal of the American Association for Cancer Research, 2010, Oct-01, Volume: 16, Issue:19 Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Proliferation; Chromatography, High Pressure Liquid; Colonic Neoplasms; Disease Models, Animal; Humans; Irinotecan; Kaplan-Meier Estimate; Liver; Liver Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Micelles; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2010
Mesenchymal mode of migration participates in pulmonary metastasis of mouse osteosarcoma LM8. Clinical & experimental metastasis, 2010, Volume: 27, Issue:8 Topics: Animals; Camptothecin; cdc42 GTP-Binding Protein; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Models, Animal; Irinotecan; Lung Neoplasms; Mesoderm; Mice; Mice, Inbred C3H; Osteosarcoma; Signal Transduction	2010
Effect of kaempferol on lipid peroxidation and antioxidant status in 1,2-dimethyl hydrazine induced colorectal carcinoma in rats. European journal of pharmacology, 2011, Mar-01, Volume: 654, Issue:1 Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic; Antioxidants; Camptothecin; Colorectal Neoplasms; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Irinotecan; Kaempferols; Lipid Peroxidation; Male; Rats; Rats, Wistar; Species Specificity	2011
Selection of housekeeping genes for gene expression studies in a rat model of irinotecan-induced mucositis. Chemotherapy, 2011, Volume: 57, Issue:1 Topics: 14-3-3 Proteins; Actins; Animals; Camptothecin; Colon; Disease Models, Animal; Gene Expression Regulation; Glyceraldehyde-3-Phosphate Dehydrogenases; Irinotecan; Jejunum; Male; Matrix Metalloproteinase 2; Molecular Chaperones; Mucositis; Rats; Succinate Dehydrogenase; Ubiquitin C; Up-Regulation	2011
Humanized anti-Trop-2 IgG-SN-38 conjugate for effective treatment of diverse epithelial cancers: preclinical studies in human cancer xenograft models and monkeys. Clinical cancer research : an official journal of the American Association for Cancer Research, 2011, May-15, Volume: 17, Issue:10 Topics: Animals; Antigens, Neoplasm; Antineoplastic Agents; Camptothecin; Cell Adhesion Molecules; Cell Line, Tumor; Disease Models, Animal; Female; Humans; Immunoconjugates; Immunoglobulin G; Irinotecan; Macaca fascicularis; Male; Mice; Mice, Nude; Models, Biological; Monkey Diseases; Neoplasms, Glandular and Epithelial; Treatment Outcome; Xenograft Model Antitumor Assays	2011
Involvement of nitric oxide on the pathogenesis of irinotecan-induced intestinal mucositis: role of cytokines on inducible nitric oxide synthase activation. Cancer chemotherapy and pharmacology, 2012, Volume: 69, Issue:4 Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cytokines; Disease Models, Animal; Enzyme Activation; Immunohistochemistry; Intestinal Mucosa; Irinotecan; Mice; Mice, Inbred C57BL; Mice, Knockout; Mucositis; Nitric Oxide; Nitric Oxide Synthase Type II	2012
A cell-delivered and cell-activated SN38-dextran prodrug increases survival in a murine disseminated pancreatic cancer model. Small (Weinheim an der Bergstrasse, Germany), 2012, Mar-26, Volume: 8, Issue:6 Topics: Animals; Camptothecin; Dextrans; Disease Models, Animal; Irinotecan; Mice; Pancreatic Neoplasms; Prodrugs; Rabbits	2012
Augmented anti-metastatic efficacy of a selective matrix metalloproteinase inhibitor, MMI-166, in combination with CPT-11. Clinical & experimental metastasis, 2002, Volume: 19, Issue:6 Topics: Animals; Antineoplastic Agents; Camptothecin; Colonic Neoplasms; Disease Models, Animal; Humans; Irinotecan; Liver Neoplasms; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Metastasis; Sulfonamides; Transplantation, Heterologous	2002
Quantification of tumor tissue populations by multispectral analysis. Magnetic resonance in medicine, 2004, Volume: 51, Issue:3 Topics: Adipose Tissue; Animals; Antineoplastic Agents, Phytogenic; Apoptosis Regulatory Proteins; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; Disease Models, Animal; fas Receptor; Female; Humans; Irinotecan; Ligands; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Membrane Glycoproteins; Mice; Mice, Nude; Necrosis; Neoplasm Transplantation; Remission Induction; Skin Neoplasms; Time Factors; TNF-Related Apoptosis-Inducing Ligand; Topoisomerase I Inhibitors; Transplantation, Heterologous; Tumor Necrosis Factor-alpha	2004
A novel mouse model of rectal cancer established by orthotopic implantation of colon cancer cells. Cancer science, 2004, Volume: 95, Issue:6 Topics: Animals; Camptothecin; Cell Line, Tumor; Disease Models, Animal; Humans; Irinotecan; Male; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Rectal Neoplasms; Transplantation, Heterologous	2004
Development of a chemoresistant orthotopic human nonsmall cell lung carcinoma model in nude mice: analyses of tumor heterogenity in relation to the immunohistochemical levels of expression of cyclooxygenase-2, ornithine decarboxylase, lung-related resista Cancer, 2004, Oct-15, Volume: 101, Issue:8 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Brain Neoplasms; Camptothecin; Carcinoma, Non-Small-Cell Lung; Cyclooxygenase 2; Disease Models, Animal; Drug Resistance, Neoplasm; Female; Glutathione S-Transferase pi; Glutathione Transferase; Humans; Intramolecular Oxidoreductases; Irinotecan; Isoenzymes; Liver Neoplasms; Lung Neoplasms; Membrane Proteins; Mice; Mice, Nude; Neoplasm Proteins; Organoplatinum Compounds; Ornithine Decarboxylase; Oxaliplatin; Paclitaxel; Prostaglandin-E Synthases; Prostaglandin-Endoperoxide Synthases; Survival Rate; Transplantation, Heterologous; Vault Ribonucleoprotein Particles	2004
Enhanced therapeutic efficacy of a novel liposome-based formulation of SN-38 against human tumor models in SCID mice. Anti-cancer drugs, 2004, Volume: 15, Issue:8 Topics: Animals; Biomedical Enhancement; Camptothecin; Cell Line, Tumor; Clinical Trials, Phase I as Topic; Colonic Neoplasms; Disease Models, Animal; Drug Carriers; Female; HT29 Cells; Humans; Injections, Intravenous; Irinotecan; Liposomes; Mice; Mice, SCID; Technology, Pharmaceutical; Transplantation, Heterologous; Xenograft Model Antitumor Assays	2004
Suppressive effect of CPT-11 on rat esophageal tumorigenesis induced by N-nitrosomethylbenzylamine. Oncology reports, 2004, Volume: 12, Issue:6 Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Carcinoma, Squamous Cell; Dimethylnitrosamine; Disease Models, Animal; DNA, Single-Stranded; Esophageal Neoplasms; Immunohistochemistry; Irinotecan; Male; Precancerous Conditions; Proliferating Cell Nuclear Antigen; Rats; Tumor Suppressor Protein p53	2004
Vector targeting makes 5-fluorouracil chemotherapy less toxic and more effective in animal models of epithelial neoplasms. Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Nov-15, Volume: 10, Issue:22 Topics: Adenoviridae; Animals; Antimetabolites, Antineoplastic; Camptothecin; Carboxylesterase; Cell Line, Tumor; Combined Modality Therapy; Cytosine Deaminase; Disease Models, Animal; Drug Delivery Systems; Female; Fluorouracil; Genetic Therapy; Genetic Vectors; Humans; Inhibitory Concentration 50; Irinotecan; Mice; Mice, Nude; Microscopy, Fluorescence; Neoplasms, Glandular and Epithelial; Promoter Regions, Genetic; Ribosomes; RNA, Messenger; Thymidylate Synthase; Time Factors; Transcription, Genetic	2004
A mouse model for developing treatment for secondary liver tumors. International journal of oncology, 2005, Volume: 27, Issue:1 Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Colorectal Neoplasms; Disease Models, Animal; Humans; Immunohistochemistry; Irinotecan; Liver; Liver Neoplasms; Magnetic Resonance Imaging; Male; Mice; Mice, Nude; Neoplasm Metastasis; Time Factors	2005
The radical scavenger edaravone enhances the anti-tumor effects of CPT-11 in murine colon cancer by increasing apoptosis via inhibition of NF-kappaB. Cancer letters, 2005, Nov-18, Volume: 229, Issue:2 Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antipyrine; Apoptosis; Blotting, Western; Camptothecin; Caspase 3; Caspases; Cell Line, Tumor; Colonic Neoplasms; Disease Models, Animal; Edaravone; Electrophoretic Mobility Shift Assay; Free Radical Scavengers; In Situ Nick-End Labeling; Irinotecan; Lung Neoplasms; Male; Mice; NF-kappa B; Reactive Oxygen Species	2005
Drug Discovery Technology and Development 2005 - IBC's Tenth World Congress. Cancer mouse models and other techniques for improved prediction of efficacy. IDrugs : the investigational drugs journal, 2005, Volume: 8, Issue:10 Topics: Angiogenesis Inhibitors; Animals; Boronic Acids; Bortezomib; Camptothecin; Deoxycytidine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Forecasting; Gemcitabine; Green Fluorescent Proteins; Humans; Image Enhancement; Irinotecan; Luminescent Proteins; Mammary Neoplasms, Experimental; Mice; Mice, Transgenic; Pyrazines; Red Fluorescent Protein; Technology, Pharmaceutical; Treatment Outcome	2005
Immunotherapy with dendritic cells and CpG oligonucleotides can be combined with chemotherapy without loss of efficacy in a mouse model of colon cancer. International journal of cancer, 2006, Jun-01, Volume: 118, Issue:11 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; CpG Islands; Dendritic Cells; Disease Models, Animal; Female; Fluorouracil; Humans; Immunotherapy; Irinotecan; Mice; Mice, Inbred BALB C; Oligonucleotides	2006
Irinotecan-eluting stents inhibited neointimal proliferation in hypercholesterolemic rabbit aortas. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 2006, Volume: 68, Issue:1 Topics: Animals; Aorta, Abdominal; Atherosclerosis; Camptothecin; Cell Proliferation; Dietary Fats; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Carriers; Hypercholesterolemia; Inflammation; Irinotecan; Necrosis; Phosphorylcholine; Rabbits; Research Design; Stents; Tunica Intima	2006
Comparison of antitumor activities in tumor xenograft treatment. Contemporary clinical trials, 2007, Volume: 28, Issue:2 Topics: Algorithms; Animals; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Camptothecin; Disease Models, Animal; Humans; Irinotecan; Mice; Sesquiterpenes; Transplantation, Heterologous; Treatment Outcome	2007
A photon counting technique for quantitatively evaluating progression of peritoneal tumor dissemination. Cancer research, 2006, Aug-01, Volume: 66, Issue:15 Topics: Animals; Camptothecin; Cell Line, Tumor; Disease Models, Animal; Disease Progression; Female; Humans; Image Processing, Computer-Assisted; Irinotecan; Luciferases; Mice; Mice, Inbred BALB C; Mice, Nude; Peritoneal Neoplasms; Photons; Stomach Neoplasms; Transfection	2006
A non-invasive method for detection of intestinal mucositis induced by different classes of chemotherapy drugs in the rat. Cancer biology & therapy, 2006, Volume: 5, Issue:9 Topics: Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Breath Tests; Camptothecin; Cyclophosphamide; Disease Models, Animal; DNA Topoisomerases, Type I; Doxorubicin; Etoposide; Female; Intestine, Small; Irinotecan; Mucositis; Rats; Sucrase; Sucrose; Topoisomerase I Inhibitors	2006
St. John's wort attenuates irinotecan-induced diarrhea via down-regulation of intestinal pro-inflammatory cytokines and inhibition of intestinal epithelial apoptosis. Toxicology and applied pharmacology, 2006, Oct-15, Volume: 216, Issue:2 Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Cytokines; Diarrhea; Disease Models, Animal; Down-Regulation; Drug Therapy, Combination; Hypericum; Intestinal Mucosa; Irinotecan; Male; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley	2006
Consistent liver metastases in a rat model by portal injection of microencapsulated cancer cells. Cancer research, 2006, Dec-01, Volume: 66, Issue:23 Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Disease Models, Animal; Gemcitabine; Humans; Injections, Intravenous; Irinotecan; Liver Neoplasms, Experimental; Mice; Mice, Nude; Microspheres; Neoplasm Transplantation; Pancreatic Neoplasms; Portal Vein; Rats; Rats, Nude; Transplantation, Heterologous	2006
Efficacy of increasing the therapeutic index of irinotecan, plasma and tissue selenium concentrations is methylselenocysteine dose dependent. Biochemical pharmacology, 2007, May-01, Volume: 73, Issue:9 Topics: Administration, Oral; Animals; Bone Marrow; Camptothecin; Cysteine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Irinotecan; Kidney; Kinetics; Liver; Mice; Mice, Nude; Neoplasms; Organoselenium Compounds; Plasma; Selenium; Selenocysteine	2007
Irinotecan: a potential new chemotherapeutic agent for atypical or malignant meningiomas. Journal of neurosurgery, 2007, Volume: 106, Issue:3 Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Cell Culture Techniques; Cell Line, Tumor; Disease Models, Animal; Irinotecan; Male; Meningioma; Mice; Mice, Nude; Proto-Oncogene Proteins c-bcl-2; Soft Tissue Neoplasms; Subcutaneous Tissue	2007
Role of cytokines (TNF-alpha, IL-1beta and KC) in the pathogenesis of CPT-11-induced intestinal mucositis in mice: effect of pentoxifylline and thalidomide. Cancer chemotherapy and pharmacology, 2008, Volume: 61, Issue:5 Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Chemokines; Diarrhea; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Injections, Intraperitoneal; Interleukin-1beta; Intestine, Small; Irinotecan; Male; Mice; Mucositis; Pentoxifylline; Peroxidase; Thalidomide; Tumor Necrosis Factor-alpha	2008
Establishment of a single-dose irinotecan model of gastrointestinal mucositis. Chemotherapy, 2007, Volume: 53, Issue:5 Topics: Animals; Body Weight; Camptothecin; Diarrhea; Disease Models, Animal; Female; Irinotecan; Mucositis; Neoplasm Transplantation; Organ Size; Rats; Survival Rate	2007
Synergistic antitumor activity of the novel SN-38-incorporating polymeric micelles, NK012, combined with 5-fluorouracil in a mouse model of colorectal cancer, as compared with that of irinotecan plus 5-fluorouracil. International journal of cancer, 2008, May-01, Volume: 122, Issue:9 Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Cycle; Cell Line, Tumor; Colorectal Neoplasms; Disease Models, Animal; Drug Synergism; Fluorouracil; Humans; Irinotecan; Mice; Mice, Inbred BALB C; Mice, Nude; Micelles; Polymers; Transplantation, Heterologous	2008
Novel delivery of SN38 markedly inhibits tumor growth in xenografts, including a camptothecin-11-refractory model. Clinical cancer research : an official journal of the American Association for Cancer Research, 2008, Mar-15, Volume: 14, Issue:6 Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Camptothecin; Carcinoma; Cell Proliferation; Colorectal Neoplasms; Disease Models, Animal; Drug Delivery Systems; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Female; Humans; Irinotecan; Mice; Mice, Nude; Models, Biological; Neoplasms; Pancreatic Neoplasms; Polyethylene Glycols; Treatment Outcome; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2008
A novel molecular mechanism for anticancer drug-induced ovarian failure: Irinotecan HCl, an anticancer topoisomerase I inhibitor, induces specific FasL expression in granulosa cells of large ovarian follicles to enhance follicular apoptosis. International journal of oncology, 2008, Volume: 32, Issue:5 Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Caspase 3; Disease Models, Animal; DNA Topoisomerases, Type I; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Fas Ligand Protein; fas Receptor; Female; Granulosa Cells; Immunohistochemistry; In Situ Nick-End Labeling; Injections, Intraperitoneal; Irinotecan; Mice; Organ Culture Techniques; Primary Ovarian Insufficiency; Recombinant Proteins; Topoisomerase I Inhibitors; Up-Regulation	2008
Schedule-dependent efficacy of camptothecins in models of human cancer. Annals of the New York Academy of Sciences, 1996, Dec-13, Volume: 803 Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Enzyme Inhibitors; Female; Humans; Irinotecan; Mice; Mice, Inbred CBA; Neoplasm Transplantation; Neoplasms, Experimental; Topoisomerase I Inhibitors; Topotecan; Tumor Cells, Cultured	1996
Efficacy of oral irinotecan against neuroblastoma xenografts. Anti-cancer drugs, 1997, Volume: 8, Issue:4 Topics: Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Child, Preschool; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Enzyme Inhibitors; Female; Humans; Infant; Irinotecan; Mice; Mice, Inbred CBA; Neuroblastoma; Topoisomerase I Inhibitors; Transplantation, Heterologous	1997
Interleukin 15 offers selective protection from irinotecan-induced intestinal toxicity in a preclinical animal model. Cancer research, 1998, Aug-01, Volume: 58, Issue:15 Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Colon; Colorectal Neoplasms; Diarrhea; Disease Models, Animal; Drug Interactions; Duodenum; Female; Interleukin-15; Intestinal Mucosa; Irinotecan; Paraffin Embedding; Rats; Rats, Inbred F344	1998
Antiangiogenic effects of camptothecin analogues 9-amino-20(S)-camptothecin, topotecan, and CPT-11 studied in the mouse cornea model. Clinical cancer research : an official journal of the American Association for Cancer Research, 1999, Volume: 5, Issue:1 Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Camptothecin; Cornea; Disease Models, Animal; Fibroblast Growth Factor 2; Irinotecan; Mice; Mice, Inbred Strains; Neovascularization, Pathologic; Neovascularization, Physiologic; Topotecan; Vincristine	1999
Tumor necrosis factor-related apoptosis-inducing ligand's antitumor activity in vivo is enhanced by the chemotherapeutic agent CPT-11. Cancer research, 1999, Dec-15, Volume: 59, Issue:24 Topics: Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; Camptothecin; Colonic Neoplasms; Disease Models, Animal; Drug Screening Assays, Antitumor; Drug Synergism; Female; HT29 Cells; Humans; Irinotecan; Membrane Glycoproteins; Mice; Mice, SCID; Neoplasm Transplantation; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha	1999
Inhibitory effect of berberine on the mediastinal lymph node metastasis produced by orthotopic implantation of Lewis lung carcinoma. Cancer letters, 2001, Apr-10, Volume: 165, Issue:1 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Berberine; Camptothecin; Carcinoma, Lewis Lung; Disease Models, Animal; Female; Irinotecan; Lung Neoplasms; Lymphatic Metastasis; Mediastinal Neoplasms; Mice; Mice, Inbred C57BL; Neoplasm Invasiveness; Neoplasm Transplantation; Transcription Factor AP-1	2001
Sphingomyelin enhances chemotherapy efficacy and increases apoptosis in human colonic tumor xenografts. International journal of oncology, 2002, Volume: 20, Issue:2 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Camptothecin; Cisplatin; Colonic Neoplasms; Disease Models, Animal; Drug Synergism; Female; Fluorouracil; Humans; Irinotecan; Mice; Mice, Nude; Neoplasm Transplantation; Signal Transduction; Sphingomyelins; Time Factors; Transplantation, Heterologous; Tumor Cells, Cultured	2002