Compounds > irinotecan
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irinotecan and Carcinoma, Hepatocellular

irinotecan has been researched along with Carcinoma, Hepatocellular in 48 studies

Research

Studies (48)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (4.17)18.2507
2000's15 (31.25)29.6817
2010's16 (33.33)24.3611
2020's15 (31.25)2.80

Authors

AuthorsStudies
Chen, X; Chen, Y; Dong, S; Feng, M; He, H; Ho, M; Hu, S; Huang, L; Li, J; Li, W; Liang, R; Liang, X; Xiang, L; Zhu, Y; Zuo, D1
Chung, YM; Hu, MC; Khan, PP; Larrick, JW; Qiao, Y; Tsai, WB; Wang, H; Yu, B1
Chen, K; Cheng, Y; Feng, GY; Shi, ZR1
Liu, D; Ma, Z; Wang, J; Wen, Z; Xie, H; Yang, X; Zhang, N; Zhao, Y1
Chen, Y; Huang, P; Huang, X; Shi, G; Sun, Q; Yang, G; Zhou, Y1
Dey, C; Maraj, T; Mirrahimi, A1
Guo, L; Guo, Y; Hu, M; Lei, K; Liu, J; Liu, Y; Ye, Q; Zhou, T1
Alevisopoulos, N; Charokopakis, A; Delicha, E; Emmanouil, E; Filippiadis, DK; Glantzounis, G; Kartsouni, V; Kelekis, N; Kiakidis, T; Malagari, K; Moschouris, H; Panagiotou, I; Pellerin, O; Psarros, G; Tsavaris, N; Vergadis, C1
Honma, T; Imai, M; Ishikawa, T; Iwanaga, A; Jimbo, R; Kobayashi, Y; Sano, T; Sato, R; Sato, T; Yokoyama, J1
Chen, M; Chen, X; Gan, Y; Li, F; Li, Y; Miao, Y; Zhang, X1
Chen, J; Dai, S; Huang, X; Li, Y; Lv, Y; Yang, C1
Bakhutashvili, I; Banovac, F; Esparza-Trujillo, JA; Henman, A; Karanian, JW; Krishnasamy, VP; Levy, EB; Lewis, AL; Mikhail, AS; Negussie, AH; Pritchard, WF; Tang, Y; Wakim, PG; Willis, SL; Wood, BJ; Woods, DL1
Chen, F; Gou, S; Hua, S; Liu, Q; Wang, X1
Chen, Z; Ke, Q; Tao, Y; Wang, H; Wang, J; Xie, H; Xu, S; Xu, X; Yang, F; Zheng, S; Zhuo, J1
Bian, J; Liu, S; Wang, R; Wu, J; Zhang, Y; Zhao, G; Zhao, T; Zhou, J1
Emami, J; Hasanzadeh, F; Maghzi, P; Mirian, M; Rostami, M; Sadeghi, H1
Beeres, M; Eichler, K; Gruber-Rouh, T; Kamal, A; Langenbach, M; Naguib, NN; Vogl, TJ1
Boukouris, AE; Buitrago-Molina, LE; Hegermann, J; Kirstein, MM; Kühnel, F; Manns, MP; Marhenke, S; Orlik, J; Pothiraju, D; Schütt, J; Vogel, A1
Chen, X; Gan, Y; Jia, Z; Li, FF; Li, J; Zhang, XX; Zhao, YN1
Guo, B; Liu, J; Song, L; Wu, J; Zhao, DY1
Ardelt, MA; Brandl, L; De Toni, EN; Ehrlich, SM; Gerbes, AL; Kirchner, T; Lehr, T; Liebl, J; Mayr, D; Vollmar, AM; Zahler, S1
Ashton, A; Gupta, S; Kaseb, A; Odisio, BC; Tam, AL; Vauthey, JN; Wallace, MJ; Wei, W; Yan, Y1
Li, FY; Liu, L; Liu, ZQ; Lu, L; Peng, XJ; Qi, XX; Shi, J; Wang, Y; Zhou, FY; Zhou, J1
Jian, C; Pei-hua, L; Xiao-chun, Y; Xu, L; Yuan-run, Z1
Chen, M; He, Q; Luo, P; Peng, X; Shao, J; Xu, L; Xu, Z; Yang, B; Zhu, H; Zhu, Y1
Chang, LL; Dai, XY; Gai, RH; He, QJ; Wang, DD; Yang, B; Zhou, TY; Zhu, DF; Zhu, H; Zhuang, LH1
Chen, M; He, Q; Li, G; Luo, P; Shao, J; Xu, L; Xu, Z; Yan, H; Yang, B; Zhu, Y1
Georgiades, CC; Geschwind, JF; Hong, K; Lee, KH; Liapi, E1
Fujiki, R; Kitamura, T; Matsui, O; Motoo, Y; Mouri, H; Ohtsubo, K; Okai, T; Sanada, J; Sawabu, N; Tokuuye, K; Tsuchiyama, T; Watanabe, H; Yamaguchi, Y1
Abdulghani, J; Allen, JE; Dicker, DT; Dolloff, NG; El-Deiry, WS; Gallant, JN; Hong, B; Katz, SI; Navaraj, A; Smith, CD; Wang, W1
Agostini, V; Biasco, G; Bolondi, L; Borghi, A; Brandi, G; Cappelli, A; Costantini, S; Danesi, R; Derenzini, E; Di Paolo, A; Fanello, S; Giampalma, E; Golfieri, R; Mirarchi, MG; Pini, P; Piscaglia, F1
Kalokairinou, M; Malagari, K; Marinis, A; Moschouris, H; Papadaki, MG; Stamatiou, K1
Ambudkar, SV; Bhatnagar, J; Chen, JJ; Chen, WM; Chen, ZS; Lan, P; Ruan, ZX; Shu, C; Sodani, K; Wang, J; Xiao, ZJ; Ye, WC; Zhang, DM1
Gemici, C; Uygur-Bayramiçli, O1
Alajati, A; Ganslmayer, M; Hahn, EG; Herold, C; Lüders, M; Neureiter, D; Ocker, M; Schuppan, D; Zopf, S1
Harada, N; Hatano, E; Ikai, I; Koizumi, N; Nitta, T; Shimahara, Y; Tada, M; Taura, K1
Fu, ZD; Li, DZ; Liu, HY; Pan, XD; Wang, CY; Wu, S1
Chen, T; Chu, ZH; Liu, JP; Ou, QJ; Wang, J; Zhao, HY1
Boige, V; Debaere, T; Ducreux, M; Hannoun, L; Hebbar, M; Magherini, E; Malka, D; Mignard, D; Poynard, T; Taïeb, J1
Shi, D; Song, X; Yan, B; Yang, D; Yang, J1
Kobayashi, S; Kumai, T; Matsumoto, N; Nakaya, S; Takeba, Y; Tsuzuki, Y; Yanagida, Y1
Asakura, T; Kobayashi, S; Kumai, T; Matsumoto, N; Nakano, H; Nakaya, S; Ohtsubo, T; Sekine, S; Takeba, Y; Tsuzuki, Y; Yanagida, Y1
Meric, JB1
Fukuda, S; Kojiro, M; Nakashima, O; Ookawa, K; Sakata, Y; Suto, K; Takahata, T; Tamura, Y; Tanaka, M; Tateishi, T; Yano, H1
Kato, M; Suzuki, A1
Hashimoto, A; Matsuura, T; Murakami, K; Saiki, I; Sakukawa, R; Sano, M; Yamada, Y; Yonekura, K1
Azoulay, D; Duclos-Vallée, JC; Goldwasser, F; Gornet, JM1
Kelsen, DP; Kemeny, NE; O'Reilly, EM; Raeburn, L; Saltz, LB; Sanz-Altamira, PM; Schwartz, GK; Steger, CM; Stuart, KE1

Reviews

2 review(s) available for irinotecan and Carcinoma, Hepatocellular

ArticleYear
Drug-eluting particles for interventional pharmacology.
    Techniques in vascular and interventional radiology, 2007, Volume: 10, Issue:4

    Topics: Animals; Antineoplastic Agents; Camptothecin; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Colorectal Neoplasms; Doxorubicin; Drug Carriers; Humans; Irinotecan; Liver Neoplasms; Lung Neoplasms; Microspheres

2007
[Angiogenesis targeting in gastro-intestinal cancers].
    Bulletin du cancer, 2007, Volume: 94, Issue:7 Suppl

    Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Carcinoma, Hepatocellular; Colorectal Neoplasms; Esophageal Neoplasms; Fluorouracil; Gastrointestinal Neoplasms; Humans; Irinotecan; Leucovorin; Liver Neoplasms; Neovascularization, Pathologic; Organoplatinum Compounds; Oxaliplatin; Pancreatic Neoplasms; Stomach Neoplasms

2007

Trials

3 trial(s) available for irinotecan and Carcinoma, Hepatocellular

ArticleYear
A phase I study of continuous hepatic arterial infusion of Irinotecan in patients with locally advanced hepatocellular carcinoma.
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2011, Volume: 43, Issue:12

    Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Phytogenic; Camptothecin; Carcinoma, Hepatocellular; Catheterization; Diarrhea; Disease-Free Survival; Female; Hepatic Artery; Humans; Infusions, Intra-Arterial; Infusions, Intravenous; Irinotecan; Kaplan-Meier Estimate; Liver Neoplasms; Male; Middle Aged; Treatment Outcome

2011
Irinotecan as first-line chemotherapy in patients with advanced hepatocellular carcinoma: a multicenter phase II study with dose adjustment according to baseline serum bilirubin level.
    European journal of cancer (Oxford, England : 1990), 2006, Volume: 42, Issue:4

    Topics: Adolescent; Adult; Antineoplastic Agents, Phytogenic; Bilirubin; Biomarkers; Camptothecin; Carcinoma, Hepatocellular; Disease Progression; Dose-Response Relationship, Drug; Female; Humans; Irinotecan; Liver Cirrhosis; Liver Neoplasms; Male

2006
A phase II study of irinotecan in patients with advanced hepatocellular carcinoma.
    Cancer, 2001, Jan-01, Volume: 91, Issue:1

    Topics: Adult; Aged; Antineoplastic Agents, Phytogenic; Camptothecin; Carcinoma, Hepatocellular; Diarrhea; Fatigue; Female; Humans; Irinotecan; Liver Neoplasms; Male; Middle Aged; Nausea; Neutropenia; Prognosis; Treatment Outcome; Vomiting

2001

Other Studies

43 other study(ies) available for irinotecan and Carcinoma, Hepatocellular

ArticleYear
Combination Therapy of Hepatocellular Carcinoma by GPC3-Targeted Bispecific Antibody and Irinotecan is Potent in Suppressing Tumor Growth in Mice.
    Molecular cancer therapeutics, 2022, Volume: 21, Issue:1

    Topics: Animals; Antibodies, Bispecific; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Humans; Immunotherapy; Irinotecan; Liver Neoplasms; Mice; Survival Analysis

2022
Sensitizing tumors to anti-PD-1 therapy by promoting NK and CD8+ T cells via pharmacological activation of FOXO3.
    Journal for immunotherapy of cancer, 2021, Volume: 9, Issue:12

    Topics: Animals; Apoptosis; B7-H1 Antigen; Breast Neoplasms; Carcinoma, Hepatocellular; CD8-Positive T-Lymphocytes; Cell Proliferation; Female; Forkhead Box Protein O3; Gene Expression Regulation, Neoplastic; Humans; Immune Checkpoint Inhibitors; Immunotherapy; Irinotecan; Killer Cells, Natural; Liver Neoplasms; Mice; Mice, Inbred C57BL; Ovarian Neoplasms; Prognosis; Programmed Cell Death 1 Receptor; Topoisomerase I Inhibitors; Tumor Cells, Cultured; Tumor Microenvironment

2021
Correlation between Immunohistochemical Markers in Hepatocellular Carcinoma Cells and
    Canadian journal of gastroenterology & hepatology, 2022, Volume: 2022

    Topics: alpha-Fetoproteins; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Fluorouracil; Humans; Irinotecan; Liver Neoplasms; Oxaliplatin

2022
Treatment of unresectable intrahepatic cholangiocarcinoma using transarterial chemoembolisation with irinotecan-eluting beads: analysis of efficacy and safety.
    Cardiovascular and interventional radiology, 2022, Volume: 45, Issue:8

    Topics: Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Cholangiocarcinoma; Humans; Irinotecan; Liver Neoplasms; Retrospective Studies; Topoisomerase I Inhibitors; Treatment Outcome

2022
The Efficacy and Safety of Hepatic Arterial Infusion Chemotherapy Based on FOLFIRI for Advanced Intrahepatic Cholangiocarcinoma as Second-Line and Successive Treatment: A Real-World Study.
    Canadian journal of gastroenterology & hepatology, 2022, Volume: 2022

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Carcinoma, Hepatocellular; Cholangiocarcinoma; Cisplatin; Fluorouracil; Humans; Immune Checkpoint Inhibitors; Irinotecan; Leucovorin; Liver Neoplasms; Treatment Outcome

2022
Survival of Patients with Colorectal Liver Metastases after Transarterial Chemoembolization Using Irinotecan-Eluting Microspheres: A Single-Center Retrospective Analysis Comparing RECIST 1.1 and Choi Criteria.
    Journal of vascular and interventional radiology : JVIR, 2023, Volume: 34, Issue:6

    Topics: Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Colorectal Neoplasms; Female; Humans; Irinotecan; Liver Neoplasms; Male; Microspheres; Middle Aged; Response Evaluation Criteria in Solid Tumors; Retrospective Studies; Treatment Outcome

2023
A "Trojan Horse" Strategy: The Preparation of Bile Acid-Modifying Irinotecan Hydrochloride Nanoliposomes for Liver-Targeted Anticancer Drug Delivery System Study.
    Molecules (Basel, Switzerland), 2023, Feb-07, Volume: 28, Issue:4

    Topics: Animals; Antineoplastic Agents; Bile Acids and Salts; Carcinoma, Hepatocellular; Cholic Acids; Drug Delivery Systems; Irinotecan; Liposomes; Liver Neoplasms; Mice

2023
Prospective Series of Transarterial Chemoembolization of Metastatic Colorectal Cancer to the Liver with 30-60 μm Microspheres Loaded with Irinotecan.
    Cardiovascular and interventional radiology, 2023, Volume: 46, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Colonic Neoplasms; Colorectal Neoplasms; Humans; Irinotecan; Liver Neoplasms; Microspheres; Middle Aged; Prospective Studies; Rectal Neoplasms

2023
Prognostic Value of TACE With Irinotecan-loaded Drug-eluting Beads (DEBIRI) in Patients With Liver Metastases from Unresectable Colorectal Cancer.
    Anticancer research, 2023, Volume: 43, Issue:8

    Topics: Aged; Antineoplastic Agents, Phytogenic; Camptothecin; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Colorectal Neoplasms; Female; Humans; Irinotecan; Liver Neoplasms; Male; Prognosis; Topoisomerase I Inhibitors; Treatment Outcome

2023
Stepwise targeting and responsive lipid-coated nanoparticles for enhanced tumor cell sensitivity and hepatocellular carcinoma therapy.
    Theranostics, 2020, Volume: 10, Issue:8

    Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Carriers; Drug Liberation; Humans; Irinotecan; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Nanoparticles; Rats; Rats, Sprague-Dawley; Silicon Dioxide; Tumor Microenvironment

2020
Prognosis and personalized treatment prediction in TP53-mutant hepatocellular carcinoma: an in silico strategy towards precision oncology.
    Briefings in bioinformatics, 2021, 05-20, Volume: 22, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Computer Simulation; Disease-Free Survival; Female; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Irinotecan; Liver Neoplasms; Male; Mutation; Naphthoquinones; Precision Medicine; Survival Rate; Tumor Suppressor Protein p53

2021
Safety and Tolerability of Topotecan-Eluting Radiopaque Microspheres for Hepatic Chemoembolization in a Rabbit Preclinical Model.
    Cardiovascular and interventional radiology, 2020, Volume: 43, Issue:12

    Topics: Animals; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Humans; Irinotecan; Liver Neoplasms; Liver Neoplasms, Experimental; Microspheres; Rabbits; Topoisomerase I Inhibitors; Topotecan

2020
The introduction of immunosuppressor (TDO inhibitor) significantly improved the efficacy of irinotecan in treating hepatocellular carcinoma.
    Cancer immunology, immunotherapy : CII, 2021, Volume: 70, Issue:2

    Topics: Animals; Carcinoma, Hepatocellular; Humans; Immunotherapy; Irinotecan; Liver Neoplasms; Mice; Topoisomerase I Inhibitors

2021
Salinomycin-Loaded Small-Molecule Nanoprodrugs Enhance Anticancer Activity in Hepatocellular Carcinoma.
    International journal of nanomedicine, 2020, Volume: 15

    Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Humans; Irinotecan; Linoleic Acid; Liver Neoplasms; Male; Mice, Inbred BALB C; Mice, Nude; Nanoparticles; Neoplastic Stem Cells; Phosphatidylethanolamines; Polyethylene Glycols; Prodrugs; Pyrans; Xenograft Model Antitumor Assays

2020
Irinotecan eluting beads-transarterial chemoembolization using Callispheres® microspheres is an effective and safe approach in treating unresectable colorectal cancer liver metastases.
    Irish journal of medical science, 2022, Volume: 191, Issue:3

    Topics: Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Colorectal Neoplasms; Humans; Irinotecan; Liver Neoplasms; Microspheres; Treatment Outcome

2022
PLGA-PEG-RA-based polymeric micelles for tumor targeted delivery of irinotecan.
    Pharmaceutical development and technology, 2018, Volume: 23, Issue:1

    Topics: Camptothecin; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Carriers; Drug Delivery Systems; Hep G2 Cells; HT29 Cells; Humans; Irinotecan; Lactic Acid; Liver Neoplasms; Micelles; Nanoparticles; Particle Size; Polyethylene Glycols; Polyglactin 910; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Tretinoin

2018
Transarterial Chemoembolization (TACE) Using Mitomycin with or without Irinotecan for Hepatocellular Carcinoma in European Patients.
    Oncology research and treatment, 2018, Volume: 41, Issue:7-8

    Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Disease-Free Survival; Ethiodized Oil; Female; Humans; Irinotecan; Liver Neoplasms; Magnetic Resonance Imaging; Male; Middle Aged; Mitomycin; Outcome Assessment, Health Care; Starch

2018
Activity of the mTOR inhibitor RAD001, the dual mTOR and PI3-kinase inhibitor BEZ235 and the PI3-kinase inhibitor BKM120 in hepatocellular carcinoma.
    Liver international : official journal of the International Association for the Study of the Liver, 2013, Volume: 33, Issue:5

    Topics: Aminopyridines; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Camptothecin; Carcinoma, Hepatocellular; Cell Cycle; Cell Line; Cell Respiration; Cisplatin; Doxorubicin; Everolimus; Humans; Imidazoles; Immunoblotting; Immunohistochemistry; In Situ Nick-End Labeling; Irinotecan; Liver Neoplasms; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Quinolines; Sirolimus; TOR Serine-Threonine Kinases

2013
[Antitumor efficacy of irinotecan-loaded galactosyl modified lipid bilayer-coated mesoporous silica nanoparticles against hepatocellular carcinoma cells].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2014, Volume: 49, Issue:5

    Topics: Antineoplastic Agents; Apoptosis; Camptothecin; Carcinoma, Hepatocellular; Drug Carriers; Drug Delivery Systems; Humans; Irinotecan; Lipid Bilayers; Liver Neoplasms; Nanoparticles; Particle Size; Silicon Dioxide

2014
Chemotherapy for transarterial chemoembolization in patients with unresectable hepatocellular carcinoma.
    World journal of gastroenterology, 2014, Aug-21, Volume: 20, Issue:31

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Deoxycytidine; Disease Progression; Doxorubicin; Female; Fluorouracil; Gemcitabine; Humans; Irinotecan; Kaplan-Meier Estimate; Liver Neoplasms; Male; Middle Aged; Neoplasm Staging; Retrospective Studies; Risk Factors; Time Factors; Treatment Outcome

2014
Targeting cyclin dependent kinase 5 in hepatocellular carcinoma--A novel therapeutic approach.
    Journal of hepatology, 2015, Volume: 63, Issue:1

    Topics: Animals; Antineoplastic Agents; Camptothecin; Carcinoma, Hepatocellular; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Female; Gene Expression Regulation, Neoplastic; Humans; Irinotecan; Liver Neoplasms; Mice; Mice, SCID; Purines; RNA, Neoplasm; Roscovitine; Treatment Outcome

2015
Transarterial hepatic chemoembolization with 70-150 µm drug-eluting beads: assessment of clinical safety and liver toxicity profile.
    Journal of vascular and interventional radiology : JVIR, 2015, Volume: 26, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Bile Duct Diseases; Camptothecin; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Doxorubicin; Drug Carriers; Female; Humans; Infarction; Irinotecan; Liver Neoplasms; Male; Middle Aged; Particle Size; Patient Safety; Portal Vein; Retrospective Studies; Risk Assessment; Risk Factors; Texas; Time Factors; Treatment Outcome; Tumor Burden; Venous Thrombosis

2015
Drug-Metabolizing Activity, Protein and Gene Expression of UDP-Glucuronosyltransferases Are Significantly Altered in Hepatocellular Carcinoma Patients.
    PloS one, 2015, Volume: 10, Issue:5

    Topics: Adult; Camptothecin; Carcinoma, Hepatocellular; Genistein; Glucuronosyltransferase; Humans; Inactivation, Metabolic; Irinotecan; Liver Neoplasms; Male; Metabolic Clearance Rate; Microsomes, Liver; Middle Aged; Propofol; Tamoxifen; Zidovudine

2015
[Anticancer effect of SN-38 combined with sorafenib on hepatocellular carcinoma in vitro and its mechanism].
    Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2015, Volume: 44, Issue:5

    Topics: Apoptosis; Camptothecin; Carcinoma, Hepatocellular; Caspase 3; Caspase 8; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Histones; Humans; Irinotecan; Liver Neoplasms; Niacinamide; Phenylurea Compounds; Poly(ADP-ribose) Polymerases; Sorafenib; Tumor Suppressor Protein p53

2015
Gefitinib Synergizes with Irinotecan to Suppress Hepatocellular Carcinoma via Antagonizing Rad51-Mediated DNA-Repair.
    PloS one, 2016, Volume: 11, Issue:1

    Topics: Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Camptothecin; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; DNA Repair; Drug Resistance, Neoplasm; Drug Synergism; Gefitinib; Hep G2 Cells; Humans; Irinotecan; Liver Neoplasms; Mice; Mice, Nude; Neoplasm Transplantation; Quinazolines; Rad51 Recombinase; RNA, Small Interfering; Topoisomerase I Inhibitors

2016
Nuclear translocation and activation of YAP by hypoxia contributes to the chemoresistance of SN38 in hepatocellular carcinoma cells.
    Oncotarget, 2016, Feb-09, Volume: 7, Issue:6

    Topics: Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Camptothecin; Carcinoma, Hepatocellular; Cell Nucleus; Cell Proliferation; Drug Resistance, Neoplasm; Fluorescent Antibody Technique; Gene Expression Regulation, Neoplastic; Humans; Hypoxia; Immunoenzyme Techniques; Irinotecan; Liver Neoplasms; Mice; Mice, Nude; Phosphoproteins; Protein Transport; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Transcription Factors; Tumor Cells, Cultured; Xenograft Model Antitumor Assays; YAP-Signaling Proteins

2016
Dasatinib synergises with irinotecan to suppress hepatocellular carcinoma via inhibiting the protein synthesis of PLK1.
    British journal of cancer, 2017, Apr-11, Volume: 116, Issue:8

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Camptothecin; Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell Proliferation; Dasatinib; Drug Synergism; Female; Flow Cytometry; Humans; Irinotecan; Liver Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Polo-Like Kinase 1; Protein Biosynthesis; Protein Serine-Threonine Kinases; Protein Synthesis Inhibitors; Proto-Oncogene Proteins; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2017
Advanced hepatocellular carcinoma treated effectively with irinotecan via hepatic arterial infusion followed by proton beam therapy.
    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2009, Volume: 15, Issue:5

    Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Carcinoma, Hepatocellular; Combined Modality Therapy; Humans; Hyperthermia, Induced; Infusions, Intra-Arterial; Irinotecan; Liver Neoplasms; Male; Middle Aged; Proton Therapy; Survivors

2009
Quinacrine sensitizes hepatocellular carcinoma cells to TRAIL and chemotherapeutic agents.
    Cancer biology & therapy, 2011, Aug-01, Volume: 12, Issue:3

    Topics: Animals; Antineoplastic Agents; Benzenesulfonates; Camptothecin; Carcinoma, Hepatocellular; Cell Death; Cell Nucleus; Cytoplasm; Deoxycytidine; Doxorubicin; Drug Synergism; Etoposide; Female; Fluorouracil; Gemcitabine; Genes, p53; Humans; Irinotecan; Liver Neoplasms; Mice; Microtubule-Associated Proteins; Myeloid Cell Leukemia Sequence 1 Protein; Niacinamide; Phenylurea Compounds; Proto-Oncogene Proteins c-bcl-2; Pyridines; Quinacrine; Receptors, TNF-Related Apoptosis-Inducing Ligand; RNA, Small Interfering; Sorafenib; TNF-Related Apoptosis-Inducing Ligand; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2011
Contrast-enhanced ultrasonography with intraarterial administration of SonoVue for guidance of transarterial chemoembolization: an initial experience.
    Medical ultrasonography, 2011, Volume: 13, Issue:4

    Topics: Aged; Aged, 80 and over; Angiography, Digital Subtraction; Camptothecin; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Cholangiocarcinoma; Contrast Media; Doxorubicin; Feasibility Studies; Female; Humans; Injections, Intra-Arterial; Irinotecan; Liver Neoplasms; Male; Microspheres; Middle Aged; Phospholipids; Prospective Studies; Sulfur Hexafluoride; Treatment Outcome; Ultrasonography, Interventional

2011
BBA, a derivative of 23-hydroxybetulinic acid, potently reverses ABCB1-mediated drug resistance in vitro and in vivo.
    Molecular pharmaceutics, 2012, Nov-05, Volume: 9, Issue:11

    Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Breast Neoplasms; Calcium Channel Blockers; Camptothecin; Carcinoma, Hepatocellular; Cell Proliferation; Cells, Cultured; Cisplatin; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Fluorescent Antibody Technique; Humans; In Vitro Techniques; Irinotecan; KB Cells; Liver Neoplasms; Male; Mice; Mice, Nude; Models, Molecular; Molecular Docking Simulation; Paclitaxel; Piperidines; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Triterpenes; Verapamil

2012
Is liver disease an octreotide side effect?
    Journal of clinical gastroenterology, 2003, Volume: 37, Issue:1

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoma, Hepatocellular; Drug Administration Schedule; Female; Fluorouracil; Gastrointestinal Agents; Humans; Irinotecan; Leucovorin; Liver Neoplasms; Octreotide

2003
The histone-deacetylase inhibitor SAHA potentiates proapoptotic effects of 5-fluorouracil and irinotecan in hepatoma cells.
    Journal of cancer research and clinical oncology, 2005, Volume: 131, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Camptothecin; Carcinoma, Hepatocellular; Caspase 3; Caspase 8; Caspases; Down-Regulation; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Fluorouracil; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Irinotecan; Liver Neoplasms; Membrane Potentials; Mitochondria; Proto-Oncogene Proteins c-bcl-2; Skin; Tumor Cells, Cultured; Vorinostat

2005
Blocking of PI3K/Akt pathway enhances apoptosis induced by SN-38, an active form of CPT-11, in human hepatoma cells.
    International journal of oncology, 2005, Volume: 26, Issue:5

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Carcinoma, Hepatocellular; Drug Resistance, Neoplasm; Humans; Irinotecan; Liver Neoplasms; NF-kappa B; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Tumor Cells, Cultured

2005
Synthesis and antitumor activity of A-ring modified hexacyclic analogues of camptothecin.
    Yao xue xue bao = Acta pharmaceutica Sinica, 2005, Volume: 40, Issue:3

    Topics: Animals; Antineoplastic Agents; Camptothecin; Carcinoma, Hepatocellular; Cell Line, Tumor; Female; Humans; Irinotecan; Liver Neoplasms; Mice; Neoplasm Transplantation; Polycyclic Compounds

2005
[Application of adenosine triphosphate tumor chemosensitive assay system to individual chemotherapy for hepatocellular carcinoma].
    Ai zheng = Aizheng = Chinese journal of cancer, 2005, Volume: 24, Issue:8

    Topics: Adenosine Triphosphate; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Camptothecin; Carcinoma, Hepatocellular; Deoxycytidine; Disease-Free Survival; Drug Screening Assays, Antitumor; Female; Gemcitabine; Humans; Irinotecan; Liver Neoplasms; Male; Middle Aged; Paclitaxel; Postoperative Period; Remission Induction; Sensitivity and Specificity; Survival Rate

2005
Interleukin-6 alters the cellular responsiveness to clopidogrel, irinotecan, and oseltamivir by suppressing the expression of carboxylesterases HCE1 and HCE2.
    Molecular pharmacology, 2007, Volume: 72, Issue:3

    Topics: Adult; Aged; Antineoplastic Agents, Phytogenic; Antiviral Agents; Camptothecin; Carboxylesterase; Carboxylic Ester Hydrolases; Carcinoma, Hepatocellular; Cell Line, Tumor; Cells, Cultured; Clopidogrel; Dose-Response Relationship, Drug; Female; Hepatocytes; Humans; Interleukin-6; Irinotecan; Liver Neoplasms; Male; Middle Aged; Oseltamivir; Platelet Aggregation Inhibitors; RNA, Messenger; Ticlopidine

2007
Irinotecan activates p53 with its active metabolite, resulting in human hepatocellular carcinoma apoptosis.
    Journal of pharmacological sciences, 2007, Volume: 104, Issue:3

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; Blotting, Western; Camptothecin; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; DNA Fragmentation; DNA Probes; Electrophoretic Mobility Shift Assay; Humans; In Situ Nick-End Labeling; Irinotecan; Liver Neoplasms; Oligonucleotides; Tumor Suppressor Protein p53

2007
Irinotecan-induced apoptosis is inhibited by increased P-glycoprotein expression and decreased p53 in human hepatocellular carcinoma cells.
    Biological & pharmaceutical bulletin, 2007, Volume: 30, Issue:8

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Camptothecin; Carcinoma, Hepatocellular; Cell Line, Tumor; Humans; In Situ Nick-End Labeling; Irinotecan; Liver Neoplasms; Microscopy, Fluorescence; Oligonucleotides; Reverse Transcriptase Polymerase Chain Reaction; RNA, Neoplasm; Tumor Suppressor Protein p53

2007
Chemosensitivity determinants of irinotecan hydrochloride in hepatocellular carcinoma cell lines.
    Basic & clinical pharmacology & toxicology, 2008, Volume: 102, Issue:4

    Topics: Acridines; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Camptothecin; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Enzyme Inhibitors; Flavanones; Gene Expression Regulation, Neoplastic; Glucuronosyltransferase; Humans; Inhibitory Concentration 50; Irinotecan; Liver Neoplasms; Neoplasm Proteins; RNA, Messenger; Tetrahydroisoquinolines; Transfection

2008
Chemotherapeutic agent CPT-11 induces the new expression of the apoptosis initiator to the cytoplasm.
    Experimental cell research, 1996, Aug-25, Volume: 227, Issue:1

    Topics: Amino Acid Sequence; Animals; Apoptosis; Camptothecin; Carcinoma, Hepatocellular; Caspase 1; Cell Extracts; Cell Nucleus; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytoplasm; Dactinomycin; DNA; Humans; Irinotecan; Liver; Liver Neoplasms; Male; Molecular Sequence Data; Oligopeptides; Protein Synthesis Inhibitors; Rats; Tumor Cells, Cultured

1996
4-[3,5-Bis(trimethylsilyl)benzamido] benzoic acid (TAC-101) inhibits the intrahepatic spread of hepatocellular carcinoma and prolongs the life-span of tumor-bearing animals.
    Clinical & experimental metastasis, 1998, Volume: 16, Issue:7

    Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Benzoates; Body Weight; Camptothecin; Carcinoma, Hepatocellular; Fluorouracil; Humans; Irinotecan; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Mice; Mice, Nude; Molecular Structure; Neoplasm Invasiveness; Proto-Oncogene Proteins c-met; Receptors, Retinoic Acid; Reverse Transcriptase Polymerase Chain Reaction; Specific Pathogen-Free Organisms; Survival Rate; Trimethylsilyl Compounds; Tumor Cells, Cultured

1998
Complete remission of unresectable hepatocellular carcinoma on healthy liver by the combination of aggressive surgery and high-dose-intensity chemotherapy by CPT-11.
    Anti-cancer drugs, 2000, Volume: 11, Issue:8

    Topics: alpha-Fetoproteins; Antineoplastic Agents, Phytogenic; Camptothecin; Carcinoma, Hepatocellular; Combined Modality Therapy; DNA Topoisomerases, Type I; Female; Hepatectomy; Humans; Irinotecan; Liver Neoplasms; Middle Aged; Remission Induction

2000