iridoids has been researched along with Viremia* in 1 studies
1 other study(ies) available for iridoids and Viremia
| Article | Year |
|---|---|
Antiviral efficacy against hepatitis B virus replication of oleuropein isolated from Jasminum officinale L. var. grandiflorum.
Jasminum officinale L. var. grandiflorum (JOG) is a folk medicine used for the treatment of hepatitis in south of China. Phytochemical studies showed that secoiridoid glycosides are the typical constituents of this plant.. The present study was undertaken to evaluate the effect of oleuropein (Ole) derived from the flowers of JOG on hepatitis B virus (HBV) replication in HepG2 2.2.15 cell line in vitro and duck hepatitis B virus (DHBV) replication in ducklings in vivo.. The extracellular hepatitis B e antigen (HBeAg) and hepatitis B surface antigen (HBsAg) concentrations in cell culture medium were determined by ELISA. DHBV in duck serum was analyzed by dot blot.. Ole blocks effectively HBsAg secretion in HepG2 2.2.15 cells in a dose-dependent manner (IC(50)=23.2 microg/ml). Ole (80 mg/kg, intraperitoneally, twice daily) also reduced viremia in DHBV-infected ducks.. Ole therefore warrants further investigation as a potential therapeutic agent for HBV infection. Topics: Animals; Antiviral Agents; Cell Line; Disease Models, Animal; Dose-Response Relationship, Drug; Ducks; Flowers; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B Virus, Duck; Hepatitis, Viral, Animal; Humans; Iridoid Glucosides; Iridoids; Jasminum; Phytotherapy; Plant Extracts; Pyrans; Viremia; Virus Replication | 2009 |