iridoids has been researched along with Peritoneal-Neoplasms* in 1 studies
1 other study(ies) available for iridoids and Peritoneal-Neoplasms
| Article | Year |
|---|---|
Model-based analysis of treatment effects of paclitaxel microspheres in a microscopic peritoneal carcinomatosis model in mice.
Paclitaxel (PTX)-loaded genipin-crosslinked gelatin microspheres (GP-MS) are a prolonged IP delivery system under development for the treatment of peritoneal minimal residual disease (pMRD). Here, we show the use of a pharmacokinetic-pharmacodynamic (PKPD) modelling approach to inform the formulation development of PTX-GP-MS in a mice pMRD model.. PTX blood concentrations and survival data were obtained in Balb/c Nu mice receiving different single IP doses (7.5 and/or 35 mg/kg) of PTX-ethanolic loaded GP-MS (PTX. The model predicts that the dose range of 7.5-15 mg/kg of PTX Topics: Albumin-Bound Paclitaxel; Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cross-Linking Reagents; Drug Carriers; Gelatin; Humans; Iridoids; Mice, Inbred BALB C; Mice, Nude; Microspheres; Models, Biological; Peritoneal Neoplasms; Xenograft Model Antitumor Assays | 2019 |