iridoids and Cardiovirus-Infections

The ethanolic extracts, various fractions and two pure compounds isolated from the plant N. arbortris were tested against Encephalomyocarditis Virus (EMCV) and Semliki Forest Virus (SFV). Pronounced in vitro virus inhibitory activity was observed with the ethanolic and n-butanol fractions as well as with the pure compounds arbortristoside A and arbortristoside C. In addition, ethanolic extracts and n-butanol fraction protected EMCV infected mice to the extent of 40 and 60% respectively against SFV at a daily dose of 125 mg/kg body weight.

Topics: 1-Butanol; Administration, Oral; Alphavirus Infections; Animals; Cardiovirus Infections; Chlorocebus aethiops; Dose-Response Relationship, Drug; Encephalomyocarditis virus; Glycosides; Injections, Intraperitoneal; Iridoids; Mice; Oleaceae; Phytotherapy; Plant Extracts; Seeds; Semliki forest virus; Vero Cells