iridoids and Ankle-Injuries

iridoids has been researched along with Ankle-Injuries* in 1 studies

Other Studies

1 other study(ies) available for iridoids and Ankle-Injuries

ArticleYear
Iridoid glycosides from Gardeniae Fructus for treatment of ankle sprain.
    Phytochemistry, 2009, Volume: 70, Issue:6

    The iridoid glycosides, genipin 1-O-beta-D-isomaltoside (1) and genipin 1,10-di-O-beta-D-glucopyranoside (2), together with six known iridoid glycosides, genipin 1-O-beta-D-gentiobioside (3), geniposide (4), scandoside methyl ester (5), deacetylasperulosidic acid methyl ester (6), 6-O-methyldeacetylasperulosidic acid methyl ester (7), and gardenoside (8) were isolated from an EtOH extract of Gardeniae Fructus. The structures and relative stereochemistries of the metabolites were elucidated on the basis of 1D- and 2D-NMR spectroscopic techniques, high-resolution mass spectrometry, and chemical evidence. Geniposide (4), one of the main compounds of Gardeniae Fructus, was tested for treatment of ankle sprain using an ankle sprain model in rats. From the second to fifth day, the geniposide (4) (100mg/ml) treated group exhibited significant differences (p<0.01) with approximately 21-34% reduction in swelling ratio compared with those of the vehicle treated control group. This indicated the potential effect of geniposide (4) for the treatment of disorders such as ankle sprain.

    Topics: Animals; Ankle Injuries; Gardenia; Iridoids; Magnetic Resonance Spectroscopy; Rats; Spectrometry, Mass, Fast Atom Bombardment; Sprains and Strains

2009