ipriflavone has been researched along with Bone Loss, Osteoclastic in 32 studies
ipriflavone : A member of the class of isoflavones that is isoflavone in which the hydrogen at position 7 is replaced by an isopropoxy group. A synthetic isoflavone, it was formerly used for the treatment of osteoporosis, although a randomised controlled study failed to show any benefit. It is still used to prevent osteoporosis in post-menopausal women.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In order to evaluate the effect of Ipriflavone (BO, synthesized for the first time by the School of Pharmaceutical Sciences of WCUMS) against osteoporosis in ovariectomized (OVX) rats, 98 female Wistar rats were divided into 7 groups: bilateral OVX, sham operated (S), and 5 treatment groups after OVX, of which 3 groups were given domestic BO-25, 100, and 400 mg/kg BW (L, M, H), respectively, and the remaining two groups, BO (made in Japan)-100 mg/kg BW (J) and 17 beta-estradiol-4 mg/kg BW (E)." | 7.69 | [Experimental study on the effect of ipriflavone against osteoporosis in ovariectomized rats]. ( Li, H; Ouyang, Q; Weng, L; Zheng, Z, 1994) |
| "Its effect of hindering bone resorption works presumably also this way." | 5.28 | [A new treatment possibility for osteoporosis with osteochin (ipriflavone) tablets]. ( Bossányi, A; Bucsi, L, 1989) |
| "In order to evaluate the effect of Ipriflavone (BO, synthesized for the first time by the School of Pharmaceutical Sciences of WCUMS) against osteoporosis in ovariectomized (OVX) rats, 98 female Wistar rats were divided into 7 groups: bilateral OVX, sham operated (S), and 5 treatment groups after OVX, of which 3 groups were given domestic BO-25, 100, and 400 mg/kg BW (L, M, H), respectively, and the remaining two groups, BO (made in Japan)-100 mg/kg BW (J) and 17 beta-estradiol-4 mg/kg BW (E)." | 3.69 | [Experimental study on the effect of ipriflavone against osteoporosis in ovariectomized rats]. ( Li, H; Ouyang, Q; Weng, L; Zheng, Z, 1994) |
| " In this study, to determine if KCA-098 is therapeutically applicable for the treatment of osteoporosis, we compared the effect of KCA-098 on bone tissues with that of ipriflavone, a drug that is clinically used for the treatment of osteoporosis." | 3.69 | Effects of KCA-098 on bone metabolism: comparison with those of ipriflavone. ( Arai, N; Endo, H; Itoh, F; Kawashima, K; Kojima, M; Nagata, H; Tsutsumi, N; Tsuyuki, J; Ujiie, A, 1994) |
| "Current therapeutic approaches to postmenopausal bone loss or established osteoporosis vary widely among the different regions of the world." | 2.40 | Miscellaneous and experimental agents. ( Reginster, JY, 1997) |
| "Ipriflavone (IP) is an isoflavone derivative available in several countries for investigational and/or therapeutic use." | 2.38 | Ipriflavone: pharmacological properties and usefulness in postmenopausal osteoporosis. ( Reginster, JY, 1993) |
| "Enhanced bone resorption was also observed when unfractionated bone cells were cultured on AGE-modified dentin slices." | 1.30 | Advanced glycation end products enhance osteoclast-induced bone resorption in cultured mouse unfractionated bone cells and in rats implanted subcutaneously with devitalized bone particles. ( Horie, K; Kurokawa, K; Maeda, K; Miyata, T; Notoya, K; Taketomi, S; Yoshida, K, 1997) |
| "We found that daidzein stimulated bone resorption in the pit formation assay at the concentration of 10(-8)-10(-10) M." | 1.30 | Daidzein stimulation of bone resorption in pit formation assay. ( Komiyama, O; Komiyama, Y; Maruyama, HB; Tobe, H, 1997) |
| "Significant inhibition of bone resorption was also seen in intact animals, provided they rapidly ingested the daily meal." | 1.30 | Ipriflavone inhibits bone resorption in intact and ovariectomized rats. ( Cecchini, MG; Fleisch, H; Mühibauer, RC, 1997) |
| "Quercetin, which has a better than Ipriflavone water-solubility seems as promising as Ipriflavone in the control of the otosclerotic bone-remodelling disturbance." | 1.29 | Flavonoids alter bone-remodelling in auditory ossicle organ cultures. ( Ribári, O; Sziklai, I, 1995) |
| "When ipriflavone was added to the culture medium in combination with vitamin K2, an additive inhibitory effect on bone resorption was observed." | 1.29 | Similarities and differences between the effects of ipriflavone and vitamin K on bone resorption and formation in vitro. ( Notoya, K; Shirakawa, Y; Taketomi, S; Tsuda, M; Yoshida, K, 1995) |
| "Using bone resorption assays, video image analysis together with measurements of intracellular free calcium in isolated osteoclasts, we show here that IP directly inhibits osteoclastic activity by the modulation of intracellular free calcium." | 1.29 | Ipriflavone directly inhibits osteoclastic activity. ( Albanese, CV; Argentino, L; Cudd, A; MacIntyre, I; Zambonin-Zallone, A, 1994) |
| "Ipriflavone is an isoflavone derivative used in the prevention and treatment of postmenopausal and senile osteoporosis in humans." | 1.29 | Inhibition of parathyroid hormone-stimulated resorption in cultured fetal rat long bones by the main metabolites of ipriflavone. ( Bongrani, S; Caruso, P; Civelli, M; Giossi, M, 1996) |
| " The reduction was roughly proportional to the increase of drug dosage and reached statistical significance in rats of groups 5 and 6." | 1.28 | Ipriflavone inhibits osteoclast differentiation in parathyroid transplanted parietal bone of rats. ( Ballanti, P; Bianco, P; Bonucci, E; Brambilla, G; Bufalino, L; Martelli, A; Mereto, E, 1992) |
| "Its effect of hindering bone resorption works presumably also this way." | 1.28 | [A new treatment possibility for osteoporosis with osteochin (ipriflavone) tablets]. ( Bossányi, A; Bucsi, L, 1989) |
| "The effect of ipriflavone on bone resorption was apparently not due to its toxicity on bone cells, since the inhibition was reversible." | 1.27 | The effect of ipriflavone (TC-80) on bone resorption in tissue culture. ( Fujita, T; Ito, T; Kitazaki, T; Tsuda, M, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (9.38) | 18.7374 |
| 1990's | 25 (78.13) | 18.2507 |
| 2000's | 3 (9.38) | 29.6817 |
| 2010's | 1 (3.13) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kaneda, T | 1 |
| Yoshida, H | 1 |
| Nakajima, Y | 1 |
| Toishi, M | 1 |
| Nugroho, AE | 1 |
| Morita, H | 1 |
| Takizawa, M | 1 |
| Ishida, H | 1 |
| Suzuki, K | 1 |
| Ito, K | 1 |
| Minegishi, T | 1 |
| Takayama, T | 1 |
| Tamura, T | 1 |
| Yamada, Y | 1 |
| Sato, S | 1 |
| Polatti, F | 1 |
| Perotti, F | 1 |
| Filippa, N | 1 |
| Gallina, D | 1 |
| Manni, M | 1 |
| Sziklai, I | 1 |
| Ribári, O | 1 |
| Notoya, K | 6 |
| Yoshida, K | 4 |
| Shirakawa, Y | 1 |
| Taketomi, S | 6 |
| Tsuda, M | 4 |
| Fiore, CE | 1 |
| Gibilaro, M | 1 |
| Motta, M | 1 |
| Foti, R | 1 |
| Dieli, M | 1 |
| Ouyang, Q | 1 |
| Li, H | 1 |
| Zheng, Z | 1 |
| Weng, L | 1 |
| Bucsi, L | 2 |
| Ashton, BA | 1 |
| Tsutsumi, N | 1 |
| Kawashima, K | 1 |
| Nagata, H | 1 |
| Tsuyuki, J | 1 |
| Itoh, F | 1 |
| Arai, N | 1 |
| Kojima, M | 1 |
| Ujiie, A | 1 |
| Endo, H | 1 |
| Valente, M | 1 |
| Bufalino, L | 2 |
| Castiglione, GN | 1 |
| D'Angelo, R | 1 |
| Mancuso, A | 1 |
| Galoppi, P | 1 |
| Zichella, L | 1 |
| Albanese, CV | 1 |
| Cudd, A | 1 |
| Argentino, L | 1 |
| Zambonin-Zallone, A | 1 |
| MacIntyre, I | 1 |
| Reginster, JY | 2 |
| Azria, M | 1 |
| Behhar, C | 1 |
| Cooper, S | 1 |
| Yamazaki, I | 2 |
| Kumegawa, M | 2 |
| Brandi, ML | 2 |
| Giossi, M | 1 |
| Caruso, P | 1 |
| Civelli, M | 1 |
| Bongrani, S | 1 |
| Miyauchi, A | 2 |
| Takagi, Y | 2 |
| Fujii, Y | 2 |
| Jinnai, K | 1 |
| Takahashi, K | 1 |
| Chihara, K | 1 |
| Fujita, T | 3 |
| Miyata, T | 1 |
| Horie, K | 1 |
| Maeda, K | 1 |
| Kurokawa, K | 1 |
| Tobe, H | 1 |
| Komiyama, O | 1 |
| Komiyama, Y | 1 |
| Maruyama, HB | 1 |
| Cecchini, MG | 1 |
| Fleisch, H | 1 |
| Mühibauer, RC | 1 |
| Martini, M | 1 |
| Formigli, L | 1 |
| Tonelli, P | 1 |
| Giannelli, M | 1 |
| Amunni, F | 1 |
| Naldi, D | 1 |
| Zecchi Orlandini, S | 1 |
| Orlandini, GE | 1 |
| Halpner, AD | 1 |
| Kellermann, G | 1 |
| Ahlgrimm, MJ | 1 |
| Arndt, CL | 1 |
| Shaikh, NA | 1 |
| Hargrave, JJ | 1 |
| Tallas, PG | 1 |
| Ozawa, H | 1 |
| Nakamura, H | 1 |
| Irie, K | 1 |
| Irie, M | 1 |
| Bonucci, E | 1 |
| Ballanti, P | 1 |
| Martelli, A | 1 |
| Mereto, E | 1 |
| Brambilla, G | 1 |
| Bianco, P | 1 |
| Bossányi, A | 1 |
| Shino, A | 1 |
| Tsukuda, R | 1 |
| Odaka, H | 1 |
| Kitazaki, T | 2 |
| Matsuo, T | 1 |
| Ito, T | 1 |
4 reviews available for ipriflavone and Bone Loss, Osteoclastic
| Article | Year |
|---|---|
[Abnormality of bone mineral metabolism in type 2 diabetes mellitus].
Topics: Bone and Bones; Bone Resorption; Calcitonin; Calcium; Calcium, Dietary; Cholecalciferol; Diabetes Me | 2004 |
Ipriflavone: pharmacological properties and usefulness in postmenopausal osteoporosis.
Topics: Animals; Bone Resorption; Clinical Trials as Topic; Disease Models, Animal; Female; Humans; Hyperpar | 1993 |
New treatment strategies: ipriflavone, strontium, vitamin D metabolites and analogs.
Topics: Aged; Animals; Bone Remodeling; Bone Resorption; Female; Humans; Isoflavones; Osteogenesis; Osteopor | 1993 |
Miscellaneous and experimental agents.
Topics: Anabolic Agents; Animals; Bone Density; Bone Remodeling; Bone Resorption; Estrogen Antagonists; Estr | 1997 |
5 trials available for ipriflavone and Bone Loss, Osteoclastic
| Article | Year |
|---|---|
[Long-term assessment of bone loss in patients treated with GnRH agonists].
Topics: Adult; Antineoplastic Agents, Hormonal; Bone Resorption; Female; Humans; Isoflavones; Leuprolide | 1995 |
[Modification of cortical and trabecular mineral density of the femur, induced by ipriflavone therapy, Clinical results after 12 months].
Topics: Adult; Aged; Bone Density; Bone Resorption; Female; Femoral Fractures; Femoral Neck Fractures; Femur | 1995 |
Effects of 1-year treatment with ipriflavone on bone in postmenopausal women with low bone mass.
Topics: Absorptiometry, Photon; Aged; Biomarkers; Bone Density; Bone Resorption; Female; Humans; Isoflavones | 1994 |
Comparison of antiresorptive activities of ipriflavone, an isoflavone derivative, and elcatonin, an eel carbocalcitonin.
Topics: Acid Phosphatase; Aged; Alkaline Phosphatase; Animals; Bone Remodeling; Bone Resorption; Calcitonin; | 1999 |
The effect of an ipriflavone-containing supplement on urinary N-linked telopeptide levels in postmenopausal women.
Topics: Biomarkers; Bone Resorption; Calcium; Collagen; Collagen Type I; Dietary Supplements; Disease Progre | 2000 |
23 other studies available for ipriflavone and Bone Loss, Osteoclastic
| Article | Year |
|---|---|
Cyclolinopeptides, cyclic peptides from flaxseed with osteoclast differentiation inhibitory activity.
Topics: Amino Acid Sequence; Bone Resorption; Cell Differentiation; Flax; Humans; Osteoclasts; Peptides, Cyc | 2016 |
Effects of ipriflavone on augmented bone using a guided bone regeneration procedure.
Topics: Adipose Tissue; Animals; Bone Marrow; Bone Regeneration; Bone Resorption; Calcification, Physiologic | 2007 |
Flavonoids alter bone-remodelling in auditory ossicle organ cultures.
Topics: Animals; Bone Resorption; Collagen; Culture Techniques; Dinoprostone; Flavonoids; Guinea Pigs; Isofl | 1995 |
Similarities and differences between the effects of ipriflavone and vitamin K on bone resorption and formation in vitro.
Topics: Acid Phosphatase; Animals; Bone Development; Bone Marrow; Bone Resorption; Cell Division; Cell Fract | 1995 |
[Experimental study on the effect of ipriflavone against osteoporosis in ovariectomized rats].
Topics: Alkaline Phosphatase; Animals; Bone Density; Bone Resorption; Calcium; Female; Isoflavones; Osteopor | 1994 |
[Comparative study of the in vitro effects of calcitonin, NaF and ipriflavone in cell culture].
Topics: Bone Density; Bone Resorption; Calcitonin; Cells, Cultured; Fibroblasts; Humans; In Vitro Techniques | 1994 |
Effects of KCA-098 on bone metabolism: comparison with those of ipriflavone.
Topics: 24,25-Dihydroxyvitamin D 3; Animals; Bone and Bones; Bone Density; Bone Resorption; Calcification, P | 1994 |
Ipriflavone directly inhibits osteoclastic activity.
Topics: Animals; Animals, Newborn; Bone Resorption; Calcium; Cell Movement; Cells, Cultured; Dose-Response R | 1994 |
Lack of effect of ipriflavone on osteoclast motility and bone resorption in in vitro and ex vivo studies.
Topics: Animals; Bone Resorption; Cell Adhesion; Cell Count; Cell Movement; Female; In Vitro Techniques; Iso | 1993 |
Inhibitory effect of ipriflavone on osteoclast-mediated bone resorption and new osteoclast formation in long-term cultures of mouse unfractionated bone cells.
Topics: Animals; Bone and Bones; Bone Resorption; Calcitonin; Calcitriol; Cell Count; Cells, Cultured; Denti | 1993 |
Lack of effect of ipriflavone on osteoclast motility and bone resorption in in vitro and ex vivo studies.
Topics: Animals; Bone Resorption; Calcitonin; Calcitriol; Cells, Cultured; Isoflavones; Mice; Osteoclasts; P | 1993 |
Inhibition of parathyroid hormone-stimulated resorption in cultured fetal rat long bones by the main metabolites of ipriflavone.
Topics: Animals; Bone Resorption; Culture Techniques; Female; Isoflavones; Molecular Structure; Osteoclasts; | 1996 |
Novel ipriflavone receptors coupled to calcium influx regulate osteoclast differentiation and function.
Topics: Acid Phosphatase; Animals; Bone Remodeling; Bone Resorption; Calcium; Cell Division; Chickens; Cytos | 1996 |
Advanced glycation end products enhance osteoclast-induced bone resorption in cultured mouse unfractionated bone cells and in rats implanted subcutaneously with devitalized bone particles.
Topics: Amyloidosis; Animals; beta 2-Microglobulin; Bone Resorption; Bone Transplantation; Calcitonin; Cells | 1997 |
Daidzein stimulation of bone resorption in pit formation assay.
Topics: Animals; Bone and Bones; Bone Resorption; Cell Count; Cells, Cultured; Estrogens, Non-Steroidal; Gen | 1997 |
Ipriflavone inhibits bone resorption in intact and ovariectomized rats.
Topics: Administration, Oral; Analysis of Variance; Animals; Bone Remodeling; Bone Resorption; Diet; Disease | 1997 |
Effects of ipriflavone on perialveolar bone formation.
Topics: Alveolar Process; Animals; Bone Remodeling; Bone Resorption; Coloring Agents; Image Processing, Comp | 1998 |
Histochemical and fine structural study of bone of ipriflavone-treated rats.
Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Bone Resorption; Cell Differentiation; Endoplasmic | 1992 |
Inhibitory effect of ipriflavone on pit formation in mouse unfractionated bone cells.
Topics: Acid Phosphatase; Animals; Bone Resorption; Calcitriol; Cells, Cultured; Dentin; Isoflavones; Mice; | 1992 |
Ipriflavone inhibits osteoclast differentiation in parathyroid transplanted parietal bone of rats.
Topics: Animals; Bone Resorption; Calcium; Cell Differentiation; Female; Isoflavones; Osteoclasts; Parathyro | 1992 |
[A new treatment possibility for osteoporosis with osteochin (ipriflavone) tablets].
Topics: Aged; Aged, 80 and over; Bone Resorption; Estrogens; Female; Flavonoids; Humans; Isoflavones; Middle | 1989 |
Suppressive effect of ipriflavone on bone depletion in the experimental diabetic rat: dose response of ipriflavone.
Topics: Animals; Body Weight; Bone Resorption; Diabetes Mellitus, Experimental; Dose-Response Relationship, | 1988 |
The effect of ipriflavone (TC-80) on bone resorption in tissue culture.
Topics: Animals; Bone Resorption; Calcium; Culture Techniques; Female; Flavonoids; Isoflavones; Parathyroid | 1986 |