ipi-926 and Lung-Neoplasms

ipi-926 has been researched along with Lung-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for ipi-926 and Lung-Neoplasms

ArticleYear
Patient with Gorlin syndrome and metastatic basal cell carcinoma refractory to smoothened inhibitors.
    JAMA dermatology, 2014, Volume: 150, Issue:8

    Basal cell carcinomas (BCCs) in patients with Gorlin syndrome have been reported to be extremely sensitive to Smoothened (SMO) inhibitors, a novel targeted therapy against the Hedgehog pathway, because of characteristic mutations in these patients. A few cases of disease refractory to oral therapy with SMO inhibitors have been reported in patients with Gorlin syndrome and nonmetastatic BCCs, but refractory disease in distantly metastatic tumors has not been documented in this high-risk group.. A man with Gorlin syndrome and innumerable cutaneous BCCs presented with biopsy-proven BCC in his lungs. After SMO inhibitor therapy, almost all of his cutaneous tumors shrank, but his lung metastases did not. These lung metastases remained refractory to treatment despite institution of a second SMO inhibitor.. We report a case of Gorlin syndrome in a patient with metastatic BCC refractory to SMO inhibitors. Furthermore, clinical responses in this patient's cutaneous tumors did not parallel the responses in the distant site. However, serial imaging after diagnosis of metastatic disease can be critical to monitor for response to therapy.

    Topics: Anilides; Antineoplastic Agents; Basal Cell Nevus Syndrome; Carcinoma, Basal Cell; Drug Resistance, Neoplasm; Humans; Lung Neoplasms; Male; Middle Aged; Pyridines; Receptors, G-Protein-Coupled; Skin Neoplasms; Smoothened Receptor; Treatment Failure; Veratrum Alkaloids

2014