ipi-145 and Respiratory-Tract-Diseases

ipi-145 has been researched along with Respiratory-Tract-Diseases* in 1 studies

Other Studies

1 other study(ies) available for ipi-145 and Respiratory-Tract-Diseases

Article	Year
Evolution of a Novel, Orally Bioavailable Series of PI3Kδ Inhibitors from an Inhaled Lead for the Treatment of Respiratory Disease. Journal of medicinal chemistry, 2016, 08-11, Volume: 59, Issue:15 A four-step process of high-quality modeling of existing data, deconstruction, identification of replacement cores, and an innovative synthetic regrowth strategy led to the rapid discovery of a novel oral series of PI3Kδ inhibitors with promising selectivity and excellent in vivo characteristics. Topics: Administration, Inhalation; Animals; Biological Availability; Class Ia Phosphatidylinositol 3-Kinase; Dose-Response Relationship, Drug; Male; Models, Molecular; Molecular Structure; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Respiratory Tract Diseases; Structure-Activity Relationship	2016

Article

Year

Evolution of a Novel, Orally Bioavailable Series of PI3Kδ Inhibitors from an Inhaled Lead for the Treatment of Respiratory Disease.

Journal of medicinal chemistry, 2016, 08-11, Volume: 59, Issue:15

A four-step process of high-quality modeling of existing data, deconstruction, identification of replacement cores, and an innovative synthetic regrowth strategy led to the rapid discovery of a novel oral series of PI3Kδ inhibitors with promising selectivity and excellent in vivo characteristics.

Topics: Administration, Inhalation; Animals; Biological Availability; Class Ia Phosphatidylinositol 3-Kinase; Dose-Response Relationship, Drug; Male; Models, Molecular; Molecular Structure; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Respiratory Tract Diseases; Structure-Activity Relationship

2016