Page last updated: 2024-10-29

iothalamic acid and Cirrhosis

iothalamic acid has been researched along with Cirrhosis in 1 studies

Iothalamic Acid: A contrast medium in diagnostic radiology with properties similar to those of diatrizoic acid. It is used primarily as its sodium and meglumine (IOTHALAMATE MEGLUMINE) salts.

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Young, EW1
Ellis, CN1
Messana, JM1
Johnson, KJ1
Leichtman, AB1
Mihatsch, MJ1
Hamilton, TA1
Groisser, DS1
Fradin, MS1
Voorhees, JJ1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Randomized Conversion of Calcineurin-Inhibitors(Tacrolimus to Sirolimus),6-24 Months Post Transplant Prednisone-Free Immunosuppression Regimen: Impact of Incidence of Acute Cellular Rejection,Renal Allograft Function & Lymphocytes Function[NCT00866879]Phase 4275 participants (Actual)Interventional2007-06-30Completed
Genetic Predisposition of Chronic Nephrotoxicity From Calcineurin Inhibitors in Liver Transplant Recipients, Potential Correlation With Urinary Biomarkers[NCT00857844]207 participants (Actual)Observational2007-07-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Incidence of Acute Cellular Rejection

The primary purpose of this research study is to evaluate whether the use of mycophenolate mofetil/Cellcept ® and either tacrolimus/Prograf ® (Group #1) or mycophenolate mofetil/Cellcept ® and sirolimus/Rapamune® (Group #2) impacts the incidence of acute cellular rejection in post-kidney transplant patients. This study will examine whether switching from tacrolimus to sirolimus will better preserve long-term kidney function. (NCT00866879)
Timeframe: Assessed at 6 Months, 12 Months, 24 Months, months 24 reported

InterventionParticipants (Count of Participants)
Control7
Transition to Sirolimus Group31

Percentage of Regulatory T Cells

"Specifically we reported here the percentage of regulatory T cells that were present in the two groups at 24 months post randomization.~With peripheral leukocytes taken at baseline (first visit) prior to randomization and at 6, 12 and 24 Months post-randomization, researchers will also review possible modifications of lymphocytes function and of the lymphocytes subpopulations that might have occurred as a consequence of the switch from tacrolimus to sirolimus (randomization)." (NCT00866879)
Timeframe: Assessed at 6 Months, 12 Months, 24 Months, months 24 reported

Intervention% of Treg Cells (Mean)
Control75
Transition to Sirolimus Group98

Renal Allograft Function Calculated With e-GFR and Proteinuria

Evaluate whether CI conversion (tacrolimus→sirolimus) contributes positively or negatively on the renal allograft function calculated with e-GFR and proteinuria (NCT00866879)
Timeframe: Assessed at 6 Months, 12 Months, 24 Months, months 24 reported

InterventionmL/min (Mean)
Control57.6
Transition to Sirolimus Group58.4

Evaluate if CI Conversion Impacts on Lipid Profile, Incidence of Hypertension, Malignancies, and Opportunistic Infections and Post-transplant DM

In addition to monitoring renal allograft function, evaluation will be conducted on the incidence of acute rejection, patient and graft survival, the impact of CI conversion on the lipid profile, the incidence of hypertension, malignancies, opportunistic infections and post-transplant DM (de novo diabetes mellitus). (NCT00866879)
Timeframe: Assessed at 6 Months, 12 Months, 24 Months, months 24 reported

,
Interventionnumber of incidents (Number)
InfectionsMalignanciesProteinuraHyperlipidemiaNODATBK viremiaBK nephropathyNeutropenia
Control334129315122
Transition to Sirolimus Group8396119228535

Patient and Graft Survival

This study also reviews the impact of the immunosuppressive medications on patient and graft survival. (NCT00866879)
Timeframe: Assessed at 6 Months, 12 Months, 24 Months, months 24 reported

,
Interventionnumber of incidents (Number)
Kidney transplant lossPatient death
Control43
Transition to Sirolimus Group1210

Trials

1 trial available for iothalamic acid and Cirrhosis

ArticleYear
A prospective study of renal structure and function in psoriasis patients treated with cyclosporin.
    Kidney international, 1994, Volume: 46, Issue:4

    Topics: Adult; Aged; Creatinine; Cyclosporine; Female; Fibrosis; Glomerular Filtration Rate; Humans; Iothala

1994
A prospective study of renal structure and function in psoriasis patients treated with cyclosporin.
    Kidney international, 1994, Volume: 46, Issue:4

    Topics: Adult; Aged; Creatinine; Cyclosporine; Female; Fibrosis; Glomerular Filtration Rate; Humans; Iothala

1994
A prospective study of renal structure and function in psoriasis patients treated with cyclosporin.
    Kidney international, 1994, Volume: 46, Issue:4

    Topics: Adult; Aged; Creatinine; Cyclosporine; Female; Fibrosis; Glomerular Filtration Rate; Humans; Iothala

1994
A prospective study of renal structure and function in psoriasis patients treated with cyclosporin.
    Kidney international, 1994, Volume: 46, Issue:4

    Topics: Adult; Aged; Creatinine; Cyclosporine; Female; Fibrosis; Glomerular Filtration Rate; Humans; Iothala

1994