iothalamic acid has been researched along with Cirrhosis in 1 studies
Iothalamic Acid: A contrast medium in diagnostic radiology with properties similar to those of diatrizoic acid. It is used primarily as its sodium and meglumine (IOTHALAMATE MEGLUMINE) salts.
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 1 (100.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Young, EW | 1 |
Ellis, CN | 1 |
Messana, JM | 1 |
Johnson, KJ | 1 |
Leichtman, AB | 1 |
Mihatsch, MJ | 1 |
Hamilton, TA | 1 |
Groisser, DS | 1 |
Fradin, MS | 1 |
Voorhees, JJ | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Randomized Conversion of Calcineurin-Inhibitors(Tacrolimus to Sirolimus),6-24 Months Post Transplant Prednisone-Free Immunosuppression Regimen: Impact of Incidence of Acute Cellular Rejection,Renal Allograft Function & Lymphocytes Function[NCT00866879] | Phase 4 | 275 participants (Actual) | Interventional | 2007-06-30 | Completed | ||
Genetic Predisposition of Chronic Nephrotoxicity From Calcineurin Inhibitors in Liver Transplant Recipients, Potential Correlation With Urinary Biomarkers[NCT00857844] | 207 participants (Actual) | Observational | 2007-07-31 | Completed | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
The primary purpose of this research study is to evaluate whether the use of mycophenolate mofetil/Cellcept ® and either tacrolimus/Prograf ® (Group #1) or mycophenolate mofetil/Cellcept ® and sirolimus/Rapamune® (Group #2) impacts the incidence of acute cellular rejection in post-kidney transplant patients. This study will examine whether switching from tacrolimus to sirolimus will better preserve long-term kidney function. (NCT00866879)
Timeframe: Assessed at 6 Months, 12 Months, 24 Months, months 24 reported
Intervention | Participants (Count of Participants) |
---|---|
Control | 7 |
Transition to Sirolimus Group | 31 |
"Specifically we reported here the percentage of regulatory T cells that were present in the two groups at 24 months post randomization.~With peripheral leukocytes taken at baseline (first visit) prior to randomization and at 6, 12 and 24 Months post-randomization, researchers will also review possible modifications of lymphocytes function and of the lymphocytes subpopulations that might have occurred as a consequence of the switch from tacrolimus to sirolimus (randomization)." (NCT00866879)
Timeframe: Assessed at 6 Months, 12 Months, 24 Months, months 24 reported
Intervention | % of Treg Cells (Mean) |
---|---|
Control | 75 |
Transition to Sirolimus Group | 98 |
Evaluate whether CI conversion (tacrolimus→sirolimus) contributes positively or negatively on the renal allograft function calculated with e-GFR and proteinuria (NCT00866879)
Timeframe: Assessed at 6 Months, 12 Months, 24 Months, months 24 reported
Intervention | mL/min (Mean) |
---|---|
Control | 57.6 |
Transition to Sirolimus Group | 58.4 |
In addition to monitoring renal allograft function, evaluation will be conducted on the incidence of acute rejection, patient and graft survival, the impact of CI conversion on the lipid profile, the incidence of hypertension, malignancies, opportunistic infections and post-transplant DM (de novo diabetes mellitus). (NCT00866879)
Timeframe: Assessed at 6 Months, 12 Months, 24 Months, months 24 reported
Intervention | number of incidents (Number) | |||||||
---|---|---|---|---|---|---|---|---|
Infections | Malignancies | Proteinura | Hyperlipidemia | NODAT | BK viremia | BK nephropathy | Neutropenia | |
Control | 33 | 4 | 12 | 9 | 3 | 15 | 1 | 22 |
Transition to Sirolimus Group | 83 | 9 | 61 | 19 | 2 | 28 | 5 | 35 |
This study also reviews the impact of the immunosuppressive medications on patient and graft survival. (NCT00866879)
Timeframe: Assessed at 6 Months, 12 Months, 24 Months, months 24 reported
Intervention | number of incidents (Number) | |
---|---|---|
Kidney transplant loss | Patient death | |
Control | 4 | 3 |
Transition to Sirolimus Group | 12 | 10 |
1 trial available for iothalamic acid and Cirrhosis
Article | Year |
---|---|
A prospective study of renal structure and function in psoriasis patients treated with cyclosporin.
Topics: Adult; Aged; Creatinine; Cyclosporine; Female; Fibrosis; Glomerular Filtration Rate; Humans; Iothala | 1994 |
A prospective study of renal structure and function in psoriasis patients treated with cyclosporin.
Topics: Adult; Aged; Creatinine; Cyclosporine; Female; Fibrosis; Glomerular Filtration Rate; Humans; Iothala | 1994 |
A prospective study of renal structure and function in psoriasis patients treated with cyclosporin.
Topics: Adult; Aged; Creatinine; Cyclosporine; Female; Fibrosis; Glomerular Filtration Rate; Humans; Iothala | 1994 |
A prospective study of renal structure and function in psoriasis patients treated with cyclosporin.
Topics: Adult; Aged; Creatinine; Cyclosporine; Female; Fibrosis; Glomerular Filtration Rate; Humans; Iothala | 1994 |