iothalamate-meglumine and Urinary-Bladder-Neoplasms

We determined whether virtual cystoscopy based on helical data sets can yield urinary capabilities similar to those achieved by fiber-optic cystoscopy.. A total of 11 patients with ultrasound detected bladder tumors underwent pelvic CT as a single volumetric scan after preliminary bladder distention with saline mixed with contrast medium using a 6Fr infant feeding tube. Cystoscopy was simulated based on a 3-dimensional helical CT data set in real time. Source raw CT data for virtual cystoscopy were reconstructed and navigation was done in real time using surface rendering navigation software. These images and findings were then compared with conventional cystoscopy findings.. An attenuation gradient of 350 HU between the vesical mucosa and urine was noted. Two of the 14 tumors (11 patients) were missed and each was 0.7 cm. All tumors greater than 0.9 cm were detected. Overall sensitivity was 85.7%. There were no false-positive findings. There was good correlation with tumor location and size. The ureteral orifices and their relationship to the tumor were also well appreciated. Subtle mucosal changes on conventional cystoscopy were not delineated by virtual cystoscopy.. Our method of instilling dilute contrast medium in the bladder offers an excellent attenuation gradient. The overall sensitivity of tumor detection is better than that reported for intravenous contrast medium and pneumocystoscopy.

Topics: Administration, Intravesical; Contrast Media; Cystoscopy; Humans; Image Interpretation, Computer-Assisted; Iothalamate Meglumine; Tomography, X-Ray Computed; Urinary Bladder Neoplasms

To assess the effects of contrast material on the viability of transitional cell carcinoma (TCC) cells and the ability of such cells to attach to a recipient bed, because seeding of TCC into the upper urinary tract is a possibility during retrograde pyelography or percutaneous procedures.. Primary cultures of TCC cells were established and placed in either quarter, half, or full-strength contrast for 10 minutes or one-quarter strength contrast for 10, 30, and 60 minutes. Cells were then removed from the contrast agent, resuspended in urothelium-specific media, and incubated for 5 days, after which the cells were counted.. A pronounced decrease in cell viability was observed with increasing exposure time and contrast material concentration. Cells incubated for 10, 30, and 60 minutes with contrast yielded an average of 79%, 60%, and 12% of the control group growth, respectively (P <0.001). Likewise, plates incubated with quarter, half, and full-strength contrast yielded 79%, 27%, and 10% of the control group growth, respectively (P <0.001). The difference in the response of low-grade superficial and high-grade invasive bladder tumors was not statistically significant.. TCC cells that have been exposed to dilute contrast material for a short period are able to attach and grow on an adequate recipient bed. However, increasing the contrast concentration and/or the exposure time appears to decrease the viability and adherence of the TCC cells.

Topics: Aged; Carcinoma, Transitional Cell; Cell Count; Cell Survival; Contrast Media; Humans; Iothalamate Meglumine; Male; Middle Aged; Tumor Cells, Cultured; Urinary Bladder Neoplasms