iothalamate-meglumine and Tuberous-Sclerosis

To follow up the growth of renal angiomyolipomas (AMLs).. Patients with known AML (n = 55) were divided into three groups on the basis of initial clinical and computed tomographic (CT) findings: group 1, isolated AML (n = 43); group 2, multiple AMLs without tuberous sclerosis (TS) (n = 6); group 3, multiple AMLs with TS (n = 6). Follow-up ultrasonography (US) and CT were performed in 55 and 31 patients, respectively. Growth of the AMLs (n = 59) was evaluated on the basis of area on initial and follow-up images.. Mean percentage growth was 17%, 128%, and 47%, and mean growth rate per year was 5%, 22%, and 18% in groups 1, 2, and 3, respectively. New renal lesions were noted in three patients in groups 1 and 2, but no new lesions were detected in group 3, because of the large number of AMLs. New extrarenal lesions were observed in four, two, and three patients in groups 1, 2, and 3, respectively. No correlation was found between percentage of fatty tissue and growth rate.. Multiple AMLs show more growth than solitary AMLs.

Topics: Adipose Tissue; Adult; Aged; Aged, 80 and over; Angiomyolipoma; Contrast Media; Female; Follow-Up Studies; Humans; Iothalamate Meglumine; Kidney Neoplasms; Liver Neoplasms; Male; Middle Aged; Radiographic Image Enhancement; Splenic Neoplasms; Tomography, X-Ray Computed; Tuberous Sclerosis; Ultrasonography