iothalamate-meglumine and Thrombophlebitis

A prospective, three-center study of two contrast agents for leg venography was performed to evaluate both the relative frequency of adverse effects and whether low-osmolality agents provided significant advantages for this procedure. Fifty-four patients were studied with the standard preparation (iothalamate meglumine) and 57 with a nonionic agent (iopamidol). Both were used at an iodine concentration of 200 mg/mL, and there were no differences in volume of contrast material, duration of infusion, percentage of positive studies, or overall diagnostic adequacy. Patient discomfort was less with iopamidol than with iothalamate (18% vs. 44%), although discomfort was generally mild in both groups. By objective follow-up studies, the frequency of postvenographic thrombosis was not significantly different in the two groups (8% vs. 9%). Contrast venography, then, had a low frequency of complications when either a dilute conventional or a low-osmolality agent was employed. Although the frequency of postvenographic thrombosis was low with both agents, patient discomfort was less with the low-osmolality formulation.

Topics: Clinical Trials as Topic; Double-Blind Method; Drug Tolerance; Female; Fibrinogen; Humans; Iodine Radioisotopes; Iopamidol; Iothalamate Meglumine; Leg; Male; Middle Aged; Phlebography; Radionuclide Imaging; Random Allocation; Thrombophlebitis; Veins

Topics: Adult; Clinical Trials as Topic; Contrast Media; Double-Blind Method; Female; Humans; Iodobenzoates; Iohexol; Iothalamate Meglumine; Male; Middle Aged; Phlebography; Thrombophlebitis; Triiodobenzoic Acids; Varicose Veins

A comparison was made of the incidence of venous thrombophlebitis resulting from the use of a high-osmolality contrast medium (Conray 60%, meglumine iothalamate), and a low-osmolality contrast medium (Niopam 61%, iopamidol). In 20 patients Conray was injected into one leg and Niopam into the other. The incidence of thrombophlebitis was then determined using the iodine-125 fibrinogen uptake test in a prospective, randomised, double-blind study. There was significantly less thrombophlebitis with Niopam than with Conray and it is concluded that Niopam is a safer contrast medium for phlebography.

Topics: Adult; Aged; Clinical Trials as Topic; Contrast Media; Double-Blind Method; Female; Humans; Iopamidol; Iothalamate Meglumine; Iothalamic Acid; Male; Middle Aged; Phlebography; Thrombophlebitis

A comparison was made of the incidence of venous thrombophlebitis resulting from the use of a high-osmolality contrast medium (Conray 60%, meglumine ioxaglate) and a low-osmolality contrast medium (Hexabrix 59%, meglumine iothalamate). In 30 patients with varicose veins, Conray was injected into one leg and Hexabrix into the other. The incidence of thrombophlebitis was then determined using the iodine-125 fibrinogen uptake test in a prospective, randomized, double-blind study. There was significantly less thrombophlebitis with Hexabrix than with Conray and the authors conclude that Hexabrix is safer for phlebography. Hexabrix is also stable in solution, only slightly more expensive than Conray, and one fifth the cost of metrizamide.

Topics: Adult; Aged; Clinical Trials as Topic; Contrast Media; Female; Fibrinogen; Humans; Iodine Radioisotopes; Iodobenzoates; Iothalamate Meglumine; Ioxaglic Acid; Leg; Male; Middle Aged; Radiography; Radionuclide Imaging; Thrombophlebitis; Triiodobenzoic Acids; Varicose Veins