iothalamate-meglumine and Spinal-Neoplasms

An unusual case of iodide-induced thyrotoxicosis is documented in this article. The patient was a 64-year-old euthyroid man with acromegaly. He also had multiple follicular and papillary thyroid carcinomas with a metastatic lesion in the lumbar vertebrae. After a total thyroidectomy, he became slightly hypothyroid, and the lumbar lesion began to incorporate 131I by scintigraphy. When an iodine-containing contrast medium happened to be injected, a transient increase of serum thyroid hormone level was observed. After complete thyroid ablation with 83 mCi of 131I, the oral administration of 100 mg of potassium iodide for 7 days induced a prominent increase of serum thyroid hormone level. These findings indicated that the metastatic thyroid carcinoma could produce excess thyroid hormone insofar as a sufficient amount of iodide was given. Although this is the first report of such a case, iodide-induced thyrotoxicosis may not be rare in patients with thyroid carcinomas because the Wolff-Chaikoff effect is thought to be lost, and the organic iodinating activity and lysosomal protease activity are well-preserved.

Topics: Acromegaly; Adenocarcinoma; Contrast Media; Iodine Radioisotopes; Iothalamate Meglumine; Neoplasms, Multiple Primary; Postoperative Complications; Radionuclide Imaging; Spinal Neoplasms; Thyroid Hormones; Thyroid Neoplasms; Thyrotoxicosis

Topics: Adolescent; Adult; Child, Preschool; Female; Humans; Iothalamate Meglumine; Male; Middle Aged; Myelography; Spinal Canal; Spinal Neoplasms

Topics: Adolescent; Adult; Arachnoiditis; Cauda Equina; Child, Preschool; Ependymoma; Humans; Iothalamate Meglumine; Iothalamic Acid; Lymphoma, Large B-Cell, Diffuse; Middle Aged; Myelography; Osteochondritis; Spinal Cord Neoplasms; Spinal Injuries; Spinal Neoplasms