iothalamate-meglumine and Pinealoma

Topics: Adolescent; Adult; Brain Diseases; Brain Neoplasms; Cerebral Aqueduct; Cerebral Ventriculography; Child; Child, Preschool; Female; Hallucinations; Humans; Infant; Iothalamate Meglumine; Male; Middle Aged; Pinealoma

After the first report on ventriculography with a water-soluble contrast medium, Conray, by Campbell et al., many authors reported complications such as convulsion which are attributable to the irritating effect of this agent. On the other hand its value has been appriciated. Recently Gonsette recommended a new water-soluble contrast medium, meglumine iocarnate (Dimer-X), for ventriculography and reported that this new agent is less epileptogenic and less harmful. Because of these advantages, they have been performing ventriculography routinely with Dimer-X and recognized its usefulness. The only noticeable complication has been the transient elevation of body temperature in almost a half of the series. As far as our experience goes there is no case of convulsive seizure as complication. As compared to gas ventriculography, the fine details of dimension and configuration of the ventricles are far more beautifully delineated with the water-soluble contrast media.

Topics: Adult; Brain Neoplasms; Cerebellar Neoplasms; Cerebral Ventricle Neoplasms; Cerebral Ventriculography; Child; Child, Preschool; Craniopharyngioma; Ependymoma; Female; Humans; Infant; Iothalamate Meglumine; Iothalamic Acid; Male; Pinealoma; Teratoma

Evaluation of 60% solution of Methylglucamine iocarmate (Dimer-X) for ventriculography in animal experiment and clinical cases was reported. The experimental result was compared with that of Conray 60 and Angiografin, which was reported in our previous papers. In seven intraventricular injections of 2.0 ml, administered to 6 dogs, convulsion was observed on three occasions, facial myoclonus on 1 and no symptoms on the remaining three. However, in 7 intraventricular injections of 1.5 ml for 6 dogs, 6 were symptom-free and only residual one showed convulsion. And no dog died in either experiment. No changes were seen in a subsequent ventriculogram one month after the 1st ventriculography with Dimer-X and also no histological changes of the ventricular wall were revealed one month after the first experiment. These experimental results suggested less toxicity of Dimer-X than Conray 60 or Angiografin. Clinically, in 17 neurosurgical patients, ventriculography was performed with 1-5 ml of Dimer-X. No patients showed convulsive complication, but there was one episode of vomiting in each of 2 cases and slight headache in one case. From our experimental and clinical studies, it is concluded that the Dimer-X is to be considered the best watersoluble contrast medium for ventriculography at present.

Topics: Adolescent; Adult; Animals; Cerebral Ventricle Neoplasms; Cerebral Ventriculography; Child; Child, Preschool; Dogs; Female; Humans; Infant; Iothalamate Meglumine; Iothalamic Acid; Male; Middle Aged; Pinealoma