iothalamate-meglumine and Nausea

Four, randomized, double blind comparisons of iohexol versus ionic media for peripheral angiography are summarized. Iohexol is safe, effective, and significantly less painful than ionic media for this indication.

Topics: Angiography; Blood Pressure; Clinical Trials as Topic; Contrast Media; Diatrizoate; Diatrizoate Meglumine; Double-Blind Method; Drug Tolerance; Female; Humans; Iodobenzoates; Iohexol; Iothalamate Meglumine; Male; Middle Aged; Nausea; Pain; Paresthesia; Random Allocation; Triiodobenzoic Acids; United States

Ninety-seven patients who were undergoing excretory urography for suspected genitourinary tract abnormalities were continuously monitored for systemic blood pressure and pulse rates before (control) and after rapid intravenous injections of contrast material (1.5 ml/kg meglumine iothalamate, 60%) using a Bard pressure monitor. We report the systemic responses observed. Clinically obvious reactions to contrast medium were recorded and compared with the blood pressure and pulse rate responses. The most common response to rapid infusion of contrast medium was a transient hypotension. An increase in systemic pressure had a high association with nausea and vomiting. Significant hypotension (mean blood pressure less than 60 mm Hg) was observed in six patients (6%), but no overt clinical manifestations were present.

Topics: Adult; Aged; Blood Pressure; Heart Rate; Hemodynamics; Humans; Hypotension; Iothalamate Meglumine; Middle Aged; Nausea; Urography

Topics: Acute Disease; Contrast Media; Headache; Humans; Iothalamate Meglumine; Meningitis; Nausea; Solubility; Vomiting; Water

The adverse effects in a series of 50 lumbar myelographies with Amipaque were compared with those in a corresponding series, examined with Dimer-X. Side effects occurred in 58% of the cases examined with Amipaque and in 68% of the Dimer-X series. No seizures occurred in 58% of the cases examined with Amipaque and in 68% of the Dimer-X series. No seizures occurred in either series but slight fibrillations of fasciculations appeared in 2 Dimer-X patients. Hyperreflexia of the legs was recorded in 22% of the Amipaque and in 36% of the Dimer-X cases. Other adverse reactions to the media were mild to moderate. Some burst activity, but no definite paroxysmal abnormality was noted in EEG recordings in 2 Amipaque cases. The low epileptogenicity of Amipaque has ensured a wider safety margin of lumbar myelography.

Topics: Adult; Aged; Brain; Diazepam; Drug Evaluation; Electroencephalography; Female; Fever; Headache; Humans; Iodobenzoates; Iothalamate Meglumine; Iothalamic Acid; Lumbosacral Region; Male; Metrizamide; Middle Aged; Myelography; Nausea; Pain; Premedication; Seizures

In a comparative study between Dimer X and Amipaque (metrizamide) for lumbar myelography it was found that there is a little higher frequency of monor, but unimportant side effects after Amipaque. Amipaque has also been used for thoracocervical myelography with excellent results and without greater discomfort than after myelography in the lumbar region. A new puncture technique was used for the eximation of the cervical region alone: lateral puncture on the neck between the laminae of C1 and C2 under TV control. In more than 75 reinvestigations no arachnoid changes were observed.

Topics: Adult; Aged; Female; Fever; Headache; Humans; Iodobenzoates; Iothalamate Meglumine; Iothalamic Acid; Lumbosacral Region; Male; Metrizamide; Middle Aged; Myelography; Nausea; Neck; Seizures; Subarachnoid Space; Surveys and Questionnaires; Urination Disorders; Vomiting

Lumbar myelography with dimeglumine iocarmate was performed in 90 cases premedicated with diazepam (Valium). EEG was performed before, as well as 3 and 24 hours after myelography. The use of diazepam interfered to some extent with the interpretation of the EEG. In 3 cases EEG abnormalities occurred 3 hours after myelography, most probably ascribable to Dimer-X. No further changes were found in the 24-hour recording. Immediate side effects were few and mild and seizures did not appear. The EEG abnormalities were equally distributed among patients with and without side effects.

Topics: Adolescent; Adult; Aged; Electroencephalography; Female; Headache; Humans; Iothalamate Meglumine; Iothalamic Acid; Male; Middle Aged; Myelography; Nausea; Pain; Seizures; Time Factors

Topics: Cerebral Ventriculography; Contrast Media; Drug Tolerance; Electroencephalography; Electromyography; Headache; Humans; Iodobenzoates; Iothalamate Meglumine; Metrizamide; Myelography; Nausea; Vomiting