iothalamate-meglumine and Intracranial-Arteriovenous-Malformations

Iopamidol (280 mgI/ml) was compared with Conray 60 (iothalmate meglumine, 282 mgI/ml) during selective and superselective cerebral arteriography. Twelve patients were examined, and a total of 51 selective injections were compared. Iopamidol produced significantly less pain and burning than Conray 60 and caused no patient motion.

Topics: Adult; Aged; Cerebral Angiography; Clinical Trials as Topic; Double-Blind Method; Facial Neoplasms; Female; Hemangioma; Humans; Intracranial Arteriovenous Malformations; Iopamidol; Iothalamate Meglumine; Iothalamic Acid; Male; Meningeal Neoplasms; Meningioma; Middle Aged

Rapid Sequence Tomography is shown to be a valid instrument to study the local distribution of more or less vascularized brain structures. Functional states as hypo- or hyperperfusion become clearly visible. RSCT permits a clear differentiation between intra- and extravascular contrast enhancement and offers an excellent insight into the angioarchitecture and quality of cerebral lesions.

Topics: Brain Neoplasms; Cerebrovascular Circulation; Cerebrovascular Disorders; Humans; Intracranial Arteriovenous Malformations; Iothalamate Meglumine; Tomography, X-Ray Computed

An important computerized tomographic (CT) pattern is described, in which selective enhancement of cerebral gray matter occurs after intravenous administration of contrast medium. Analysis of 76 cases displaying the enhancement pattern revealed that the phenomenon occurs in diseases characterized by hypoxia, and may be attributed to regional vascular dysautoregulation. Eighty percent of these patients had primary cerebrovascular disease (infarctions or transient ischemic attacks); 20% with other disorders also had evidence of cerebral ischemia or infarction. When hypoxia progressed to infarction, the enhancement was accompanied by one or more parenchymal areas of decreased density. However, in transient ischemic attacks, it occurred without other parenchymal abnormality and represents the first recognized CT sign of cerebral hypoxia. Enhancement was observed within 3 weeks of onset in 80% of cases, but in 20% it persisted for up to 4 months, indicating a protracted state of dysautoregulation.

Topics: Adolescent; Aged; Brain; Cerebral Infarction; Cerebrovascular Disorders; Female; Humans; Hypoxia, Brain; Intracranial Aneurysm; Intracranial Arteriovenous Malformations; Iothalamate Meglumine; Ischemic Attack, Transient; Male; Middle Aged; Tomography, X-Ray Computed

Contrast enhancement of computerized tomography is usually performed by means of intravenous injection of iodinated contrast materials. The authors have utilized a technique of direct arterial infusion of iodinated contrast material supplying intracranial arteries during computerized axial tomography. A representative case is presented with comparison scans which were obtained without contrast enhancement and with conventional intravenous infusion of contrast. Marked improvement of the enhancement was clearly demonstrated in this case, with abnormalities readily defined that were not seen with the conventional intravenous enhancement procedure.

Topics: Cerebellopontine Angle; Cerebellum; Contrast Media; Diagnosis, Computer-Assisted; Humans; Injections, Intra-Arterial; Intracranial Arteriovenous Malformations; Iothalamate Meglumine; Male; Middle Aged; Radiographic Image Enhancement; Tomography, X-Ray; Vertebral Artery