iothalamate-meglumine and Graft-Occlusion--Vascular

To evaluate imaging characteristics and artifacts of a nitinol stent with distal tantalum markers with computed tomography (CT) angiography and magnetic resonance (MR) angiography.. A vascular phantom was built to simulate in-stent restenosis. A nitinol stent with tantalum markers (Luminexx stent) was evaluated with CT angiography in different orientations relative to the z-axis and with MR angiography in different positions relative to both B0 and the readout gradient. Stenosis measurements were compared with conventional digital subtraction angiography for both modalities. In-stent signal intensity obtained with different flip angles was assessed in two nitinol stents with distal markers (Luminexx stent and SMART stent) and one without markers (Memotherm-FLEXX stent).. Stenosis detection was not possible with CT angiography when the stent was perpendicular to the z-axis because of streak-like artifacts induced by tantalum markers. Stenosis evaluation with multiplanar reformation was accurate when the stent was in parallel and oblique orientations relative to the table axis. With MR angiography, metallic artifacts were mostly related to the stent orientation with B0, whereas orientation of the readout gradient had little influence. The mean error (overestimation) for stenosis measurements varied between 0.1% and 7.4% for CT imaging in parallel and oblique positions and 3.6% and 9.5% for MR imaging. Higher flip angles did not improve signal intensity inside the three stents tested.. CT and MR angiography can be used for evaluating the patency of stents with distal markers that are parallel or oblique relative to the table axis (iliac, carotid, or femoral stents). MR angiography is preferred if the stent is perpendicular to the table axis (renal stent).

Topics: Alloys; Angiography, Digital Subtraction; Artifacts; Contrast Media; Graft Occlusion, Vascular; Image Processing, Computer-Assisted; Iothalamate Meglumine; Magnetic Resonance Angiography; Phantoms, Imaging; Stents; Tantalum; Tomography, X-Ray Computed

A noninvasive technique for determining bypass graft patency is greatly needed. To determine if bypass graft patency could be accurately assessed with ultrafast computed tomography (CT) following an intravenous contrast injection, ten patients with 21 coronary bypass grafts were studied. All patients had cardiac catheterization and ultrafast computed tomographic studies within one month of each other. The sensitivity of detecting angiographically open grafts with ultrafast CT was 94.1% (16/17), specificity of detecting angiographically closed grafts was 100% (4/4), and accuracy was 95.2% (20/21). These preliminary results in a small clinical series indicate that ultrafast CT may be a useful, minimally invasive technique for evaluating coronary bypass graft patency.

Topics: Contrast Media; Coronary Artery Bypass; Graft Occlusion, Vascular; Humans; Iothalamate Meglumine; Tomography, X-Ray Computed