iothalamate-meglumine and Cardiomyopathies

In eighty patients with different cardiac diseases the theoretically claimed reduced cardiovascular side effects in ionic and non-ionic low osmolar contrast media compared to those in conventional ionic and high-osmolar contrast media were tested during heart catheterization. The randomized application showed that there were only few reactions during left ventricle angiography and they did not differ between various ejections, while during selective coronary angiography in most cases heart rate and aortic pressures dropped significantly (p less than 0.05). These alterations were significantly (p less than 0.05) stronger in the conventional ionic and high-osmolar ioxitalamat (Telebrix 350) than in the ionic and non-ionic low-osmolar ioxaglat (Hexabrix) or non-ionic low-osmolar iopamidol (Solutrast 370).

Topics: Adult; Aged; Angiography; Cardiomyopathies; Contrast Media; Coronary Angiography; Coronary Disease; Female; Heart Diseases; Heart Valve Diseases; Heart Ventricles; Hemodynamics; Humans; Iodobenzoates; Iothalamate Meglumine; Ioxaglic Acid; Male; Middle Aged; Triiodobenzoic Acids

The radiopacity and complications of meglumine iothalamate 52% and sodium iothalamate 26% (Vascoray) were compared with those of meglumine diatrizoate 66% and sodium diatrizoate 10% (Renografin -76) in 2258 patients with and without cardiac disease. There was no difference in radiopacity and the type and incidence of adverse reactions were similar, but the frequency was significantly higher (p less than 0.05) with Vascoray in patients with constrictive pericarditis, dissecting aortic aneurysm, and primary pulmonary hypertension. The difference in the frequency of hypotension, sinus bradycardia, and transient asystole in the Renografin -76 and Vascoray groups was statistically significant. Ventricular arrhythmias occurred in 6% of the patients with primary myocardial disease compared to an average of 0.7% in those without this cardiac abnormality (p less than 0.01), but there was no significant difference in the frequency in the two contrast agent groups. All reactions were treated and the studies were performed without mortality. Results of this study show that iothalamate formulation with sodium to meglumine ratio of 1:2 containing 410 mEq/L of sodium (Vascoray) is suitable and safe for clinical use for roentgenographic studies of the heart, and coronary artery circulation.

Topics: Adult; Aged; Cardiac Catheterization; Cardiomyopathies; Contrast Media; Coronary Angiography; Coronary Disease; Diatrizoate; Diatrizoate Meglumine; Drug Combinations; Female; Heart Defects, Congenital; Humans; Iothalamate Meglumine; Iothalamic Acid; Male; Middle Aged; Rheumatic Heart Disease