iothalamate-meglumine and Arteriosclerosis

In 41 patients peripheral angiography was performed with the non-ionic contrast medium metrizamide (Amipaque) and the ionic iothalamate meglumine (Conray 60). Amipaque was found to give less subjective adverse effects and less changes in blood pressure.

Topics: Adult; Aged; Angiography; Arteriosclerosis; Blood Pressure; Double-Blind Method; Drug Evaluation; Female; Heart Rate; Humans; Iothalamate Meglumine; Leg; Male; Metrizamide; Middle Aged; Pain; Paresthesia

Complete evaluation of the aortoiliac femoropopliteal system is necessary for the proper evaluation of lower extremity peripheal vascular ischemic disease. We have used a modified infrarenal translumbar approach since it is both safely and rapidly performed. An analysis of 212 consecutive cases (the last 182 with translumbar technic) revealed that 72 per cent of patients had significant atherosclerotic involvement of the aorta or one or more common or external iliac arteries, 43 per cent had significant bilateral involvement, and it was judged that retrograde femoral catheterization would have been difficult or impossible in 38 per cent. Biplane aortoiliac evaluation was added in our last seventy-nine studies. This provided additional diagnostic help in thirty-six of these cases and revealed an abnormality not otherwise visible in six of these patients. There were no serious complications in this series.

Topics: Aorta, Abdominal; Aortic Diseases; Aortography; Arterial Occlusive Diseases; Arteriosclerosis; Catheterization; Diatrizoate; Diatrizoate Meglumine; Humans; Iliac Artery; Iothalamate Meglumine