iothalamate-meglumine and Arrhythmias--Cardiac

The incidence of cardiac arrhythmias in patients with coronary artery disease receiving intravenous contrast medium has been studied and comparison made between a conventional ionic medium (meglumine iothalamate) and a low osmolar medium (sodium meglumine ioxaglate). Occasional ventricular and atrial ectopics were frequently observed both before and during administration of the contrast medium and were regarded as insignificant. Significant arrhythmias occurred in five cases. Three of these however, were in the presence of acute myocardial ischaemia or recent infarction. There was no significant difference in the incidence of arrhythmias between the two contrast media. These results show that, in the absence of acute myocardial ischaemia, the incidence of life threatening arrhythmias in patients with proven coronary artery disease receiving intravenous contrast media is much lower than previously suspected.

Topics: Arrhythmias, Cardiac; Coronary Disease; Humans; Infusions, Intravenous; Iothalamate Meglumine; Ioxaglic Acid; Radiography

The relation between ionic composition and cardiotoxicity of two dimers, iocarmate and iozomate, was investigated by selective injection into the left and right coronary arteries, Least toxic reactions developed at a sodium concentration of 263 to 315 mmol/l for sodium-meglumine iocarmate and 271 to 379 mmol/l for sodium-meglumine iozomate.

Topics: Animals; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Coronary Angiography; Diatrizoate; Drug Evaluation, Preclinical; Heart Block; Heart Conduction System; Injections, Intra-Arterial; Iothalamate Meglumine; Iothalamic Acid; Osmolar Concentration; Rabbits; Ventricular Fibrillation

Topics: Adolescent; Angiocardiography; Arrhythmias, Cardiac; Bronchial Spasm; Cardiac Catheterization; Child; Contrast Media; Cough; Dyspnea; Geriatrics; Headache; Heart Defects, Congenital; Humans; Hypotension; Infant; Infant, Newborn; Iothalamate Meglumine; Iothalamic Acid; Mortality; Pulmonary Edema; Taste; Toxicology; Urticaria; Vomiting