Page last updated: 2024-10-29

iohexol and Disease Models, Animal

iohexol has been researched along with Disease Models, Animal in 81 studies

Iohexol: An effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality.
iohexol : A benzenedicarboxamide compound having N-(2,3-dihydroxypropyl)carbamoyl groups at the 1- and 3-positions, iodo substituents at the 2-, 4- and 6-positions and an N-(2,3-dihydroxypropyl)acetamido group at the 5-position.

Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.

Research Excerpts

ExcerptRelevanceReference
"To investigate the effect of Kashin-Beck disease (KBD)-affected feed and T-2 toxin on the bone development of Wistar rats."7.76The effect of Kashin-Beck disease-affected feed and T-2 toxin on the bone development of Wistar rats. ( Deng, J; Duan, L; Huang, H; Kang, P; Pei, FX; Shen, B; Yan, D; Yang, J; Zhou, Z, 2010)
" In our study, dehydration duration and the iohexol dosage were found to be the two most important factors to develop a rat CIN model."3.91A novel rat model of contrast-induced nephropathy based on dehydration. ( Chen, LH; Cheng, WJ; Hu, C; Li, DY; Liu, K; Wang, JL; Xie, YL; Yin, WJ; Zhou, G; Zhou, LY; Zuo, SR; Zuo, XC, 2019)
"The application of iodinated contrast medium has become a risk factor for metformin-associated lactic acidosis (MALA), which leads to the accumulation of metformin in vivo is one of the principal reasons for MALA."3.88Involvement of organic cation transporter 2 in the metformin-associated increased lactate levels caused by contrast-induced nephropathy. ( Dai, Y; Huo, X; Liu, K; Liu, Z; Ma, X; Meng, Q; Peng, J; Sun, H; Wang, C; Yang, S, 2018)
"We exposed mouse and human acinar cells to the radiocontrast agent iohexol (Omnipaque; GE Healthcare, Princeton, NJ) and measured intracellular release of Ca(2+), calcineurin activation (using a luciferase reporter), activation of nuclear factor-κB (NF-κB, using a luciferase reporter), and cell necrosis (via propidium iodide uptake)."3.81Exposure to Radiocontrast Agents Induces Pancreatic Inflammation by Activation of Nuclear Factor-κB, Calcium Signaling, and Calcineurin. ( Bottino, R; Eisses, JF; Husain, SZ; Javed, TA; Jin, S; Le, T; Molkentin, JD; Orabi, AI; Sah, S, 2015)
"Rats received nitric oxide synthase inhibitor L-NAME (10 mg/kg) and cyclooxygenase inhibitor indomethacin (10 mg/kg) to induce the risk for developing iodinated contrast-induced acute kidney injury before receiving one of the interventions: NAC, furosemide, or placebo."3.80Efficacy of preventive interventions for iodinated contrast-induced acute kidney injury evaluated by intrarenal oxygenation as an early marker. ( Franklin, T; Li, LP; Lu, J; Papadopoulou, MV; Prasad, PV; Solomon, R; Thacker, J; Zhou, Y, 2014)
"To investigate the effect of Kashin-Beck disease (KBD)-affected feed and T-2 toxin on the bone development of Wistar rats."3.76The effect of Kashin-Beck disease-affected feed and T-2 toxin on the bone development of Wistar rats. ( Deng, J; Duan, L; Huang, H; Kang, P; Pei, FX; Shen, B; Yan, D; Yang, J; Zhou, Z, 2010)
"The use of MRX-320 as an oral contrast agent with an intravenous bolus of iohexol at CT increased reader confidence for the diagnosis of intestinal ischemia and improved subjective measures of image quality."3.70Evaluation of an experimental low-attenuation gastrointestinal contrast agent for CT imaging of intestinal ischemia in an animal model. ( Chosy, SG; Krupinski, EA; Kuhlman, JE; Lee, FT; Spilde, JM; Yandow, DR, 1999)
"EEDA is superior to iohexol for imaging liver abscesses."3.69Hepatic imaging with iodinated nanoparticles: a comparison with iohexol in rabbits. ( Bacon, ER; Gazelle, GS; Halpern, EF; McIntire, GL; Na, G; Toner, JL; Wolf, GL, 1995)
"This study evaluates the use of iohexol as a radiographic diagnostic contrast agent in normal animals and those with experimental bowel ischemia and obstruction."3.67Use of iohexol in the radiographic diagnosis of ischemic bowel. ( Billmire, DF; Block, T; Cohen, M; Grosfeld, JL; Gunter, M; Schwartzentruber, DJ, 1986)
"Contrast-induced acute renal injury (CI-AKI) has become a common cause of hospital-acquired renal failure."1.43Salvianolic Acid B Prevents Iodinated Contrast Media-Induced Acute Renal Injury in Rats via the PI3K/Akt/Nrf2 Pathway. ( Jiachang, H; Nana, S; Shaopeng, L; Ting, Z; Tongqiang, L; Xialian, X; Xiaofang, Y; Xiaoqiang, D, 2016)
"Iohexol 300 mgI/mL was administered followed by images obtained in diastole."1.42Delayed contrast enhancement imaging of a murine model for ischemia reperfusion with carbon nanotube micro-CT. ( Burk, LM; Kang, E; Lee, YZ; Lu, J; Wait, JM; Wang, KH; Willis, M; Zhou, O, 2015)
"Hematoma is a common complication following arterial puncture."1.39Animal experimental evaluation of a new sealing device for indwelling arterial catheters. ( Bruners, P; Günther, RW; Isfort, P; Mahnken, AH; Penzkofer, T; Pfeffer, J; Schmitz-Rode, T; Steinseifer, U; Urban, U, 2013)
"In histology, percentage area of stenosis (BMS+PCB=29."1.39Stent healing response following delivery of paclitaxel via durable polymeric matrix versus iopromide-based balloon coating in the familial hypercholesterolaemic swine model of coronary injury. ( Afari, M; Buszman, PP; Cheng, Y; Conditt, GB; Granada, JF; Kaluza, GL; McGregor, JC; Milewski, K; Stenoien, M; Tellez, A, 2013)
"Paclitaxel tissue uptake was assessed in 20 iliofemoral arteries of a domestic swine."1.39Tissue uptake, distribution, and healing response after delivery of paclitaxel via second-generation iopromide-based balloon coating: a comparison with the first-generation technology in the iliofemoral porcine model. ( Afari, ME; Buszman, PP; Conditt, GB; Granada, JF; Kaluza, GL; McGregor, JC; Peppas, A; Rousselle, SD; Stenoien, M; Tellez, A, 2013)
"Intraoperative arrhythmias occurred in 14 cases: premature ventricular complexes with (5) or without (3) ventricular tachycardia, 2nd degree atrio-ventricular block (1), and ventricular fibrillation (6)."1.39Embozene™ microspheres induced nonreperfused myocardial infarction in an experimental swine model. ( Brott, BC; Elgavish, GA; Kiss, P; Simor, T; Varga-Szemes, A; Wang, D, 2013)
"Data from one rabbit with airway obstruction were excluded because of post-procedure pneumatothorax."1.37Dual energy CT ventilation imaging after aerosol inhalation of iodinated contrast medium in rabbits. ( Chai, X; Lu, GM; Lu, L; Peng, J; Wang, ZJ; Zhang, LJ; Zhao, YE; Zhu, K, 2011)
"Similar trends for increased cortical intracerebral hemorrhage were seen in the contrast-only (P=0."1.36Intra-arterial iodinated radiographic contrast material injection administration in a rat middle cerebral artery occlusion and reperfusion model: possible effects on intracerebral hemorrhage. ( Carrozzella, JA; Clark, JF; Khatri, P; Khoury, J; Kurosawa, Y; Lu, A; Tomsick, TA, 2010)
"Acute pericardial tamponade is a life-threatening complication of invasive cardiovascular procedures."1.33Decrease in fluoroscopic cardiac silhouette excursion precedes hemodynamic compromise in intraprocedural tamponade. ( Epstein, AE; Ideker, RE; Johnson, PL; Kay, GN; Killingsworth, CR; Lan, D; Nanthakumar, K; Plumb, VJ; Smith, WM; Zheng, X, 2005)
"The HOCM, diatrizoate, was more toxic to rat kidneys than the LOCM iohexol; PLA2, LPO and calcium load played a role in producing renal function impairment induced by diatrizoate meglumine; amlodipine protected the renal tissue from nephrotoxicity induced by diatrizoate."1.31Nephrotoxicity of high- and low-osmolar contrast media. The protective role of amlodipine in a rat model. ( Duan, SB; Liu, FY; Liu, RH; Luo, JA; Peng, YM; Wu, HW; Yang, XL, 2000)
"Thrombosis was measured over a blood exposure period of 2 hours by gamma camera imaging of 111In-platelets and by gamma counting of deposited 125I-fibrin."1.31Antithrombotic effects of ionic and non-ionic contrast media in nonhuman primates. ( Chronos, NA; Hanson, SR; Markou, CP, 2001)

Research

Studies (81)

TimeframeStudies, this research(%)All Research%
pre-19901 (1.23)18.7374
1990's11 (13.58)18.2507
2000's18 (22.22)29.6817
2010's44 (54.32)24.3611
2020's7 (8.64)2.80

Authors

AuthorsStudies
Abrams, RPM1
Yasgar, A1
Teramoto, T1
Lee, MH1
Dorjsuren, D1
Eastman, RT1
Malik, N1
Zakharov, AV1
Li, W1
Bachani, M1
Brimacombe, K1
Steiner, JP1
Hall, MD1
Balasubramanian, A1
Jadhav, A1
Padmanabhan, R1
Simeonov, A1
Nath, A1
Fang, D1
Wang, Y1
Zhang, Z2
Yang, D1
Gu, D2
He, B3
Zhang, X1
He, D2
Wang, H2
Jose, PA1
Han, Y2
Zeng, C2
Wu, J1
Shen, J1
Wang, W1
Jiang, N2
Jin, H1
Che, X1
Ni, Z2
Fang, Y3
Mou, S2
Kalogirou, TE1
Meditskou, S1
Davidopoulou, S1
Savvas, I1
Pitoulias, AG1
Pitoulias, GA1
Liu, K2
Zhou, LY1
Li, DY1
Cheng, WJ1
Yin, WJ1
Hu, C1
Xie, YL1
Wang, JL1
Zuo, SR1
Chen, LH1
Zhou, G1
Zuo, XC1
Chen, F1
Lu, J3
Yang, X2
Xiao, B1
Chen, H1
Pei, W1
Jin, Y1
Wang, M1
Li, Y1
Zhang, J2
Liu, F1
Gu, G1
Cui, W1
Shi, Y1
Gong, Z1
Xia, T1
Ren, H1
Yang, J2
Shibata, S1
Moniwa, N1
Kuno, A1
Kimura, A1
Ohwada, W1
Sugawara, H1
Gocho, Y1
Tanaka, M1
Yano, T1
Furuhashi, M1
Tanno, M1
Miki, T1
Miura, T1
Chen, G1
Liu, B1
Chen, S1
Li, H2
Liu, J2
Mai, Z1
Chen, E1
Zhou, C1
Sun, G1
Guo, Z1
Lei, L1
Huang, S1
Zhang, L1
Li, M1
Tan, N1
Liao, Y1
Chen, J2
Liu, Y1
Rollins, K1
Noorani, A1
Janeckova, L1
Jones, T1
Griffiths, M1
Baker, MP1
Boyle, JR1
Rossfeld, KK1
Justiniano, SE1
Ding, H1
Gong, L1
Kothandaraman, S1
Sawant, D1
Saji, M1
Wright, CL1
Kirschner, LS1
Ringel, MD1
Tweedle, MF1
Phay, JE1
Van Cauteren, T1
Van Gompel, G1
Tanaka, K1
Verdries, DE1
Belsack, D1
Nieboer, KH1
Willekens, I1
Evans, P1
Macholl, S1
Verfaillie, G1
Droogmans, S1
de Mey, J1
Buls, N1
Sun, K1
Han, R1
Zhao, R1
Bai, S1
Wang, J1
Hu, J1
Lu, B1
Cheng, W1
Zhao, F1
Tang, CY1
Li, XW1
Luo, M1
Duan, SB2
Yang, S1
Dai, Y1
Liu, Z1
Wang, C1
Meng, Q1
Huo, X1
Sun, H2
Ma, X1
Peng, J2
Shao, X1
Gu, L1
Li, S1
Lin, Q1
He, Y1
Zhang, M1
Zhou, W1
Dobrivojević, M1
Bohaček, I1
Erjavec, I1
Gorup, D1
Gajović, S1
Isfort, P1
Urban, U1
Mahnken, AH5
Penzkofer, T1
Bruners, P5
Pfeffer, J1
Steinseifer, U1
Günther, RW4
Schmitz-Rode, T1
Anayama, T1
Nakajima, T1
Dunne, M1
Zheng, J1
Allen, C1
Driscoll, B1
Vines, D1
Keshavjee, S1
Jaffray, D1
Yasufuku, K1
Wang, JH1
Sun, GF1
Shao, CW1
Zuo, CJ1
Hao, J1
Zheng, JM1
Feng, XY1
Buszman, PP2
Tellez, A2
Afari, M1
Cheng, Y1
Conditt, GB2
McGregor, JC2
Milewski, K1
Stenoien, M2
Kaluza, GL2
Granada, JF2
Afari, ME1
Peppas, A1
Rousselle, SD1
Schwarz, F1
Hinkel, R1
Baloch, E1
Marcus, RP1
Hildebrandt, K1
Sandner, TA1
Kupatt, C1
Hoffmann, V1
Wintersperger, BJ1
Reiser, MF1
Theisen, D1
Nikolaou, K1
Bamberg, F1
Sun, S1
Zhang, T2
Nie, P1
Hu, L1
Yu, Y1
Cui, M1
Cai, Z1
Shen, L1
Li, LP1
Thacker, J1
Franklin, T1
Zhou, Y1
Papadopoulou, MV1
Solomon, R1
Prasad, PV1
Wang, YC1
Tang, A1
Chang, D1
Zhang, SJ1
Ju, S1
Potretzke, TA1
Brace, CL1
Lubner, MG1
Sampson, LA1
Willey, BJ1
Lee, FT2
Liu, T1
Liu, S1
Yu, X1
Zhang, H2
Liang, M1
Ding, X1
Liu, TQ1
Luo, WL1
Tan, X1
Yu, XF1
Cai, JR1
Ding, XQ1
Burk, LM1
Wang, KH1
Wait, JM1
Kang, E1
Willis, M1
Zhou, O1
Lee, YZ1
Elliott, JT1
Samkoe, KS1
Gunn, JR1
Stewart, EE2
Gardner, TB1
Tichauer, KM1
Lee, TY3
Hoopes, PJ1
Pereira, SP1
Hasan, T1
Pogue, BW1
Jin, S1
Orabi, AI1
Le, T1
Javed, TA1
Sah, S1
Eisses, JF1
Bottino, R1
Molkentin, JD1
Husain, SZ1
Xiao, X1
Zhang, W1
Ma, Z1
Zhang, JL1
Tang, L1
Bartneck, M1
Warzecha, KT1
Tag, CG1
Sauer-Lehnen, S1
Heymann, F1
Trautwein, C1
Weiskirchen, R1
Tacke, F1
Kim, JI1
Lee, HJ1
Goo, JM1
Kim, MA1
Chung, DH1
Cordaro, M1
Impellizzeri, D1
Bruschetta, G1
Siracusa, R1
Crupi, R1
Di Paola, R1
Esposito, E1
Cuzzocrea, S1
Rowe, ES1
Rowe, VD1
Biswas, S1
Mosher, G1
Insisienmay, L1
Ozias, MK1
Gralinski, MR1
Hunter, J1
Barnett, JS1
Tongqiang, L1
Shaopeng, L1
Xiaofang, Y1
Nana, S1
Xialian, X1
Jiachang, H1
Ting, Z1
Xiaoqiang, D1
Sun, SQ1
Ding, D1
Zhang, WF1
Wang, XL1
Sun, Z1
Hu, LH1
Qin, SY1
Shen, LH1
Matsunami, T1
Hino, K1
Dosho, R1
Miyatake, S1
Ebisu, G1
Kuwatsuru, R1
Jost, G1
Sieber, M1
Seidensticker, PR1
Pietsch, H1
Cao, ZY1
Sun, JB1
Yoon, SK1
Choi, JC1
Cho, JH1
Oh, JY1
Nam, KJ1
Jung, SI1
Kwon, HC1
Kim, DC1
Rha, SH1
Wu, H1
Xu, X1
Ying, H1
Hoffman, MR1
Shen, N1
Sha, Y1
Zhou, L1
Bornikoel, CM1
Krämer, N1
Guenther, RW1
Kurosawa, Y1
Lu, A1
Khatri, P1
Carrozzella, JA1
Clark, JF1
Khoury, J1
Tomsick, TA1
Yan, D1
Kang, P1
Shen, B1
Zhou, Z1
Duan, L1
Deng, J1
Huang, H1
Pei, FX1
Zhang, LJ1
Wang, ZJ1
Lu, L1
Zhu, K1
Chai, X1
Zhao, YE1
Lu, GM1
Wong, JT2
Le, H2
Suh, WM1
Chalyan, DA1
Mehraien, T1
Kern, MJ1
Kassab, GS1
Molloi, S2
Chalyan, D1
Tomkowiak, MT1
Klein, AJ1
Vigen, KK1
Hacker, TA1
Speidel, MA1
VanLysel, MS1
Raval, AN1
So, A1
Hsieh, J1
Li, JY1
Hadway, J1
Kong, HF1
Guo, CW1
Shen, SD1
Zhang, Y1
Yi, XL1
Liang, C1
Luo, W1
Smets, PM1
Lefebvre, HP1
Aresu, L1
Croubels, S1
Haers, H1
Piron, K1
Meyer, E1
Daminet, S1
Varga-Szemes, A1
Kiss, P1
Brott, BC1
Wang, D1
Simor, T1
Elgavish, GA1
Chen, X1
Schafer, PH1
Chen, Y1
Garcia, BM1
Liss, P1
Carlsson, PO1
Nygren, A1
Palm, F1
Hansell, P1
Spilde, JM1
Chosy, SG1
Krupinski, EA1
Kuhlman, JE1
Yandow, DR1
Hörmann, M1
Philipp, MO1
Eberl, H1
Windberger, U1
Matzek, W1
Schäfer-Prokop, C1
Metz, VM1
Shionoya, H1
Sugihara, Y1
Okano, K1
Sagami, F1
Mikami, T1
Katayama, K1
Nanthakumar, K1
Kay, GN1
Plumb, VJ1
Zheng, X1
Killingsworth, CR1
Smith, WM1
Ideker, RE1
Epstein, AE1
Lan, D1
Johnson, PL1
Katoh, M1
Wildberger, JE2
Buecker, A1
Ding, YH1
Dai, D1
Danielson, MA1
Kadirvel, R1
Lewis, DA1
Cloft, HJ1
Kallmes, DF1
Mühlenbruch, G1
Emmerich, M1
Hohl, C1
Apodaca-Torrez, FR1
Goldenberg, A1
Lobo, EJ1
Farah, JF1
Triviño, T1
Montero, EF1
Schraibman, V1
Benvenuto, RB1
Artigiani Neto, R1
Thomsen, HS2
Dorph, S2
Larsen, S2
Horn, T2
Hemmingsen, L2
Skaarup, P2
Golman, K2
Svendsen, O2
Schmitz, SA1
Wagner, S1
Schuhmann-Giampieri, G1
Wolf, KJ1
Gazelle, GS1
Wolf, GL1
McIntire, GL1
Bacon, ER1
Na, G1
Halpern, EF1
Toner, JL1
Idée, JM1
Bourgoin-Balut, C1
Lefevre, T1
Zamia, P1
Goulas, V1
Gaillard, S1
Mathias, C1
Bonnemain, B1
Donadio, C1
Tramonti, G1
Lucchesi, A1
Auner, I1
Bianchi, C1
Bell, MR1
Lerman, LO1
Rumberger, JA1
Liu, FY1
Luo, JA1
Wu, HW1
Liu, RH1
Peng, YM1
Yang, XL1
Aguejouf, O1
Malfatti, E1
Doutremepuich, F1
Doutremepuich, C1
Markou, CP1
Chronos, NA1
Hanson, SR1
Omary, RA1
Henseler, KP1
Unal, O1
Maciolek, LJ1
Finn, JP1
Li, D1
Nemcek, AA1
Vogelzang, RL1
Grist, TM1
Zhu, Y1
Tomasiak, R1
Fay, WP1
Wells, HD1
Hyrnchak, MA1
Burbridge, BE1
Solheim, KE1
Laerum, F1
Stordahl, A1
Aase, S1
Theobaldy, S1
Haupt, W1
Feistel, H1
Hofmann-Preiss, K1
Schwartzentruber, DJ1
Billmire, DF1
Cohen, M1
Block, T1
Gunter, M1
Grosfeld, JL1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Safety, Feasibility and Accuracy of Dynamic Computed Tomography Myocardial Perfusion Imaging for Detection of Coronary Artery Disease[NCT03324308]10 participants (Actual)Interventional2018-03-30Active, not recruiting
Functional MRI-based Assessment of Terlipressin vs. Octreotide on Renal Function in Cirrhotic Patients With Acute Variceal Bleeding (CHESS1903): A Multicenter, Single-blind, Randomised Controlled Trial[NCT04028323]Phase 460 participants (Anticipated)Interventional2019-07-16Recruiting
Intravenous vs. Oral Hydration to Reduce the Risk of Post-Contrast Acute Kidney Injury After Intravenous Contrast-Enhanced Computed Tomography in Patients With Severe Chronic Kidney Disease (ENRICH): A Randomized Controlled Trial[NCT05283512]254 participants (Anticipated)Interventional2022-04-20Recruiting
Noninvasive Evaluation of Ischemia Causing Coronary Stenosis, Wall Shear Stress, and Total Plaque Force Using Coronary CT Angiography (CCTA) and Physics-based Analytic Model Derived From Conservation of Energy[NCT01857687]100 participants (Anticipated)Observational2013-05-31Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

81 other studies available for iohexol and Disease Models, Animal

ArticleYear
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
    Proceedings of the National Academy of Sciences of the United States of America, 2020, 12-08, Volume: 117, Issue:49

    Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr

2020
Calorie Restriction Protects against Contrast-Induced Nephropathy via SIRT1/GPX4 Activation.
    Oxidative medicine and cellular longevity, 2021, Volume: 2021

    Topics: Animals; Apoptosis; Caloric Restriction; Contrast Media; Cytokines; Disease Models, Animal; Enzyme A

2021
A novel contrast-induced acute kidney injury mouse model based on low-osmolar contrast medium.
    Renal failure, 2022, Volume: 44, Issue:1

    Topics: Acute Kidney Injury; Animals; Contrast Media; Disease Models, Animal; Furosemide; Iohexol; Kidney; M

2022
Investigating the Possible Protective Role of Direct Intra-arterial Administration of Mannitol and N-Acetylcysteine and Per Os Administration of Simvastatin Against Contrast-Induced Nephropathy: An Experimental Study in a Rabbit Model.
    Cardiovascular and interventional radiology, 2019, Volume: 42, Issue:12

    Topics: Acetylcysteine; Acute Kidney Injury; Administration, Oral; Animals; Contrast Media; Disease Models,

2019
A novel rat model of contrast-induced nephropathy based on dehydration.
    Journal of pharmacological sciences, 2019, Volume: 141, Issue:1

    Topics: Acute Kidney Injury; Animals; Biomarkers; Contrast Media; Creatinine; Dehydration; Disease Models, A

2019
Acetylbritannilactone attenuates contrast-induced acute kidney injury through its anti-pyroptosis effects.
    Bioscience reports, 2020, 02-28, Volume: 40, Issue:2

    Topics: Acute Kidney Injury; Animals; Apoptosis Regulatory Proteins; Cell Line; Disease Models, Animal; Epit

2020
AdipoRon, an adiponectin receptor agonist, protects contrast-induced nephropathy by suppressing oxidative stress and inflammation via activation of the AMPK pathway.
    Clinical and experimental nephrology, 2020, Volume: 24, Issue:11

    Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Blood Urea Nitrogen; Cell Adhesion Molecules; Cel

2020
Involvement of necroptosis in contrast-induced nephropathy in a rat CKD model.
    Clinical and experimental nephrology, 2021, Volume: 25, Issue:7

    Topics: Acute Kidney Injury; Animals; Contrast Media; Disease Models, Animal; Iohexol; Kidney Tubules, Proxi

2021
Novel biomarkers for post-contrast acute kidney injury identified from long non-coding RNA expression profiles.
    International journal of biological sciences, 2021, Volume: 17, Issue:3

    Topics: Acute Kidney Injury; Aged; Animals; Biomarkers; Contrast Media; Disease Models, Animal; Female; Gene

2021
Ascorbic acid ameliorates renal injury in a murine model of contrast-induced nephropathy.
    BMC nephrology, 2017, 03-24, Volume: 18, Issue:1

    Topics: Acute Kidney Injury; Animals; Antioxidants; Apoptosis; Ascorbic Acid; Caspase 3; Contrast Media; Cre

2017
Biological Evaluation of a Fluorescent-Imaging Agent for Medullary Thyroid Cancer in an Orthotopic Model.
    The Journal of clinical endocrinology and metabolism, 2017, 09-01, Volume: 102, Issue:9

    Topics: Animals; Biopsy, Needle; Calcitonin; Carcinoma, Neuroendocrine; Disease Models, Animal; Fluorescent

2017
The Impact of Combining a Low-Tube Voltage Acquisition with Iterative Reconstruction on Total Iodine Dose in Coronary CT Angiography.
    BioMed research international, 2017, Volume: 2017

    Topics: Animals; Body Mass Index; Computed Tomography Angiography; Contrast Media; Coronary Angiography; Cor

2017
Evaluation of dual energy computed tomography iodine mapping within the myocardial blood pool for detection of acute myocardial infarction: correlation with histopathological findings in a porcine model.
    The British journal of radiology, 2018, Volume: 91, Issue:1087

    Topics: Animals; Cardiac-Gated Imaging Techniques; Computed Tomography Angiography; Contrast Media; Coronary

2018
Comparison of iohexol and iodixanol induced nephrotoxicity, mitochondrial damage and mitophagy in a new contrast-induced acute kidney injury rat model.
    Archives of toxicology, 2018, Volume: 92, Issue:7

    Topics: Acute Kidney Injury; Animals; Contrast Media; Disease Models, Animal; Iohexol; Kidney Function Tests

2018
Involvement of organic cation transporter 2 in the metformin-associated increased lactate levels caused by contrast-induced nephropathy.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 106

    Topics: Acidosis, Lactic; Acute Kidney Injury; Animals; Cell Line; Contrast Media; Disease Models, Animal; H

2018
Caspase-11-mediated tubular epithelial pyroptosis underlies contrast-induced acute kidney injury.
    Cell death & disease, 2018, 09-24, Volume: 9, Issue:10

    Topics: Acute Kidney Injury; Animals; Caspases; Caspases, Initiator; Cells, Cultured; Contrast Media; Diseas

2018
Computed microtomography visualization and quantification of mouse ischemic brain lesion by nonionic radio contrast agents.
    Croatian medical journal, 2013, Volume: 54, Issue:1

    Topics: Animals; Brain Edema; Brain Ischemia; Coloring Agents; Contrast Media; Disease Models, Animal; Infar

2013
Animal experimental evaluation of a new sealing device for indwelling arterial catheters.
    Acta radiologica (Stockholm, Sweden : 1987), 2013, Volume: 54, Issue:5

    Topics: Angiography; Animals; Catheters, Indwelling; Contrast Media; Disease Models, Animal; Equipment Desig

2013
A novel minimally invasive technique to create a rabbit VX2 lung tumor model for nano-sized image contrast and interventional studies.
    PloS one, 2013, Volume: 8, Issue:6

    Topics: Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; Contrast Media; Disease Models, Animal; Fluorod

2013
Infective severe acute pancreatitis: a comparison of 99mTc-ciprofloxacin scintigraphy and computed tomography.
    World journal of gastroenterology, 2013, Aug-14, Volume: 19, Issue:30

    Topics: Animals; Biopsy; Chi-Square Distribution; Ciprofloxacin; Contrast Media; Disease Models, Animal; Esc

2013
Stent healing response following delivery of paclitaxel via durable polymeric matrix versus iopromide-based balloon coating in the familial hypercholesterolaemic swine model of coronary injury.
    EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 2013, Aug-22, Volume: 9, Issue:4

    Topics: Angioplasty, Balloon, Coronary; Animals; Cardiovascular Agents; Constriction, Pathologic; Coronary A

2013
Tissue uptake, distribution, and healing response after delivery of paclitaxel via second-generation iopromide-based balloon coating: a comparison with the first-generation technology in the iliofemoral porcine model.
    JACC. Cardiovascular interventions, 2013, Volume: 6, Issue:8

    Topics: Angioplasty, Balloon; Animals; Arterial Occlusive Diseases; Cardiovascular Agents; Cell Proliferatio

2013
Myocardial CT perfusion imaging in a large animal model: comparison of dynamic versus single-phase acquisitions.
    JACC. Cardiovascular imaging, 2013, Volume: 6, Issue:12

    Topics: Adenosine; Animals; Area Under Curve; Contrast Media; Coronary Circulation; Coronary Stenosis; Coron

2013
A novel rat model of contrast-induced acute kidney injury.
    International journal of cardiology, 2014, Mar-01, Volume: 172, Issue:1

    Topics: Acute Kidney Injury; Animals; Contrast Media; Disease Models, Animal; Iohexol; Male; Rats, Sprague-D

2014
Efficacy of preventive interventions for iodinated contrast-induced acute kidney injury evaluated by intrarenal oxygenation as an early marker.
    Investigative radiology, 2014, Volume: 49, Issue:10

    Topics: Acetylcysteine; Acute Kidney Injury; Acute-Phase Proteins; Animals; Biomarkers; Contrast Media; Dise

2014
Significant perturbation in renal functional magnetic resonance imaging parameters and contrast retention for iodixanol compared with iopromide: an experimental study using blood-oxygen-level-dependent/diffusion-weighted magnetic resonance imaging and com
    Investigative radiology, 2014, Volume: 49, Issue:11

    Topics: Acute Kidney Injury; Analysis of Variance; Animals; Contrast Media; Diffusion Magnetic Resonance Ima

2014
Early small-bowel ischemia: dual-energy CT improves conspicuity compared with conventional CT in a swine model.
    Radiology, 2015, Volume: 275, Issue:1

    Topics: Animals; Contrast Media; Cross-Over Studies; Disease Models, Animal; Intestine, Small; Iohexol; Isch

2015
Limb ischemic preconditioning protects against contrast-induced acute kidney injury in rats via phosphorylation of GSK-3β.
    Free radical biology & medicine, 2015, Volume: 81

    Topics: Acute Kidney Injury; Androstadienes; Animals; Apoptosis; Chromones; Contrast Media; Disease Models,

2015
A novel contrast-induced acute kidney injury model based on the 5/6-nephrectomy rat and nephrotoxicological evaluation of iohexol and iodixanol in vivo.
    Oxidative medicine and cellular longevity, 2014, Volume: 2014

    Topics: Acute Kidney Injury; Animals; Contrast Media; Disease Models, Animal; Iohexol; Kidney; Male; Nephrec

2014
Delayed contrast enhancement imaging of a murine model for ischemia reperfusion with carbon nanotube micro-CT.
    PloS one, 2015, Volume: 10, Issue:1

    Topics: Animals; Contrast Media; Diagnostic Imaging; Disease Models, Animal; Humans; Imaging, Three-Dimensio

2015
Perfusion CT estimates photosensitizer uptake and biodistribution in a rabbit orthotopic pancreatic cancer model: a pilot study.
    Academic radiology, 2015, Volume: 22, Issue:5

    Topics: Animals; Contrast Media; Disease Models, Animal; Iohexol; Pancreatic Neoplasms; Photosensitizing Age

2015
Exposure to Radiocontrast Agents Induces Pancreatic Inflammation by Activation of Nuclear Factor-κB, Calcium Signaling, and Calcineurin.
    Gastroenterology, 2015, Volume: 149, Issue:3

    Topics: Animals; Calcineurin; Calcineurin Inhibitors; Calcium Signaling; Chlorocebus aethiops; Contrast Medi

2015
Imaging of acute superior mesenteric artery embolus using spectral CT in a canine model.
    The British journal of radiology, 2015, Volume: 88, Issue:1053

    Topics: Acute Disease; Animals; Contrast Media; Disease Models, Animal; Dogs; Embolism; Female; Iodine Compo

2015
Isolation and time lapse microscopy of highly pure hepatic stellate cells.
    Analytical cellular pathology (Amsterdam), 2015, Volume: 2015

    Topics: Animals; Cell Differentiation; Cell Separation; Cell Survival; Cells, Cultured; Centrifugation, Dens

2015
Correlation of volumetric perfusion CT parameters with hypoxia inducible factor-1 alpha expression in a rabbit VX2 tumor model.
    Acta radiologica (Stockholm, Sweden : 1987), 2016, Volume: 57, Issue:6

    Topics: Animals; Cone-Beam Computed Tomography; Contrast Media; Disease Models, Animal; Hypoxia-Inducible Fa

2016
A novel protective formulation of Palmitoylethanolamide in experimental model of contrast agent induced nephropathy.
    Toxicology letters, 2016, Jan-05, Volume: 240, Issue:1

    Topics: Acute-Phase Proteins; Amides; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Ur

2016
Preclinical Studies of a Kidney Safe Iodinated Contrast Agent.
    Journal of neuroimaging : official journal of the American Society of Neuroimaging, 2016, Volume: 26, Issue:5

    Topics: Acute Kidney Injury; Animals; Apoptosis; beta-Cyclodextrins; Cell Line; Contrast Media; Disease Mode

2016
Salvianolic Acid B Prevents Iodinated Contrast Media-Induced Acute Renal Injury in Rats via the PI3K/Akt/Nrf2 Pathway.
    Oxidative medicine and cellular longevity, 2016, Volume: 2016

    Topics: Acute Kidney Injury; Animals; Antioxidants; Apoptosis; Benzofurans; Biomarkers; Cell Line, Tumor; Co

2016
Circulating MicroRNA-188, -30a, and -30e as Early Biomarkers for Contrast-Induced Acute Kidney Injury.
    Journal of the American Heart Association, 2016, 08-15, Volume: 5, Issue:8

    Topics: Acute Kidney Injury; Animals; Biomarkers; Circulating MicroRNA; Contrast Media; Disease Models, Anim

2016
Efficacy of oral supplemental hydration for the prevention of contrast-induced nephropathy in rats.
    Japanese journal of radiology, 2017, Volume: 35, Issue:4

    Topics: Acute Kidney Injury; Animals; Contrast Media; Disease Models, Animal; Fluid Therapy; Indomethacin; I

2017
Multidetector computed tomography (MDCT) evaluation of myocardial viability: intraindividual comparison of monomeric vs. dimeric contrast media in a rabbit model.
    European radiology, 2009, Volume: 19, Issue:2

    Topics: Animals; Contrast Media; Disease Models, Animal; Heart; Iohexol; Male; Myocardial Contraction; Myoca

2009
[Effects of contrast medium on the pancreatic pathology in severe acute pancreatitis experiment with rats].
    Zhonghua yi xue za zhi, 2008, Mar-25, Volume: 88, Issue:12

    Topics: Animals; Contrast Media; Disease Models, Animal; Iohexol; Male; Pancreas; Pancreatitis, Acute Necrot

2008
Radiofrequency ablation of renal VX2 tumors with and without renal artery occlusion in a rabbit model: feasibility, therapeutic efficacy, and safety.
    Cardiovascular and interventional radiology, 2009, Volume: 32, Issue:6

    Topics: Animals; Balloon Occlusion; Catheter Ablation; Contrast Media; Creatinine; Disease Models, Animal; F

2009
Preliminary study of indirect CT lymphography-guided sentinel lymph node biopsy in a tongue VX2 carcinoma model.
    International journal of oral and maxillofacial surgery, 2009, Volume: 38, Issue:12

    Topics: Animals; Carcinoma; Coloring Agents; Contrast Media; Disease Models, Animal; Feasibility Studies; Io

2009
Assessment of myocardial edema by computed tomography in myocardial infarction.
    JACC. Cardiovascular imaging, 2009, Volume: 2, Issue:10

    Topics: Acute Disease; Animals; Chronic Disease; Contrast Media; Disease Models, Animal; Edema, Cardiac; Gad

2009
Intra-arterial iodinated radiographic contrast material injection administration in a rat middle cerebral artery occlusion and reperfusion model: possible effects on intracerebral hemorrhage.
    Stroke, 2010, Volume: 41, Issue:5

    Topics: Animals; Cerebral Hemorrhage; Contrast Media; Disease Models, Animal; Infarction, Middle Cerebral Ar

2010
The effect of Kashin-Beck disease-affected feed and T-2 toxin on the bone development of Wistar rats.
    International journal of rheumatic diseases, 2010, Volume: 13, Issue:3

    Topics: Age Factors; Animal Feed; Animals; Bone Development; Cartilage, Articular; Chondrocytes; Collagen; D

2010
Dual energy CT ventilation imaging after aerosol inhalation of iodinated contrast medium in rabbits.
    European journal of radiology, 2011, Volume: 78, Issue:2

    Topics: Administration, Inhalation; Aerosols; Airway Obstruction; Analysis of Variance; Animals; Contrast Me

2011
Quantification of fractional flow reserve based on angiographic image data.
    The international journal of cardiovascular imaging, 2012, Volume: 28, Issue:1

    Topics: Animals; Blood Flow Velocity; Contrast Media; Coronary Angiography; Coronary Stenosis; Disease Model

2012
Estimation of coronary artery hyperemic blood flow based on arterial lumen volume using angiographic images.
    The international journal of cardiovascular imaging, 2012, Volume: 28, Issue:1

    Topics: Animals; Blood Flow Velocity; Cone-Beam Computed Tomography; Contrast Media; Coronary Angiography; C

2012
Targeted transendocardial therapeutic delivery guided by MRI-x-ray image fusion.
    Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 2011, Sep-01, Volume: 78, Issue:3

    Topics: Animals; Cardiac Catheterization; Contrast Media; Dextrans; Disease Models, Animal; Endocardium; Fea

2011
Quantitative myocardial perfusion measurement using CT perfusion: a validation study in a porcine model of reperfused acute myocardial infarction.
    The international journal of cardiovascular imaging, 2012, Volume: 28, Issue:5

    Topics: Animals; Blood Flow Velocity; Cineangiography; Contrast Media; Coronary Angiography; Coronary Circul

2012
Perfusion computed tomography evaluation of partial hepatic ischemia reperfusion in a rabbit model.
    Academic radiology, 2011, Volume: 18, Issue:10

    Topics: Analysis of Variance; Animals; Blood Flow Velocity; Contrast Media; Diffusion; Disease Models, Anima

2011
Renal function and morphology in aged Beagle dogs before and after hydrocortisone administration.
    PloS one, 2012, Volume: 7, Issue:2

    Topics: Animals; Atrophy; Biopsy; Creatinine; Disease Models, Animal; Dogs; Enzyme-Linked Immunosorbent Assa

2012
Embozene™ microspheres induced nonreperfused myocardial infarction in an experimental swine model.
    Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 2013, Volume: 81, Issue:4

    Topics: Animals; Arrhythmias, Cardiac; Coloring Agents; Contrast Media; Coronary Circulation; Disease Models

2013
Effect of an angiogenesis inhibitor on hepatic tumor perfusion and the implications for adjuvant cytotoxic therapy.
    Radiology, 2012, Volume: 264, Issue:1

    Topics: Angiogenesis Inhibitors; Animals; Contrast Media; Disease Models, Animal; Immunohistochemistry; Iohe

2012
Et-A receptor antagonist BQ123 prevents radiocontrast media-induced renal medullary hypoxia.
    Acta radiologica (Stockholm, Sweden : 1987), 2003, Volume: 44, Issue:1

    Topics: Animals; Antihypertensive Agents; Contrast Media; Disease Models, Animal; Endothelin Receptor Antago

2003
Evaluation of an experimental low-attenuation gastrointestinal contrast agent for CT imaging of intestinal ischemia in an animal model.
    Academic radiology, 1999, Volume: 6, Issue:2

    Topics: Administration, Oral; Analysis of Variance; Animals; Contrast Media; Disease Models, Animal; Dogs; F

1999
The effect of varying low-dose protocols on perceived image quality in multidetector CT in a rabbit model of acute appendicitis.
    European radiology, 2004, Volume: 14, Issue:8

    Topics: Acute Disease; Algorithms; Animals; Appendicitis; Appendix; Contrast Media; Disease Models, Animal;

2004
Studies on experimental iodine allergy: 2. Iodinated protein antigens and their generation from inorganic and organic iodine-containing chemicals.
    The Journal of toxicological sciences, 2004, Volume: 29, Issue:2

    Topics: Adoptive Transfer; Albumins; Animals; Antigens; Antioxidants; Ascitic Fluid; Contrast Media; Disease

2004
Decrease in fluoroscopic cardiac silhouette excursion precedes hemodynamic compromise in intraprocedural tamponade.
    Heart rhythm, 2005, Volume: 2, Issue:11

    Topics: Acute Disease; Animals; Blood Pressure; Cardiac Tamponade; Catheter Ablation; Contrast Media; Diseas

2005
Dynamic multi-section CT imaging in acute myocardial infarction: preliminary animal experience.
    European radiology, 2006, Volume: 16, Issue:3

    Topics: Animals; Contrast Media; Disease Models, Animal; Feasibility Studies; Gadolinium DTPA; Iohexol; Magn

2006
Intra-arterial digital subtraction angiography through the ear artery for experimental aneurysm imaging.
    AJNR. American journal of neuroradiology, 2006, Volume: 27, Issue:8

    Topics: Angiography, Digital Subtraction; Animals; Arteries; Cerebral Angiography; Contrast Media; Disease M

2006
Low tube voltage improves computed tomography imaging of delayed myocardial contrast enhancement in an experimental acute myocardial infarction model.
    Investigative radiology, 2007, Volume: 42, Issue:2

    Topics: Animals; Contrast Media; Disease Models, Animal; Iohexol; Myocardial Infarction; Radiographic Image

2007
Evaluation of the effects of noniodinized and iodinized ionic contrast media and gadoteric acid in acute necrotizing pancreatitis: experimental study in rabbits.
    Pancreas, 2007, Volume: 35, Issue:4

    Topics: Animals; Contrast Media; Disease Models, Animal; Heterocyclic Compounds; Injections, Intravenous; Io

2007
Urine profiles and kidney histologic findings after intravenous injection of mannitol and iohexol in the degeneration phase of gentamicin nephropathy in rats.
    Investigative radiology, 1993, Volume: 28, Issue:2

    Topics: Animals; Blood Chemical Analysis; Disease Models, Animal; Gentamicins; Injections, Intravenous; Iohe

1993
Evaluation of gadobutrol in a rabbit model as a new lanthanide contrast agent for computed tomography.
    Investigative radiology, 1995, Volume: 30, Issue:11

    Topics: Angiography; Animals; Aortography; Contrast Media; Disease Models, Animal; Female; Gadolinium; Image

1995
Urine profiles and kidney histology after ionic and nonionic radiologic and magnetic resonance contrast media in rats with cisplatin nephropathy.
    Academic radiology, 1995, Volume: 2, Issue:8

    Topics: Animals; Antineoplastic Agents; Cisplatin; Contrast Media; Diatrizoate; Disease Models, Animal; Dose

1995
Hepatic imaging with iodinated nanoparticles: a comparison with iohexol in rabbits.
    Academic radiology, 1995, Volume: 2, Issue:8

    Topics: Animals; Contrast Media; Diatrizoate; Disease Models, Animal; Dose-Response Relationship, Drug; Drug

1995
Role of sodium in contrast medium-induced polymorphic ventricular tachycardia: results in a rabbit model of lengthened QT interval.
    Academic radiology, 1998, Volume: 5, Issue:6

    Topics: Adrenergic alpha-Agonists; Animals; Anti-Arrhythmia Agents; Contrast Media; Coronary Angiography; Co

1998
Early glomerular effects of contrast media in rats: evaluation with a simple method.
    Renal failure, 1998, Volume: 20, Issue:5

    Topics: Animals; Contrast Media; Diatrizoate; Disease Models, Animal; Glomerular Filtration Rate; Injections

1998
Validation of minimally invasive measurement of myocardial perfusion using electron beam computed tomography and application in human volunteers.
    Heart (British Cardiac Society), 1999, Volume: 81, Issue:6

    Topics: Adenosine; Adolescent; Adult; Animals; Contrast Media; Coronary Angiography; Coronary Circulation; D

1999
Nephrotoxicity of high- and low-osmolar contrast media. The protective role of amlodipine in a rat model.
    Acta radiologica (Stockholm, Sweden : 1987), 2000, Volume: 41, Issue:5

    Topics: Acute Kidney Injury; Amlodipine; Analysis of Variance; Animals; Blood Urea Nitrogen; Calcium; Calciu

2000
Thrombogenic potential of contrast media in an experimental model of laser-induced thrombosis.
    Thrombosis research, 2000, Nov-01, Volume: 100, Issue:3

    Topics: Animals; Contrast Media; Diatrizoate; Disease Models, Animal; Dose-Response Relationship, Drug; Iohe

2000
Antithrombotic effects of ionic and non-ionic contrast media in nonhuman primates.
    Thrombosis and haemostasis, 2001, Volume: 85, Issue:3

    Topics: Animals; Arteriovenous Shunt, Surgical; Blood Flow Velocity; Contrast Media; Disease Models, Animal;

2001
Comparison of intraarterial and IV gadolinium-enhanced MR angiography with digital subtraction angiography for the detection of renal artery stenosis in pigs.
    AJR. American journal of roentgenology, 2002, Volume: 178, Issue:1

    Topics: Angiography, Digital Subtraction; Animals; Contrast Media; Disease Models, Animal; Dose-Response Rel

2002
Do clinically relevant circulating concentrations of radiographic contrast agents inhibit platelet-dependent arterial thrombosis?
    Thrombosis research, 2002, Mar-01, Volume: 105, Issue:5

    Topics: Animals; Arterial Occlusive Diseases; Blood Circulation; Blood Coagulation; Blood Flow Velocity; Car

2002
Direct effects of contrast media on rat lungs.
    Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes, 1991, Volume: 42, Issue:4

    Topics: Animals; Contrast Media; Diatrizoate Meglumine; Disease Models, Animal; Extravasation of Diagnostic

1991
Urinary excretion of iohexol after enteral administration in rats with radiation injury of the small intestine.
    Scandinavian journal of gastroenterology, 1991, Volume: 26, Issue:10

    Topics: Animals; Disease Models, Animal; Intestinal Mucosa; Intestine, Small; Iodine; Iohexol; Male; Microsc

1991
[Experimental detection of hemorrhage in the circulation area of the superior mesenteric artery by intra-arterial nuclide angiography].
    RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin, 1990, Volume: 153, Issue:2

    Topics: Angiography, Digital Subtraction; Animals; Disease Models, Animal; Dogs; Gastrointestinal Hemorrhage

1990
Use of iohexol in the radiographic diagnosis of ischemic bowel.
    Journal of pediatric surgery, 1986, Volume: 21, Issue:6

    Topics: Animals; Contrast Media; Diagnosis, Differential; Diatrizoate Meglumine; Disease Models, Animal; Dru

1986