Page last updated: 2024-10-29

iohexol and Delayed Hypersensitivity

iohexol has been researched along with Delayed Hypersensitivity in 19 studies

Iohexol: An effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality.
iohexol : A benzenedicarboxamide compound having N-(2,3-dihydroxypropyl)carbamoyl groups at the 1- and 3-positions, iodo substituents at the 2-, 4- and 6-positions and an N-(2,3-dihydroxypropyl)acetamido group at the 5-position.

Research Excerpts

ExcerptRelevanceReference
" This presented a management challenge as the patient had experienced 2 episodes of delayed anaphylaxis to Omnipaque (iohexol) RCM, and based on a literature review, there was no known or established precedent on a safe procedure in these situations."7.88Successful Graded Dose Challenge to Iodixanol Radiocontrast Media in a Patient With Delayed Anaphylaxis to Iohexol. ( Cohen, B; Edelman, D; Garg, K; Jariwala, S; Soffer, G; Toh, J, 2018)
" We report a case in which delayed hypersensitivity to iohexol, a nonionic intravenous contrast agent commonly used in excretory urography, resulted in a bi-phasic allergic response."4.79Delayed hypersensitivity reaction after infusion of nonionic intravenous contrast material for an excretory urogram: a case report and review of the literature. ( Resnick, MI; Seftel, AD; Stovsky, MD, 1995)
" This presented a management challenge as the patient had experienced 2 episodes of delayed anaphylaxis to Omnipaque (iohexol) RCM, and based on a literature review, there was no known or established precedent on a safe procedure in these situations."3.88Successful Graded Dose Challenge to Iodixanol Radiocontrast Media in a Patient With Delayed Anaphylaxis to Iohexol. ( Cohen, B; Edelman, D; Garg, K; Jariwala, S; Soffer, G; Toh, J, 2018)
"Cross-reactivity was assessed by skin testing and measurement of T-cell activation (CD69 upregulation) and proliferation ((3)H-thymidine uptake, 5,6-carboxyfluorescein diacetate succinimidyl ester staining) of PBMCs, T-cell lines, and T-cell clones of 2 patients with delayed hypersensitivity reactions to iohexol and iomeprol, respectively."3.74Cross-reactivity patterns of T cells specific for iodinated contrast media. ( Beeler, A; Bircher, AJ; Britschgi, M; Christiansen, C; Gerber, BO; Kanny, G; Keller, M; Lerch, M; Luethi, M; Pichler, WJ; Schmid, DA; Tache, V, 2007)
"To prospectively evaluate adverse events (AEs) in patients who underwent nonionic monomeric or dimeric contrast media-enhanced computed tomography (CT) and to compare these effects with AEs in patients who underwent unenhanced CT."2.72Adverse events after unenhanced and monomeric and dimeric contrast-enhanced CT: a prospective randomized controlled trial. ( Böhm, I; Hübner-Steiner, U; Kuhl, CK; Schild, HH; Speck, U, 2006)
"In Japan, drug eruptions to nonionic iodinated contrast media have been reported since the products appeared on the market in 1986."1.33Drug eruptions to contrast media in Japan. ( Akiyama, M; Iijima, M; Kato, A; Maibach, HI; Nakada, T, 2006)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (21.05)18.2507
2000's9 (47.37)29.6817
2010's6 (31.58)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Soffer, G1
Cohen, B1
Toh, J1
Edelman, D1
Garg, K1
Jariwala, S1
Corbaux, C1
Seneschal, J1
Taïeb, A1
Cornelis, F1
Martinet, J1
Milpied, B1
Chuang, FR1
Chen, TC1
Wang, IK1
Chuang, CH1
Chang, HW1
Ting-Yu Chiou, T1
Cheng, YF1
Lee, WC1
Chen, WC1
Yang, KD1
Lee, CH1
Loh, S1
Bagheri, S1
Katzberg, RW1
Fung, MA1
Li, CS1
Hasdenteufel, F1
Waton, J1
Cordebar, V1
Studer, M1
Collignon, O1
Luyasu, S1
Beaudouin, E1
Renaudin, JM1
Morisset, M1
Kanny, G2
Barbaud, A1
Gracia Bara, MT2
Moreno, E2
Laffond, E2
Muñoz, FJ2
Macias, E2
Davila, I2
Romano, A1
Artesani, MC1
Andriolo, M1
Viola, M1
Pettinato, R1
Vecchioli-Scaldazza, A1
Munechika, H3
Hiramatsu, Y2
Kudo, S2
Sugimura, K2
Hamada, C2
Yamaguchi, K2
Katayama, H2
Shionoya, H1
Sugihara, Y1
Okano, K1
Sagami, F1
Mikami, T1
Katayama, K1
Nakada, T1
Akiyama, M1
Iijima, M1
Kato, A1
Maibach, HI1
Schild, HH1
Kuhl, CK1
Hübner-Steiner, U1
Böhm, I1
Speck, U1
Lerch, M1
Keller, M1
Britschgi, M1
Tache, V1
Schmid, DA1
Beeler, A1
Gerber, BO1
Luethi, M1
Bircher, AJ2
Christiansen, C1
Pichler, WJ1
Stovsky, MD1
Seftel, AD1
Resnick, MI1
Yasuda, R1
Pedersen, SH1
Svaland, MG1
Reiss, AL1
Andrew, E1
Courvoisier, S1
Sedano, E1
Vega, JM1
Rebollo, S1
Callejo, A1
Asensio, T1
Almendros, R1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Prospective Clinical Trial to Investigate Adverse Reactions to MR and CT-examinations (Enhanced and Unenhanced)[NCT01132339]1,467 participants (Actual)Observational2010-05-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for iohexol and Delayed Hypersensitivity

ArticleYear
Delayed hypersensitivity reaction after infusion of nonionic intravenous contrast material for an excretory urogram: a case report and review of the literature.
    The Journal of urology, 1995, Volume: 153, Issue:5

    Topics: Aged; Contrast Media; Drug Eruptions; Drug Hypersensitivity; Humans; Hypersensitivity, Delayed; Iohe

1995
Late allergy-like reactions following vascular administration of radiography contrast media.
    Acta radiologica (Stockholm, Sweden : 1987), 1998, Volume: 39, Issue:4

    Topics: Contrast Media; Drug Hypersensitivity; Europe; Humans; Hypersensitivity, Delayed; Hypersensitivity,

1998

Trials

3 trials available for iohexol and Delayed Hypersensitivity

ArticleYear
Comparison of iodixanol and iohexol in patients undergoing intravenous pyelography: a prospective controlled study.
    Renal failure, 2009, Volume: 31, Issue:3

    Topics: Acute Kidney Injury; Adult; Aged; Contrast Media; Creatinine; Cytokines; Double-Blind Method; Drug E

2009
Adverse events after unenhanced and monomeric and dimeric contrast-enhanced CT: a prospective randomized controlled trial.
    Radiology, 2006, Volume: 240, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Contrast Media; Female; Humans; Hypersensitivity, Delayed; Iohexol;

2006
Late allergy-like reactions following vascular administration of radiography contrast media.
    Acta radiologica (Stockholm, Sweden : 1987), 1998, Volume: 39, Issue:4

    Topics: Contrast Media; Drug Hypersensitivity; Europe; Humans; Hypersensitivity, Delayed; Hypersensitivity,

1998

Other Studies

15 other studies available for iohexol and Delayed Hypersensitivity

ArticleYear
Successful Graded Dose Challenge to Iodixanol Radiocontrast Media in a Patient With Delayed Anaphylaxis to Iohexol.
    Vascular and endovascular surgery, 2018, Volume: 52, Issue:1

    Topics: Aged, 80 and over; Anaphylaxis; Angiography; Anti-Allergic Agents; Contrast Media; Drug Administrati

2018
Delayed cutaneous hypersensitivity reactions to iodinated contrast media.
    European journal of dermatology : EJD, 2017, 04-01, Volume: 27, Issue:2

    Topics: Aged; Contrast Media; Cross Reactions; Delayed Diagnosis; Drug Hypersensitivity; Humans; Hypersensit

2017
Delayed adverse reaction to contrast-enhanced CT: a prospective single-center study comparison to control group without enhancement.
    Radiology, 2010, Volume: 255, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Case-Control Studies; Chi-Square Distribution; Contrast Media; Femal

2010
Delayed hypersensitivity reactions caused by iodixanol: an assessment of cross-reactivity in 22 patients.
    The Journal of allergy and clinical immunology, 2011, Volume: 128, Issue:6

    Topics: Contrast Media; Drug Hypersensitivity; Female; Humans; Hypersensitivity, Delayed; Iohexol; Iopamidol

2011
Selection of contrast media in patients with delayed reactions should be based on challenge test results.
    The Journal of allergy and clinical immunology, 2012, Volume: 130, Issue:2

    Topics: Contrast Media; Drug Hypersensitivity; Female; Humans; Hypersensitivity, Delayed; Iohexol; Iopamidol

2012
Reply: Selection of contrast media in patients with delayed reactions should be based on challenge test results.
    The Journal of allergy and clinical immunology, 2012, Volume: 130, Issue:4

    Topics: Contrast Media; Drug Hypersensitivity; Female; Humans; Hypersensitivity, Delayed; Iohexol; Iopamidol

2012
Effective prophylactic protocol in delayed hypersensitivity to contrast media: report of a case involving lymphocyte transformation studies with different compounds.
    Radiology, 2002, Volume: 225, Issue:2

    Topics: Adult; Cerebral Angiography; Contrast Media; Cyclosporine; Drug Eruptions; Embolization, Therapeutic

2002
A prospective survey of delayed adverse reactions to iohexol in urography and computed tomography.
    European radiology, 2003, Volume: 13, Issue:1

    Topics: Contrast Media; Drug Hypersensitivity; Female; Humans; Hypersensitivity, Delayed; Injections, Intrav

2003
Studies on experimental iodine allergy: 2. Iodinated protein antigens and their generation from inorganic and organic iodine-containing chemicals.
    The Journal of toxicological sciences, 2004, Volume: 29, Issue:2

    Topics: Adoptive Transfer; Albumins; Animals; Antigens; Antioxidants; Ascitic Fluid; Contrast Media; Disease

2004
Drug eruptions to contrast media in Japan.
    Clinical and experimental dermatology, 2006, Volume: 31, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochon

2006
Cross-reactivity patterns of T cells specific for iodinated contrast media.
    The Journal of allergy and clinical immunology, 2007, Volume: 119, Issue:6

    Topics: Aged; Cell Line; Clone Cells; Contrast Media; Female; Humans; Hypersensitivity, Delayed; Iohexol; Io

2007
Delayed adverse reactions to nonionic monomeric contrast-enhanced media.
    Investigative radiology, 1998, Volume: 33, Issue:1

    Topics: Chi-Square Distribution; Contrast Media; Female; Humans; Hypersensitivity, Delayed; Iohexol; Iopamid

1998
Delayed-type hypersensitivity to a nonionic, radiopaque contrast medium.
    Allergy, 1998, Volume: 53, Issue:12

    Topics: Angioplasty, Balloon, Coronary; Contrast Media; Humans; Hypersensitivity, Delayed; Iohexol; Iopamido

1998
Delayed exanthema to nonionic contrast medium.
    Allergy, 2001, Volume: 56, Issue:10

    Topics: Aged; Contrast Media; Exanthema; Female; Humans; Hypersensitivity, Delayed; Iohexol; Male; Middle Ag

2001
Delayed adverse reactions to nonionic contrast medium (iohexol) in IV use: multicentric study.
    Academic radiology, 2002, Volume: 9 Suppl 1

    Topics: Contrast Media; Humans; Hypersensitivity, Delayed; Injections, Intravenous; Iohexol; Prevalence; Ris

2002