Page last updated: 2024-10-29

iohexol and Anaphylactic Reaction

iohexol has been researched along with Anaphylactic Reaction in 25 studies

Iohexol: An effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality.
iohexol : A benzenedicarboxamide compound having N-(2,3-dihydroxypropyl)carbamoyl groups at the 1- and 3-positions, iodo substituents at the 2-, 4- and 6-positions and an N-(2,3-dihydroxypropyl)acetamido group at the 5-position.

Research Excerpts

ExcerptRelevanceReference
" This presented a management challenge as the patient had experienced 2 episodes of delayed anaphylaxis to Omnipaque (iohexol) RCM, and based on a literature review, there was no known or established precedent on a safe procedure in these situations."7.88Successful Graded Dose Challenge to Iodixanol Radiocontrast Media in a Patient With Delayed Anaphylaxis to Iohexol. ( Cohen, B; Edelman, D; Garg, K; Jariwala, S; Soffer, G; Toh, J, 2018)
" Iodine is the main functional group of iohexol, and it can induce delayed anaphylaxis."4.02MRGPRX2 mediates immediate-type pseudo-allergic reactions induced by iodine-containing iohexol. ( Che, D; Cheng, L; Li, T; Pan, B; Sun, M; Wu, D; Yuan, F; Zhang, C, 2021)
" This presented a management challenge as the patient had experienced 2 episodes of delayed anaphylaxis to Omnipaque (iohexol) RCM, and based on a literature review, there was no known or established precedent on a safe procedure in these situations."3.88Successful Graded Dose Challenge to Iodixanol Radiocontrast Media in a Patient With Delayed Anaphylaxis to Iohexol. ( Cohen, B; Edelman, D; Garg, K; Jariwala, S; Soffer, G; Toh, J, 2018)
"Administration of iopromide for pulmonary angiography in patients with pulmonary hypertension resulted in no appreciable hemodynamic alterations associated with the observed changes in atrial natriuretic peptide, antidiuretic hormone, and renin."3.69Pulmonary hypertension. Response of vasoactive peptides to a nonionic contrast medium in patients undergoing pulmonary angiography. ( Flueckiger, F; Horina, J; Preidler, K; Riepl, T; Saeed, M; Stiskal, MA; Szolar, DH; Watzinger, N, 1995)
"Allergic reactions, including anaphylactoid shock due to contrast material, are not uncommon."2.39Refractory anaphylactoid shock potentiated by beta-blockers. ( Javeed, H; Javeed, N; Javeed, S; Moussa, G; Rezai, F; Wong, P, 1996)
"Three reported variants of Kounis Syndrome include: vasospastic allergic angina, allergic myocardial infarction, and stent thrombosis."1.91Allergic myocardial infarction (Kounis Syndrome)- non-ST elevation MI following Omnipaque contrast. ( Bajaj, BS; Bray Lindsay, A; Chuquin, D; Singh, S, 2023)
"Drug-induced anaphylaxis is a fatal medical condition whose incidence has been increasing continuously."1.72Risk factors of anaphylaxis in Korea: Identifying drug-induced anaphylaxis culprits using big data. ( Ahn, KM; Kim, BK; Yang, MS, 2022)
"Although ICM anaphylaxis is rare, it can be life-threatening, but currently, there is no biomarker that can identify individuals at risk of ICM anaphylaxis."1.56HLA-DRB1*15: 02 Is Associated With Iodinated Contrast Media-Related Anaphylaxis. ( Chung, SJ; Jung, JW; Kang, DY; Kang, HR; Kang, MG; Kim, S; Lee, SB; Lee, SE; Lee, W; Park, KH; Sim, DW; Yun, J, 2020)
"Because most anaphylactic reactions are mild and nonallergic, clinically mimicking immunoglobulin E (IgE)-mediated allergy, diagnostic skin testing has been discussed controversially in the past and prophylactic pretreatment drug regimens are recommended instead."1.35Anaphylaxis to iodinated contrast material: nonallergic hypersensitivity or IgE-mediated allergy? ( Bröcker, EB; Gross, GE; Schmidt, C; Seitz, CS; Trautmann, A; Trcka, J, 2008)
"We report a case of fatal anaphylactoid shock caused by a CT examination using nonionic contrast medium."1.31[A fatal case of anaphylactoid shock after administration of nonionic contrast medium]. ( Kawasaki, Y; Kisanuki, A; Ochiai, E; Shimizu, T, 2002)
"Any patient who has had a severe anaphylactoid reaction following injection of a contrast agent should undergo an allergological assessment to confirm the diagnosis and identify the culprit contrast agent."1.31[Severe reactions to iodinated contrast agents: is anaphylaxis responsible?]. ( Dewachter, P; Mouton-Faivre, C, 2001)
"A 44-year-old woman presented with cardiopulmonary arrest (CPA) immediately following the administration of nonionic iodinated contrast media for an intravenous pyelography."1.31Cardiopulmonary arrest induced by anaphylactoid reaction with contrast media. ( Aikawa, N; Aoki, K; Fujishima, S; Funabiki, T; Hori, S; Kimura, H; Kuribayashi, S; Nakamura, I; Sekine, K, 2002)
"To investigate the mechanism of anaphylactoid reactions to contrast media, in vitro histamine release induced by magnetic resonance imaging, and iodinated contrast agents was examined in a dog mastocytoma cell line."1.29In vitro histamine release induced by magnetic resonance imaging and iodinated contrast media. ( Baxter, AB; Brasch, RC; Lazarus, SC, 1993)

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-19901 (4.00)18.7374
1990's9 (36.00)18.2507
2000's6 (24.00)29.6817
2010's5 (20.00)24.3611
2020's4 (16.00)2.80

Authors

AuthorsStudies
Ahn, KM1
Kim, BK1
Yang, MS1
Singh, S1
Bajaj, BS1
Chuquin, D1
Bray Lindsay, A1
Chung, SJ1
Kang, DY1
Lee, W1
Lee, SB1
Kim, S1
Lee, SE1
Sim, DW1
Kang, MG1
Park, KH1
Jung, JW1
Yun, J1
Kang, HR1
Yuan, F1
Zhang, C1
Sun, M1
Wu, D1
Cheng, L1
Pan, B1
Li, T1
Che, D1
Soffer, G1
Cohen, B1
Toh, J1
Edelman, D1
Garg, K1
Jariwala, S1
Borras, J1
El-Qutob, D1
Lopez, R1
Enrique, E1
Ahn, YH1
Koh, YI1
Kim, JH1
Ban, GY1
Lee, YK1
Hong, GN1
Jin, UR1
Choi, BJ1
Shin, YS1
Park, HS1
Ye, YM1
Rodrigo-Mocholí, D1
Willems, A1
Schauvliege, S1
Bosmans, T1
Alimohammadi, H1
Abdalvand, A1
Safari, S1
Mazinanian, A1
Shimizu, T1
Kawasaki, Y1
Ochiai, E1
Kisanuki, A1
Furuichi, S1
Yasuda, S1
Arita, Y1
Miyawaki, M1
Nomura, K1
Nonogi, H1
Shindo, T1
Malinovsky, JM1
Mertes, PM1
Demoly, P1
Trcka, J1
Schmidt, C1
Seitz, CS1
Bröcker, EB1
Gross, GE1
Trautmann, A1
Confino-Cohen, R1
Barak, N1
Goldberg, A1
Mekori, YA1
Mikkonen, R1
Kontkanen, T1
Kivisaari, L1
Baxter, AB1
Lazarus, SC1
Brasch, RC1
Baltaoğlu, F1
Balkancì, F1
Tìrnaksìz, B1
Szolar, DH1
Saeed, M1
Flueckiger, F1
Preidler, K1
Stiskal, MA1
Watzinger, N1
Riepl, T1
Horina, J1
Javeed, N1
Javeed, H1
Javeed, S1
Moussa, G1
Wong, P1
Rezai, F1
McHugh, K1
Shaw, M1
Dewachter, P1
Mouton-Faivre, C1
Nakamura, I1
Hori, S1
Funabiki, T1
Sekine, K1
Kimura, H1
Fujishima, S1
Aoki, K1
Kuribayashi, S1
Aikawa, N1
Agìldere, AM1
Halìloglu, M1
Cìla, A1
Ozmen, M1
Siegle, RL1
Halvorsen, RA1
Dillon, J1
Gavant, ML1
Halpern, E1
Hoem, NO1
Briseid, G1
Ekelund, S1
Salvesen, S1

Reviews

2 reviews available for iohexol and Anaphylactic Reaction

ArticleYear
[Anaphylactoid reactions to radiocontrast media].
    Harefuah, 1995, Volume: 129, Issue:1-2

    Topics: Anaphylaxis; Contrast Media; Drug Hypersensitivity; Humans; Iohexol

1995
Refractory anaphylactoid shock potentiated by beta-blockers.
    Catheterization and cardiovascular diagnosis, 1996, Volume: 39, Issue:4

    Topics: Adrenergic beta-Antagonists; Anaphylaxis; Angina Pectoris; Atenolol; Cardiac Catheterization; Combin

1996

Trials

1 trial available for iohexol and Anaphylactic Reaction

ArticleYear
The use of iohexol in patients with previous reactions to ionic contrast material. A multicenter clinical trial.
    Investigative radiology, 1991, Volume: 26, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Anaphylaxis; Diphenhydramine; Ephedrine; Female; Humans; Iohexol; Ma

1991

Other Studies

22 other studies available for iohexol and Anaphylactic Reaction

ArticleYear
Risk factors of anaphylaxis in Korea: Identifying drug-induced anaphylaxis culprits using big data.
    Medicine, 2022, Sep-02, Volume: 101, Issue:35

    Topics: Anaphylaxis; Big Data; Cefaclor; Cross-Over Studies; Drug Hypersensitivity; Humans; Iohexol; Retrosp

2022
Allergic myocardial infarction (Kounis Syndrome)- non-ST elevation MI following Omnipaque contrast.
    The American journal of emergency medicine, 2023, Volume: 67

    Topics: Acute Coronary Syndrome; Anaphylaxis; Humans; Iohexol; Kounis Syndrome

2023
HLA-DRB1*15: 02 Is Associated With Iodinated Contrast Media-Related Anaphylaxis.
    Investigative radiology, 2020, Volume: 55, Issue:5

    Topics: Anaphylaxis; Case-Control Studies; Contrast Media; Female; Gene Frequency; Genetic Predisposition to

2020
MRGPRX2 mediates immediate-type pseudo-allergic reactions induced by iodine-containing iohexol.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 137

    Topics: Anaphylaxis; Animals; Calcium; Contrast Media; Cytokines; Drug Hypersensitivity; Extravasation of Di

2021
Successful Graded Dose Challenge to Iodixanol Radiocontrast Media in a Patient With Delayed Anaphylaxis to Iohexol.
    Vascular and endovascular surgery, 2018, Volume: 52, Issue:1

    Topics: Aged, 80 and over; Anaphylaxis; Angiography; Anti-Allergic Agents; Contrast Media; Drug Administrati

2018
Hypothesized Epitope Localization in Hypersensitivity Reactions to Iodinated Contrast Media.
    Journal of investigational allergology & clinical immunology, 2019, Volume: 29, Issue:1

    Topics: Aged; Anaphylaxis; Basophils; Contrast Media; Drug Hypersensitivity; Epitopes; Female; Humans; Immun

2019
The potential utility of iodinated contrast media (ICM) skin testing in patients with ICM hypersensitivity.
    Journal of Korean medical science, 2015, Volume: 30, Issue:3

    Topics: Anaphylaxis; Contrast Media; Cross Reactions; Dermatitis, Contact; Drug Hypersensitivity; Female; Hu

2015
Cardiopulmonary arrest in a cat as a result of a suspected anaphylactic reaction to an intravenously administered iodinated contrast agent.
    Veterinary anaesthesia and analgesia, 2015, Volume: 42, Issue:5

    Topics: Anaphylaxis; Animals; Cat Diseases; Cats; Contrast Media; Diagnosis, Differential; Fatal Outcome; Fe

2015
Status epilepticus after myelography with iohexol (Omnipaque).
    The American journal of emergency medicine, 2012, Volume: 30, Issue:9

    Topics: Anaphylaxis; Contrast Media; Disseminated Intravascular Coagulation; Fatal Outcome; Heart Arrest; Hu

2012
[A fatal case of anaphylactoid shock after administration of nonionic contrast medium].
    Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica, 2002, Volume: 62, Issue:13

    Topics: Aged; Anaphylaxis; Autopsy; Contrast Media; Edema; Fatal Outcome; Female; Humans; Injections, Intrav

2002
Gadopentetate dimeglumine as a potential alternative contrast medium during percutaneous coronary intervention: a case report.
    Circulation journal : official journal of the Japanese Circulation Society, 2004, Volume: 68, Issue:10

    Topics: Aged; Anaphylaxis; Angiography, Digital Subtraction; Angioplasty, Balloon, Coronary; Anti-Inflammato

2004
[Iodine allergy: myth or reality?].
    Annales francaises d'anesthesie et de reanimation, 2005, Volume: 24, Issue:1

    Topics: Anaphylaxis; Anesthesia; Contrast Media; Drug Hypersensitivity; Humans; Iodine; Iohexol; Povidone-Io

2005
Anaphylaxis to iodinated contrast material: nonallergic hypersensitivity or IgE-mediated allergy?
    AJR. American journal of roentgenology, 2008, Volume: 190, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Anaphylaxis; Basophil Degranulation Test; Cohort Studies; Contrast M

2008
Late and acute adverse reactions to iohexol in a pediatric population.
    Pediatric radiology, 1995, Volume: 25, Issue:5

    Topics: Acute Disease; Adolescent; Adult; Anaphylaxis; Body Weight; Child, Preschool; Contrast Media; Drug H

1995
In vitro histamine release induced by magnetic resonance imaging and iodinated contrast media.
    Investigative radiology, 1993, Volume: 28, Issue:4

    Topics: Anaphylaxis; Animals; Cell Line; Contrast Media; Diatrizoate Meglumine; Dogs; Gadolinium; Gadolinium

1993
Fatal reaction after intraarterial injection of nonionic contrast medium.
    AJR. American journal of roentgenology, 1994, Volume: 162, Issue:1

    Topics: Anaphylaxis; Contrast Media; Fatal Outcome; Humans; Injections, Intra-Arterial; Iohexol; Male; Middl

1994
Pulmonary hypertension. Response of vasoactive peptides to a nonionic contrast medium in patients undergoing pulmonary angiography.
    Investigative radiology, 1995, Volume: 30, Issue:9

    Topics: Adult; Aged; Aldosterone; Anaphylaxis; Angiography, Digital Subtraction; Angiotensin II; Atrial Natr

1995
Prophylaxis in asthmatic patients prior to intravenous contrast.
    Pediatric radiology, 1999, Volume: 29, Issue:1

    Topics: Adult; Anaphylaxis; Asthma; Child; Contrast Media; Drug Administration Schedule; Follow-Up Studies;

1999
[Severe reactions to iodinated contrast agents: is anaphylaxis responsible?].
    Journal de radiologie, 2001, Volume: 82, Issue:9 Pt 1

    Topics: Aged; Aged, 80 and over; Anaphylaxis; Contrast Media; Female; Humans; Iohexol; Ioxaglic Acid; Male;

2001
Cardiopulmonary arrest induced by anaphylactoid reaction with contrast media.
    Resuscitation, 2002, Volume: 53, Issue:2

    Topics: Adrenergic Agonists; Adult; Anaphylaxis; Contrast Media; Electrocardiography; Epinephrine; Female; G

2002
Laryngeal edema, following the injection of iohexol into the subarachnoid space.
    Neuroradiology, 1991, Volume: 33, Issue:3

    Topics: Adult; Anaphylaxis; Humans; Injections, Spinal; Iohexol; Laryngeal Edema; Male; Myelography

1991
Effects of intravenous radiographic contrast media on the blood pressure and on factors of the contact activation system in the rat.
    Acta pharmacologica et toxicologica, 1986, Volume: 59, Issue:3

    Topics: Anaphylaxis; Animals; Benzamidines; Blood Pressure; Contrast Media; Dextrans; Esterases; Factor XII;

1986