Page last updated: 2024-10-29

iofetamine and Intracranial Aneurysm

iofetamine has been researched along with Intracranial Aneurysm in 8 studies

Iofetamine: An amphetamine analog that is rapidly taken up by the lungs and from there redistributed primarily to the brain and liver. It is used in brain radionuclide scanning with I-123.

Intracranial Aneurysm: Abnormal outpouching in the wall of intracranial blood vessels. Most common are the saccular (berry) aneurysms located at branch points in CIRCLE OF WILLIS at the base of the brain. Vessel rupture results in SUBARACHNOID HEMORRHAGE or INTRACRANIAL HEMORRHAGES. Giant aneurysms (

Research Excerpts

ExcerptRelevanceReference
"Prediction of cerebral infarction due to vasospasm (VS) following aneurysmal subarachnoid haemorrhage (SAH) was investigated using acetazolamide-activated (A-A) N-isopropyl-p-[123I]iodoamphetamine (123I-IMP) single photon emission computed tomography (SPECT) in 79 SAH patients."7.68Prediction of cerebral infarction due to vasospasm following aneurysmal subarachnoid haemorrhage using acetazolamide-activated 123I-IMP SPECT. ( Funakoshi, T; Kimura, T; Shinoda, J, 1993)
"Prediction of cerebral infarction due to vasospasm (VS) following aneurysmal subarachnoid haemorrhage (SAH) was investigated using acetazolamide-activated (A-A) N-isopropyl-p-[123I]iodoamphetamine (123I-IMP) single photon emission computed tomography (SPECT) in 79 SAH patients."3.68Prediction of cerebral infarction due to vasospasm following aneurysmal subarachnoid haemorrhage using acetazolamide-activated 123I-IMP SPECT. ( Funakoshi, T; Kimura, T; Shinoda, J, 1993)
"Chronic hydrocephalus after aneurysmal sub-arachnoid haemorrhage (SAH) is easily diagnosed in most cases."2.69Role of 123I-IMP SPET in the early diagnosis of borderline chronic hydrocephalus after aneurysmal subarachnoid haemorrhage. ( Kondoh, I; Ohkuma, H; Suzuki, S; Tanaka, M, 2000)
"Postoperative amnesia after surgery for anterior communicating artery aneurysm might be associated with the damage of the basal forebrain."1.56Relationship between decreased cerebral blood flow and amnesia after microsurgery for anterior communicating artery aneurysm. ( Kikuchi, H; Mori, E; Mori, N; Mugikura, S; Takahashi, S; Takase, K, 2020)
"After recovery from symptomatic cerebral vasospasm, the patient became restless and suffered from right hemiparesis on post-SAH day 12."1.56Symptomatic Cerebral Hyperperfusion After Cerebral Vasospasm Associated with Aneurysmal Subarachnoid Hemorrhage. ( Endo, H; Fujimura, M; Niizuma, K; Sakata, H; Tominaga, T, 2020)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19901 (12.50)18.7374
1990's3 (37.50)18.2507
2000's2 (25.00)29.6817
2010's0 (0.00)24.3611
2020's2 (25.00)2.80

Authors

AuthorsStudies
Mugikura, S1
Mori, N1
Kikuchi, H1
Mori, E1
Takahashi, S1
Takase, K1
Sakata, H1
Endo, H1
Fujimura, M1
Niizuma, K1
Tominaga, T1
Ohkuma, H2
Suzuki, S2
Kudo, K1
Islam, S1
Kikkawa, T1
Walker, BS1
Mathews, D1
Batjer, H1
Allen, BC1
Purdy, PD1
Kimura, T1
Shinoda, J1
Funakoshi, T1
Tanaka, M1
Kondoh, I1
Kamiya, K1
Yamashita, N1
Nagai, H1
Mizawa, I1
Ueda, T1
Kinoshita, K1
Watanabe, K1
Hoshi, H1
Jinnouchi, S1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
C-arm Cone Beam CTA and CTP With Acetazolamide Challenge in Aneurysmal Subarachnoid Hemorrhage: Evaluating Predictability for Early Ischemia in Cerebral Vasospasm[NCT03377049]Phase 411 participants (Actual)Interventional2019-07-28Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Number of Participants Who Develop Delayed Cerebral Vasospasm

Clinical neurological deterioration not attributable to other causes, mores specifically not due to re-bleeding, hydrocephalus, or metabolic changes. (NCT03377049)
Timeframe: Day 1-14 during the hospitalization

InterventionParticipants (Count of Participants)
Acetazolamide Challenge2

Percent Change in Left Hemisphere Brain Imaging Maps

Using perfusion map values, relative percent change will be calculated (NCT03377049)
Timeframe: pre and post perfusion during imaging procedure, up to an hour

Interventionpercent change (Mean)
Acetazolamide Challenge19.785

Percent Change in Right Hemisphere Brain Imaging Maps

Using perfusion map values, relative percent change will be calculated (NCT03377049)
Timeframe: pre and post perfusion during imaging procedure, up to an hour

Interventionpercent change (Mean)
Acetazolamide Challenge21.659

Relative Percent Change in Cerebral Blood Flow

The data that will be statistically compared is the pre-diamox perfusion in comparison to the post-diamox perfusion. A statistically significant change increase in CBF represents an appropriate response to Diamox. Lack of change in CBF or decrease in CBF could be suggestive of potential for developing vasospasm. (NCT03377049)
Timeframe: pre and post perfusion during imaging procedure, up to an hour

Interventionpercent change (Mean)
Acetazolamide Challenge20.722

Trials

1 trial available for iofetamine and Intracranial Aneurysm

ArticleYear
Role of 123I-IMP SPET in the early diagnosis of borderline chronic hydrocephalus after aneurysmal subarachnoid haemorrhage.
    European journal of nuclear medicine, 2000, Volume: 27, Issue:5

    Topics: Aged; Cerebral Ventricles; Cerebrovascular Circulation; Female; Humans; Hydrocephalus; Intracranial

2000

Other Studies

7 other studies available for iofetamine and Intracranial Aneurysm

ArticleYear
Relationship between decreased cerebral blood flow and amnesia after microsurgery for anterior communicating artery aneurysm.
    Annals of nuclear medicine, 2020, Volume: 34, Issue:3

    Topics: Adult; Aged; Amnesia; Basal Forebrain; Brain Mapping; Cerebrovascular Circulation; Female; Gyrus Cin

2020
Symptomatic Cerebral Hyperperfusion After Cerebral Vasospasm Associated with Aneurysmal Subarachnoid Hemorrhage.
    World neurosurgery, 2020, Volume: 137

    Topics: Aged; Aneurysm, Ruptured; Antihypertensive Agents; Cerebral Angiography; Cerebrovascular Circulation

2020
Cortical blood flow during cerebral vasospasm after aneurysmal subarachnoid hemorrhage: three-dimensional N-isopropyl-p-[(123)I]iodoamphetamine single photon emission CT findings.
    AJNR. American journal of neuroradiology, 2003, Volume: 24, Issue:3

    Topics: Adult; Aged; Angiography, Digital Subtraction; Blood Flow Velocity; Blood Volume; Brain Ischemia; Ce

2003
Detection of cerebral hypoperfusion during trial carotid occlusion with reversal following extracranial-intracranial bypass prior to permanent occlusion.
    Clinical nuclear medicine, 1994, Volume: 19, Issue:6

    Topics: Aged; Amphetamines; Brain; Carotid Artery Diseases; Carotid Artery, Internal; Catheterization; Cereb

1994
Prediction of cerebral infarction due to vasospasm following aneurysmal subarachnoid haemorrhage using acetazolamide-activated 123I-IMP SPECT.
    Acta neurochirurgica, 1993, Volume: 123, Issue:3-4

    Topics: Acetazolamide; Adult; Aged; Aged, 80 and over; Amphetamines; Aneurysm, Ruptured; Brain; Cerebral Inf

1993
Investigation of normal pressure hydrocephalus by 123I-IMP SPECT.
    Neurologia medico-chirurgica, 1991, Volume: 31, Issue:8

    Topics: Aged; Amphetamines; Brain Diseases; Cerebrospinal Fluid Shunts; Cerebrovascular Circulation; Frontal

1991
[Local cerebral blood flow measurement using 123I-IMP SPECT in patients with cerebrovascular diseases].
    Neurologia medico-chirurgica, 1987, Volume: 27, Issue:5

    Topics: Adult; Amphetamines; Brain; Cerebrovascular Circulation; Cerebrovascular Disorders; Female; Humans;

1987