iodouracil and Sarcoma-180

Complexes of 5-iodouracil (5IU) with Mn(II), Co(II), Cu(II), Zn(II), and Cd(II) ions have been prepared, characterized, and subjected to a screening system for evaluation of antitumor activity against Sarcoma-180 (S-180) and L 929 tumor cells. The complexes were characterized by their elemental analysis, infrared spectra, electronic spectra, magnetic measurements, and powder x-ray diffraction. The antitumor activity results indicate that some complexes have good antitumor activity both in vivo and in vitro against S-180 and L 929 tumor cells.

Topics: Animals; Antineoplastic Agents; Cadmium; Cobalt; Copper; Electron Spin Resonance Spectroscopy; Female; Male; Manganese; Mice; Mice, Inbred C3H; Molecular Structure; Neoplasm Transplantation; Neoplasms, Experimental; Sarcoma 180; Spectrophotometry, Infrared; Uracil; X-Ray Diffraction; Zinc