iodohydroxybenzylpindolol and Bipolar-Disorder

Binding of 125I-iodohydroxybenzylpindolol to beta-adrenoceptors has been examined in lymphoblastoid cell lines from members of 5 families affected by manic-depressive disorder. Cell lines from 6 manic-depressives, 7 unaffected relatives and 11 non-psychiatric controls were examined. Binding was reduced to less than half of control values in cell lines from 4 out of 6 manic-depressives and only 1 out of 18 unaffected relatives or controls. All the cell lines with reduced beta-adrenoceptor binding came from 3 families; members of the remaining 2 families showed normal binding. These findings suggest that genetic heterogeneity is present in manic-depressive disorder and that a beta-adrenoceptor defect may influence genetic susceptibility to the disorder.

Topics: 5'-Nucleotidase; Adolescent; Adult; B-Lymphocytes; Bipolar Disorder; Cell Line; Female; Humans; Male; Nucleotidases; Ouabain; Pedigree; Pindolol; Receptors, Adrenergic, beta