iododiflunisal has been researched along with Amyloid-Neuropathies--Familial* in 1 studies
1 other study(ies) available for iododiflunisal and Amyloid-Neuropathies--Familial
| Article | Year |
|---|---|
Tuning transthyretin amyloidosis inhibition properties of iododiflunisal by combinatorial engineering of the nonsalicylic ring substitutions.
Two series of iododiflunisal and diflunisal analogues have been obtained by using a two step sequential reaction solution-phase parallel synthesis. The synthesis combined an aqueous Suzuki-Miyaura cross-coupling and a mild electrophilic aromatic iodination step using a new polymer-supported iodonium version of Barluenga's reagent. From a selected set of 77 noniodinated and 77 iodinated diflunisal analogues, a subset of good transthyretin amyloid inhibitors has been obtained with improved turbidimetry inhibition constants, high binding affinity to transthyretin, and good selectivity for TTR compared to other thyroxine binding proteins. Topics: Amyloid Neuropathies, Familial; Combinatorial Chemistry Techniques; Diflunisal; Humans; Structure-Activity Relationship | 2015 |